C****i
发帖数: 1776 | 1 当代正统神学的任务﹝十﹞
俄利根 (Origen) 之一
抽象的上帝，次等的基督：猜测性的系统神学
早期基督教历经几波的思潮。先有使徒后的教父(Post-Apostolic Fathers)，竭力护教
，称为护教士 (Apologists)；后有反诺斯底主义的教父，如爱任纽 (Irenaeus)和特土
良 (Tertullian)。到了第三世纪则有亚历山大教父学派，主要的发起人是革利免 (Cle
ment of Alexandria)。革利免之后有俄利根(Origen) 神学思想的兴起，深深影响了第
三、第四世纪教义的发展。正统信仰不断面对异端与世俗哲学，响应的时候又不免受到
它们的影响。
正统信仰，却受世俗哲学影响
俄利根生长于基督教家庭，深受基督教信仰的熏陶，后来继承了他的老师 – 革利免，
任亚历山大教义学校的校长。他研究当时流行的哲学，尤其是新柏拉图主义(Neo-Plato
nism)，和当时在基督教圈子最流行的异端 –诺斯底主义 (Gnosticism)。他是早期教会
中最有学问、思想最深奥的思想家；他的名著《原道》 (De Principiis)是教会历史中
第一部... 阅读全帖 |
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e****i
发帖数: 2152 | 2 From: The Dark Side of Christian History
by Helen Ellerbe
Chapter Eight: 1450 - 1750 C.E.
The Reformation did not convert the people of Europe to orthodox
Christianity through preaching and catechisms alone. It was the 300 year
period of witch-hunting from the fifteenth to the eighteenth century, what R
.H. Robbins called "the shocking nightmare, the foulest crime and deepest
shame of western civilization." The Church created the elaborate concept of
devil worship and then, used the persecution ... 阅读全帖 |
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l**********t
发帖数: 5754 | 3
24. Wherefore God also gave them up to uncleanness through the lusts of
their own hearts, to dishonour their own bodies between themselves:
"God therefore gave them up, etc. As impiety is a hidden evil, lest they
should still find an evasion, he shows, by a more palpable demonstration,
that, they cannot escape, but must be held fast by a just condemnation,
since such fruits have followed this impiety as cannot be viewed otherwise
than manifest evidences of the Lord’s wrath. As the Lord’s wrath ... 阅读全帖 |
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l**********t
发帖数: 5754 | 4
相较量，或以为是，或以为非
2:15. Which shew the work of the law written in their hearts, their
conscience also bearing witness, and their thoughts the mean while accusing
or else excusing one another;)
"
15. Who show the work of the law [73]written, etc.; that is, they prove that
there is imprinted on their hearts a discrimination and judgment by which
they distinguish between what is just and unjust, between what is honest and
dishonest. He means not that it was so engraven on their will, that they
sought ... 阅读全帖 |
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P******l
发帖数: 1648 | 5 Here is my email to Victor Chang a few days ago. There is no response yet.
I also have friends in NCBI who may help me check this(verifying through
multiple samples) with existing online source.
"Are there any paper or tool to show that all these 789 sequences are same
for multiple people from all over the world? (2q13–2q14.1 789 nucleotide
sequence 108305-109093)
It doesn't have to be a big number of samples. Only 38 samples(from
different locations in the world) were tested to draw the con... 阅读全帖 |
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T*******y
发帖数: 6523 | 6 Okay, I see. Nobody can ever change another human being, that's why practice
is such a personal experience.
I am not a Buddhist, and I don't know what the 大乘 meant by your
understanding exactly.
I'll clarify my statement about making mistakes. I never wanted to
intentionally make mistakes, and I would make choices based on my best
judgement at each moment. Things would turn out in a way that I expected or
not, and if it had some adverse effects that I didn't intent to, I felt like
I made a mista... 阅读全帖 |
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l*******2
发帖数: 98 | 7 我知道你会这样说,在我看来这是狡辩,这里多数会喜欢你说的,没什么奇怪的.
我不知道我为什么还要争辩,我的脑子不笨,我懂了,我不好被说服,改变,
我的大脑我做主.
你说的非常圆滑,因为你用英文,听起来很冠冕堂皇,很高贵正确.
你用中文,说说看呢?我选择用中文,因为我在确切表达我的意思.
不要给自己找借口,错了,就是错了,是就是是,而非就是非,
:I am for "all in", rather than avoidance, and what might be surprising for
:some people is that there's no way to avoid things actually (many memories
:or experiences are imprinted in the subconscious, even if people
consciously
:want to forget).
这算是什么借口?人是理性的,人可以控制自己的思想和行为,人给自己找借口,
不对自己的行为负责任了,在我眼里,就是错误的.这是天理,我其实并不老,可能
比这里很多... 阅读全帖 |
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l*******2
发帖数: 98 | 8
First of all, I am not arguing, nor against you personally. I am asking what
your thoughts are, or what your sentences mean. Your thoughts are not you (
It takes me a long time to see my thoughts and emotions as separate from
myself, or that witness), and I don't know whether you believe all the
thoughts in your head.
============================================
你不用道歉,你用中文说,既然你看得懂中文,用中文,因为英文在这里乱搅,
这本来就是很乱的事情,我的智慧是有限的.我对我的思想也是分析鉴别的,
虽然我用有限的智慧来做.我当然知道思想不是我,但是我还没能力
看到思想,但是我基本的准则是有的.
==============... 阅读全帖 |
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c*******h
发帖数: 51 | 9 I am so moved by your beautiful song. That is why Chinese boys here are
likely to marry Chinese girls becuase we are imprinted by the same language
culture. |
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a*****a
发帖数: 1038 | 10 Any Alumni's donation exceeds RMB 1,000, and his name will be imprinted on
the chair of the existing Tongji Auditorium. Currently, 3,000 chairs are
available there. |
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t*****r
发帖数: 448 | 11 Good to see you again, artesia.
Have you gotten your name imprinted? :) |
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f**********r
发帖数: 18251 | 12 【 以下文字转载自 Military 讨论区 】
发信人: justinezeus (Justine), 信区: Military
标 题: 苏州大学浮萍新报料：孙中山抚养了我爷爷
发信站: BBS 未名空间站 (Wed Feb 13 10:05:07 2013, 美东)
http://www.guardian.co.uk/books/2013/feb/13/ping-fu-controversy
A successful US entrepreneur faces mounting questions over her widely lauded
tale of childhood torment in China's cultural revolution, as fresh
contradictions emerge and experts cast doubt on key elements of her story.
Ping Fu's rags-to-riches memoir Bend Not Break says she was torn away from
her ... 阅读全帖 |
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b***t
发帖数: 1104 | 14 这个功能对digital camera没有任何意义
非要加上的话可以用eye batch, photocap等等批处理
或者ACDSee看的时候也可以设置让它直接叠加显示这个信息 |
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s*****t
发帖数: 1994 | 15 Opportunity's Horizon
Credit: Mars Exploration Rover Mission, JPL, NASA
Explanation: Remarkably, the Opportunity Mars rover lies in a small martian impact crater about 3 meters deep and 22 meters wide. For 360 degrees, Opportunity's horizon stretches to the right in this new color mosaic image from the rover's panoramic
camera. Notable in this view of the generally dark, smooth terrain are surface imprints left by the lander's airbags and an outcropping of light-colored, layered rock about 8 met |
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w**********9
发帖数: 242 | 16 There is a girl of seven years old, with a progressive muscle weakness and
is diagnosed with Duchenne muscular dystrophy. She has a normal identical
twin sister and another brother with no problems. What is the reason her
identical twin sister does not have the disease ?
A), parental imprinting
B), Screwed X inactivation
C), Trinucleatide repeat
D), Genetical anticipation
E), Variable expression
which one is the reason? Or anybody could give better answer to this
question.
thanks. |
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z*t
发帖数: 863 | 17 circuit有人做了吧，用opticgenetics控制larva的游动方向。
关于epigenetics的话fish有没有imprinting这种现象?要做的话做什么呢?Histone
modification? DNA methylation?Histone modification还好说，因为整套系统相对比
较保守的，但DNA methylation 上因为genome GC含量的不同fish和mammal差的还是挺
多的。您有什么好的idea呢？
又快
一个
fis
/r
非常
optomot |
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M*****n
发帖数: 16729 | 18 难道fish 没有imprinting?
不可能吧。
BTW, 你也晚了点了，今天来jobtalk的那位，人家已经开始研究epigenetics了 |
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a****d
发帖数: 1919 | 19 genomic imprinting目前确实只在placental mammals 和 flowering plants中有报道。
机制
xenopus |
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A******y
发帖数: 2041 | 20 I am not a real biologist. So I might be missing something. If you
continue culture the iPS, it will be as good as ESC due to lost of
imprinting through propagation, that's why a mouse can be made from it. |
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m***f
发帖数: 1622 | 21
扯淡呢，看看高最近两年发表的文章吧
CELL STEM CELL, JBC, STEM CELL, PNAS，都是很不错的
就这样还不能PROMOTION? 在美国都可以tennure了
1. Wu T., Wang H., He J., Kang L., Jiang Y., Liu J., Zhang Y., Kou
Z., Liu L., Zhang X., Gao S. (2011) Reprogramming of trophoblast stem
cells into pluripotent stem cells by Oct4. Stem Cells 2011 Feb 8.
[Epub ahead of print].
2. Kang L., Wu T., Tao Y., Yuan Y., He J., Zhang Y., Luo T., Kou Z.,
Gao S. (2010) Viable mice produced from 3-factor induced pluripotent
stem (iPS) cells through tetrapl... 阅读全帖 |
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g*****y
发帖数: 6325 | 22 Randy Jirtle
Director of the Epigenetics and Imprinting Laboratory
Duke University |
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n***g
发帖数: 5027 | 23 这个总结不错：
申请精华帖：我了解的Epigenetics牛人一览
我是从C.D.Allis，Danny Reinberg，Tony Kouzarides，Yi Zhang， Yang Shi这几个
人发的文章看起的，这几个人基本上就是目前做表观遗传最牛的一批人了。然后你看看
他们文章citation里面出现频率比较高的人名，那往往就是大牛了，然后一点一点扩展
。个人感觉看CNS及其子刊还是王道。另外推荐一个很好的网站，http://www.epidna.com/ 可以查这个领域最top的lab，也可以查该领域最新的论文。
# ^2 P/ }, _0 h" U8 m) P6 b
; l* o$ y- |- V5 g0 I0 T然后在申请选校的过程中，我也逐渐了解到一些
epigenetics领域的big names和rising stars。所以我感觉看各个牛校的faculty也是
了解一个领域的好学校好lab的方法。我的做法是每看一个学校，就把相关领域做
epigenetics的faculty留下来，然后以后看CNS时或者Journal club上看到熟悉的名字
，就重点关注下。$ ... 阅读全帖 |
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z*t
发帖数: 863 | 24 现在不是很清楚，比如在Neuro Spora中先有H3K9me3然后有dna methylation,哺乳动物
里Dnmt3a/3b/3L形成复合物binding到H3K9me3的site然后methylate DNA,LSD1 KO会造
成defiency in imprinting, G9a KO也会造成methylation decrease
而早一点的发现dna methylation也可以招募MBD/MePG之类造成histone去乙酰化，还可
以招募H3K36的demethylase。这两者是interwine的关系,谁先谁后目前还没定论。。。 |
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z*t
发帖数: 863 | 25 现在不是很清楚，比如在Neuro Spora中先有H3K9me3然后有dna methylation,哺乳动物
里Dnmt3a/3b/3L形成复合物binding到H3K9me3的site然后methylate DNA,LSD1 KO会造
成defiency in imprinting, G9a KO也会造成methylation decrease
而早一点的发现dna methylation也可以招募MBD/MePG之类造成histone去乙酰化，还可
以招募H3K36的demethylase。这两者是interwine的关系,谁先谁后目前还没定论。。。 |
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g*********d
发帖数: 233 | 26 目前表观遗传学(Epigenetics)通常被定义为基因表达通过有丝分裂或减数分裂发生了
可遗传的改变, 而DNA 序列不发生改变[1, 2]。表观遗传学的机
制主要包括DNA 甲基化、组蛋白修饰及非编码RNA。DNA 甲基化(DNA methylation)是指
在DNA甲基转移酶(DNA-methyltransferases, DNMTs)的催化下, CpG 二核苷酸中的胞嘧
啶被选择性地添加甲基, 形成5-甲基胞嘧啶[3, 4]。DNA 甲基转移酶有两种, 其中
DNMT1 主要起维持甲基化的作用, 能使半甲基化的DNA 双链分子上与甲基胞嘧啶相对应
的胞嘧啶甲基化, 可参与DNA 复制双链中新合成链的甲基化[5]; 而DNMT3a 和DNMT3b
主要起形成甲基化的作用, 能在未发生甲基化的DNA 双链上进
行甲基化[6]。DNA 甲基化一般与基因的沉默相关,DNA 去甲基化则与基因的活化相关[7
~9]。
组蛋白修饰(Histone modifications) 是指组蛋白的基础氨基末端尾部突出于核小体,
常在转录后发生变化, 包括甲基化、乙酰化、磷酸化和泛素化等翻译后的修饰... 阅读全帖 |
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n**********s
发帖数: 228 | 27 研究的基因是一个酶，很简单的knock in模型，就是将GFP-Neo同源重组到基因的第一
个exon前面，这样homozygous的老鼠该酶实际上是knock out的。
理论上GFP表达细胞是受该基因调控的，现在的结果是，在已知正常情况下该基因表达
的器官，homozygous的老鼠GFP细胞数大概是heterozygous的2倍多，比较的是相似位置
的切片，做过统计，基本上是这个结果。
请教这种现象准确原因是什么？Allelic Imbalance造成的吗？好像没什么理论基础支
持这个？另外，该基因也不存在明显的imprinting，应该不是这个原因吧。请高人指教
！ |
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s******s
发帖数: 13035 | 28 不是imprinting, x-inactivation一类的？我就不知道了 |
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x*********g
发帖数: 927 | 29 Multifunctional conjugation of proteins on/into bio-nanoparticles prepared
by amphiphilic poly(γ-glutamic acid)
Authors: Akagi, Takami; Kaneko, Tatsuo; Kida, Toshiyuki; Akashi, Mitsuru
Source: Journal of Biomaterials Science, Polymer Edition, Volume 17, Number
8, 2006 , pp. 875-892(18)
Publisher: VSP, an imprint of Brill
求paper, j**********[email protected]
谢谢 |
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l**********1
发帖数: 5204 | 30 sent both, please check your mail box
Ps: hopeful BAOZI three transfer to my financial account here MITBBS, please
.
insect imprinting. |
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l*****1
发帖数: 8 | 31 Need a paper again.
Thank you so much!
Please email to : l*******[email protected]
http://www.ncbi.nlm.nih.gov/pubmed/7956042
DNA methylation, genomic imprinting, and mammalian development.
Li E, Beard C, Forster AC, Bestor TH, Jaenisch R.
SourceMassachusetts General Hospital-East, Cardiovascular Research Center,
Charlestown 02129. |
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u**********d
发帖数: 573 | 32 re
典型的H19 gene imprinting |
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a******k
发帖数: 1190 | 33 I played it a lot, and I love the tech quotes...
Oh biochemists, pray that your non-specific bands be clean and your specific
bands clear. – Virgil
It is entirely seemly for a young biologist killed in his experiment to lie
mangled by broken test tubes and spilled reagents. In his death all
experiments start to work. – Homer
Give a man a knockout mouse and you fool him for a project. Teach a man to
knockout mice and you fool him for a lifetime. - Lao Tzu
I am the PI thy God. Thou shalt have no o... 阅读全帖 |
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u**********d
发帖数: 573 | 34 在技术方面我有两点理解：
1. 可以用来研究gene imprinting；
2. 一代就可以做出transgene小鼠。不过tetraploid complementation也是可以一代就做
出transgene小鼠的。两种方法都太难，成功率很低，就是不知道比较下来优劣如何。 |
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i**y
发帖数: 71 | 35 If your paper is substantial enough, you should try Science. Otherwise you'
ll probably have to go for the fast tracks like PlosOne. Think about the
examples of the controversial RNA editing paper and brain imprinting paper (
both in Science). The re-analyses were published in Plos Genetics and Plos
One, if I remember correctly.
highlight |
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z**b
发帖数: 192 | 36 Genetics and Epigengetics 审稿机会一个，关于imprinting的。有意者请在9号中午
前将姓名，E-mail和简单的研究背景介绍PM在下。 |
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x********6
发帖数: 986 | 37 非常感谢您的指教，受益匪浅。我所研究的疾病是一种罕见的先天退化症，病人总数就
很少，关注的人也不多，自从10年前确认是这个单基因突变导致后至今也没再发现其他
的突变基因，已经构建相同突变的果蝇和小鼠模型也可以完全复制了病人的缺陷表型。
我已经做了一些前期试验发现了几个相关的基因组调节因素h3k4me3和imprinted gene
以及其他一些epigenetic modification的alterations, 所以正如您所言，我们的设想
就是用这几个有代表性的样本来assumpt这种疾病的普遍的致病机理。根据我们的初步
结果，exome sequencing是一个比较好的方法来进行基因组缺陷的多角度分析。不过我
们这种小lab无法像大牛那样做海量的样品和大规模的分析，只能根据自己现有的资源
，资金和实验室条件量力而行。依您看像这类的工作适合投什么样的杂志好？自己以前
主要做表型分析多，对这种基因组学的文章确实没什么经验。
sanger |
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p*****c
发帖数: 20445 | 38 Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖 |
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z*t
发帖数: 863 | 39 MPD是应该有的，不过没有CBC/bone marrow imprint不好说
for |
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b****r
发帖数: 17995 | 40 显然没有好好学遗传学101，imprinting都不知道 |
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f******g
发帖数: 1003 | 41 我问了三个问题，１。 同性如何繁殖后代。２。小鼠和人类基因９０％相似，为何染
色体数目不同。３。体外受精导致寿命缩短。
你说的imprinting和我提到的哪个问题有关系呢 |
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