W*T
发帖数: 359 | 1 其实GAO的文章里面有一个非常重要的data他们没有讨论，也可能他们自己也没有意识
到该如何解释，他们就回避了。这个问题和治疗有直接的关系。 |
|
O**********a
发帖数: 317 | 2 contact inhibition为啥也是伪科学？ |
|
O******e
发帖数: 4845 | 3 不同cancer但结论一致的两篇文章一块儿发的。你看看它们的题目几乎一样。这么影响
重大的文章，单独一篇很难发。 |
|
|
s******y
发帖数: 28562 | 5 contact inhibition其实准确来说是细胞在体外培养体系里的表现。
在体内不好说这个contact inhibition到底有没有发生。 |
|
Z**********g
发帖数: 222 | 6 生长缓慢或停滞（quiescent或dormant）细胞对化疗耐药可以理解，但不解为何生长缓
慢或停滞的细胞需要transition到M状态(或者说为何细胞需到M态以延缓增殖以达到抗
药性) |
|
s******y
发帖数: 28562 | 7 在我的理解中，EMT是细胞基因变化的一个常见指标／结果，而不是抗药性的原因。
也就是说，如果发生了EMT，则说明细胞内部的基因表达产生了比较大的变化。 |
|
O**********a
发帖数: 317 | 8 体内为啥没有？Yap这类蛋白不就是感受力的么
体内长到一起，肯定有力的传递，Yap就磷酸化了，细胞停止proliferation啊。 |
|
s******y
发帖数: 28562 | 9 好像是因为体内的所谓contact inhibition 和体外的contact inhibition的概念有很
大相差，虽然名称都一样。 |
|
b*****u
发帖数: 75 | 10 体外的contact inhibition assay几乎都是用fibroblast做的，而实体瘤源于上皮细胞
。 |
|
m*****e
发帖数: 129 | 11 Rank Full Journal Title Total Cites Journal Impact Factor
1 CA-A CANCER JOURNAL FOR CLINICIANS 20,488 131.723
2 NEW ENGLAND JOURNAL OF MEDICINE 283,525 59.558
3 NATURE REVIEWS DRUG DISCOVERY 25,460 47.12
4 LANCET 195,553 44.002
5 NATURE BIOTECHNOLOGY 48,650 43.113
6 NATURE REVIEWS IMMUNOLOGY 31,545 39.416
7 NATURE MATERIALS 72,306 38.891
8 NATURE REVIEWS MOLECULAR CELL BIOLOGY 36,784 38.602
9 NATURE 627,846 ... 阅读全帖 |
|
发帖数: 1 | 12 Collecting plasma exosomes/extracellular vesicles, check exosomal RNAs (
mainly microRNAs) as well as proteins (oncogenic proteins involved in tumor
metastasis). |
|
b******k
发帖数: 2321 | 13 Faculty and Postdoctoral Positions at the Life Sciences Institute, Zhejiang
University
The Institute
The Life Sciences Institute of Zhejiang University (LSI-ZJU) was founded in
2009. Dr. Xin-Hua Feng was appointed as the founding director and Dr. Kun-
Liang Guan as the co-director. Located in the scenic city of Hangzhou, LSI
is now a world’s leading center of biological and biomedical research in
China.
As the first special academic zone of ZJU, LSI runs its own graduate program
and enjoys unpar... 阅读全帖 |
|
w*******2
发帖数: 75 | 14 诚恳求审稿！！！
The key words related to my research field is listed below:
Biology and Life Sciences, Biochemistry, Apoptosis, Caspase-3, Galectin-3,
Matrix Metalloproteinase-1, Melanoma, Oncology, Cancer Metastasis, Cancer
Treatment, Neogenin-1, Photodynamic Therapy, Radio-frequency Ablation;
Clostridium Difficile Infection (CDI), vaccine, toxicology, Immunology,
Infectious Disease, Inflammation, TPL2, MAPK signaling cascades, Signal
transduction.
My email:
[email protected]/* */
Thank you so m... 阅读全帖 |
|
发帖数: 1 | 15 A few postdoctoral positions are available immediately at Fox Chase Cancer
Center (Philadelphia, PA) for highly motivated individuals in the field of
cell signaling and protein biochemistry.
The main focus of the lab is to understand the molecular basis for the cell
signaling events that affect cell adhesion. For this, we employ a
combination of techniques including functional assays in mammalian cells,
binding kinetics analysis, protein biochemistry characterization, X-ray
crystallography, elec... 阅读全帖 |
|
k********r
发帖数: 12 | 16 Breast Cancer: Basic and Clinical Research杂志招收4-6名guest editors。
主要任务：
在四个月内招收3到5篇关于Molecular Basis of Breast Cancer Progression and
Metastasis主题的投稿。这些投稿会经过peer review, 发表在Breast Cancer: Basic
and Clinical Research。最后，另外四个月所有的editor和 journal staff 一起编辑
发表。
出版费：
Authors in North America: USD$1386
Authors in other countries: GBP￡1040
福利：
每个guest editor手下如果有两篇或者以上投稿被接受的话，可以有选择一篇给予免出
版费的权利。
出版后，所有guest editor都会成为杂志deitor board的一员。个人信息会被陈列在网
站guest editorial一栏里。
自己或者同一单位的同事有在Breast Cancer: Basic and ... 阅读全帖 |
|
k********r
发帖数: 12 | 17 Breast Cancer: Basic and Clinical Research杂志招收4-6名guest editors。
主要任务：
在四个月内招收3到5篇关于Molecular Basis of Breast Cancer Progression and
Metastasis主题的投稿。这些投稿会经过peer review, 发表在Breast Cancer: Basic
and Clinical Research。最后，另外四个月所有的editor和 journal staff 一起编辑
发表。
出版费：
Authors in North America: USD$1386
Authors in other countries: GBP￡1040
福利：
每个guest editor手下如果有两篇或者以上投稿被接受的话，可以有选择一篇给予免出
版费的权利。
出版后，所有guest editor都会成为杂志deitor board的一员。个人信息会被陈列在网
站guest editorial一栏里。
自己或者同一单位的同事有在Breast Cancer: Basic and ... 阅读全帖 |
|
b*****n
发帖数: 34 | 18 这两个文章结果不错，但是病人样本太小，病人可能都是精挑细选，更倾向对免疫疗法
有反应的（这个是根据以前一些一期试验的经验，没有依据）。个人对cancer vaccine
持怀疑态度，主要是因为：
1. 这个mutational load theory本身就很有瑕疵，如果看看几篇N Eng J Med的文章，
有疗效和没有疗效的患者mutational burden本身重叠部分就很大，加上现在很多被认
为是low mutational burden的肿瘤类型，对checkpoint反应率也没差太多。所以
antigen response 到了一定程度后，就是看microenvironment的抑制情况了。如果只
是作为maintenance therapy，那就回到20年前了，很难和新一代的制剂抗衡。
2. 即便是早期的cancer testis antigen vaccine, long peptide vaccine 也可以产
生类似于这个文章里的T 细胞反应，不过疗效在established tumour里微乎其微。这两
个文章也是看的复发率，大量的suppressive fact... 阅读全帖 |
|
w***a
发帖数: 4361 | 19 当然可以了，施一公肯定是个好工匠，毫无疑问。
但是匠就不要冒充大师在媒体上指点江山。
你提到癌症转移，施的博后老板Joan Massague就是metastasis权威，
人家一个lab把TGFb通道上上下下都搞清楚,CNS照样发
得嗖嗖的，这就立下了山头。 |
|
w***a
发帖数: 4361 | 20 当然可以了，施一公肯定是个好工匠，毫无疑问。
但是匠就不要冒充大师在媒体上指点江山。
你提到癌症转移，施的博后老板Joan Massague就是metastasis权威，
人家一个lab把TGFb通道上上下下都搞清楚,CNS照样发
得嗖嗖的，这就立下了山头。 |
|
b****n
发帖数: 75 | 21 Faculty and Qin Qian positions at the CSBC at JLU
http://csbc.org.cn/
We are looking for energetic and talented people to join our faculty (吉林大
学中日联谊医院肿瘤系统生物学中心, http://csbc.org.cn/). We are particularly interested in receiving applications from candidates with background in
(1) cancer systems biology;
(2) cancer metabolomics;
(3) studies of relationships between chronic inflammation and cancer;
(4) cancer initiation and metastasis using animal models;
(5) cancer drug development.
Successful app... 阅读全帖 |
|
发帖数: 1 | 22 读了一下这篇文章，不喜欢这种研究思路，不能够称之为科学。
该实验室主页上面所挂出来的以下一些文章中，有很多引用率非常的低。
ROCKII inhibition promotes the maturation of human pancreatic beta-like
cells. Nature Communications. 2017 Academic Article GET IT
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Cell Stem Cell. 2017 Academic Article GET IT
A Modular Platform for Differentiation of Human PSCs into All Major
Ectodermal Lineages. Cell Stem Cell. ... 阅读全帖 |
|
发帖数: 1 | 23 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
l*****k
发帖数: 587 | 24 are you sure you know what you are talking about?
they don't ask why there is tumor? what cause it, what
make them metastasis? |
|
g*******r
发帖数: 95 | 25 癌症是很麻烦的事情。西医中医都难办。
西医观念最粗糙：割掉就是了。精密一些的是生物研究，现在还在泥潭里，还是不
清楚，癌症有 oncogene之说，后来发现tumor supressor，再后来发现是DNA damage
repair，现在干脆沉默，有说是cancer stem cell，但无确论。还有针对tumor
antigen治
疗。反正我觉得没有好办法，癌症涉及的很多机制都是细胞通用的，制药学很难找
到专属的‘癌症蛋白’动手。我对西医和制药学很不乐观，我认为未来100年癌症仍
然是泥潭。
有些癌症，不割是死，割了也是死。割了以后，人体有出血凝血，创伤愈合机制，
这里面涉及很多growth factors，active peptides，有时残留的癌症组织在这过程
中激活了，
所以，不割慢死，割了反而来个转移Metastasis，良性变成恶性。
抗生素算微生物学的功劳，西医只是应用；就好象西医用了些精密仪器，其实是电
子工程的功劳一样。可笑，西医饭把功劳算在自己身上 |
|
发帖数: 1 | 26 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
a****9
发帖数: 773 | 27 今年生日的时候LD让我许愿，我很想cs pass，但是觉得还是家人健康比什么都重要。
。。。一个我最亲的人刚被发现maligancy distal metastasis. 心里好难过，想快考
完CK回国看他，大家如果觉得我上面发的帖子有点用，请帮祝福他，能少点痛苦，多点
平静。谢谢大家！ |
|
r********0
发帖数: 22 | 28 来自主题: MedicalCareer版 - 肝癌求助 you don't have liver cancer but breast cancer metastasis to the liver.
Nexavar will not work. your doctor should follow metastatic breast cancer
treatment algorithm, eg aggressive liver resection, hormonal therapy, or
systemic chemotherapy with or without her2 targeted agents. |
|
r********0
发帖数: 22 | 29 来自主题: MedicalCareer版 - 肝癌求助 She should be referred to an oncology specialist who could offer better
advice. If that means she has to go to Shanghai to find an oncologist then
by all means she should go.
It would be hard to answer your question without knowing more details about
her disease. The key piece missing is histo-pathology findings. Primary
cancers of skin, breast and liver and their histology subtypes have very
different prognosis and life expectancy.
Therefore before she leaves for Shanghai, she should take all... 阅读全帖 |
|
N***a
发帖数: 149 | 30 MEDICAL ETHICS 137 cases:
________________________
1. A 25- year old mother refused immunization for her 2-month old son. The
social worker spoke to the mother. (Important for Board examination)
Next step in management: immunization should be given for the benefit of the
child.
2. A 30-year old mother refused surgery for suspected appendicitis for her 6
-year old daughter. The social worker spoke to the mother. (Important for
Board examination)
Next step in management: surgical removal of the ap... 阅读全帖 |
|
z******1
发帖数: 666 | 31 http://www.mdanderson.org/patient-and-cancer-information/care-c
Dr.Curley is director. He is really excellent. He did surgery in liver
metastasis from colon cancer. In china most of this kind of patients were
given up. I did not see his contact information.
I followed Dr. Skibber. He is also great. His colon operation is perfect.He
is good at local invasion from colon or rectal cancer.He treat patients pre
and during operation with radiation.
Thank you for your 50 weibi.
as: 我想问一下这个center哪个胃... 阅读全帖 |
|
A*******s
发帖数: 9638 | 32 昨天有同仁对我的一个case感兴趣， 我今天查了下病历， 给大家写个完整的。
53 yrs old WM, previously healthy, presented with intractable fatigue and
weight loss for 3 months. A comprehensive workup by his PCP including a CT
of chest was reported as unremarkable.
PMH: Asthma, seeing a pulmonologist who reviewed CT and agreed with
radiologist's report.
Soical. Smoker 1 ppd. No ETOH/Drug.
FMH: neg for CA.
ROS: Not remarkable, no diplopia, dysphagia, no fever, no joint pain, no
muscle ache.
PE: Vital normal.
No positive findings on P... 阅读全帖 |
|
l**x
发帖数: 296 | 33 III score 8 is high grade, not good
Low grade: score 3-5
Intermediate grade: score 6,7
High grade: score 8,9
This is histological grading of invasive ductal carcinoma of breast, based on tubular formation, mitotic count, and nuclear grade.
The link is about cancer staging, which means how extensive the tumor is involved, eg if there is axillary lymph node involved, if there's distant metastasis. |
|
g******p
发帖数: 111 | 34 Update:
I attended an webinar by NCCN on adjuvant therapy for NSCLC pts and asked the case. The presenter is leaning towards using adjuvant chemo therapy. I am still collecting more openion on this. My mom will have first first follow up CT in Aug. I guess (guess only) if obvious disease progression were seen, chemo should be used. I still have the hope that if she can rest well and build up her immuine system, she will be able to keep the cancer in check.
Also I put together my mom's diagnosis ... 阅读全帖 |
|
A*G
发帖数: 256 | 35 （左上肺叶肿块，左下肺叶肿块) (Mass at left superior lung lobe, and left
lower lung lobe)
高分化腺癌，以细支气管肺泡癌为主，肿块大小分别为1.5*1.0*0.8cm和1.0*0.6*0.8cm
，局部累犯脏层胸膜。Well differentiated adenocarcinoma, mainly bronchioloalveolar (
BAC), tumor size:1.5*1.0*0.8cm & 1.0*0.6*0.8cm，locally invaded to visceral
pleural.
未见明确脉管内癌拴及神经侵犯。There is no tumor emboli and no perineural invasion.
（左上肺叶后段肿块）可见部分肺泡扩张，符合肺气肿改变。另见部分区肺泡上皮不典
型增生伴癌变，病灶大小φ 0.5cm。
(mass at left superior lobe posterior lung segment) There are some alveolar inflation, ... 阅读全帖 |
|
a******8
发帖数: 231 | 36 15. A 60-year-old woman is undergoing surgical excision of a renal cell
carcinoma thrombus that extends in to the right renal vein. During the
procedure, the vena cava is temporarily occluded above the renal veins.
Increased venous pressure is most likely to be noted in which of the
following veins during the period of occlusion?
A) External iliac
B) Hepatic
C) Inferior mesenteric
D) Portal
E) Splenic
23. A 35-year-old woman is brought to the emergency department after having
a stroke. Evaluatio... 阅读全帖 |
|
h**s
发帖数: 1757 | 37 What do u wanna take? B?
1) T3 N0 M0 epidermoid carcinoma. This means he had no metastasis at the
very beginning.
2)smoking history
so primary has more possibility. |
|
d********y
发帖数: 616 | 38 Heart & Blood Vessels
Flask-shaped / Pear-shaped / Leathe- bottle / Money-bag shaped heart -
Pericardial effusion
Boot-shaped heart / Coer-en-sabot - Fallot's tetralogy
Box shaped appearance - Tricuspid atresia
Jug Handle appearance - Primary pulmonary artery hypertension
"3" like appearance - Coarctation of Aorta
Egg on side appearance - Transposition of great vessels
Egg in cup appearance - Constrictive pericarditis
Snow-man heart - TAPVC (total anomalous pulmon... 阅读全帖 |
|
b*****l
发帖数: 8603 | 39 2007年的，不知道你们说的是不是这个。祝好。
medical ethics more than hundred cases
Sep 24th, 2007, 12:17pm
1. A 25- year old mother refused immunization for her 2-month old son. The
social worker spoke to the mother. (Important for Board examination)
Next step in management: immunization should be given for the benefit of the
child.
2. A 30-year old mother refused surgery for suspected appendicitis for her 6
-year old daughter. The social worker spoke to the mother. (Important for
Board examination)
Next step in ma... 阅读全帖 |
|
yf
发帖数: 272 | 40 http://jop.ascopubs.org/content/early/2013/03/26/JOP.2012.00081
Perspective
Practicing Western Oncology in Shanghai, China: One
Group’s Experience
By David H. Garfield, MD, Harold Brenner, MD, FRCR (Lond), and Lucy Lu, RN
ProMed Cancer Centers–Shanghai, Shanghai, People’s Republic of China
In October 2011, we—David H. Garfield, MD, medical oncologist,
United States; Harold Jacob Brenner, MD, FRCR,
radiation oncologist, Israel; and Lucy Lu, oncology nurse,
Shanghai, China—were part of a group tha... 阅读全帖 |
|
i*****r
发帖数: 265 | 41 帮个朋友问的，57岁，下面是病理报告：
Examination Findings
Specimen of right breast mass 4X2X3CM was sent for inspection. A grey nodule
with size of 2.5X2CM was found in the section. Endoscope finding: The tumor
cells were in nest shape and glandular tube. The cells arranged solidly and
grew invasively. Nuclear fission was easy to see, and nuclear atypia was
obvious. No cancer metastasis was found in the 3 pieces of lymph nodes in
the right paracardial region for inspection.
ER(++70%) PR(-) P35(++75%) C-erbB-... 阅读全帖 |
|
s**********1
发帖数: 4651 | 42 No cancer metastasis was found in the 3 pieces of lymph nodes in
the right paracardial region for inspection.
就是没有淋巴转移对吗？ |
|
t******e
发帖数: 195 | 43 信息给的不全，HER2是positive吗？
有没有做PET/CT看全身metastasis?
,
+)。 |
|
l**x
发帖数: 110 | 44 知道这个版的专业医生很多，所以占宝地求指点。恳请大家一点给点指导，下一步怎么
办合适？
患者44岁，男，6年前因为肝癌做了肝移植 （符合米兰标准），之后无灾无病好几年。
去年2016年初发现轻微贫血，血色素12，因为当时在服小剂量阿司匹林，于是停服，看
看有没好转。托托拉拉到了年底，还是贫血，血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤，内镜医生直觉是GIST。随后CT，但CT却没有异常。4月初第二次胃镜
，GIST依然还在，取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm，说比较第一次32mm变大了。可能第一次看片医生那天喝多了？肿瘤位置在
Fundus，非常接近GOJ。
AFP好久没有查了，因为肝上的情况一直很好，肝移植前AFP 100多，移植后AFP一直小
于2。上一次至少是2，3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移，
要么是HAC。
下周二医生还要安排一次PETCT，周三见外科医生，估计排除转移外就安排切除了。 求
这里的专家教授指点，这个情况如何是好？下面我贴上最近几个报告。
个人感觉肝移植后5，6年转... 阅读全帖 |
|
t*d
发帖数: 1290 | 45 【 以下文字转载自 Biology 讨论区 】
发信人: ttd (oldcat), 信区: Biology
标 题: better way to conquer cancer
发信站: BBS 未名空间站 (Wed Jan 16 14:57:14 2013, 美东)
IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', ... 阅读全帖 |
|
a*y
发帖数: 119 | 46 你说的情况是癌症后期， metastasis，涉及到癌细胞随血液运输和
血管壁通透性变大的问题。 我比较感兴趣的是原发性肝癌的产生 |
|
a*y
发帖数: 119 | 47 你说的情况是癌症后期， metastasis，涉及到癌细胞随血液运输和
血管壁通透性变大的问题。 我比较感兴趣的是原发性肝癌的产生 |
|
j****u
发帖数: 1413 | 48 新闻与图片花絮请见：http://www.ustcif.org/default.php/content/1605/
加USTCIF为微信好友，即可订阅每日一期中国科大手机新闻报，科大要闻与校友动态尽
在掌握
扫一扫二维码，即可在微信添加好友，每天收到中国科大新闻：
2013年5月2日，肺癌新药发明人、辉瑞公司科学家崔景荣博士（803校友）在北京为中
国
科大校友带来精彩的科普报告《癌症的发生，演变与个体化治疗》。她还介绍她作为主
导发明人的抗癌药克唑替尼 (Crizotinib) 的研发历程，并阐述了她对癌症治疗的抗药
性及抗癌的新理念的看法。
崔景荣领衔的辉瑞公司团队，因发明治疗肺癌新药“克里唑替尼”（Xalkori），2011
年
荣获美国第38届年度国家发明奖，该药2011年在美国上市，之后在北京协和医院、解放
军307医院等地进行中国临床三期实验。2013年，中国食品药品监督管理局（SFDA）批
准
该药在中国上市。
崔景荣介绍癌症的相关基础知识，癌症是细胞生长失控的表现、长期基因突变累积的结
果。她简单列举了诱发癌症的原因，并指出“癌症的复杂性在于癌细胞与周边环境的相
辅... 阅读全帖 |
|
发帖数: 1 | 49 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
|
s**4
发帖数: 490 | 50 pancreatic cancer with lung metastasis???
我瞎翻的啊 |
|
