o***o
发帖数: 194 | 1 http://www.mdlinx.com/news/third-mrna-dose-may-boost-antibody-quantity-but-not-quality/6kFMU0APF29etRp4tIzULz
抗原原罪
Among fully vaccinated people who never had COVID-19, getting a third dose
of an mRNA vaccine from Pfizer/BioNTech or Moderna would likely increase
levels of antibodies, but not antibodies that are better able to neutralize
new virus variants, Rockefeller University researchers reported on bioRxiv
ahead of peer review.
They note that in COVID-19 survivors, the immune system's antibodies evolve
during the first year, becoming more potent and better able to resist new
variants.
In 32 volunteers who never had COVID-19, they found that antibodies induced
by mRNA vaccines did evolve between the first and second shots. But five
months later, vaccine-induced antibodies were "equivalent" to those seen
after the second dose, with "little measurable improvement" in the
antibodies' ability to neutralize a broad variety of new variants, said
coauthor Michel Nussenzweig.
Therefore, he said, giving those individuals a third dose of the same
vaccine would likely result in higher levels of antibodies that remain less
effective against variants. | o***o
发帖数: 194 | 2 新冠自然感染痊愈的抗体，可以对付变种
自然感染更好
第三针看来就是为了对付ADE的，效率差的抗体变不了，只能boost了 | l*****u
发帖数: 94 | 3 你把一个关键定语给忽略了“... a third dose of the same vaccine ...”。但是第
三针未必是“same vaccine”。比如辉瑞7月初初宣布的boost是针对Delta开发的，和
以前的并不完全一样。 | o***o
发帖数: 194 | 4 产生针对delta的抗体失败了，这就是文章的意思
抗原原罪，你自己查一下啥意思，看一下文章日期
【在 l*****u 的大作中提到】
: 你把一个关键定语给忽略了“... a third dose of the same vaccine ...”。但是第
: 三针未必是“same vaccine”。比如辉瑞7月初初宣布的boost是针对Delta开发的，和
: 以前的并不完全一样。
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