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最新进展！非洲猪瘟疫苗创制成功，向产业化应用迈出坚实一步
2020-03-01 11:15 来源:澎湃新闻
原标题：最新进展！非洲猪瘟疫苗创制成功，向产业化应用迈出坚实一步
中国农业科学院哈尔滨兽医研究所在SCIENCE CHINA Life Sciences（《中国科学：生
命科学》英文版）在线发表了题为”A seven-gene-deleted African swine fever
virus is safe and effective as a live attenuated vaccine in pigs”的研究论文
，报道了一株人工缺失七个基因的非洲猪瘟弱毒活疫苗对家猪具有良好的安全性和有效
性。
非洲猪瘟是由非洲猪瘟病毒（ASFV）引起的一种急性、烈性、高度接触性传染病，发病
率和致死率可高达100%，给全球养猪业造成严重影响。非洲猪瘟自2018年8月以来在全
国范围内大规模爆发流行，使我国生猪出栏量减少40%，猪肉价格翻了一倍。依靠生物
安全和扑杀措施控制非洲猪瘟难度极大，迫切需要研发有效疫苗。
基因缺失减毒活疫苗被认为是非洲猪瘟... 阅读全帖 |
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f***y
发帖数: 4447 | 2 中国农业科学院哈尔滨兽医研究所在SCIENCE CHINA Life Sciences（《中国科学：生
命科学》英文版）在线发表了题为”A seven-gene-deleted African swine fever
virus is safe and effective as a live attenuated vaccine in pigs”的研究论文
，报道了一株人工缺失七个基因的非洲猪瘟弱毒活疫苗对家猪具有良好的安全性和有效
性。
非洲猪瘟是由非洲猪瘟病毒（ASFV）引起的一种急性、烈性、高度接触性传染病，发病
率和致死率可高达100%，给全球养猪业造成严重影响。非洲猪瘟自2018年8月以来在全
国范围内大规模爆发流行，使我国生猪出栏量减少40%，猪肉价格翻了一倍。依靠生物
安全和扑杀措施控制非洲猪瘟难度极大，迫切需要研发有效疫苗。
基因缺失减毒活疫苗被认为是非洲猪瘟疫苗最有希望的研发技术策略。研究人员以我国
第一株非洲猪瘟病毒分离株Pig/HLJ/2018为骨架，利用同源重组技术构建了一系列具有
不同基因缺失的重组病毒（图1）。通过在猪体内进行的系统的致病力、免疫原性和免
疫... 阅读全帖 |
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N***r
发帖数: 2539 | 3 大气相当于十米厚的水是从气压这个方面说的。
rho(water)*g*h(water) = 1atm
h(water) = 10m
而从“挡住宇宙射线”的角度说，两者并不是一回事。
这是另一个话题，Radiation Attenuation，不同的物质对不同射线有不同的衰减作用
，机理也不同。比如轻核物质对alpha粒子的防护比较好，而重核物质对gamma射线的防
护比较好。所以你会经常听见铅砖阿，铅防辐射服一类的东西。 |
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N***r
发帖数: 2539 | 4 对于xray，干空气和水的mass attenuation coefficient还真是基本重合的，你牛，学辐射防护的？ |
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m******1
发帖数: 19713 | 5 Fed Judge Won't Throw Out Prop. 8 Decision
By Andrew Harmon
VAUGHN WALKER X390 (SFGATE) | ADVOCATE.COM
Supporters of California’s Proposition 8 were dealt a blow Tuesday when a
federal judge refused their request to throw out Judge Vaughn Walker’s
trial court decision because he is in a same-sex relationship.
“The sole fact that a federal judge shares the same circumstances or
persnal characteristics with other members of the general public, and that
the judge could be affected by the outcome of... 阅读全帖 |
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l****z
发帖数: 29846 | 6 By John W. Howard
As perennial as the season itself, is the annual emergence of the secular
left to file lawsuits challenging the presence of Christian symbols, however
benign, on public property. It is, I suppose, a festive tradition for some
whose lives are otherwise joyless except to the extent they can snatch
seasonal delight from others who enjoy more spiritual richness with which to
color their days.
So, as the Christmas season winds down, the good citizens of Flathead Valley
, Colorado, ... 阅读全帖 |
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t**x
发帖数: 20965 | 7 请你仔细看看，
良性的三个报告。其中一个是这个德国医生自己的，他承认自己从来没有看过。第一个
genedx，是我们出院(04/13)后一个月报的(05/13)， 这个极有可能就是我们宝宝的结
果，被报呈良性。
https://www.ncbi.nlm.nih.gov/clinvar/variation/92429/
这个变异发现10多年，欧洲基因库收录为恶性。只有美国报称良性，在我们宝宝刚刚出
院。你真得仔细看看时间和事情了。
你没有看到跨国界作假反而。。。你看看荷兰医生的回信。我真怀疑你到底是干什么的
？
这个变异发现了10多年了， 这个德国医生的链接的文献没有说是良性的， 你自己看看
下面德国医生附上的文献。我不是医生，我看不出来说这个变异是良性的。你如果愿意
看看我家宝宝cpt2的两个结果， 一个1.5%酶活性，一个15%酶活性，跟下面的温度相关
吻合得多好。
我家宝宝的下降更多，大概是因为他的变异更多。这个特征的变异很多年了，但是
cchmc和Baylor都没有查出来。你说说他们不知道？！
Here the excerpt von OMIM regarding this mut... 阅读全帖 |
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t**x
发帖数: 20965 | 8 yangyi和aning我没有跟她/他斗， 我劝你们好好看看德国医生给的参考资料, 这个资
料你怎么得出是benign的结论的：
0018 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 4
CPT2, PHE352CYS AND VAL368ILE [dbSNP:rs2229291] [dbSNP:rs1799821] [ClinVar]
Chen et al. (2005) found an association between 2 thermolabile polymorphisms
in the CPT1 gene and susceptibility to infection-induced acute
encephalopathy-4 (IIAE4; 614212) in Japanese children. The variants were a
1055T-G transversion, resulting in a phe352-to-cys (F352C) substitution (
rs... 阅读全帖 |
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t**x
发帖数: 20965 | 9 我可以跟你说这个写这个文章的医生是一个十恶不赦的王八蛋！因为这个德国医生就是
跟西雅图儿童医院勾结的个婊子养的畜生。
这是我的信：
Von: Andrew Xie [mailto:[email protected]/* */]
Gesendet: Montag, 19. September 2016 13:24
An: Wieser, Dr. Thomas, Chefarzt
Betreff: RE: Question on a benign mutation / NM_000098.2(CPT2):c.1102G>A (p.
Val368Ile) Simple - Variation Report - ClinVar – NCBI
Dear Dr. Wieser,
Thanks for your reply.
In the link it says 3 sources reporting ‘benign’ :
1. GeneDX on May 29, 2013
2. Emory Genetics Laboratory on Apr 16, 2014... 阅读全帖 |
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c******y
发帖数: 114 | 10 这个路噪/风噪纯粹是被ConsumerReports炒起来的。他们在这辆车上实在找不出其他缺
点，就把这个夸大了。
70MPH巡航的噪音水平比较：
CX-5: 70 dB
Forester: 70 dB
RAV-4: 69 dB.
2016款new sound attenuation material让噪音水平比2015款再降10%。 |
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c******y
发帖数: 114 | 11 这个路噪/风噪纯粹是被ConsumerReports炒起来的。他们在这辆车上实在找不出其他缺
点，就把这个夸大了。
70MPH巡航的噪音水平比较：
CX-5: 70 dB
Forester: 70 dB
RAV-4: 69 dB.
2016款new sound attenuation material让噪音水平比2015款再降10%。 |
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f*i
发帖数: 531 | 12 【 以下文字转载自 HiFi 讨论区 】
发信人: fei (嘻嘻), 信区: HiFi
标 题: Yard sale on some AV accessories and home appliances
发信站: BBS 未名空间站 (Sun Apr 3 22:47:20 2011, 美东)
Audio Video
- Apex DVD player, also play MP3, JPEG etc, with Karaoke dual mic inputs
and echo function, $10 obo, no original remote, an universal remote included
- Component video cables: 32 ft NXG Pro Sapphire Series, not sure the
wire gauge anymore, bought long time ago, but thick enough with no
antenuation of video signal $20 obo (same as ... 阅读全帖 |
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f*******e
发帖数: 8974 | 13 嗯，这是琴谱的数据，我那套东西的数据晚上找找
Input Power
110V-240V AVAILABLE
Output Tube
16.5W×2 (8Ω RMS)
Vacuum Tube
6N3 x2
Harmonic Distortion
< 2%
Crosstalk Attenuation
>50dB
Frequency
20Hz-50kHz
Signal/Noise Ratio
>80dB (A weight)
Overloading Level
>20V
Input Impedance
10KΩ
Input sensitivity
450mV
Load Impedance
8ohms
Audio Output
2 groups speaker out, 1 x 3.5 mini jack out (Line/Phone)
Audio Input
1 x RCA, 1 x Aux, 1 x MP3/I-pod |
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a**d
发帖数: 4285 | 14 跟我开始用ＳＵＰＥＲ Ｔ推ＡＫＧ ２４０的感觉一样，按照网上说的，每声道的正
相（红线）串了个水泥电阻，能听了。去ＲＡＤＩＯ ＳＨＡＣＫ看看有没有承受电压
等指标够用的试试，应该没多钱。 |
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z*a
发帖数: 92 | 15 还查到有个 Shure Level Attenuator，哪个好一些？ |
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D**********s
发帖数: 3139 | 17 堆着比较占地方，试着买一下，觉得价钱不好可以砍价。
Sony dvp s9000es 75+shipping
朋友家抱回来的一直也没用，cleaned and ready to work，遥控器找不到了。很久以
前左侧面蹭了一下墙，留了几道白。其他没什么问题。
Pioneer elite dv37 60+shipping
Everything like new in box。以前看dvd用，CD嘛基本不读刻录碟。
# Dual 96KHz/24-bit Audio DAC for superb sound quality
* 3 Chamber Isolation (Video / Audio / Power Supply)
* Double Layered Chassis for chassis stability
* Acoustic Damper Tray for supressing transport noise
Analog Output x 2
Grundig satellit 800 250+shipping
Drake比较早期的一批，短波接收一般，noise floo... 阅读全帖 |
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d******0
发帖数: 22800 | 22 我觉得煲了40小时到位了，今天早上和昨晚听到没啥变化了。
找到一片review，里面说到t7和HD25的比较，正是我的感觉，比我用词表达得好多了，
http://www.headfonia.com/a-dynamic-driver-fostex-fostex-th-7b/
。。。The treble is smooth, not as bright as the Sennheiser HD25-1, but not
as dark as the Audio Technica M-50. The midrange reminds me of the smooth
Fostex T50RP midrange, but with more forward vocal presence for a more
engaging music presentation. The pace is moderate, not extremely energetic
like the HD25-1, and also not as laid back as the M-50.
我没有M50不知道，但是高音... 阅读全帖 |
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j********b
发帖数: 565 | 23 over表示已經出現波形削頂失真了，所以能听到一些distortion。如果disable 並不會
消除失真，只會由得你更大地失真。 |
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a******u
发帖数: 239 | 24 Sorry. Cannot input Chinese.
I was interviewed by GE Global yesterday. Feel bad and summarize something
here.
I searched the background of the Hiring Manager --- more than 60
publications and 90 patents! During the interview, four questions were
impressive:
1. Asked the persons / researchers in my research field. I told him some
researchers working in companies because I know them from the conference.
These researchers are managers in the opponent companies:) However, HM doesn
't know the guys.
... 阅读全帖 |
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c*********0
发帖数: 923 | 25 The Center for Infectious Diseases and Vaccinology at the Biodesign
Institute at Arizona State University is seeking applications for
postdoctoral investigators.
An expanding innovative vaccine development research program http://cidv.biodesign.asu.edu is focused on the design, construction, and evaluation of recombinant attenuated Salmonella antigen and DNA vaccine delivery vaccines to induce mucosal, systemic and/or cellular immune responses, as appropriate, to confer protection to agricultur... 阅读全帖 |
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F***Q
发帖数: 6599 | 26
RF
http://en.wikipedia.org/wiki/Non-thermal_microwave_effect
consider human body a sack of saline water, microwave attenuates
exponentially with the high conductivity ...
if you keep worrying about, it probably can cause more psychological damage
than the actual biological one ... |
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L*****a
发帖数: 3080 | 27 问了一下老公，他说chicago metra是heavy rail. He also said whether the
windows will substantially reduce the train noise or not depends on the STC
(sound transmission class) level of the windows, also it's a question of
soil type, mass, distance, landscape, visibility that would affect air borne
or ground borne vibrations, each having different characteristics and sound
attenuation techniques.
他学的就是architecture and urban planning，又在local government作相关工作，
应该比较懂行吧 |
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g*****j
发帖数: 1211 | 28 The vaccine is attenuated virus. It won't provide prevention if you don't
have immunity and have contracted the virus this time. However, it wouldn't
do you harm and can protect you from future infections.
Acyclovir won't eliminate the virus. It simply slows down the replication.
If you already contracted the virus, acyclovir may make your symptom milder
, but cannot prevent you from becoming a chronic varicella carrier |
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t*******n
发帖数: 4445 | 29 Found another article:
"Assessment of the efficacy and effectiveness of influenza
vaccines in healthy children: systematic review"
Lancet 2005; 365: 773–80
http://cmbi.bjmu.edu.cn/news/report/2005/flu/94.pdf
Summary: World-wide literature review of flu vaccine on children up to 16
yrs. When measured in terms of lab-confirmed flu cases, live attenuated
vaccine has 79% efficacy (i.e. ideal usage) and 38% effectiveness (i.e. real
-world usage). Inactivated vaccines has 65% efficacy, and in childr |
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I**********e
发帖数: 118 | 30 大概三周前开始,饭后腹部疼痛得厉害.集中在肚脐眼下部,后来就在肚脐眼四周疼痛,没
隔几分钟在上下转换,不是那种尖锐的痛,是那种揪住的感觉,后来就感觉上腹部不舒服,
感觉向上涌,犯酸,要吐又吐不出的那种.后来这疼痛一直持续了大概六七个小时就慢慢
好了.再后每隔几天发作过几次,现在不是很疼,但下腹部还是隐隐不舒服.两周前看了医
生,验血查了肝胆肾都正常,随后做了CT.CT结果如下,好象说是CBD肿大,肝部有点小东西
.听医生的建议约ERCP专家,但专家要一个月后才能见我.我现在拿不准是不是就等这个
专家,还是坚持家庭医生先做MRCP.麻烦专家指点下.多谢.
下面是我的CT报告.
Visualized intrathoracic (胸内) contents appear unremarkable. No aortic (主
动脉) dissection/transaction/aneurysm (解剖/横段/动脉瘤) identified.
Abdomen
Liver shows homogeneous enhancement with tiny faint low-attenuation |
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f*******0
发帖数: 508 | 31 求助：左下腹疼痛一个月（B超，CT, Urine test normal）
大概从一个月前发现左下腹疼痛，就是和肚脐平行靠近腰的位置，有时还放射到相同位
置的背侧疼。不分时候，白天晚上都会时不时的疼，没有规律。刚发现是站起来走路时
加重。这几天几乎一直疼。
• 疼痛一周后去见obgyn，给physically 检查了子宫什么的，说正常。
• 一周后疼痛不减，就给做了妇科的B超，也都正常。
• 又过了一周，做urine test排除肾结石，也negative.
• 当时obgyn说他能想到的一个可能是endometriosis, but need to use
laprascopy to confirm. 因为是创伤性的检查，不建议马上做。 所以先做了个之后又
做了腹部CT （oral and IV contrast）, 结果总的说也正常。具体内容如下。我怀疑
是不是liver cyst 造成的？上周我没有觉得特别不舒服。可是从周六开始，腹部疼痛
厉害。用了热敷，有点帮助。今天上班扛不住了，吃了2颗Advil 200... 阅读全帖 |
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h****n
发帖数: 2094 | 32 Lung bases clear
tiny too small to characterize low-attenuation lesions within the liver
A striated nephrogram involving both kidneys
Prominent heterogeneous uterus could relate to uterine myomas
Small right ovarian cysts partially evaluated
这是有病没病啊？谢谢！ |
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c******r
发帖数: 3778 | 33 第二章 疫苗种类介绍和常见副作用的处理
现在市场上用的疫苗有以下几种：
减毒活疫苗（attenuated）：这是从活病毒的培养中挑选出毒性低的菌株来生产的活病
毒疫苗。其好处是抗原性好，免疫效果比较明显。但是缺点是副作用一般比较明显。黄
热病、MMR（联合或者单独的疫苗）等都是减毒活疫苗。由于疫苗中有活病毒，理论上
孕妇，尤其是怀孕前三个月不应该使用活疫苗。所以为安全起见，如果需要应该在孕前
1-3个月（医生见解会有点差异）完成疫苗注射，然后再怀孕。但是，即使如此，目前
临床上还没有发现因为使用疫苗导致的流产，畸形等问题。所以如果不小心在孕早期，
或者孕前一个月内打了疫苗也不必悲观。应该是没有问题的。当然，对于计划怀孕的母
亲，这个问题还是应该尽力避免。这种疫苗由于含有活病毒，有很小的机会有可能会感
染这种病。但由于病毒毒性很低，一般不会引起严重症状。其他几类疫苗由于不含活菌
，因此不可能因为疫苗而感染。
灭活疫苗（killed）：这是把病毒或者细菌培养之后灭活，然后用灭活菌培养的疫苗。
比较常见的如流感疫苗和甲肝疫苗。由于病菌被灭活，不能复制，所以其缺点就是免疫
效果比活疫苗要打点折 |
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b********0
发帖数: 116 | 34 宝宝一岁时打了MMR（麻疹，腮腺炎，风疹）疫苗，当晚手脚发凉，然后立即高烧一整
天，两颊，下巴，胸口胳膊出疹子，打针的地方很痒，四肢皮肤肿胀，病秧秧的，5、6
天才消。
14个月的时候（5月27日）要打VZ（Live Attenuated Varicella-Zoster Vaccine, 就
是水痘）疫苗，想问一下大家，会不会反应也象MMR疫苗这样啊？很担心。
另外还约了4月13日打第一针甲肝和乙肝疫苗，5月17日还要打第二针甲肝和乙肝疫苗。
准备5月27日打VZ（水痘）疫苗, 10天后带宝宝坐飞机回国。大家觉得可行吗？ |
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w****a
发帖数: 2049 | 35 high risk ultrasound is just ultrasound for high risk mom. ultrasound is
quite safe.
Ultraschall Med. 2012 Jun;33(3):215-7. doi: 10.1055/s-0032-1312759. Epub
2012 Jun 14.
[Obstetrical ultrasound: can the fetus hear the wave and feel the heat?].
[Article in German]
Abramowicz JS, Kremkau FW, Merz E.
Abstract
"Fetuses can hear ultrasound and the sound is as loud as a subway train
entering a station." This statement originates in a single report in a non-
peer reviewed journal, despite its name 1, ... 阅读全帖 |
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r*********d
发帖数: 12 | 36 make sure you ask for preservative free flu shot
don't take flu nasal spray which is made with live attenuated virus |
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k******e
发帖数: 8870 | 37 我们单位那时也有free vaccine，一开始听说是喷的那个，我就说attenuated LIVE
virus,我不去。后来别人回来说是注射的，我才去，而且是因为家里有小孩才去,要不
就不去了。 |
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z*********8
发帖数: 1203 | 38 现在大部分疫苗都不是live attenuated vaccine啦。你这个理论过时了！ |
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c*********0
发帖数: 923 | 39 The Center for Infectious Diseases and Vaccinology at the Biodesign
Institute at Arizona State University is seeking applications for
postdoctoral investigators.
An expanding innovative vaccine development research program http://cidv.biodesign.asu.edu is focused on the design, construction, and evaluation of recombinant attenuated Salmonella antigen and DNA vaccine delivery vaccines to induce mucosal, systemic and/or cellular immune responses, as appropriate, to confer protection to agricultur... 阅读全帖 |
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d*****s
发帖数: 5610 | 41 "OPEC should not expect to see any impact on U.S. shale growth in the first
half of the year and the impact in the second half is being attenuated
significantly by producer hedging," says Ed Morse, global head of
commodities research at Citigroup, one of the biggest U.S. banks involved
hedging. |
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发帖数: 1 | 42 http://finance.yahoo.com/news/tesla-says-fatal-crash-involved-013430100.html
Tesla has provided another update to last week's fatal crash. As it turns
out, Tesla said the driver had Autopilot on with the adaptive cruise control
follow-distance set to minimum. However, it seems the driver ignored the
vehicle's warnings to take back control.
"The driver had received several visual and one audible hands-on warning
earlier in the drive and the driver’s hands were not detected on the wheel
for six se... 阅读全帖 |
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t**********8
发帖数: 404 | 43 一周前做的体检， 医生问以前做没做过PPD test, 我说没做过中国人大多数人因为打
过BCG疫苗（Attenuated Mycoplasma Bovis）应该都阳性。医生说如果以前TB test
positive, 就不用做了直接chest X-ray。没有问需不需要文件证明，还是口头说算。
结果我的是阳性，他说以后以后千万不要再做了。 |
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T**7
发帖数: 264 | 44 牙科学的顶尖杂志，影响因子是3-4之间。
这个杂志并且包含生物技术，生化，微生物，免疫学等基础学科的稿件。
稿件题目：
Mesenchymal stem cells as active pro-healing and immunosuppressive agents in
periapical environment: evidences from human and experimental periapical
lesions
摘要：
Abstract:
Introduction: Previous studies describe contrasting molecular profiles of
active and inactive periapical granulomas characterized by distinct
expression of cytokines, osteoclastogenic factors and wound healing markers.
Although the molecular mechanisms underlying such... 阅读全帖 |
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b******j
发帖数: 361 | 45 1. FGF, TGFβ and Wnt crosstalk: embryonic to in vitro cartilage development
from mesenchymal stem cells, journal of tissue engineering and regenerative
medicine.
DOI: 10.1002/term.1744
2. Enhancing human nucleus pulposus cells for biological treatment
approaches of degenerative intervertebral disc diseases: a systematic review
，journal of tissue engineering and regenerative medicine. DOI: 10.1002/term
.1583
3. Use of Knockout and Transgenic Mouse Models in Disc Research，The
Intervertebral Disc，2... 阅读全帖 |
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l******n
发帖数: 372 | 46 Journal: Journal of Pharmacy and Pharmacology, IF=2.3
Manuscript:Astralagus injection attenuates bleomycin-induced pulmonary
fibrosis via Jagged1/Notch1 signaling pathway
If you are interested and have relevant research background, please PM me a
brief summary of your research experience and publications, I will recommend
to editor.
Thanks. |
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b*********4
发帖数: 3542 | 47 vibration attenuation/sensor
站内信，留给我完整的名字和email |
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i********n
发帖数: 171 | 48 MS 1. Overview on experimental models of interactions between
nanoparticles and the immune system
MS 2. Long non-coding RNA MEG3 inhibits microRNA-125a-5p expression and
induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura
MS 3. BZ-26, Novel GW9662 Derivate, Attenuated Inflammation by Inhibiting
Inflammatory Macrophages Differentiation and Activation
Send your CV and MS # to [email protected]/* */, and please reply here with MS #.
Thanks |
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i********n
发帖数: 171 | 49 请发简历以及相应的审稿文章编号到[email protected]/* */
1. Possible Contributions of Thyroid Hormone Replacement to Specific
Behaviors of Cancer
2. ATTENUATING EFFECT OF GYMNEMA SYLVESTRE ON STREPTOZOTOCIN-NICOTINAMIDE
INDUCED DIABETIC NEPHROPATHY IN RATS
3. Estrogen and Thyroid Cancer is a stem affair. A preliminary study
4. Therapeutic outcomes of autologous CIK cells as a maintenance therapy
in the treatment of lung cancer patients: A retrospective study
5. Role of gastrointestinal motili... 阅读全帖 |
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wh
发帖数: 141625 | 50 排名见下。你们去过几个？我也一直很喜欢Yale Center for British Art，宽敞明亮
，袖珍而精。喜欢Constable，Turner的画作，很有代表性。
台北故宫上榜，北京故宫没上，倒是北京的789工厂榜上有名。
第50名是波士顿的museum of bad art，听着很好玩，有人去过吗？
The Times
The world’s 50 greatest galleries
May 4 2013
1 Uffizi Gallery, Florence
The word masterpiece can be bandied about too easily in Italy but the Uffizi
is packed with them. It was here that the Medici
family displayed its magnificent collections. The gallery’s architect,
Giorgio Vasari, said it was here that the greatest artists of
th... 阅读全帖 |
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