s*******0
发帖数: 249 | 1 ARDS, CHF,
PEEP of 15 is too high for CHF, it will obstruct the blood return and thus
cause heart to overload in order to maintain tissue oxygen perfusion. High
heart rate is VERY bad for CHF patient. Very very bad. Vasopressin and
phenylephrine is good, levophed will be used to support the heart pumping
function, but it will also put the patient in a down spiral path if used
inappropriately.
RT only says the picture from their side, can't see the whole picture.
Jet ventilation might be the trea... 阅读全帖 |
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s*******0
发帖数: 249 | 2 ARDS, CHF,
PEEP of 15 is too high for CHF, it will obstruct the blood return and thus
cause heart to overload in order to maintain tissue oxygen perfusion. High
heart rate is VERY bad for CHF patient. Very very bad. Vasopressin and
phenylephrine is good, levophed will be used to support the heart pumping
function, but it will also put the patient in a down spiral path if used
inappropriately.
RT only says the picture from their side, can't see the whole picture.
Jet ventilation might be the trea... 阅读全帖 |
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d***3
发帖数: 181 | 3 Position: Full-Time Regular
Open date: Jan 18, 2011 10:33:36 PM
Functional area: Scientific
Location: Research Triangle Park, North Carolina
Required degrees: Master's Level Degree
Experience required: 5 years
Relocation: Not Indicated
Basic qualifications:
The ideal Physiologist / Cell Biologist candidate will have experience with
a focus in Enteroendocrine biology.
We are looking for an individual with a PhD in physiology or cell biology
with postdoctoral experience... 阅读全帖 |
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U*******a
发帖数: 16 | 4 Senior Director, Commercial Cell Culture Development (req #31735)
Location: Framingham, Massachusetts
Department: Late Stage Process Development, Biologics Development/Science
The Senior Director of Commercial Cell Culture Development (CCCD) reports to
the Vice President of Late Stage Process Development (LSPD), Biologics
Development/Science, and is responsible for directing and managing various
activities related to cell culture development for Genzyme’s processes that
are in late stage devel... 阅读全帖 |
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s*********a
发帖数: 412 | 5 感觉最近几个月上游的职位好像很少，是不是已经饱和了？各位有什么想法？能预测一
下 process development 前景？fed-batch or perfusion? |
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r********r
发帖数: 352 | 6 我觉得你记反了。
E for exit没错，不过kidney perfusion requires vasodilation of afferent blood
vessel and vasoconstriction of efferent blood vessel (想像一个管子，进口要
大，出口要小，这样管子里才有足够的水压，如果进口小，出口大，就没水压了，不是
吗) vasodilation of afferent blood vessel requires prostaglandins, so
NSAIDs inhibits the vasodilation.
ACEI causes vasodilation of efferent blood vessel, buy it self, this
mechanism is very good for lowering BP and protecting the kidneys, but with
the combination of NSAIDs, it may cause kidney injury, especially ... 阅读全帖 |
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r********r
发帖数: 352 | 7 我觉得你记反了。
E for exit没错，不过kidney perfusion requires vasodilation of afferent blood
vessel and vasoconstriction of efferent blood vessel (想像一个管子，进口要
大，出口要小，这样管子里才有足够的水压，如果进口小，出口大，就没水压了，不是
吗) vasodilation of afferent blood vessel requires prostaglandins, so
NSAIDs inhibits the vasodilation.
ACEI causes vasodilation of efferent blood vessel, buy it self, this
mechanism is very good for lowering BP and protecting the kidneys, but with
the combination of NSAIDs, it may cause kidney injury, especially ... 阅读全帖 |
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p*******g
发帖数: 2976 | 8 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
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J****C
发帖数: 1465 | 9 Paraplegia is not an uncommon complication of TAA(or AAA) surgery. It's
hard to believe what you said "其实这类手术出现的并发症全美国只有4例". I
personally have seen 2 cases so far. Fortunately one case had relief
after emergent spinal drainage placement. The etiology is spinal
anterior column ischemia from underperfusion of the artery of Adamkewicz
which is a branch of the aorta and an important supplier of anterior
spinal artery, however with quite variable origin point. This is
described in every textbook and ... 阅读全帖 |
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J****C
发帖数: 1465 | 10 Paraplegia is not an uncommon complication of TAA(or AAA) surgery. It's
hard to believe what you said "其实这类手术出现的并发症全美国只有4例". I
personally have seen 2 cases so far. Fortunately one case had relief
after emergent spinal drainage placement. The etiology is spinal
anterior column ischemia from underperfusion of the artery of Adamkewicz
which is a branch of the aorta and an important supplier of anterior
spinal artery, however with quite variable origin point. This is
described in every textbook and ... 阅读全帖 |
|
|
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m********4
发帖数: 607 | 13 Have this patient done CTA and perfusion image?
It is not rare to see a patient with higher glucose level than 550 in
hospital. Last week, we had a STEMI pt with glucose level>550.(pt doesn't
have DM history).
It is common to see pt with DM has all kind of vascular disease.
But, hyperglycemia induced chorea-like movement disorder isn't common.
she |
|
A*******s
发帖数: 9638 | 14 Why CTA with perfusion? She did not have a stroke and DWI was negative. |
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m********4
发帖数: 607 | 15 Thank the God, he is discharge home.
The brief HPI----22yoM, previously healthy, who was found down while
out for a run. He received CPR by bystanders until EMS arrived. He then
received several shocks for VF before regaining a perfusing rhythm. He was
intubated, emergently cathed (normal coronaries). |
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d****y
发帖数: 2180 | 16 UW 题目里面列了肌注和皮下注射，然后选了肌注，说是肌注起效快。我觉得这题目真
是坑爹啊。（ 另外还有一个怀疑Cushing syndrome到底是先做Dexamethasone
overnight suppression test 还是先测24小时cortisol的也是很让人抓狂。传统的是
先做Dexamethasone overnight suppression test， 然后Mayo Clinic 是推崇先测24
小时cortisol的。考试如果碰到这两个同时出现的，到底选哪个？ 肯定要晕了。 ）
另外我从Medscape 找到的：
The pros and cons of epinephrine administration through various routes are
summarized in Table 2.[1,8•,12–18,19•,20•] Intramuscular
injection into the mid-anterolateral aspect of the thigh is recommended as
t... 阅读全帖 |
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d****y
发帖数: 2180 | 17 选A还是E？
Paracentesis 虽说是比较general 的抽液，在这题可以理解为心包抽液吗？
18. A 50-year-old woman has had progressive dyspnea over the past 2
weeks
and constant, sharp chest pain for 4 days. The pain is localized to the
center of the chest and is worse while supine. She underwent a right,
modified radical mastectomy and adjuvant chemotherapy for breast cancer
3
years ago. She has a history of hypothyroidism treated with thyroid
replacement therapy. She has smoked one pack of cigarettes daily for 30
years and drinks t... 阅读全帖 |
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n*******c
发帖数: 501 | 18 要回答你这些问题，光有CT和MRI是不太够的。
你父亲没有心绞痛的症状，所以主要的考虑是选择可以减少死亡率的治疗（有些病人因
为心绞痛发作药物控制不理想，所以会更加倾向于手术减少症状）
不管是否手术，你父亲都要开始药物治疗，积极控制危险因素的，其中用药有无副作用
也是是否手术的重要考量。
然后就是心功能的测试，一方面了解以前的心梗对心脏造成了多大的损害。另一方面了
解myocardial viability（PET，thallium perfusion，MRI，ECHO），这个就说有多少
还没死的心肌细胞能通过手术救活，这也是掌握手术时机的一个要点。
无论考虑上支架或搭桥，术前都是需要做血管造影评估血管及循环的真实情况，来帮助
下一步决定。
个人认为这个情况不适合支架，至于是否手术还是纯药物治疗要看其他检查结果。
如果俺是你的话，
先让父亲做一个冠脉造影，以及以上其他检查（都是无创的），然后再找能找到的最好
的心脏科专家包括心外科医生给意见，然后和你父亲讨论一下，这时候，病人自己的意
向也很重要。
另外需要考虑的是，如果决定手术，医生的技能也很重要，有时候也取决于你能找到什么样的外科医... 阅读全帖 |
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R*******t
发帖数: 367 | 19 冠心病在心梗发作之前彩超和心电图都正常。可以考虑做冠状动脉造影，比如CCTA
with calcium score。还可以做核素心脏造影，Tc-99m sestamibi的cardiac
perfusion, gated wall motion and ejection fraction.
她还要吃阿司匹林，降血脂降血压，积极运动起来。不要坐等发病了再治疗。预防比什
么都管用。 |
|
R*******t
发帖数: 367 | 20 冠心病在心梗发作之前彩超和心电图都正常。可以考虑做冠状动脉造影，比如CCTA
with calcium score。还可以做核素心脏造影，Tc-99m sestamibi的cardiac
perfusion, gated wall motion and ejection fraction.
她还要吃阿司匹林，降血脂降血压，积极运动起来。不要坐等发病了再治疗。预防比什
么都管用。 |
|
h*****1
发帖数: 429 | 21 Update:
<1> adrenal gland: CT examination shows “Normal”.
<2> problem with flexible blood pressure. In the past 24 hours, the
patient has a systolic pressure ranging from 192 to 116 with diastolic
pressure from 115 to 67.He fells dizzy when the blood pressure goes down.
<3> The flexible blood pressure could be associated with the muscularly
injection of naloxone hydrochloride (an opioid antagonist) at8mg/day.
Naloxone hydroxylase is said to improve perfusion in the ischemic stroke.
This drug ha... 阅读全帖 |
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A*******s
发帖数: 9638 | 22 先简单的说一下evidence的分类（详细的请自己google）：
CLASS I
Benefit >>> Risk， Procedure/treatment SHOULD be performed/administered
CLASS II
Benefit > Risk Additional studies with focused objectives needed
IT IS REASONABLE to perform procedure/administer treatment
CLASS III No Benefit/harm
怎样运用EBM，是医疗实践的艺术。
如果一个中老年病人突然大面积中风，用tPA无效，而perfusion CT显示有penumbra，
很多医生会选择endovascular intervention，这个intervention到目前为止顶多是
Class II。
尽管各种治疗手段，病人还是昏迷不醒，并出现脑疝的迹象，有医生会做craniectomy
，这个手术曾经很流行，但几个trials包括HAMLET证明手术与药物治疗没区别，所以现
在也挺... 阅读全帖 |
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w******y
发帖数: 4871 | 23 这个打完tracer后，杀鼠，perfuse，取脑，泡福尔马林，再自己切片啊。很简单的啊 |
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l*w
发帖数: 567 | 24 最近碰到的一个问题，估计做过冷冻切片的人都碰到过。
希望有大侠探讨一下啊。
就是鼠脑冷冻切片后经常有气泡trapped在里面。
光学显微镜下看，有气泡的地方呈暗色。
My procedure is as follows:
Perfusion: 1x PBS 3 min, 4% PFA 3min.
Fixation: 4% PFA overnight
Sucrose: 30% sucrose until samples sink. Normally 16 to 24 hours.
Embedding: OCT on dry ice.
Sectioning: -18 C with Leica cryostat machine.
有哪位大侠指点一二？先谢了。 |
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c******o
发帖数: 487 | 25 two-year program. MS or BS degree. Only 16 programs in USA
an email from An American student:
----------------------------------
I was a business major and started dental school at 30. I had a 3.1 in
undergrad. I had to take all the prereqs but was much more focused at 28
than I was at 18 and got those done with a 3.98. GPA matters of course but
real life work experience and quality recommendations are very important as
well. If I knew more about health care jobs prior to getting into dental
sc... 阅读全帖 |
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c******o
发帖数: 487 | 26 two-year program. MS or BS degree. Only 16 programs in USA
an email from An American student:
----------------------------------
I was a business major and started dental school at 30. I had a 3.1 in
undergrad. I had to take all the prereqs but was much more focused at 28
than I was at 18 and got those done with a 3.98. GPA matters of course but
real life work experience and quality recommendations are very important as
well. If I knew more about health care jobs prior to getting into dental
sc... 阅读全帖 |
|
|
t**u
发帖数: 1572 | 28 shit, I just buy 1600 share this morning.
Delcath Announces Updated Efficacy Results From Phase 3 Trial of
Chemosaturation for Melanoma Metastases in the Liver Presented at European
Multidisciplinary Cancer Congress
Delcath Systems (NASDAQ:DCTH - News) announced today that James F. Pingpank,
MD, FACS, Associate Professor of Surgery at the University of Pittsburgh
School of Medicine, will present updated investigator results from the Phase
3 randomized trial of Delcath's chemosaturation system wi... 阅读全帖 |
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