R******d
发帖数: 5739 | 1
--------------------
i am not a christian and I am neither proud of being one nor proud of not
being one. and I don't think i am arrogant either, merely to point out that
attacking a scientific point without even understanding it is foolish
your
----------------------------
diamond is a metastable state of carbon occuring in nature.
http://en.wikipedia.org/wiki/Metastability
according to this:
http://www.physicsforums.com/showthread.php?t=138720
quote:
----------------------------
For any comp... 阅读全帖 |
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R******d
发帖数: 5739 | 2
--------------------
all I am seeing is that your judgement on the plausibility is based on your
feeling about the "primitive" conditions in nature, forgive me if this is
again offending you.
what are the "primitive" conditions? there are no "primitive" in chemical
conditions.
http://en.wikipedia.org/wiki/Miller-Urey_experiment
this experiment set up to mimic the "primitive" conditions in early earth,
and proved in principle that organic components can be synthesized in nature
. the influx en... 阅读全帖 |
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E*****m
发帖数: 25615 | 3 November 12, 2010
For Catholics, Interest in Exorcism Is Revived
By LAURIE GOODSTEIN
The rite of exorcism, rendered gory by Hollywood and ridiculed by many
modern believers, has largely fallen out of favor in the Roman Catholic
Church in the United States.
There are only a handful of priests in the country trained as exorcists, but
they say they are overwhelmed with requests from people who fear they are
possessed by the Devil.
Now, American bishops are holding a conference on Friday and Saturda... 阅读全帖 |
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s******0
发帖数: 13782 | 4 http://www.cnbc.com/id/47818860
全美各州经济科技排行榜 --
Texas Is America's Top State for Business 2012
• Texas (#1)
• Utah (#2)
• Virginia (#3)
• North Carolina (#4)
• North Dakota (#5)
• Nebraska (#6)
• South Dakota (#7)
• Colorado (#8)
• Georgia (#9)
• Wyoming (#10)
Each year, we score all 50 states on the criteria they use to sell
themselves. This year’s analysis is the most comprehensive yet, using 51
metrics... 阅读全帖 |
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y*******u
发帖数: 930 | 5 德州现在在美帝的牛逼程度简直是。。
http://www.cnbc.com/id/47818860
全美各州经济科技排行榜 --
Texas Is America's Top State for Business 2012
• Texas (#1)
• Utah (#2)
• Virginia (#3)
• North Carolina (#4)
• North Dakota (#5)
• Nebraska (#6)
• South Dakota (#7)
• Colorado (#8)
• Georgia (#9)
• Wyoming (#10)
Each year, we score all 50 states on the criteria they use to sell
themselves. This year’s analysis is the most comprehensive ye... 阅读全帖 |
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t******4
发帖数: 2300 | 6 【 以下文字转载自 Seattle 讨论区 】
发信人: tocheer4 (tocheer4), 信区: Seattle
标 题: 美国人对李娜的评价， 也够损的了
发信站: BBS 未名空间站 (Fri Jan 28 13:27:31 2011, 美东)
Li Na Is Smart, Funny, Good, but Can She Keep US Interested?.
Li Na is not going to sell. Let's just cut right to it. If that's sexist,
xenophobic, whatever. She has all the personality and color and warmth in
the world, but she speaks broken English and doesn't have drop dead good
looks. In the U.S., that stuff is mandatory. She is not going to sell women'
s tennis ... 阅读全帖 |
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n***3
发帖数: 663 | 7 I plan to measure the calcium influx via a channel on cell membrane by
flurescence.
I found that furo 2 and fluro 3 might be the calcium indicator dyes to use.
Can someone give me some suggestions about which one to use? Is there any
difference for these two dyes? |
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v******l
发帖数: 235 | 8 求Paper, 请发到 j********[email protected]. 包子答谢!
PMID: 19546862
[PubMed - indexed for MEDLINE]
Nat Rev Nephrol. 2009 Aug;5(8):441-9. Epub 2009 Jun 23.
The role of transient receptor potential channels in kidney disease.
Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG.
Source
Department of Physiology, Radboud University Nijmegen Medical Centre,
Nijmegen, The Netherlands.
Abstract
The transient receptor potential (TRP) superfamily consists, in mammals, of
six protein subfamilies, TRPC, TRPM, TRPV, T... 阅读全帖 |
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i*****g
发帖数: 11893 | 9 我们就是把负责做那个修饰的酶给KO了，然后pathway A 和 B 同时出问题了。
然后我们把修饰好的蛋白扔进去，发现该蛋白和pathway B colocalizes, 而且recue
了pathway B，但是对pathway A就没有这个效果。
其实这个东西对pathway A到底有没有作用我们不太关心（阴性结果不说明就没有关系
）因为针对于那个蛋白和pathway A的文章超过一千篇，所以是一个没有什么意思的方
向，所以我们那个文章里面没有对pathway A下任何结论。
不过对于pathway B的结论应该是没有问题的吧？因为能够很明确的rescue, 而且很明
确的colocalizes.
批注：全部症结在此，这个叫Involved，确实没有mechanistic，
所谓mechanistic，就是A蛋白作用B蛋白，B蛋白作用C蛋白，C蛋白是公认的教科书功能
，无需多说。这就是我们这个时代的研究路数。
比如说，C是myosin，解释了宏观肌肉收缩，B是myosin kinase，A是某蛋白，能在某个
场景（Ca influx etc etc）on/off B，这个就可以了... 阅读全帖 |
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s******y
发帖数: 28562 | 10 你说得很有道理。我们那片文章确实没有所谓的mechanistic insight,
这个我们也知道。只不过一开始我们以为我们做的东西非常新，而且在组织里面
找到了直接证据，所以以为很重要。相比之下，那个发了上千篇文章，以及超过50篇
CNS的pathway A, 其实就是在培养的细胞里面最明显而已，在组织里很难找到支持证据
，以至已经有人开始质疑那个pathway A在动物体内到底有没有用。
所以我们觉得我们找到的那个蛋白对pathway B的关系可能才是真正在体内有作用的关
系。在此前提之下，我们天真的认为，那些什么mechanistic insight 是follow-up 的
文章做得。
不过，真的要找mechanistic insight 其实也不是不可以，就是看要花多少时间的问题
了。
所谓mechanistic，就是A蛋白作用B蛋白，B蛋白作用C蛋白，C蛋白是公认的教科书功能
，无需多说。这就是我们这个时代的研究路数。
比如说，C是myosin，解释了宏观肌肉收缩，B是myosin kinase，A是某蛋白，能在某个
场景（Ca influx etc etc）on/off... 阅读全帖 |
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B*M
发帖数: 1418 | 11 中国选上了7个人，可喜可贺！
http://news.sciencemag.org/scienceinsider/2012/01/hhmi-funds-28
The Howard Hughes Medical Institute (HHMI) today announced the 28 winners of
a new $20 million program to jump-start the labs of young biomedical
scientists in countries outside of the United States.
The giant biomedical research charity in Chevy Chase, Maryland, created the
International Early Career Scientist awards after recognizing that starting
a career in science is "even more difficult in other countries" than ... 阅读全帖 |
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l**********1
发帖数: 5204 | 12 sure
add one recent paper
Levy S at al. (2011)
The competitive advantage of a dual-transporter system.
Science. 334: 1408-12.
Abstract
Cells use transporters of different affinities to regulate nutrient influx.
When nutrients are depleted, low-affinity transporters are replaced by high-
affinity ones. High-affinity transporters are helpful when concentrations of
nutrients are low, but the advantage of reducing their abundance when
nutrients are abundant is less clear. When we eliminated such red... 阅读全帖 |
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O******e
发帖数: 4845 | 13 我推荐大家都读一下这篇文章：
http://www.pnas.org/content/111/16/5773.full
全文：
By Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus
By many measures, the biological and medical sciences are in a golden age.
That fact, which we celebrate, makes it all the more difficult to
acknowledge that the current system contains systemic flaws that are
threatening its future. A central flaw is the long-held assumption that the
enterprise will constantly expand. As a result, there is now a severe
imbalan... 阅读全帖 |
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h**********r
发帖数: 671 | 14 Title:
Evidence for trehalose-6-phosphate-dependent and -independent mechanisms in
the control of sugar influx into yeast glycolysis
Journal:
Molecular Microbiology
Volume 20, Issue 5, pages 981–991, June 1996
My email is [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(... 阅读全帖 |
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v**********m
发帖数: 5516 | 15 在今后十年或二十年内，社会上包括基础研究和企业对生物基础研究的需求不会改变。
即使需求加大，社会上也已经有巨大的后备人选库，这些人目前都在挣扎找工作岗位，
美国至少有6万到8万的PhD千老，每年还有8000左右的新PhD毕业，这里面中国人的比例
不低。这些事有统计数据支持的。
施确实不应该劝新人入行，即浪费新人的青春，也浪费国家社会财富。
这个道理应该不难理解，劳动力市场已经严重失衡，已经不是个人喜好的问题了。如果
你愿意可以去NIH官网下载biomedical research work force report.
http://biomedicalresearchworkforce.nih.gov/index.htm
The working group's analysis led to two major conclusions:
The large upsurge in U.S.-trained Ph.D.s, increasing influx of foreign-
trained Ph.D.s, and aging of the academic biomedical r... 阅读全帖 |
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s*******e
发帖数: 1389 | 16 任何一个和铁结合的蛋白，我都可以说它是一个“磁受体”。
MagR是不是“真的磁受体”，关键在于这个蛋白对动物的“磁感应能力”是不是必要的
。而这种感应能力，是神经行为，意识层面的现象。没有体内的功能实验，谁也不知道
MagR是不是“真的磁受体”。
张生家的文章的着眼点不在于动物的磁场感应能力，而是MagR能否在操纵外加磁场的条
件下改变细胞的活动状态。所以他一直说自己做的和谢灿做的没关系。也确实如他所说。
张生家的data如果是真的，我觉得他的文章的新颖性非常高，比谢灿的这篇文章还要好
。因为我读了谢灿的文章，想不到人的MagR转染HEK-293细胞在外加磁场的条件下可以
引起calcium influx。能用外加磁场改变细胞活动状态是很重要的发现，这个我是承认
的。
我对张生家的意见有两点：一是张生家的data有可能不consistent，拿到的图就做出过
来一次或几次。大家不能重复的话张生家就丢人丢到姥姥家了。二是没有经过谢灿的允
许就先行发表，而且是恶意的，不经peer review的抢先发表。还说谢灿没贡献，MagR
是一个已知蛋白，这种把大家当傻子的行为无论受了多大的委屈都是... 阅读全帖 |
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h*******l
发帖数: 359 | 17 你正好说反了,actually the problem 16th-17th century Europe ran into was not
deflation but huge inflation due to large influx of gold and silver from
America. That is why this period is called "price revolution" in history.
Fiat money全世界铺开是布雷顿森林体系完蛋之后的事情，之前也就打仗的时候大家用用。
at |
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l*****n
发帖数: 1034 | 18
的又愿意sponsor H-1B的好学区，更是占一小部分的一小
There are many openings out in the West, especially in those "minority
states", where there have been a huge influx of immigrants in the recent
years. And I don't just mean California, which is colonized by Mexicans now.
Idaho, Nebraska, New Mexico, Arizona and even Washington state... All these
states are looking for teachers like crazy. Many districts in these states
can provide H1-B sponsorship. If you are a licensed teacher with good
English command, and you |
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a*****g
发帖数: 19398 | 19 Seven New York City schools are participating in a pilot program aimed at
making the schools more diverse. The schools will retain a portion of their
available seats for low-income students and English-language learners.
NEW YORK (AP) — Gentrification has been coming fast to Brooklyn's Crown
Heights neighborhood. The influx of wealthier, white residents is being
reflected in the hallways of Public School 705.
The elementary school is still half black and more than a quarter Hispanic,
but Princip... 阅读全帖 |
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o****e
发帖数: 195 | 20 Not sure about incoming JDs, but there are many LLMs who plan to go back.
So far I know Orrick and WSGR are hiring Chinese IP litigators -- there is a
big influx of litigation from China/Taiwan, and they simply don't have enough
people who has a tech/law/language combination.
4.
other
each
case
happens
write
a
lower,
essentially
billable
better
another |
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m****p
发帖数: 404 | 21 原文
http://forums.studentdoctor.net/showthread.php?t=884279
念药学院的学长学姐有什么评论么
德州 加州 pharmacy school 一家一家的开 2015-2020 铁定会过饱和了吧
最后几段是讲his family 自己开店30年的经验/挫折
还有文中提到的 MTM 是什么缩写?
1st -- Before you jump on me, understand this: I am only speaking about what
I know from extensive analysis of the California market (maybe some of this
will translate into other states but again this is for California people
primarily). If you attend, UCSF, USC, Western, UCSD, etc this job market
post is for you.
2nd -- Feel... 阅读全帖 |
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S*******h
发帖数: 7021 | 22 【 以下文字转载自 USANews 讨论区 】
发信人: gemini2012 (双子AB), 信区: USANews
标 题: 美国有望年内超额完成接收一万名难民指标
发信站: BBS 未名空间站 (Fri Aug 5 22:36:15 2016, 美东)
U.S. Could Exceed Goal of Accepting 10,000 Syrian Refugees
By JULIE HIRSCHFELD DAVIS
AUGUST 5, 2016
BALTIMORE — When Madiha Algothany and her family, Syrian refugees who had
fled to Jordan, arrived in the United States in June, they braced for
rejection from a new culture and country they feared did not want them.
They knew that, like Donald J. Trump, many Americans... 阅读全帖 |
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A*******s
发帖数: 9638 | 23 Sorry， cybermd， I don't understand what you mean on your things #1:
1. We speak Chinese and know how to navigate US medical system (and to play
with insurance benefit, if you know what I am talking about)
For the part 2， I don't think it is important.
2. We have contact in Chinese hospitals to get patients from China.
But I have to take hats off to your idea. It could be a very successful
business model. Once the rich chinese patients influx into US for
healthcare, the most important direct imp... 阅读全帖 |
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A*******s
发帖数: 9638 | 24 Sorry， cybermd， I don't understand what you mean on your things #1:
1. We speak Chinese and know how to navigate US medical system (and to play
with insurance benefit, if you know what I am talking about)
For the part 2， I don't think it is important.
2. We have contact in Chinese hospitals to get patients from China.
But I have to take hats off to your idea. It could be a very successful
business model. Once the rich chinese patients influx into US for
healthcare, the most important direct imp... 阅读全帖 |
|
l**n
发帖数: 60 | 25 出诊给9元！医师拒收Medi-Cal
柏克莱市外科医师卡普兰（Dr. Jerold Kaplan）去年到一名脚伤病人家里看诊。由于
是加州医疗补助计画（Medi-Cal）的病人，所以他向Medi-Cal开了90元的诊疗费。他以
为自己的收费已经很便宜，但是Medi-Cal只给他8.96元。
去年，卡普兰还出诊看了一个小儿麻痺症病人，Medi-Cal也只付他13.44元，事后还向
他解释，因为他的收费单寄得太晚，所以将收费减半。也就是说，就算全额也只不过27
元。
加州正全力迎接联邦健保改革法的到来，并且将Medi-Cal扩大，纳入150万无健保人士
，另外还要吸收90万名「健康家庭计画」（Healthy Families ）的儿童，因为原来为
贫穷家庭儿童提供健保的「健康家庭」已经取消。
但是，Medi-Cal付给医师的医疗费太低，让专家担心到2014年新健保法推行时，根本没
有医师愿意为Medi-Cal病人看病。
卡普兰医师说：「Medi-Cal给医师的极低费用，已成为笑话，所以很多医师根本不感兴
趣。」
有770万病人的Medi-Cal是联邦医疗补助计画（Medicaid）的加州版... 阅读全帖 |
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d*****y
发帖数: 1 | 26 I agree with you. as a hospitalist, I think hospitalists are more and more
important to hospitals.
I also noticed that hiring hospitalists was getting harder and harder.
strong demands makes recruitment very hard. hiring qualified mid-levels is
also hard. They don't have enough training to deal with difficult and
complex situations. it takes time to train them. The large influx of PA/NPs
is due to shortage of hospitalists. They will never replace hospitalists( I
guess I should never say never). ... 阅读全帖 |
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f*******p
发帖数: 338 | 27 正在做一个关于sodium fMRI 的实验...
谢谢!!! |
|
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z*******n
发帖数: 1034 | 29 2014 was a big year for big data, a term that gradually gained momentum to
become one of the most talked-about subjects in the tech world. With 2015
fast approaching, prepare for big data’s total domination, as it, along
with the Internet of Things, is set to be the focus of web and mobile.
It will become standard for businesses to try and benefit from it by
analyzing as much as possible.
But what it actually is and what it does isn’t always clear to app
publishers.
Boom-beach-general-2375 mobil... 阅读全帖 |
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a***a
发帖数: 2493 | 30 We have recently been notified that due to an influx of BYOD customers our
network provider is having temporary activation issues. Please know that the
issue should be resolved in the next 24 hours.
We would like to apologize for any inconvenience on behalf of our network
provider. If you have any other questions or concerns please visit our help
center at support.freedompop.com.
Thanks!
FreedomPop Team |
|
h******2
发帖数: 1498 | 31 Time for USAT and ITU to adopt doping test procedures a-la-tour-de-france.
And there will be an influx of over-weight middle aged man who want to
follow suit. Pretty soon we'll see beer-bellied weekend warriors wearing
pro team kits and dimpled aero helmets, riding $12k Cervelo P7's for their
20-mile ride followed by a 3 mile jog.
Woohoo!!! |
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w*******y
发帖数: 60932 | 32 Just got an email stating that they are increasing their data. Here is the
email I recieved.
Back on October 25th, 2011, Page Plus Cellular announced the introduction of
the Unlimited Talk n Text $55 plan with 300mb of data. It was WILDLY
popular, but now, we are bracing for an even great influx of new customers
since.....
Effective tomorrow, November 9th, 2011, Unlimited Talk n Text $55 is
increasing from 300mb to 500mb of data! AMAZING! Wow!
Anyone who is CURRENTLY on the $55 plan will se... 阅读全帖 |
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u*****n
发帖数: 778 | 33 Sam Stovall, Chief Investment Strategist: Much to the surprise of many,
operating earnings for the large-, mid- and small-cap components of the S&P
Composite 1500 came in better than expected last quarter. The S&P 500
recorded a 51% increase in year-over-year results, while the S&P MidCap 400
saw a 45% rise. But the S&P SmallCap 600 wowed everybody by recording a 134%
surge in year-over-year results. This quarter, S&P is forecasting operating
results for the S&P 500, MidCap 400 and SmallCap 600 ... 阅读全帖 |
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g****d
发帖数: 3461 | 34
你不是做翻译的么？！
这书里的话尤其不好懂。有次给个哥们看，虽然他是母语，
也是几分钟内没有反应的。
When the ego is brought to its knees in the dust,
humiliated in its own eyes, however esteemed or feared,
envied or respected in other men's eyes, the way is opened
for Grace's influx. Be assured that this complete humbling
of the inner man will happen again and again until he is
purified of all pride.
Out of the ego-crushing, pride-humbling experience he may rise,
chastened, heedful, and obeisant to the higher will.
If he is willing to look f |
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g********n
发帖数: 2314 | 35 【 以下文字转载自 SanFrancisco 讨论区 】
发信人: dadabear (bless you), 信区: SanFrancisco
标 题: [合集] goldenrain的观点未免偏颇
发信站: BBS 未名空间站 (Thu Feb 8 16:24:51 2007), 站内
☆─────────────────────────────────────☆
MSJ (Mission San Jose) 于 (Tue Feb 6 00:42:38 2007) 提到:
看完他blog的《现在在哪里买房风险小》，我只能笑着摇摇头。在我眼里，这个列表与
其说是“风险小”列表，不如说是“房子难涨地区列表”。试论证一二：
1. 常言道“强者恒强，弱者恒弱”。NYC, SF地区房价高企不是一年两年了，支撑房价
的不是那个affordability的percentage，而是能afford的人口数和房子总数的比例。
这里看百分比是没有多大意义的。只要还有人能买得起还愿意买，即使affordability
只有15%又如何呢？
2. 正如high tech公司的P/E要远大于... 阅读全帖 |
|
