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全部话题 - 话题: necrosis
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c****1
发帖数: 1095
1
来自主题: Biology版 - Cell death最全面的review
不知有没有做cell death方面的朋友。最近做的一个课题,发现一个compound诱导的细
胞死亡,既不是necrosis,也不是apoptosis(有少量,但是只占10%左右)。而且各种
死亡的抑制剂,也不能抑制这个compound诱导的细胞死亡。想找一篇很全面的,讲cell
death的review。也没有好的发现。大家可以推荐下么?
X*******8
发帖数: 3895
2
来自主题: Biology版 - Cell death最全面的review
你判断不是necrosis的标准是什么?

cell
c****1
发帖数: 1095
3
来自主题: Biology版 - Cell death最全面的review
好问题!其实究竟是不是necrosis,我们并没有严谨的判断。只是细胞死亡很慢,要到
48小时后,才有明显死亡。另外,镜下看,死亡细胞的膜似乎没有破裂。
X*******8
发帖数: 3895
4
来自主题: Biology版 - Cell death最全面的review
既然什么都没做,就不要下结论了。abcam有kit鉴定healthy, apoptosis 和necrosis。
w******e
发帖数: 953
5
Curr Stem Cell Res Ther. 2016;11(7):593-602.
The Effect of Tumour Necrosis Factor-α on Periodontal Ligament Stem Cell
Differentiation and the Related Signaling Pathways.
c******r
发帖数: 889
6
Glutathione太少,细胞就会被各种高反应性有害物质OVERWHELM,蛋白被氧化,DNA被
修饰,细胞会启动NECROSIS坏死程序。然后肝坏死。反正自杀别选这个,是非常慢而且
痛苦的死亡。TYLENOL主要是肝毒性。因为那里是他被代谢氧化的地方。
TYLENOL的代谢物基本(做RESEARCH习惯,不说都,其实我认为都)被identify了,有
害的就NAPQI一种。
其实他没什么可怕的。细胞里线粒体里一个辅酶Q,也是quinone化合物,和NAPQI一样
。我们有氧呼吸,制造ATP,我们能量分子离不开他。生命离不开辅酶Q。你在nutrient
supplement柜台能看到卖这玩意儿的。
结论是,化合物毒和无毒不是绝对的。量,地点什么都是因素。
谈西药变色是没有根据的恐惧,因噎废食了。
中药其实本质上一样。
g*****j
发帖数: 1211
7
来自主题: ChineseMed版 - 胰岛素的副作用--糖尿病(转载)
You can find adverse effect on everything. The question is about how
often do you see adverse effect, and what is the consequence if you do
not treat. It is all about risk and benefit. That is why you need a
doctor to prescribe insulin.
For the side effect you sited:
1. 低血糖反应
This is not a side effect of insulin, but a side effect of inappropriate
use.
2. 过敏反应
Every drug on this planet has this side effect. So, what the hell ..
3. 胰岛素性水肿
As you said, it is an evidence of improvement. And it... 阅读全帖
K**********n
发帖数: 1197
8
来自主题: EE版 - 版上有人懂这个技术没?
学术界珍稀有限的原版外文资料,
Remote Mind Control Technology

Reprinted from SECRET AND SUPPRESSED: BANNED IDEAS AND HIDDEN
HISTORY, edited by Jim Keith, $12.95, available from
1-800-680-INET.
There had been an ongoing controversy over health effects of electromagnetic
fields (EMF) for years (e.g., extremely low frequency radiation and the
Navy's Project Seafarer; emissions of high power lines and video display
terminals; radar and other military and industrial sources of radio
frequencies and micr... 阅读全帖
w*******4
发帖数: 17
9
来自主题: MedicalCareer版 - Clinical Pearls 7/7/08
Pearls:
1. Treatment for rhabdomyolysis involves intravenous saline infusions to
maintain a high urine output and alkalization of urine with a target pH of 7
-8 to prevent myoglobin deposition.
2. Aortic dissecting aneurysm caused by degeneration of tunica media-cystic
medial necrosis.
3. Cardiac rupture most common 4-7 days post MI.; ventricular free wall
rupture leads to cardiac tamponade.
4. New onset serous discharge from a laparotomy wound should raise the
suspicion of wound dehiscence.
5.
l********z
发帖数: 810
10
来自主题: MedicalCareer版 - step1 NBME4 behavior science qs need correction
1. A 20-year-old woman feel sad, cries occasionally, and doubts her ability
to take care of her healthy 3-day-old newborn. She has started to breastfeed
, and her sleep and appetite are normal. Which of the following is the most
likely explanation for her feelings?
A) Adjustment disorder with depressed mood
B) Brief reactive psychosis
C) Major depressive episode
D) Normal reaction to birth
E) Pospartum pituitary necrosis
2.A couple has just learned that their 3-year-old son has fragile X syndrom
c*****0
发帖数: 9
11
Thanks.
For a septic shock itself, the , most common consequence is acute renal
failure from acute renal necrosis, ARDS and DIC. All these did not happen to
this patient. Without prompt release of obstruction from kidney stone would
be the first to be blamed for this case. The other thing we need to careful
think about is the risk-benefit of maintaining the optimal level of the Bp
for a shock patient (temporally) and the dosage of epi.( the lowest accepted
level?)
I agree with happydoc, the ambu
f*****w
发帖数: 1451
12
来自主题: MedicalCareer版 - A ck nbme form3 question
20. A 25-year-old woman has had painless vaginal postcoital bleeding for 2
hours. Her last menstrual period was 10 weeks ago. A pregnancy test is
positive. There is a small amount of dark blood in the vaginal canal. She
has a reddened, friable cervical os.
O A)Abortion of a blighted twin
O B)Cervicitis
O C)Ectopic pregnancy
O D)Focal decidual necrosis
O E) Gestational trophoblastic disease
0 F) Incomplete abortion
0 G) Ovarian torsion
0 H) Ruptured ovarian cyst
0 I) Threatened abortion
B or I?
t
w********n
发帖数: 202
13
来自主题: MedicalCareer版 - NBME form2
41. A 49-year-old woman is admitted to the hospitalbecause of renal failure.
She has had episodes of flank pain over thepast 20 years. She has also had
nocturia 2 to 3 times nightly for 10years. Her blood pressure is 160/100 mm
Hg. Examination shows palemucous membranes. A mass is palpated in the right
flank. Which of thefollowing is the most likely diagnosis?
A) Horseshoe kidney
B) Nephrolithiasis
C) Papillary necrosis
D) Polycystic kidney disease
E) Renal cell carcinoma
How about E
p******9
发帖数: 114
14
1. A 5-year-old boy is brought to the physician 1 hour after urinating
bright red blood. He has been taking ibuprofen since injuring his right
flank while wrestling with friends yesterday; he also has been taking
penicillin for 3 days for streptococcal pharyngitis. His temperature is 36.7
C (98 F), blood pressure is 90/48mm Hg, pulse is 108/min, and respirations
are 18/min. Examination shows purple ecchymoses over the shins and right
flank; there is tenderness of the right costovertebral area. T... 阅读全帖
L********a
发帖数: 576
15
来自主题: MedicalCareer版 - 再请教一个Kaplan题目
A 42 year old man is admitted to the local hospital with a diagnosis of deep
vein thrombosis. On physical exam, he has bilateral pitting edema of the
lower extremities. On standard chemistry testing, his albumin is 2.5g/dl.
During further interview, the patient states that this past year he noticed
he had more "cold" than usual. A 24 hour urinalysis shows 4 g of protein
with no hematuria or red blood cells. If a renal biopsy is performed, which
of the following findings would be expected?
A) Nor... 阅读全帖
l****n
发帖数: 64
16
来自主题: MedicalCareer版 - FA step 1 2011 vs. 2010
There are some additional points in 2011 regarding
BEHAVIOUR SCIENCE
Sleep patterns in a depressed person
Sleep terror disorder
Ethical issues 3 additional points added
BIOCHEM
A few points added on in the Catecholamine synthesis reaction
EMBRYO
Types of error in organ morphogenesis
Descent of testes and ovaries
MICRO
Campylobactor jejuni
Vibrio cholera
Herpesviruses latency
Hepatitis chart modified
Pyrazinamide drug
HAART drugs details
Antiprotozoal chart
Antihelminthic chart
IMMUNO
TH1 & TH2 c... 阅读全帖
s*******d
发帖数: 1079
17
来自主题: MedicalCareer版 - FA 2011 vs 2010 对照分析
学友MILK找到的这个FA 2011版 vs 2010版的详细对照,我觉得很有帮助,放
在这儿给大家做参考吧。
原文见 http://forums.studentdoctor.net/showthread.php?t=785943
Overall:
- FA 2011 corrects some of the 2010 errata
- FA 2011 has darker print and thicker pages
- FA 2011 increases the size of most figures/images (although only slightly)
- FA 2011 removes several images that are difficult to see/interpret
Behavioral Science:
p. 59-60 2010 (57-58 2011) -2011 reorganized a couple items into "Advance
directives" and got rid of "Good Samaritan Law.... 阅读全帖
S******9
发帖数: 2837
18
来自主题: MedicalCareer版 - UW CK study partner
pregnancy-related Liver disease:
Normal physiological changes of pregnancy: mild ↑AKP ( placental secretion
of the enzyme), normal bilirubin, AST/ALT and r-GT.
Acute fatty liver of pregnancy:
- Cx of the 3rd trimester of pregnancy
- asymptomatic , or complain of severe nausea , malaise , headache , and
abdominal pain; Over half of patients also have preeclampsia, and 60% will
develop acute renal failure.
- can also cause a prolonged prothrombin time and moderate to severe
elevation of tra... 阅读全帖
D*****l
发帖数: 554
19
来自主题: MedicalCareer版 - 看EHEC疫情新闻复习FA/UW
肆虐欧美 全球恐慌 研究称恶菌与艾滋肠毒同源
中新网6月4日电 据香港《文汇报》4日报道,肆虐欧洲的肠出血性大肠杆菌(EHEC)疫情
持续蔓延,更有向全球扩散迹象。世界卫生组织(WHO)表示,美国与捷克也相继传出确
诊病例,现时疫情已蔓延至13个国家。中国深圳华大基因研究院和德国一家大学昨日宣
布,中德科学家联合对本次流行的病菌进行了全基因组测序,结果显示,该病菌与艾滋
病患者腹泻标本中的大肠杆菌同源性超过93%,兼具侵袭、产毒、抗药等多种“凶性”
,难以治疗,死亡率偏高。
深圳华大的初步分析结果显示,这次肆虐欧洲的血清型0104大肠杆菌,该病菌带有
新型特异基因,与2002年从中非共和国艾滋病患者腹泻标本中分离的肠聚集性大肠杆菌
55989菌株,同源性超过93%,同时它还通过基因水平转移,获得肠出血性大肠杆菌的毒
力基因和毒力相关质粒,这可能与该菌株强毒性和重症感染有关。
变种新基因 夺18人命
同日德国明斯特大学医学院卫生研究所表示,造成本次疫情的菌株是0104:H4大肠
杆菌的一个变种。然而世卫发言人表示,是次导致多人死亡的大肠杆菌,过往曾在人类
身上出现。
EHEC疫情蔓延,德... 阅读全帖
f****i
发帖数: 129
20
来自主题: MedicalCareer版 - CK NBME form3 cervicitis or threatened abortion??
20. A 25-year-old woman has had painless vaginal postcoital bleeding for 2
hours. Her last menstrual period was 10 weeks ago. A pregnancy test is
positive. There is a small amount of dark blood in the vaginal canal. She
has a reddened, friable cervical os.
O A)Abortion of a blighted twin
O B)Cervicitis
O C)Ectopic pregnancy
O D)Focal decidual necrosis
O E) Gestational trophoblastic disease
0 F) Incomplete abortion
0 G) Ovarian torsion
0 H) Ruptured ovarian cyst
0 I) Threatened abortion
Does cerv... 阅读全帖
z**********o
发帖数: 106
21
来自主题: MedicalCareer版 - 求答案 step 1 nmbe form 4 block 2 q 25 and q41
Can anyone give the correct answer for the following two questions? thanks!
Q25
a 45-year old man has four episodes of involuntary twitch of the right foot.
following the last episodes, he had a tonic-clonic seizure. Which of the
following structures on the left is the most likely origin of the seizure?
A. inferior frontal cortex
B. inferior temporal cortex
c. insular cortex
D. Primary motor cortex
E. Supplementary motor cortex
I think B is the correct answer. For partial seizures, most common... 阅读全帖
h*******y
发帖数: 1220
22
来自主题: MedicalCareer版 - some board questions about cardiology
did some search:
myocardial troponin can also be released in the setting of increased
membrane permeability (4). With increased membrane permeability, smaller
troponin fragments could be released into the systemic circulation. In this
setting, myocyte damage may not be permanent and necrosis does not occur.
J**b
发帖数: 182
23
来自主题: MedicalCareer版 - 求临床医学考题答案(练习题)
1. Sarah is recovering from pneumonia. She is 93 and a resident of a local
nursing home, where she was diagnosed with behavioral and cognitive
disturbances. She is refusing food, drink and medication. Her BUN is 60
and her serum Creatinine is 1.0 . Her potassium level is 4.8.
Which of the following is most likely to be true?
A. Her serum creatinine is “normal” because her kidneys have not
been injured
B. Her renal function will return to normal with adequate rehydration
... 阅读全帖
J**b
发帖数: 182
24
来自主题: MedicalCareer版 - 求临床医学考题答案(练习题)
这是我试着选的答案,如果哪位兄弟姐妹同意我的一个答案,答谢一个包子,指正一个
错误,2个包子。
1. Sarah is recovering from pneumonia. She is 93 and a resident of a local
nursing home, where she was diagnosed with behavioral and cognitive
disturbances. She is refusing food, drink and medication. Her BUN is 60
and her serum Creatinine is 1.0 . Her potassium level is 4.8.
Which of the following is most likely to be true?
A. Her serum creatinine is “normal” because her kidneys have not
been injured
B. Her renal function wil... 阅读全帖
J*********4
发帖数: 1274
25
来自主题: MedicalCareer版 - 求临床医学考题答案(练习题)
11. characteristic of myoglobinuria:
A. White blood cell casts
B. Red blood cell casts
C. Muddy brown casts
D. Positive blood on dipstick
E. Hyaline cast
C or D?
======
D: dipstick can not differentiate myoglobin or hemoglobin, both of which
have heme.
C is not right because myoglobinuria does not necessarily, even though it
might, causes renal tubule necrosis
J*********4
发帖数: 1274
26
来自主题: MedicalCareer版 - 求临床医学考题答案(练习题)
一家之言, just for discussion
1. C, 2. C, 3.don't know 4. E, 5.C, 6.C, 7.B, 8.E
1. The old lady has dehydration, which causes pre-renal azotemia and
eventrually leads to renal tubule necrosis. The low creatinine is due to the
lack of muscle mass in old people, which underestimates the actual renal
insufficiency.
8. RBC cast indicates damage in GBM. Here is a paragraph from wiki
Hyaline casts
The most common type of cast, hyaline casts are solidified Tamm-Horsfall
mucoprotein secreted from the tubula... 阅读全帖
h*******r
发帖数: 182
27
来自主题: MedicalCareer版 - Emergency: tick Bite
Update:
Now after 48h bite, the lesion is more like lyme's erythema migran: 5X6cm
erythematous rash, second ring is 1x1cm, center is 3x3mm necrosis, around
the center to the second ring is clearing.
The lesson: When you see a small tick such as the size of sesame, go to
clinic or ER to have it extracted. At home, most people are not experienced
or don't have good tick forceps, tweeser to pull it out without breaking it.
If you hold the body, very likely you squeeze the tick's gut and the
spiroch... 阅读全帖
r**********n
发帖数: 9
28
Sorry for the sad news about your lovely baby.
ATRT的预后非常差,是肯定的。
如果你想尝试St. Jude or Boston,您可以直接与他们联系。复制并翻译所有的医疗记
录。如果他们接受你的宝宝,通常你需要提前支付作为一个国际病人。St. Jude 是研
究医院,可能对美国人免费。不知对国际病人如何。
因为它是ATRT,你要想清楚你花代价是想要什么结果。
以下转自UpToDate:
Atypical teratoid/rhabdoid tumors — CNS atypical teratoid/rhabdoid tumors (
ATRTs) are highly malignant tumors primarily occurring in young children
less than three years old [91]. Histologically, ATRTs are characterized by
rhabdoid cells and are similar to that of other small ro... 阅读全帖
l******p
发帖数: 71
29
1. A 16-year-old girl comes to the clinic because of vaginal itching for
the past 5 days. She requests that her parents not be informed about the
appointment. During the examination, she says she occasionally has
unprotected sexual intercourse and asks for oral contraceptives. Preliminary
laboratory studies show gram-negative diplococci. Which of the following is
the most appropriate next step in patient care?
A) Consult a colleague for advice about treating a minor without parental
consent
... 阅读全帖
i**********d
发帖数: 853
30
来自主题: MedicalCareer版 - Steps口诀总结帖-2014
我的MTB2书就要送人了,最后把记在书上的一些口诀记录下来:
1). 儿科最后一页上的Musculockeletal Diseases是考试的重点,在CK和Step3中考了
很多次,不是诊断就是治疗
A. Congenital Hip Dysplasia: 小小Baby骑在马具(harness)上操纵(maneuver)玩具小
马.
B. Legg-Calve-Perthes disease: 2-8岁,"Terrible two"两岁的孩子坏死了(
Avascular necrosis),两侧hip同时手术(Legg=leg+leg).
C. Slipped capital femoral epiphysis: 肥胖的青少年,逃课(slip)到学校外(
externally rotated leg),用钉子(pinning)把他/她固定在教室内(internal
fixation)椅子上。
2). 含有egg成分的vaccine:influenza + yellow fever:流蛋黄。
3). 低钾 or 高钙 à inhibit V2 related adenylate cycl... 阅读全帖
i**********d
发帖数: 853
31
来自主题: MedicalCareer版 - Steps口诀总结帖-2014
我的MTB2书就要送人了,最后把记在书上的一些口诀记录下来:
1). 儿科最后一页上的Musculockeletal Diseases是考试的重点,在CK和Step3中考了
很多次,不是诊断就是治疗
A. Congenital Hip Dysplasia: 小小Baby骑在马具(harness)上操纵(maneuver)玩具小
马.
B. Legg-Calve-Perthes disease: 2-8岁,"Terrible two"两岁的孩子坏死了(
Avascular necrosis),两侧hip同时手术(Legg=leg+leg).
C. Slipped capital femoral epiphysis: 肥胖的青少年,逃课(slip)到学校外(
externally rotated leg),用钉子(pinning)把他/她固定在教室内(internal
fixation)椅子上。
2). 含有egg成分的vaccine:influenza + yellow fever:流蛋黄。
3). 低钾 or 高钙 à inhibit V2 related adenylate cycl... 阅读全帖
z******8
发帖数: 844
32
来自主题: MedicalCareer版 - [合集] Steps口诀总结帖-2014
☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:08:37 2014, 美东) 提到:
一个好的口诀胜读10遍书,记住的知识点那是经久不忘,真是受益匪浅。我和Jeff一起
学习的时候编了不少好的口诀,现在Jeff考试考完了,match完了,抽点时间和我一起
把我们之前的口诀总结出来,一来是奉献麦地,也希望能够帮助后来的同学,二来是防
止我们的口诀继续在那里吃灰,这可都是我们耗费了多少脑细胞的成果。我们打算每天
抽点时间把口诀贴到此贴,如果有同学有自己的口诀想要分享,欢迎跟帖!
☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:12:40 2014, 美东) 提到:
☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:19:23 2014, 美东) 提到:
Toxopl... 阅读全帖
E***a
发帖数: 60
33
来自主题: MedicalCareer版 - NBME 精神题求解
11) A 20 y/o F cries occasionally, feels sad, and doubts her ability to take
care of her healthy 3d old newborn. She has started to breast feed and her
sleep and appetite are normal. The most likely explanation for her feelings
is:
a) Adjustment disorder with depressed mood
b) Brief reactive psychosis
c) Major depressive episode
d) Normal reaction to birth
e) Postpartum pituitary necrosis
A??? My second choice would be D???
T****g
发帖数: 705
34
来自主题: MedicalCareer版 - Lingas’s Step 3 & Jet’s CK 讲座笔录
“临床思维,解题思路”
举个例子:
An 82 year-old man has been mechanically ventilated in the hospital for the
past 48 hours because of an exacerbation of chronic obstructive pulmonary
disease. He has passed no urine since removal of a urinary catheter 12 hours
ago. Current medications include intravenous methylprednisolone and
albuterol, ipratropium. And fluticasone by inhalation. Which of the
following is the most likely diagnosis?
A) Acute interstitial nephritis
B) Acute urethral obstruction
C) Contr... 阅读全帖
l**x
发帖数: 110
35
知道这个版的专业医生很多,所以占宝地求指点。恳请大家一点给点指导,下一步怎么
办合适?
患者44岁,男,6年前因为肝癌做了肝移植 (符合米兰标准),之后无灾无病好几年。
去年2016年初发现轻微贫血,血色素12,因为当时在服小剂量阿司匹林,于是停服,看
看有没好转。托托拉拉到了年底,还是贫血,血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤,内镜医生直觉是GIST。随后CT,但CT却没有异常。4月初第二次胃镜
,GIST依然还在,取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm,说比较第一次32mm变大了。可能第一次看片医生那天喝多了?肿瘤位置在
Fundus,非常接近GOJ。
AFP好久没有查了,因为肝上的情况一直很好,肝移植前AFP 100多,移植后AFP一直小
于2。上一次至少是2,3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移,
要么是HAC。
下周二医生还要安排一次PETCT,周三见外科医生,估计排除转移外就安排切除了。 求
这里的专家教授指点,这个情况如何是好?下面我贴上最近几个报告。
个人感觉肝移植后5,6年转... 阅读全帖
f****o
发帖数: 2770
36
我讲话难听由于家庭遗传,真不好意思。
我吧书本上的东西全部贴出来,你能看懂多少算多少吧。
Heart Failure
DEFINITION
Heart failure (HF) is a clinical syndrome caused by the inability of the
heart to pump sufficient blood to meet the metabolic needs of the body.
Heart failure can result from any disorder that reduces ventricular filling
(diastolic dysfunction) and/or myocardial contractility (systolic
dysfunction).
PATHOPHYSIOLOGY
Causes of systolic dysfunction (decreased contractility) are reduction in
muscle mass (e.g., myocardial infarctio... 阅读全帖
f****o
发帖数: 2770
37
GENERAL PRINCIPLES
The first step in managing chronic HF is to determine the etiology or
precipitating factors. Treatment of underlying disorders (e.g., anemia,
hyperthyroidism) may obviate the need for treatment of HF.
Nonpharmacologic interventions include cardiac rehabilitation and
restriction of fluid intake (maximum 2 L/day from all sources) and dietary
sodium (approximately 1.5 to 2 g of sodium per day).
Stage A: The emphasis is on identifying and modifying risk factors to
prevent developm... 阅读全帖
a*********8
发帖数: 296
38
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
我们step1讲的HIT的病人不要用warfarin因为容易引起skin necrosis,还有抗十因子
确实也用,想问问argatroban和hirudin就是单价双价什么区别?
l******k
发帖数: 27533
39
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
Warfarin用没问题
引起skin necrosis机理是什么?rate是多少?
Argatroban 不是唯一选择,用这个是因为formulary

★ 发自iPhone App: ChineseWeb 8.6
a*********8
发帖数: 296
40
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
关于skin necrosis, 是我们那个pathoma 录像里提了一句,我不知道具体临床的例子。
a*********8
发帖数: 296
41
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
http://www.medscape.com/viewarticle/784963
Skin necrosis is a pretty rare problem, but our experience indicates that a
large proportion of these cases may have underlying HIT
好像有点关系。
l******k
发帖数: 27533
42
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
谢谢分享
这是个observational 推理,没有很强的联系,所以不是contraindication
Monitoring necrosis/skin reaction是合理的
Rivaroxiban 也有这个risk吗?还是就是warfarin?

a
★ 发自iPhone App: ChineseWeb 8.6
a*********8
发帖数: 296
43
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
我们step1讲的HIT的病人不要用warfarin因为容易引起skin necrosis,还有抗十因子
确实也用,想问问argatroban和hirudin就是单价双价什么区别?
l******k
发帖数: 27533
44
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
Warfarin用没问题
引起skin necrosis机理是什么?rate是多少?
Argatroban 不是唯一选择,用这个是因为formulary

★ 发自iPhone App: ChineseWeb 8.6
a*********8
发帖数: 296
45
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
关于skin necrosis, 是我们那个pathoma 录像里提了一句,我不知道具体临床的例子。
a*********8
发帖数: 296
46
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
http://www.medscape.com/viewarticle/784963
Skin necrosis is a pretty rare problem, but our experience indicates that a
large proportion of these cases may have underlying HIT
好像有点关系。
l******k
发帖数: 27533
47
来自主题: Pharmacy版 - 第一次argatroban dosing for HIT patient
谢谢分享
这是个observational 推理,没有很强的联系,所以不是contraindication
Monitoring necrosis/skin reaction是合理的
Rivaroxiban 也有这个risk吗?还是就是warfarin?

a
★ 发自iPhone App: ChineseWeb 8.6
p*******g
发帖数: 2976
48
【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖
g***j
发帖数: 40861
49
有全文链接
【 以下文字转载自 Biology 讨论区 】
发信人: brownu (brownu), 信区: Biology
标 题: 法国学者发现白老鼠吃转基因玉米后患上巨大肿瘤zt
发信站: BBS 未名空间站 (Thu Sep 20 17:31:13 2012, 美东)
发信人: PortlandOR (Portland, OR), 信区: Military
标 题: 法国学者发现白老鼠吃转基因玉米后患上巨大肿瘤
发信站: BBS 未名空间站 (Thu Sep 20 17:22:09 2012, 美东)
Abstract
The health effects of a Roundup-tolerant genetically modified maize (from 11
% in the diet), cultivated with or without Roundup, and Roundup alone (from
0.1 ppb in water), were studied 2 years in rats. In females, all treated
grou... 阅读全帖
e******e
发帖数: 118
50
I know houston orthopedic group at TX medical center does that, but not sure
if it's the best place. one of the pts I saw had marrow stem cell injection
to treat avascular necrosis of the hip.
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