e****o
发帖数: 268 | 1 Press Release
5 October 2009
The Nobel Assembly at Karolinska Institutet has today decided to award
The Nobel Prize in Physiology or Medicine 2009 jointly to
Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak
for the discovery of
"how chromosomes are protected by telomeres and the enzyme telomerase"
Summary
This year's Nobel Prize in Physiology or Medicine is awarded to three
scientists who have solved a major problem in biology: how the chromosomes
can be copied in a complete way duri | a****o
发帖数: 1786 | | m****g
发帖数: 530 | 3 one of my friends is working for szostak in mgh, he is a nice guy, never
push people. | m****g
发帖数: 530 | 4 how long has been for Harvard Med not obtain a Nobel? 20 years? | s****y
发帖数: 682 | 5 wow, this kind of faculty is really rare at HMS
【在 m****g 的大作中提到】
: one of my friends is working for szostak in mgh, he is a nice guy, never
: push people.
| s****y
发帖数: 682 | 6 To be honest, I don't see the impact of telemerase on medicine as much as
signal pathways or even siRNA. Someone proves me wrong please.
【在 a****o 的大作中提到】
: 前两年刚得Lasker Award，早该得了
| a****o
发帖数: 1786 | 7 telomere gets shorter after cells devide for many times and cause cell death
(aging). To be imortal (cancer cells or stem cells), telomerase need to be
active to repair chromosome ends. If you can inhibit telomerase activity,
you should be able to limit proliferation of cancer cells.
I don't believe what I wrote already.
someone in caner field please write something.
【在 s****y 的大作中提到】
: To be honest, I don't see the impact of telemerase on medicine as much as
: signal pathways or even siRNA. Someone proves me wrong please.
| m****g
发帖数: 530 | 8 1. therapeutically targeting RNA is not a preferred drug discovery program,
at least until now, because selectivity can not be controlled, hence the
mechanistic side effects would be a big concern and under current drug
regualtion it would not get approved. unless there is a significant break
through in the manipulating RNA or DNA's structure, in the near future those
can only be thought as great ideas but lacking the practical application
bases. of course, just like the signal transduction pa | a****o
发帖数: 1786 | 9 good to know.
Why inhibit telomerase activity is insufficient to inhibit tumor? Is there
other forms of telomerases, or cells use other means such as recombination,
ligation to repair telomere?
,
those
pharma
【在 m****g 的大作中提到】
: 1. therapeutically targeting RNA is not a preferred drug discovery program,
: at least until now, because selectivity can not be controlled, hence the
: mechanistic side effects would be a big concern and under current drug
: regualtion it would not get approved. unless there is a significant break
: through in the manipulating RNA or DNA's structure, in the near future those
: can only be thought as great ideas but lacking the practical application
: bases. of course, just like the signal transduction pa
| m****g
发帖数: 530 | 10 that is a good question, I can not give a clear answer. generally speaking,
only critical way could be served as drug target, for example, if you want
to go to NYC, you have choice of driving car, ride your bike, walk to there,
or take flight. if you want block people to NYC, you should consider all
these possibilities, apparently, you may have difficulty in blocking
people from walking, or bike, the flight might be easiest way to block it.
same on drug discovery, some targets blocking can |
|
