M*V
发帖数: 3205 | 1 【 以下文字转载自 GayStudy 俱乐部 】
发信人: msgc (为了下一代免遭变态残害), 信区: GayStudy
标 题: Gay-related immune deficiency
发信站: BBS 未名空间站 (Thu Nov 8 09:19:57 2012, 美东)
Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of Kaposi's sarco... 阅读全帖 |
|
m**c
发帖数: 7299 | 2 Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of Kaposi's sarcoma and pneumocystis pneumonia among gay
males in Southern California and New York City.[1]
During the early history of AIDS, when it was consid... 阅读全帖 |
|
m**c
发帖数: 7299 | 3 gay spread it to normal population!
Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of Kaposi's sarcoma and pneumocystis pneumonia among gay
males in Southern California and New York City.[1]
During the early... 阅读全帖 |
|
m**c
发帖数: 7299 | 4 【 以下文字转载自 GayStudy 俱乐部 】
发信人: msgc (为了下一代免遭变态残害), 信区: GayStudy
标 题: Gay-related immune deficiency
发信站: BBS 未名空间站 (Thu Nov 8 09:19:57 2012, 美东)
Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of Kaposi's sar... 阅读全帖 |
|
t******r
发帖数: 8600 | 5 Kaposi's sarcoma (KS) is a tumor caused by Human herpesvirus 8 (HHV8), also
known as Kaposi's sarcoma-associated herpesvirus (KSHV). It was originally
described by Moritz Kaposi (KA-po-she), a Hungarian dermatologist practicing
at the University of Vienna in 1872.[1] It became more widely known as one
of the AIDS defining illnesses in the 1980s. The viral cause for this cancer
was discovered in 1994. Although KS is now well-established to be caused by
a virus infection, there is widespread lack ... 阅读全帖 |
|
s******y
发帖数: 28562 | 6
大致看了一下，数据很有意思啊。是否暗示了Kaposi's sarcoma, non-Hodgkin's
lymphomas, and nonmelanoma skin cancers是用免疫法治疗最有前途的几种癌症？
For most common tumors, e.g. colon, lung, prostate, stomach, esophagus,
pancreas, ovary and breast, cancer rates were roughly twofold higher after
kidney transplantation compared with the general population. Melanoma,
leukemia, hepatobiliary tumors, cervical and vulvovaginal tumors were each
approximately fivefold more common. Testicular and bladder cancers were
increased approximately t... 阅读全帖 |
|
m**c
发帖数: 7299 | 7 【 以下文字转载自 Military 讨论区 】
发信人: msgc (为了下一代免遭变态残害), 信区: Military
标 题: 从历史看，AIDS(gay plague)就是变态制造出来并广泛传播来祸害人类的
发信站: BBS 未名空间站 (Thu Mar 28 11:47:49 2013, 美东)
Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of K... 阅读全帖 |
|
m**c
发帖数: 7299 | 8 Gay-related immune deficiency
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gay-related immune deficiency (GRID) (sometimes informally called the gay
plague) was the 1982 name first proposed to describe an "unexpected cluster
of cases"[1] of what is now known as AIDS,[2] after public health scientists
noticed clusters of Kaposi's sarcoma and pneumocystis pneumonia among gay
males in Southern California and New York City.[1]
During the early history of AIDS, when it was consid... 阅读全帖 |
|
g********d
发帖数: 4174 | 9 Do people infected with human immunodeficiency virus (HIV) have an increased
risk of cancer?
Yes. People infected with HIV have a substantially higher risk of some types
of cancer than uninfected people of the same age (1–4). Three of these
cancers are known as "acquired immunodeficiency syndrome (AIDS)-defining
cancers" or "AIDS-defining malignancies": Kaposi sarcoma, non-Hodgkin
lymphoma, and cervical cancer. A diagnosis of any one of these cancers marks
the point at which HIV infection has pr... 阅读全帖 |
|
S**********e
发帖数: 1789 | 10 给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications
Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖 |
|
i**********d
发帖数: 853 | 11 首先声明：我的分数很普通，所以这个帖子也没有任何炫耀的意思，只是我在考前
，每天都来看看有没有考经，也经常拿自己的模考成绩和考经中的对照一下，看看自己
复习的效果，从前辈的考经中学到很多。所以，本贴得唯一目的是：希望能给还在准备
step1的朋友们一点提示，吸取我的教训，都考出一个好成绩。
正文：
我是8/06/2012考的Step1，昨天（8/29/2012）早上9:19am拿到成绩---242/85，还
好，和自己估计的成绩240 +/- 5基本一致。万分感谢我的家人的理解和支持，十分感
谢曾经一起学习的战友们和校友们的鼓励和帮助，感谢麦地版的前辈们的考经和经验介
绍。曾经许诺一旦成绩上了230，就写一篇考经，下面就把我的备考经历和一点心得体
会向麦地版的战友们作一汇报，也算是对自己这段人生的一个总结：
一、题库、模考及考试成绩+时间：
UW qBank: 正确率最早25%，考前80-90%
Kaplan qBank: 只做了解剖、遗传，没有统计正确率
Dec 18, 2011, Form3 --- 350
Feb 25, 2012， F... 阅读全帖 |
|
i**********d
发帖数: 853 | 12 Jeff的75条口诀：
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人（城管？）挡道--> 不让别人换地方translocation
2).
下肢淋巴回流：
小隐隐于城外蝈蝈窝棚，大隐隐于城内富人水沟
（小隐收集小腿外侧淋巴液，注入腘窝；
大隐收集下肢内侧淋巴液，注入腹股沟；）
3)
imprinting diseas... 阅读全帖 |
|
i**********d
发帖数: 853 | 13 首先声明：我的分数很普通，所以这个帖子也没有任何炫耀的意思，只是我在考前
，每天都来看看有没有考经，也经常拿自己的模考成绩和考经中的对照一下，看看自己
复习的效果，从前辈的考经中学到很多。所以，本贴得唯一目的是：希望能给还在准备
step1的朋友们一点提示，吸取我的教训，都考出一个好成绩。
正文：
我是8/06/2012考的Step1，昨天（8/29/2012）早上9:19am拿到成绩---242/85，还
好，和自己估计的成绩240 +/- 5基本一致。万分感谢我的家人的理解和支持，十分感
谢曾经一起学习的战友们和校友们的鼓励和帮助，感谢麦地版的前辈们的考经和经验介
绍。曾经许诺一旦成绩上了230，就写一篇考经，下面就把我的备考经历和一点心得体
会向麦地版的战友们作一汇报，也算是对自己这段人生的一个总结：
一、题库、模考及考试成绩+时间：
UW qBank: 正确率最早25%，考前80-90%
Kaplan qBank: 只做了解剖、遗传，没有统计正确率
Dec 18, 2011, Form3 --- 350
Feb 25, 2012， F... 阅读全帖 |
|
i**********d
发帖数: 853 | 14 Jeff的75条口诀：
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人（城管？）挡道--> 不让别人换地方translocation
2).
下肢淋巴回流：
小隐隐于城外蝈蝈窝棚，大隐隐于城内富人水沟
（小隐收集小腿外侧淋巴液，注入腘窝；
大隐收集下肢内侧淋巴液，注入腹股沟；）
3)
imprinting diseas... 阅读全帖 |
|
i**********d
发帖数: 853 | 15 75条口诀：
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人（城管？）挡道--> 不让别人换地方translocation
2).
下肢淋巴回流：
小隐隐于城外蝈蝈窝棚，大隐隐于城内富人水沟
（小隐收集小腿外侧淋巴液，注入腘窝；
大隐收集下肢内侧淋巴液，注入腹股沟；）
3)
imprinting disease: ch... 阅读全帖 |
|
i**********d
发帖数: 853 | 16 75条口诀：
1).
Chloramphenicol inhibits 50S peptidyltransferase.
喷着氯气的ram(羊)拦住(抑制) 50岁的亚裔太太搬家(转移)(50S亚基肽键转移酶)
Clindamycin & chloramphenicol block peptide bond formation.
克林顿用氯气 吓唬老婆 --> 防止太太贱(肽键)形成
Aminoglycosides bind 30S and inhibit formation of the initiation complex and
cause misreading of mRNA.
Amigo绑架了30S亚裔,抑制了她婚姻的起始,造成她男友的误读
Macrolides block translocation.
带着大沿帽子的人（城管？）挡道--> 不让别人换地方translocation
2).
下肢淋巴回流：
小隐隐于城外蝈蝈窝棚，大隐隐于城内富人水沟
（小隐收集小腿外侧淋巴液，注入腘窝；
大隐收集下肢内侧淋巴液，注入腹股沟；）
3)
imprinting disease: ch... 阅读全帖 |
|
发帖数: 1 | 17
吃翔老酱看得懂英文吗？
Discovery
AIDS was first clinically observed in 1981 in the United States.[130] The
initial cases were a cluster of injection drug users and gay men with no
known cause of impaired immunity who showed symptoms of Pneumocystis
pneumonia (PCP or PJP, the latter term recognizing that the causative agent
is now called Pneumocystis jirovecii), a rare opportunistic infection that
was known to occur in people with very compromised immune systems.[131] Soon
thereafter, additional gay men de... 阅读全帖 |
|
l****z
发帖数: 29846 | 18 【 以下文字转载自 USANews 讨论区 】
发信人: lczlcz (lcz), 信区: USANews
标 题: 研究：男同性恋癌症率一般男性两倍
发信站: BBS 未名空间站 (Fri May 13 13:01:25 2011, 美东)
周一公布一项大型研究发现，患癌症的男性同性恋者比正常男人多两倍。这项研究是根
据“加州健康访
问调查”的自我报告数据，是美国最大的州级调查，经时三年，受访对象逾12万人。
调查中共有3,690男子有癌症，其中男同性恋者有癌症的比率是正常男人的1.9倍。女同
性恋者与正常
女性的癌症比率则没有区别。但在患癌症后，男同性恋和双性恋女性说自己健康情况不
佳的比率是同龄
异性恋者的两倍。
这一调查并没有分析不同性倾向的癌症患者的存活率，因此不能反映实际癌症率的真正
差别，因为它用
的是幸存者的数据。但研究人员认为，依靠性接触来传播的人类乳头状瘤病毒（
papilloma）及人类免
疫缺陷病毒（human immunodeficiency virus）导致肛门癌的发病率较高，可能是导致
男性同性恋
癌症比率高的部分原因。
报告还说，“同性恋男子有较大的... 阅读全帖 |
|
l****z
发帖数: 29846 | 19 周一公布一项大型研究发现，患癌症的男性同性恋者比正常男人多两倍。这项研究是根
据“加州健康访
问调查”的自我报告数据，是美国最大的州级调查，经时三年，受访对象逾12万人。
调查中共有3,690男子有癌症，其中男同性恋者有癌症的比率是正常男人的1.9倍。女同
性恋者与正常
女性的癌症比率则没有区别。但在患癌症后，男同性恋和双性恋女性说自己健康情况不
佳的比率是同龄
异性恋者的两倍。
这一调查并没有分析不同性倾向的癌症患者的存活率，因此不能反映实际癌症率的真正
差别，因为它用
的是幸存者的数据。但研究人员认为，依靠性接触来传播的人类乳头状瘤病毒（
papilloma）及人类免
疫缺陷病毒（human immunodeficiency virus）导致肛门癌的发病率较高，可能是导致
男性同性恋
癌症比率高的部分原因。
报告还说，“同性恋男子有较大的癌症患病率，可能是由于有肛门癌的缘故，早期的研
究也指出，肛门
癌的风险很高。”
艾滋病毒和艾滋病都与一系列的癌症有关，这些癌症包括：卡波西氏肉瘤（Kaposi
sarcoma）和非霍
奇金淋巴瘤（non-Hodgkin lymphoma）及肛门癌... 阅读全帖 |
|
|
j***x
发帖数: 1469 | 21 Review
Nature Reviews Immunology 7, 391-401 (May 2007) | doi:10.1038/nri2076
Immune evasion by Kaposi's sarcoma-associated herpesvirus
Laurent Coscoy1 About the author
Top of page
Abstract
please send to : l************[email protected]
Thans! |
|
b****r
发帖数: 17995 | 22 我觉得这么说更合适：提高免疫力对于 预 防 Kaposi's sarcoma, non-Hodgkin's
肿瘤发生后的治疗和预防发病可能机制完全不一样
比如补充叶酸，有一些证据表明，没有得肿瘤的时候补充叶酸可以降低肿瘤发病率，但
是得了肿瘤后补充叶酸，患者死得更快。甲氨喋呤之所以可以作为抗癌药就是使用它模
拟叶酸但不具有methyl donor功能
15-
nonmelanoma |
|
E**********y
发帖数: 991 | 23 那么多种癌症，为什么偏偏就选Merkel cell carcinoma测序，然后发现了MCV。最开始
发现KSHV也是，为什么偏偏选个Kaposi sarcoma测？那么多未知的virus-driven tumor
中，下一个又该选什么？ |
|
k**********n
发帖数: 438 | 24 ☆─────────────────────────────────────☆
JDJ (小兔乖乖) 于 (Mon Jul 21 02:34:52 2008) 提到:
HIV positive patient, CD4 count<200, presents with bloody diarrhea.
Colonoscopy showed reddish lesions with crypt abscesses.
What is the associated pathology?
1. adenocarcinoma
2. Kaposi's sarcoma
☆─────────────────────────────────────☆
soaplover (Ha) 于 (Mon Jul 21 02:40:55 2008) 提到:
interesting...2?
☆─────────────────────────────────────☆
magua08 (麦地麻瓜~回归) 于 (Mon Jul 21 03:09:29 2008) 提到:
it's int |
|
m****g
发帖数: 530 | 25 旧金山加利福尼亚大学（UCSF）的研究人员已经识别了一个新的潜在的药物靶标（drug
target）来抵抗疱疹病毒。总所
周知，这种病毒会导致卡波西肉瘤（Kaposi's Sarcoma）。这项新发现为使用一种蛋白
质抑制剂类的药物来抵抗疱疹病毒
提供了可能。
据研究人员介绍，这个新的药物靶标，被认为是一种蛋白酶二聚体，可以作为一种模型
来研发治疗从癌症到老年痴呆症这
类疾病的新疗法。这项研究结果发表在《Nature Chemical Biology》的网站上。
目前大部分的抗病毒药物都会攻击病毒的活性部位，那些部位的酶和受体是以锁和钥匙
那样的方式工作的，通过这种方式
或者激活或是抑制一些特殊蛋白质的活性。传统意义上说，药物开发也主要是关注“琐
”和“钥匙”的活性来使酶或受体起效。
一些病毒的酶，比如做所周知的蛋白酶，还包括HIV和疱疹病毒家族，它们最稳定的状
态是以二聚体的形式结合，非常像一
个完全开放的蛤壳。这些蛋白酶在病毒传染方面有重要的作用，但是还需要和蛤的两个
半体结合才会起效。
研究人员解释说，HIV蛋白酶已经可以通过阻碍二聚体的活性位点成功定位，但是疱疹
病毒蛋白酶二聚 |
|
