h**********r
发帖数: 671 | 1 Title: Tumour suppressors miR-1 and miR-133a target the oncogenic function
of purine nucleoside phosphorylase (PNP) in prostate cancer
Journal: British Journal of Cancer , (8 November 2011)
Online: doi:10.1038/bjc.2011.462
http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2011462
My email is, m******[email protected]
Thank you so much for your time!
One Baozi will be sent to you after getting the paper.
Thanks! |
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t*d
发帖数: 1290 | 2 IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', puts them in tiny moulds,
cures them and then turns them out. He can mould almost any shape: discs,
cubes, long sticks, roughened doughn... 阅读全帖 |
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t*d
发帖数: 1290 | 3 【 以下文字转载自 Biology 讨论区 】
发信人: ttd (oldcat), 信区: Biology
标 题: better way to conquer cancer
发信站: BBS 未名空间站 (Wed Jan 16 14:57:14 2013, 美东)
IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', ... 阅读全帖 |
|
t****z
发帖数: 8931 | 4 今天活检出来
脂肪里长出癌
一个腹部
一个屁股上？'
Toronto Mayor Rob Ford has been diagnosed with a rare type of cancer, his
doctor said Wednesday.
“It is a difficult and very rare type of tumour,” Dr. Zane Cohen said in a
Wednesday evening press conference, describing Ford’s cancer as a
malignant liposarcoma.
“It’s a fairly aggressive tumour…but we are treating this aggressively in
order to irradiate the tumour. We are optimistic about this tumour.”
Dr. Cohen said he is “optimistic” that chemotherapy could be successf... 阅读全帖 |
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i****x
发帖数: 17565 | 5 你那个国内烂校学报的”科研“结论跟以下所有结论矛盾的时候，你说我们该信谁呢？
In 2006 a large Danish group's study about the connection between mobile
phone use and cancer incidence was published. It followed over 420,000
Danish citizens for 20 years and showed no increased risk of cancer.[21] A
2011 follow-up confirmed these findings.[22]
The following studies of long time exposure have been published:
The 13 nation INTERPHONE project – the largest study of its kind ever
undertaken – was published in 2011 and did not find a solid li... 阅读全帖 |
|
l******a
发帖数: 1203 | 6 France orders probe after rat study links GM corn, cancer
(AFP) – 1 day ago
PARIS — France's government on Wednesday asked a health watchdog to carry
out a probe, possibly leading to EU suspension of a genetically-modified
corn, after a study in rats linked the grain to cancer.
Agriculture Minister Stephane Le Foll, Ecology Minister Delphine Batho and
Health and Social Affairs Minister Marisol Touraine said they had asked the
National Agency for Health Safety (ANSES) to investigate the finding.
... 阅读全帖 |
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i****x
发帖数: 17565 | 7 认英文的话，随便读读这些权威机构的报告吧。注意，别拿”没有证据证明辐射有害“
说话，再解释一遍，统计学的假设检验理论根本不可能给出辐射无害的证明，只能要么
证明辐射有害要么无法证明辐射有害。
In 2006 a large Danish group's study about the connection between mobile
phone use and cancer incidence was published. It followed over 420,000
Danish citizens for 20 years and showed no increased risk of cancer.[21] A
2011 follow-up confirmed these findings.[22]
The authors reported the following conclusion:
Overall, no increase in risk of glioma or meningioma was observed with use
of mobile phones. ... 阅读全帖 |
|
f******g
发帖数: 1003 | 8 A vaccine targeting mutant IDH1 induces antitumour immunity
Monoallelic point mutations of isocitrate dehydrogenase type 1 (IDH1) are an
early and defining event in the development of a subgroup of gliomas1, 2, 3
and other types of tumour4, 5, 6. They almost uniformly occur in the
critical arginine residue (Arg 132) in the catalytic pocket, resulting
in a neomorphic enzymatic function, production of the oncometabolite 2-
hydroxyglutarate (2-HG)7, 8, genomic hypermethylation9, 10, 11, genet... 阅读全帖 |
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l**x
发帖数: 110 | 9 下面这个患者希望能得到版上医生专家的指导意见，危险多大，如何治疗，预后如何？
患者44岁，男，6年前因为肝癌做了肝移植 （符合米兰标准），之后无灾无病好几年。
去年2016年初发现轻微贫血，血色素12，因为当时在服小剂量阿司匹林，于是停服，看
看有没好转。托托拉拉到了年底，还是贫血，血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤，内镜医生直觉是GIST。随后CT，但CT却没有异常。4月初第二次胃镜
，GIST依然还在，取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm，说比较第一次32mm变大了。可能第一次看片医生那天喝多了？肿瘤位置在
Fundus，非常接近GOJ。
AFP好久没有查了，因为肝上的情况一直很好，肝移植前AFP 100多，移植后AFP一直小
于2。上一次至少是2，3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移，
要么是HAC。
下周二医生还要安排一次PETCT，周三见外科医生，估计排除转移外就安排切除了。 求
这里的专家教授指点，这个情况如何是好？下面我贴上最近几个报告。
个人感觉肝移植后5，6年转移到胃实在... 阅读全帖 |
|
s******y
发帖数: 28562 | 10 David Venet from the Université Libre de Bruxelles 用胡乱挑选的基因组合
和已经发表的所谓的癌基因的marker 用在未知的病人的数据上，发现胡乱挑选
的基因的准确率比那些所谓的marker 还要好。
文章结尾直接点了几个杂志的名：Cell, Nature Genetics, PNAS, 认为这些杂志
过分鼓吹所谓的 gene marker 的意义。从文章里面的行文来看，估计这些也是
把这个文章据掉的杂志 （lol)
文章最后发表在
PLoS Comput Biol. 2011 Oct;7(10):e1002240. Epub 2011 Oct 20.
http://blog.f1000.com/2012/01/10/random-gene-sets-can-predict-b
Random gene sets can predict breast cancer survival better than cancer-
related signatures
And top-tier journals did not want to pu... 阅读全帖 |
|
s******y
发帖数: 28562 | 11 David Venet from the Université Libre de Bruxelles 用胡乱挑选的基因组合
和已经发表的所谓的癌基因的marker 用在未知的病人的数据上，发现胡乱挑选
的基因的准确率比那些所谓的marker 还要好。
文章结尾直接点了几个杂志的名：Cell, Nature Genetics, PNAS, 认为这些杂志
过分鼓吹所谓的 gene marker 的意义。从文章里面的行文来看，估计这些也是
把这个文章据掉的杂志 （lol)
文章最后发表在
PLoS Comput Biol. 2011 Oct;7(10):e1002240. Epub 2011 Oct 20.
http://blog.f1000.com/2012/01/10/random-gene-sets-can-predict-b
Random gene sets can predict breast cancer survival better than cancer-
related signatures
And top-tier journals did not want to pu... 阅读全帖 |
|
l**x
发帖数: 110 | 12 知道这个版的专业医生很多，所以占宝地求指点。恳请大家一点给点指导，下一步怎么
办合适？
患者44岁，男，6年前因为肝癌做了肝移植 （符合米兰标准），之后无灾无病好几年。
去年2016年初发现轻微贫血，血色素12，因为当时在服小剂量阿司匹林，于是停服，看
看有没好转。托托拉拉到了年底，还是贫血，血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤，内镜医生直觉是GIST。随后CT，但CT却没有异常。4月初第二次胃镜
，GIST依然还在，取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm，说比较第一次32mm变大了。可能第一次看片医生那天喝多了？肿瘤位置在
Fundus，非常接近GOJ。
AFP好久没有查了，因为肝上的情况一直很好，肝移植前AFP 100多，移植后AFP一直小
于2。上一次至少是2，3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移，
要么是HAC。
下周二医生还要安排一次PETCT，周三见外科医生，估计排除转移外就安排切除了。 求
这里的专家教授指点，这个情况如何是好？下面我贴上最近几个报告。
个人感觉肝移植后5，6年转... 阅读全帖 |
|
v*****e
发帖数: 30 | 13 国内的好朋友最近诊断乳腺癌。她有一个年幼的孩子，真的很替她着急担心。最近化疗
两个疗程之后，白细胞下降得很厉害。这里附上她的诊断和问题，这里哪位好心的大侠
能给回答一下？ 她已经把问题翻译成了英文.
Specimen Type: Specimen of modified radical mastectomy right breast
Tumour Site/Location: 2.5 cm from the top of the nipple
Size of Tumour: 2.5 x 2.3 x 1.4 cm
Tumour Type: Mucinous carcinomas, ductal carcinoma in situ was seen around
the surrounding area (low and intermediate grade)
Histologic Grade: (blank)
Intravenous Tumor Thrombus: (+) Nerve Invasion: ( - )
Nipple: no cancer cell ... 阅读全帖 |
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f*********1
发帖数: 189 | 14 Breast cancer breakthrough announced - thanks to Cambridge-led study
Carlos Caldas
Carlos Caldas
A major breakthrough in the treatment of breast cancer has been announced
today - thanks to a groundbreaking study led by a team of scientists in
Cambridge.
Researchers have reclassified breast cancers into 10 completely new
categories based on their genetic "fingerprints".
Several entirely new breast cancer genes that drive the disease have also
been uncovered.
The wealth of new data is expected to ... 阅读全帖 |
|
|
h***e
发帖数: 146 | 16 It can work in E.coli in tumour? I mean if I express a protein under this
HRE promoter in E.coli or other tumour-targeting bacteria, it can express in
the hypoxia of tumour cells but not in normal cell.
Thanks
thing
background |
|
g*********d
发帖数: 233 | 17 据英国《每日邮报》1月7日报道，英国科学家找到了“急性癌症”的形成原因：细胞内
的染色体发
生“爆炸”破坏了DNA，从而让人有可能在短时间内患上癌症。相关论文发表于《细胞
》。
传统理论认为癌症是人体经历成千上万次的细胞突变后，慢慢演化的结果。但英国著名
的疾病研究机
构桑格研究所的新发现推翻了这种看法。这暗示了不管人们怎么努力保持身体健康，也
不能保证命运
不会拿他们开玩笑。同时还说明了为什么有些人在体检时根本没发现癌症痕迹，但数月
后突然就被诊
断患上这种疾病了。
桑格学院的科学家是通过研究750个肿瘤的遗传缺陷后得出以上结论的。其中大部分的
案例都与传统
理论相符，染色体的损坏是常年累积的结果。然而，其中至少有1/40的肿瘤不符合“标
准模式”，有的
染色体似乎是在一夜之间遭到破坏的。
参与此项研究的坎贝尔博士称：“测验结果太让我们惊讶了。在一个细胞里面，染色体
经过一次或者是
多次爆炸成为碎片。如果这个细胞开始笨拙地修补，把碎片杂乱的缝合起来，这样就破
坏了原来的
DNA结构，为癌症的快速形成提供了条件。”
坎贝尔博士表示：“这个细胞应该说‘好吧，我放弃’，而不是像对待昂贵的瓷... 阅读全帖 |
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h******y
发帖数: 351 | 18 Metabolism: Warburg effect revisited
http://www.nature.com/nrc/journal/v8/n4/full/nrc2364.html
It was Otto Warburg who first noted the difference between metabolism in
cancer cells and that in normal adult tissues: cancer cells take up glucose
at higher rates than normal tissue but use a smaller fraction of this
glucose for oxidative phosphorylation.
But how do tumour cells achieve this altered metabolic phenotype? The
authors reasoned that tumour tissue switches pyruvate kinase expression from
... 阅读全帖 |
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c******o
发帖数: 1184 | 19 Hide
Wiki Loves Monuments: The world's largest photography competition is now
open! Photograph a historic site, learn more about our history, and win
prizes.
Otto Skorzeny
From Wikipedia, the free encyclopedia
[hide]This article has multiple issues. Please help improve it or discuss
these issues on the talk page. (Learn how and when to remove these template
messages)
This article needs additional citations for verification. (December 2016)
This article possibly contains inappropriate or misint... 阅读全帖 |
|
l******n
发帖数: 35 | 20 不用客气，大家都在尽力帮忙
你说的参考和我说的应该是同源的，都是2010年修正的。我觉得对staging来讲，这应
该是现在最权威的文章了。
你所引的文章中这一句“Patients previously considered T4 if additional tumour
nodules were found in the same lobe are now classified as T3. Additional
tumour nodules outside the primary lobe but in the same lung, are now down
staged from M1 to T4 and they may be suitable for a pneumonectomy. ” 我的理
解是如果是一个肿瘤影响了两片肺叶，算T3，如果是两个肿瘤在同侧不同的肺叶里面，
算T4。这里并没有提到具体的肿瘤分类。
你的心情大家都理解，我们也希望是更早期的诊断，这样预后回更好。你也不用太纠结
于现有的survival，因为这个时间只是统计意义上的，对于每一个病人来讲，术后成活
... 阅读全帖 |
|
l******n
发帖数: 35 | 21 不用客气，大家都在尽力帮忙
你说的参考和我说的应该是同源的，都是2010年修正的。我觉得对staging来讲，这应
该是现在最权威的文章了。
你所引的文章中这一句“Patients previously considered T4 if additional tumour
nodules were found in the same lobe are now classified as T3. Additional
tumour nodules outside the primary lobe but in the same lung, are now down
staged from M1 to T4 and they may be suitable for a pneumonectomy. ” 我的理
解是如果是一个肿瘤影响了两片肺叶，算T3，如果是两个肿瘤在同侧不同的肺叶里面，
算T4。这里并没有提到具体的肿瘤分类。
你的心情大家都理解，我们也希望是更早期的诊断，这样预后回更好。你也不用太纠结
于现有的survival，因为这个时间只是统计意义上的，对于每一个病人来讲，术后成活
... 阅读全帖 |
|
H***0
发帖数: 11 | 22 http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?c
Sunitinib malate is used to treat a type of gastrointestinal cancer called a
stromal tumour. It is also used to treat kidney cancer and pancreatic
neuroendocrine tumours that have progressed or cannot be removed with
surgery.
Your prescriber may only prescribe this medicine with special care or may
not prescribe it at all if you:
are about to have or have recently had a surgical procedure
这是英国政府的网站。明确说这个药不能在手术后马上吃。 |
|
l*********e
发帖数: 5385 | 23 ☆─────────────────────────────────────☆
kaka814 (kaka) 于 (Tue Feb 19 14:51:42 2013, 美东) 提到:
一个月前娃爹抓我胳膊，无意间摸到皮下长了个硬结。
本来没当回事，娃爹催了一周去看医生，约了个皮肤科医生，结果约到三周后。
昨天去看了，医生说是个肿瘤，要马上切掉送去化验。
当场挨了一刀，缝了三针。一点思想准备都没有啊。
躺那挨刀时我就想，万一是恶性肿瘤，切掉一只手臂，我还能陪我娃长大，万一我死了
，我娃好可怜啊。
今天我就琢磨，哎呀，我是不是得准备个遗书啥的。虽然没啥财产，娃大了总能给娃个
念想嘛。
☆─────────────────────────────────────☆
alibaba1128 (alibaba) 于 (Tue Feb 19 14:55:28 2013, 美东) 提到:
呸呸呸，大吉大利大吉大利。
割掉了就ok了。
☆─────────────────────────────────────☆
alibaba1128 (alibaba) 于 (Tue F... 阅读全帖 |
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L****a
发帖数: 572 | 24 2009:
Ben. Bernanke : Green Shoots
Obama : Glimmer of hopes
Roubini : Green shoots turn to brown weeds
Soros : The recovery will look like "an inverted square root sign"
James Rogers (April 2009) : I am short J.P. Morgan !
Geitner : ???
Nassim Taleb : The doctor has shown up and relieved the patient's symptoms
– and transformed the tumour into a metastatic tumour
2010:
Summers : We have a statistical recovery and human recession
..... ?? |
|
l**********n
发帖数: 8443 | 25 caused by inactivation of the INI1 gene (SMARCB1)on chromosome 22q which
functions as a classic tumour suppressor gene.
Inactivation of INI1 can occur via deletion, mutation, or acquired UPD.
Uniparental disomy (UPD) occurs when a person receives two copies of a
chromosome, or part of a chromosome, from one parent and no copies from the
other parent.
In a recent study[4], SNP array karyotyping identified deletions or LOH of
22q in 49/51 rhabdoid tumours. Of these, 14 were copy neutral LOH (or
ac... 阅读全帖 |
|
w*****3
发帖数: 1582 | 26 李铁（ironman)献了25次了，我现在争取每年冬歇的时候献。献血的好处还是很多的，
锻炼造血机能，更新旧的免疫细胞，稀释血液。不好的地方是刚献完血，会有抵抗力轻
度低下， 运动能力也会降低。
献血以后，液体电解质当时就补足了，血浆蛋白需要1周，细胞需要1个月。
献血一般认为会降低心血管病的危险，这篇文章认为献血也会降低肿瘤的发生。
老的T细胞如果不被新生取代的话，容易生成tumor。
Cell competition is a tumour suppressor mechanism in the thymus
Cell competition is an emerging principle underlying selection for cellular
fitness during development and disease. Competition may be relevant for
cancer, but an experimental link between defects in competition and
tumorigenesis is elusive... 阅读全帖 |
|
S******6
发帖数: 3138 | 27 上个月的文章，不是泛泛的某“科学杂志”，是 Science。你说的这个观点，在什么地
方，请给个出处。
Most cancers are caused by bad luck not genes or lifestyle, say scientists
Scientists at Johns Hopkins University School of Medicine in the US found
that the majority of cancers are not linked to environment or lifestyle
Sarah Knapton By Sarah Knapton, Science Editor7:00PM GMT 01 Jan 2015
Comments707 Comments
The majority of cancers are the result of bad luck rather than unhealthy
lifestyles or inherited genetic faults, scientists have discover... 阅读全帖 |
|
g****g
发帖数: 1828 | 28 Straight Dope Message Board > Main > In My Humble Opinion > Which pocket do
you put your wallet in?
PDA
View Full Version : Which pocket do you put your wallet in?
Rodgers01
02-20-2006, 12:39 AM
I have always, always kept my wallet in the front, right hand pocket of my
pants (I am male). It seems to me to be simply the most logical place: it is
typically the biggest pocket, allowing the wallet to slide down a bit more,
leaving less chance that it will be pick-pocketed. When you're in a crowded
r... 阅读全帖 |
|
n**e
发帖数: 2026 | 29 今年初，美国科学促进会（AAAS）和皮尤研究中心（Pew Research Center）联合公布
的一项调查显示，88％的科学家认为转基因食品可安全食用，持这一看法的公众只有37
％。报告认为差距如此之大的一个可能原因是，三分之二的公众认为科学家对转基因食
品的健康后果没有清晰认识。这就是真正的原因吗？
根据报告全文，皮尤中心给19，984名科学家发出了调查问卷，3748人（18.8%）完成了
问卷调查。其中生物医学学科背景的科学家占50%。报告没有说明50%的生物医学背景是
否能够代表科学家总体的学科构成。更大问题是在这50%的科学家人群中，有多少人的
工作是与转基因作物的研究有关，以什么样的方式相关。报告没有提供任何信息。
由于这些关键信息缺失，88%的科学家相信转基因安全的说法毫无意义。在一个没有代
表性并且无法排除偏向性的样本中调查，科学家相信转基因安全从1%到99%与88%没有任
何不同。好消息是超过半数的美国民众认为转基因不安全。
2012年10月，美国科学发展协会以官方名义（Board of Directors ）抛出了一个反对
转基因标识声明（附录1）。目的就是诱导民... 阅读全帖 |
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s****t
发帖数: 17096 | 30 搞大肚子好控制，不放养问题不大
咔嚓了体型偏胖是有数据的
有不少research studies，show neutered dog 例如10% increase
spayed情况不一样，具体数据不清楚
当然这个因狗而异
当然咔嚓最大的好处就是不发情，不留种。只不过vet们不promote这个理由，反而拿一
些健康的factor来说事儿
转个neutered/spayed risk看一下
(1) Neutered dogs have been scientifically shown to be 2 times more likely
to suffer from prostate adenocarcinoma, 4 times more likely to suffer from
prostate carcinoma, 4 times more likely to suffer from malignant bladder
cancer, and 8 times more likely to suffer from prostate transitional cell
carcino... 阅读全帖 |
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x**s
发帖数: 1085 | 31 你这消息是哪里来的？从Jobs在standford的2005年给毕业生演讲上，他是1年前知道有
癌症，当时就做了手术的。
About a year ago I was diagnosed with cancer. I had a scan at 7.30 in the
morning and it clearly showed a tumour on my pancreas. I didn't even know
what a pancreas was. The doctors told me this was almost certainly a type of
cancer that is incurable and that I should expect to live no longer than
three to six months. My doctor advised me to go home and get my affairs in
order, which is doctor's code for "prepare to die". It means to tr... 阅读全帖 |
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h********n
发帖数: 4079 | 32 see these 2 papers about recovery of p53 in lung cancer mouse models:
Selective activation of p53-mediated tumour suppression in high-grade
tumours
Nature 2010, page 567
Stage-specific sensitivity to p53 restoration during lung cancer progression
Nature, 2010, page 572 |
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m********7
发帖数: 1791 | 33 Link,
http://www.ncbi.nlm.nih.gov/pubmed/21073431
Recent Pat CNS Drug Discov. 2011 Jan;6(1):31-40.
Towards drug discovery for brain tumours: interaction of kinins and tumours
at the blood brain barrier interface.
Harford-Wright E, Lewis KM, Vink R.
Adelaide Centre for Neuroscience Research, and the Discipline of Anatomy and
Pathology, University of Adelaide, Adelaide, South Australia.
email, m********[email protected] |
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f******g
发帖数: 1003 | 34 老的T细胞如果不被新生取代的话，容易生成tumor。
Cell competition is a tumour suppressor mechanism in the thymus
Cell competition is an emerging principle underlying selection for cellular
fitness during development and disease. Competition may be relevant for
cancer, but an experimental link between defects in competition and
tumorigenesis is elusive. In the thymus, T lymphocytes develop from
precursors that are constantly replaced by bone-marrow-derived progenitors.
Here we show that in mice this turnover is regula... 阅读全帖 |
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w***r
发帖数: 709 | 35 1. Nature. 2002 Jan 3;415(6867):45-53.
p53 mutant mice that display early ageing-associated phenotypes.
Tyner SD(1), Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu
X,
Soron G, Cooper B, Brayton C, Park SH, Thompson T, Karsenty G, Bradley A,
Donehower LA.
Author information:
(1)Cell and Molecular Biology Program, Baylor College of Medicine, Houston,
TX
77030, USA.
Comment in
Nature. 2002 Jan 3;415(6867):26-7.
The p53 tumour suppressor is activated by numerous stressors to ind... 阅读全帖 |
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n**e
发帖数: 2026 | 36 【 以下文字转载自 WaterWorld 讨论区 】
发信人: nile (nile), 信区: WaterWorld
标 题: 美国科学促进会《科学》大旗下的转基因谎言
发信站: BBS 未名空间站 (Fri Oct 30 10:18:45 2015, 美东)
今年初，美国科学促进会（AAAS）和皮尤研究中心（Pew Research Center）联合公布
的一项调查显示，88％的科学家认为转基因食品可安全食用，持这一看法的公众只有37
％。报告认为差距如此之大的一个可能原因是，三分之二的公众认为科学家对转基因食
品的健康后果没有清晰认识。这就是真正的原因吗？
根据报告全文，皮尤中心给19，984名科学家发出了调查问卷，3748人（18.8%）完成了
问卷调查。其中生物医学学科背景的科学家占50%。报告没有说明50%的生物医学背景是
否能够代表科学家总体的学科构成。更大问题是在这50%的科学家人群中，有多少人的
工作是与转基因作物的研究有关，以什么样的方式相关。报告没有提供任何信息。
由于这些关键信息缺失，88%的科学家相信转基因安全的说法毫无意义。在一个没有代
表性并且无法排除... 阅读全帖 |
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b*****n
发帖数: 34 | 37 这两个文章结果不错，但是病人样本太小，病人可能都是精挑细选，更倾向对免疫疗法
有反应的（这个是根据以前一些一期试验的经验，没有依据）。个人对cancer vaccine
持怀疑态度，主要是因为：
1. 这个mutational load theory本身就很有瑕疵，如果看看几篇N Eng J Med的文章，
有疗效和没有疗效的患者mutational burden本身重叠部分就很大，加上现在很多被认
为是low mutational burden的肿瘤类型，对checkpoint反应率也没差太多。所以
antigen response 到了一定程度后，就是看microenvironment的抑制情况了。如果只
是作为maintenance therapy，那就回到20年前了，很难和新一代的制剂抗衡。
2. 即便是早期的cancer testis antigen vaccine, long peptide vaccine 也可以产
生类似于这个文章里的T 细胞反应，不过疗效在established tumour里微乎其微。这两
个文章也是看的复发率，大量的suppressive fact... 阅读全帖 |
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f*********1
发帖数: 189 | 38 响应号召，参加[医学文献阅读活动]，
贴个icetea喜欢的，哈哈，4天前的Nature 关于 breast cancer的
The genomic and transcriptomic architecture of 2,000 breast tumours reveals
novel subgroups
Nature
(2012)
doi:10.1038/nature10983
Published online
18 April 2012
The elucidation of breast cancer subgroups and their molecular drivers
requires integrated views of the genome and transcriptome from
representative numbers of patients. We present an integrated analysis of
copy number and gene expression in a discovery an... 阅读全帖 |
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G*********a
发帖数: 1080 | 39 那流多少呢？一丁磕了碰了最多一次把衣服前胸弄湿了一块，平时就是几滴的样子。这
两天早上一起床都床上都是一片，实在有点儿害怕。
医生，哎，我也挺生气的，可是就是这个制度。她还算最有经验的一个，本来我一早就
带着一丁去clinic了，特意没吃饭，后来看上午都是年轻的几个医生，就约了下午五点
的又去了一趟，等到5：30，医生就看了一下鼻子说没事儿，我把前后情况说了一下，
就被数落了。。。我可能是有点儿唠叨担心，以前我手指骨头有了tumour，也是去看两
三次看不出来，他们老说就是骨折了自己会好的，后来回了国照了x光才发现是tumour
，做了手术才好了。所以我不太相信他们的水平，每次都自己查半天，可能说的也多些
。尤其看到这个血液病，主要就是白血病，很担心。网上没说频繁流鼻血就一定是，但
是建议验血排除一下。 |
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k*******3
发帖数: 918 | 40 Master Li Hongzhi in June 10th on their website published a new verse" what
assist master in Fa rectification", regardless of is the disciple or often
see always feel a bit sour, a generation of master, the Dharmakaya countless
, called" the Lord Buddha" the Falun Gong Cult founder so depressed, suffer
unspeakably, hated by scum, people there is immeasurably vast difference, a
sad. But most lets people sadly as dying like a segment of words aroused all
extremely guess.
Scripture says:" for a Daf... 阅读全帖 |
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b*****p
发帖数: 117 | 42 也说汉语的“词汇量”
长期以来，汉语不但以难学著称，而且还常常被指责为词汇欠缺、表达贫乏。生为汉人
，真可谓双倍之不幸——语言学习所需的时间本来就已经比别人多了好几倍，不料最终
学到的东西还不及人家几分之一。
毛喻原先生便为这种论点提供了具体数据：“我们知道，汉语一部普通的《新华字典》
所收单字（含繁体、异体）是一万一千一百个左右，清初所编的《康熙字典》所收汉字
是四万七千多个，最近出的《汉语大字典》所收汉字也才五万六千个。与英语相比，汉
语的词汇量是非常小的。即使一部欧美普通学生所用的字典所收单词也至少在十六至十
七万个以上。如著名的《牛津字典》所收单词是六十多万个。篇幅最大的《韦伯斯特大
词典》所收单词几乎达到一百万之多。仅从词汇量来比较，汉语和英语在这方面的差别
是非常巨大的。”
显然，毛先生“汉语词汇量非常小”这一结论，是用“科学方法”计算出来的，即：拿
英语单词总量减去汉字字数总量。显然，这么简单的题目，连小学生都难不倒，根本用
不着毛先生亲自动手。不过，小学生同时还知道，加减法的运算有一个先决条件，即“
单位”必须相等。例如，五匹马与四头牛就不好相加；七颗白菜减三根萝卜也不... 阅读全帖 |
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t****z
发帖数: 8931 | 43 这两个月田纳西一个妈妈杀死自己四个孩子，
再前两个月亚利桑那母亲杀死自己三个孩子
同时得克萨斯母亲杀死自己两个孩子
每个月都有几起母亲抑郁，为了不让孩子受苦，杀死自己孩子事件
这种事要找到病根，对症下药，而不是装逼乱开药
最近有些名媛好像也想自杀
家有孩子吗？
真得报警
Memphis mother who stabbed her four children to death
www.dailymail.co.uk/.../Tennessee-mother-cut-four-children-s-throats-open-
butchers-kn...
Jul 2, 2016 - Four small children stabbed to death, mother in custody ....
Channel 4 · Grandmother of survivor says 'I forgive' mom accused of killing
4 kids ...
MOTHERS WHO KILL CHILDREN
motherswhokillchildren.blogspot.... 阅读全帖 |
|
t****z
发帖数: 8931 | 44 这两个月田纳西一个妈妈杀死自己四个孩子，
再前两个月亚利桑那母亲杀死自己三个孩子
同时得克萨斯母亲杀死自己两个孩子
每个月都有几起母亲抑郁，为了不让孩子受苦，杀死自己孩子事件
这种事要找到病根，对症下药，而不是装逼乱开药
最近有些名媛好像也想自杀
家有孩子吗？
真得报警
Memphis mother who stabbed her four children to death
www.dailymail.co.uk/.../Tennessee-mother-cut-four-children-s-throats-open-
butchers-kn...
Jul 2, 2016 - Four small children stabbed to death, mother in custody ....
Channel 4 · Grandmother of survivor says 'I forgive' mom accused of killing
4 kids ...
MOTHERS WHO KILL CHILDREN
motherswhokillchildren.blogspot.... 阅读全帖 |
|
D**S
发帖数: 24887 | 45 http://www.bbc.com/news/world-asia-china-40446269
Terminally ill Chinese Nobel peace laureate Liu Xiaobo has asked to be
allowed to go abroad for liver cancer treatment, his friends say.
His wife has formally requested to leave China but it is not clear if the
authorities will approve it, they add.
Mr Liu, 61, has been in hospital after gaining medical parole.
He was jailed in 2009 for "inciting subversion" after calling for multi-
party democracy and respect for human rights in China.
A stateme... 阅读全帖 |
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发帖数: 1 | 46 大奶子有惊喜
Women with larger breasts are more likely to develop breast cancer, scientis
ts believe
A study of more than 16,000 women found those with a larger bra size were at
greater risk of the disease.
The link could be down to the sex hormone oestrogen that can trigger the gro
wth of mammary glands and tumours.
The researchers found seven genetic factors significantly associated with br
east size - three of which are strongly correlated with mutations already li
nked to breast cancer.
Dr Nichola... 阅读全帖 |
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k**********4
发帖数: 16092 | 47 Scientists from Anglia Ruskin University in Cambridge asked more than 5,000
adults how many people they had “been intimate” with.
Read more: The simple 'finger trick' that could 'diagnose' lung cancer
The participants then rated their health, noting any long-standing
conditions.
Results revealed the women who had 10 or more lifetime sexual partners were
91% more likely to be diagnosed with any form of cancer than those who were
virgins or had slept with just one person.
Men with 10 or more sexua... 阅读全帖 |
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ri
发帖数: 56 | 48 【 以下文字转载自 Biology 讨论区 】
发信人: ri (ri), 信区: Biology
标 题: 求一篇文章下载 谢谢
发信站: BBS 未名空间站 (Wed Mar 1 17:11:23 2017, 美东)
The p53-independent induction of apoptosis in breast cancer cells in
response to proteasome inhibitor bortezomib
Yerlikaya A1, Okur E, Ulukaya E.
Tumour Biol. 2012 Oct;33(5):1385-92. doi: 10.1007/s13277-012-0386-3. Epub
2012 Apr 4.
请回复此贴或发邮件至[email protected]/* */
谢谢！ |
|
发帖数: 1 | 49
Download pdf published by SfN (Chapter from 'The History of Neuroscience in
Autobiography, Volume 8' edited by Larry R. Squire)
Yuh-Nung Jan's CV
Lily Jan's CV
Yuh-Nung Jan and Lily Jan
Birth
Family History and Growing Up
National Taiwan University
The Hiking Trip to Shitou in the Spring of 1967
Graduate School Application
Graduate Study at Caltech (1968锟974)
Seymour Benzer Lab (1974锟977)
Steve Kuffler锟絪 Lab at H... 阅读全帖 |
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h******k
发帖数: 1478 | 50 我看了下文章的表格1, 上面的数据表明, 离高压线近, 虽然Leukaemia病例上升了, 但
CNS/brain tumours & Other diagnoses 病例却减少了. 以一个病种上生换来了很多
病例下降, 好象有预防作用.
个人觉得该文可信度不高. |
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