HI,你们好,
这个是我的临床实验设计。
医院----randomization-----A or B---在每个subgroup的病人,再进行
randomization,C OR D。在接下来的12 个月内,每个病人有3 次repeated
measurements for the outcome response。
Q1。 想知道intervention effect on outcome.
OUTCOME1(BINARY)
proc glimmix ;
class Hosp_id time trt_grp patient_id;
model outcome=trt_grp|time/link=logit dist=binomial solution;
random intercept/subject=Hosp_id type=un solution;
random time/subject=patient_id type=cs residual S;
run;
Fist it is like 3-level model,is any problem?
OUTCOME2(Continuous)
proc mixed ;
class Hosp_id time trt_grp patient_id;
model outcome= trt_grp|Time / s ;
random Hosp_id ;
Repeated time /type=un subject=pid r rcorr;
run;
Q2。有很多MISSING DATA。
怎么解决