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发帖数: 194 | 1 https://www.researchsquare.com/article/rs-1749502/v1
risk and burden of sequelae in people with SARS-CoV-2 reinfection vs one
infection by vaccination status prior to second infection. Risk of all-cause
mortality, hospitalization, at least one sequela, and sequelae by organ
system are plotted. Incident outcomes were assessed from reinfection to end
of follow-up. Results are in comparison of SARS-CoV-2 reinfection (n=38,926)
to first SARS-CoV-2 infection (n=257,427). At time of comparison, there
were 69.49%, 9.09%, and 21.42% with no, one, and two or more vaccinations,
respectively, among those with reinfection. At time of comparison, there
were 59.86%, 9.18%, and 30.96% with no, one, and two or more vaccinations,
respectively, among the first reinfection group. Adjusted hazard ratios (
dots) and 95% confidence intervals (error bars) are presented.
Those with reinfections had a higher risk of all-cause mortality, with HR of
2.14 and an excess burden of all-cause mortality of 23.8 per 1000 persons
at six months. These individuals also had a higher hospitalization risk,
with an HR of 2.98. In addition, people with reinfection exhibited an
increased risk of sequelae in the pulmonary and several extrapulmonary organ
systems. Accordingly, reinfection increased the risk of adverse health
outcomes in people with cardiovascular disorders, kidney problems,
gastrointestinal issues, and musculoskeletal and neurological disorders.
Overall, reinfection adversely impacted several extrapulmonary organ systems
and the pulmonary system. |
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