wh
发帖数: 141625 | 1 刚看到版上在讨论画画是否追求逼真写实，又看到苏轼这首诗。没查原诗是哪首，呵呵：
Who Says a Painting Must Look Like Life?
Written on paintings of flowering branches by Secretary Wang of Yen-ling...
（这里没复印） two poems.
Who says a painting must look like life?
He sees only with children's eyes.
Who says a poem must stick to the theme?
Poetry is certainly lost on him.
Poetry and painting share a single goal -
clean freshness and effortless skill.
Pien Luan's sparrows live on paper;
Chao Chang's flowers breathe with soul.
But what are they ... 阅读全帖 |
|
wh
发帖数: 141625 | 2 刚看到版上在讨论画画是否追求逼真写实，又看到苏轼这首诗。没查原诗是哪首，呵呵：
Who Says a Painting Must Look Like Life?
Written on paintings of flowering branches by Secretary Wang of Yen-ling...
（这里没复印） two poems.
Who says a painting must look like life?
He sees only with children's eyes.
Who says a poem must stick to the theme?
Poetry is certainly lost on him.
Poetry and painting share a single goal -
clean freshness and effortless skill.
Pien Luan's sparrows live on paper;
Chao Chang's flowers breathe with soul.
But what are they ... 阅读全帖 |
|
v*******e
发帖数: 3714 | 3 【 以下文字转载自 Exile 讨论区 】
【 原文由 vieplivee 所发表 】
在那个年代还没有“科幻小说”这个类别，直到一百年后人们说，它就是科幻
小说的开山鼻祖。在这一百多年的时间里，小说被太多次地拍成电影、舞台剧
等各种表演形式，在绝大部分情况下，它都未能逃脱“恐怖电影”这一仿佛是
必然的命运。对读者来说，简单地称之为“哥特小说”也许不失方便和贴切。
它的出名被认为是因为作者的身世。因为作者的父亲母亲都是出名的文人，
并且更为出名的是她的丈夫，举世闻名的著名诗人。在这么多名人的包围
下，它作为作者唯一流传后世的作品，却是写作于１９岁少女之手这个事实，
直到现在还是被广为流传的佳话。
关于它的副标题，也是值得津津乐道的话题。“现代的prometheus”，这同
作者丈夫的诗歌《prometeus unbounded》有什么关联？是否后发表的那个
有受到先者的提示？不过这一些答案并不重要了，因为作者１９岁时的初版
中，小说里的叙说者固然是那个prometheus般的破禁忌者，而小说实际上的
主人公却是三个人，而且小说主题也同prometheus的神话或寓意没什么
联系。也许这 |
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s******l
发帖数: 278 | 5 Part iii
THE
GALAXY
So I walk on uplands unbounded,
and know that there is hope
for that which Thou didst mold out of dust
to have consort with things eternal.
-The Dead Sea Scrolls
CHAPTER 19
Naked Singularity
.mount to paradise
By the stairway of surprise.
- Ralph Waldo Emerson
"Merlin," Poems (1847)
It is not impossible that to some infinitely superior being
the whole universe may be as one plain, the distance between
planet and planet be ing `only as the pores in a grain of
sand, and the spa |
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c********y
发帖数: 98 | 6 【 以下文字转载自 Economics 讨论区,原文如下 】
发信人: complexity (unbounded irrationality), 信区: Economics
标 题: An Encounter with Experimental Economics
发信站: Unknown Space - 未名空间 (Wed Jun 1 04:15:25 2005) WWW-POST
***Experimental Economics, Social Science Theories, and Philosophy***
------Or why some economists should be damned
Last week I went to GMU to attend the annual conference outreach of the Center
for the Study of Public Choice. Meeting the usual suspects like James Buchanan
and Gordon Tullock |
|
l*r
发帖数: 79569 | 7 来一个速成无调版，写完才发现换了韵，呵呵
Raindrops on the steps, the night drizzled.
Cold and alone in bed, as time trickled.
Should I look in the mirror, my face would be smile dimpled.
Languid hair unbound, jade petals unjeweled.
Leaning over the terrace,
Can't stop thinking, the willows sweeping, this time of spring.
How I envy the innocent swallows, passing by the rails, chirping.
For my love bid me farewell, all these years of longing.
I am dying to be a cuckoo, come back, come back, I will be calling. |
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D*****r
发帖数: 6791 | 8 43 'If I have rightly understood your words,'
44 replied the shade of that great soul,
45 'your spirit is assailed by cowardice,
46 'which many a time so weighs upon a man
47 it turns him back from noble enterprise,
48 the way a beast shies from a shadow.
49 'To free you from this fear
50 I'll tell you why I came and what I heard
51 when first I felt compassion for you.
52 'I was among the ones who are suspended
53 when a lady called me, so ... 阅读全帖 |
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D*****r
发帖数: 6791 | 9 http://www.gutenberg.org/files/37726/37726-h/37726-h.htm
IN GOD'S WAY
SCHOOL-DAYS
I.
In the melting snow on the hill-side by the sea, in the last rays of the
evening sun, stood a boy of fourteen, awestruck. He looked toward the west,
out across the sea; he looked toward the east, over town and shore and the
broad hills; in the background still higher peaks rose far away in the clear
sky.
The storm had lasted a long time; it had been more terrible, too, than any
the old people could remember. In ... 阅读全帖 |
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l*****a
发帖数: 38403 | 10 没找到，找到这个了
“It was, of course, a lie what you read about my religious convictions, a
lie which is being systematically repeated. I do not believe in a personal
God and I have never denied this but have expressed it clearly. If something
is in me which can be called religious then it is the unbounded admiration
for the structure of the world so far as our science can reveal it. |
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l*****a
发帖数: 38403 | 11 正视吧，你们基督徒各种撒谎造谣还少么，老爱名言
“It was, of course, a lie what you read about my religious convictions, a
lie which is being systematically repeated. I do not believe in a personal
God and I have never denied this but have expressed it clearly. If something
is in me which can be called religious then it is the unbounded admiration
for the structure of the world so far as our science can reveal it.” |
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g*********n
发帖数: 808 | 12 背景
网上流传有关「爱因斯坦证明了神存在」的故事，散播速度已经达到外国所谓病毒的程
度(has gone viral)。其实这故事在十几年前已经存在，消失了一段时间后，随互联网
的发展又再死灰复燃。故事指爱因斯坦还是学生的时候，反驳一位宣称无神的老师，问
得老师哑口无言。在不同版本中，「爱因斯坦」有时是小学生，有时是大学生，但是内
容和论据都是一样的，而许多标题都指「爱因斯坦」所说的，证明了神的存在。
以下是故事的大纲：
1.老师/教授说世上无神，因为若神造万物，也造了邪恶。
2.一学生反驳说「冷」是「热」的不存在，「暗」是「光」的不存在，同样「邪恶」是
「善良」的不存在。
3.老师无言，作者称此学生名为「阿尔伯特·爱因斯坦」。
供读者参考，本人选择了几个中英文的，比较典型的版本[1][2][3][4]，其中一个是前
几年这故事重生时的一套youtube外语短片。[3]
这故事被网民疯传，受宗教人士称颂，成为神存在的「有力见证」；另外一些人当这是
有趣的故事。许多网友阅读后，在社交网络上分享，其他人看见了也「讚」和分享，这
故事一传十，十传百，有如病毒一般地传播开去。
这故事受注目当然... 阅读全帖 |
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l*****a
发帖数: 38403 | 13 Thomas Jefferson, (1743-1826) 3rd American president, author, scientist,
architect, educator, and diplomat. Deist, avid separationist.
"Millions of innocent men, women, and children, since the introduction of
Christianity, have been burned, tortured, fined, and imprisoned, yet we have
not advanced one inch toward uniformity. What has been the effect of
coercion? To make one half of the world fools and the other half hypocrites.
" [Notes on Virginia]
"I do not find in orthodox Christianity one re... 阅读全帖 |
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S**U
发帖数: 7025 | 14 杂阿含64经与SN 22.54都说到阿罗汉的识。
杂阿含64经
识无所住故不增长，不增长故无所为作，无所为作故则住，住故知足，知足故解脱，解
脱故于诸世间都无所取，无所取故无所著，无所著故自觉涅盘∶我生已尽，梵行已立，
所作已作，自知不受后有。比丘！我说识不住东方，南、西、北方，四维，上、下，除
欲见法，涅盘、灭尽、寂静、清凉」。
SN 22.54
Consciousness, thus unestablished, not proliferating, not performing any
function, is released. Owing to its release, it is steady. Owing to its
steadiness, it is contented. Owing to its contentment, it is not agitated.
Not agitated, he (the monk) is totally unbound right within. He discerns
that 'Birth is ended, the holy |
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S**U
发帖数: 7025 | 15 SN 22.54
慧见
"Like the earth property, monks, is how the four standing-spots for
consciousness should be seen. Like the liquid property is how delight &
passion should be seen. Like the five means of propagation is how
consciousness together with its nutriment should be seen.
......
断贪爱
"If a monk abandons passion for the property of form...
"If a monk abandons passion for the property of feeling...
"If a monk abandons passion for the property of perception...
"If a monk abandons passion for the ... 阅读全帖 |
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a**u
发帖数: 8107 | 16 ☆─────────────────────────────────────☆
SeeU (See you) 于 (Wed Nov 3 00:15:05 2010, 美东) 提到:
中国佛教徒大多听过一句话∶你不要执著。这可能做到吗？
从佛法来说，执著有两种∶从见解而来的执著，与从情感而来的执著。
佛与阿罗汉没有这两种执著。其他有学与凡夫，必然有这两种执著，只是程度不同。
从见解而来的执著,从原始佛法来说，是与自我相应，与常乐我净相应的所有见解。从大乘唯识来说，是遍计所执。从大乘中观来说，是自性见。只有修习现观才能彻底断除从见解而来的执著。
从情感而来的执著是依靠从见解而来的执著。继续修习现观，也终将破除从情感而来的执著。
☆─────────────────────────────────────☆
xiaoputi (xiaoputi) 于 (Wed Nov 3 00:20:30 2010, 美东) 提到:
我执是最大的痛苦。
看人家容易，反观自己且是易事。
☆─────────────────────────────────────☆
robbin ... 阅读全帖 |
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r****n
发帖数: 8253 | 17 [作者] 坦尼沙罗尊者
[中译]良稹
We all know what happens when a fire goes out. The flames die down
and the fire is gone for good. So when we first learn that the name for the
goal of Buddhist practice, nibbana (nirvana), literally means the
extinguishing of a fire, it's hard to imagine a deadlier image for a
spiritual goal: utter annihilation. It... 阅读全帖 |
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o*****s
发帖数: 1445 | 18 你的search space有问题。that is an unbounded problem。
that means you ask it to do a global search. so it tells you:
mam, here is your result:
maximum iteration is exceeded.
exitflag="海底捞月"
consult with those from stat./o.r. for more help.
same thing to the good /bad answer:
you can set year=2005 or year=[2005,200x] or year=[2005,)
so the algorithm will search the space with different constraint set.
it could return a same or different result. you can add something special,
like:
best: f=my husband
st: |
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B*****g
发帖数: 34098 | 19 你得给我发包子！！！！！
SELECT a.mon, a.x, a.y, a.z,
(SELECT SUM(b.z) F
FROM TAB_SAMPLE b
WHERE b.mon <= a.mon) SUM
FROM tab_sample a
如果你用oracle（刚搞出来，似乎一般，我记得有更好的，找不到了）
SELECT a.mon, a.x, a.y, a.z,
SUM (SUM (a.z)) OVER (ORDER BY a.mon ROWS BETWEEN UNBOUNDED
PRECEDING AND CURRENT ROW) AS SUM
FROM tab_sample a
GROUP BY a.mon, a.x, a.y, a.z
ORDER BY a.mon |
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w*r
发帖数: 2421 | 20 怎么发了文看不见？？再来！
-- table setup
CREATE VOLATILE TABLE T
(
ID INTEGER,
STARTDATE DATE,
ENDDATE DATE)
PRIMARY INDEX(ID)
ON COMMIT PRESERVE ROWS;
INSERT INTO T VALUES(1,'2011-12-02','2012-01-16');
INSERT INTO T VALUES(1,'2012-03-04','2012-03-24');
INSERT INTO T VALUES(1,'2012-04-05','2012-04-26');
INSERT INTO T VALUES(1,'2012-04-29','2012-05-06');
INSERT INTO T VALUES(1,'2012-05-14','2012-06-07');
INSERT INTO T VALUES(2,'2012-03-05','2012-07-30');
INSERT INTO T VALUES(2,'2012-08-04','2012-09-15');
INS... 阅读全帖 |
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w*r
发帖数: 2421 | 21 这个code不是MYSQL,在Teradata上测试通过，基本的语法应该和ANSI接近
解释一下解题的思路
目标：使用ID做为group by用min/max处理begin/end
第一步：要把不同行的begin/end放到同一行，这样便于比较start/end. Beijing和其
他的同学提到lag,不幸的是我这里木的用，所以用row_number()给数据按照startdate
排序做left join seq = seq+1
code:
(
SELECT T.*,
ROW_NUMBER() OVER (PARTITION BY ID ORDER BY STARTDATE) AS SEQ
FROM T
) A
LEFT OUTER JOIN
(
SELECT T.*,
ROW_NUMBER() OVER (PARTITION BY ID ORDER BY STARTDATE) AS SEQ
FROM T
) B
ON
A.ID = B.ID AND
B.SEQ = A.SEQ+1
第二步：把能够merge的行标上。注意：第一步的结果中最后一行的右边是null,所以这
里有一个la... 阅读全帖 |
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l******b
发帖数: 39 | 22
俺来班门弄斧一下, 看这样行不行?
为简化起见, 根据OP的要求, 先建两张表,一张放数据, 一张放参数.
CREATE TABLE t7(
CATEGORY INT,
ID INT,
num int
);
INSERT INTO t7(CATEGORY, ID, num) VALUES(1,1,2) ;
INSERT INTO t7(CATEGORY, ID, num) VALUES(1,2,1) ;
INSERT INTO t7(CATEGORY, ID, num) VALUES(1,3,6) ;
INSERT INTO t7(CATEGORY, ID, num) VALUES(1,4,3) ;
INSERT INTO t7(CATEGORY, ID, num) VALUES(1,5,5) ;
INSERT INTO t7(CATEGORY, ID, num) VALUES(2,1,2) ;
INSERT INTO t7(CATEGORY, ID, num) VALU... 阅读全帖 |
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r******s
发帖数: 602 | 23 select
ID ,
NUMBER,
sum(number) over (order by id rows between unbounded preceding and current
row)
from TB a; |
|
C********r
发帖数: 145 | 24 Sorry, I have no Chinese software on this machine...
I am new to WPF and Infragistics Controls. I am trying to accomplish a
seemly simple task. use Xamdatagrid to display a collection of data records
retrieved from database.Besides the columns from the data records, I want an
additional unbounded column to contain a checkbox. I am having a really
hard time to get the databinding to work. I have spend 2 days to look up
examples and tutorials but none are complete or easy to understand(for me at
l... 阅读全帖 |
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m******t
发帖数: 2416 | 25
I don't think political correctness means what you think it does.
制这样百分比的信息搜索，在这个
Yes, it is a problem, but not as big as what a government can and will do,
because google still has to work within the limitation of a market, while
the power of a government can be virtually unbounded.
I'm not going to expand on that simply because this isn't the right
board.
And you don't think the Chinese government playing favoritism with baidu
is even a bigger, more worrisome issue than google's dominant mark |
|
j******n
发帖数: 271 | 26 The problem is not about locking the variable or not. It is about you cannot
reliably detect *ALL* senders using a simple variable to identify the sender
.
One can use a struct such as a list to store the sender ids. Then there is
the
problem that when the consumer is too slow, the list may grow unbounded. |
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s*****n
发帖数: 5488 | 27 The only issue I can see is unbounded threads and the cost of thread
creation/destory. So at the first step, you can use threadpool.
So change to ExecutorService with fixedthreadpool is enough unless you need
to fine control of the tasks. |
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c******o
发帖数: 1277 | 28 好像不是“重写整个文件”, mongodb file grow unbounded. you can adjust
padding factor to optimize.
当然，最后需要 compaction (which have to be offline per collection, which
sucks)
我们最大的devops问题在于那几个sharding config servers, implementation 完全不
make sense. |
|
g*****g
发帖数: 34805 | 29 傻逼你不死撑没完是吧？给你看看http spec.
3.2.1 General Syntax
The HTTP protocol does not place any a priori limit on the length of a URI.
Servers MUST be able to handle the URI of any resource they serve, and
SHOULD be able to handle URIs of unbounded length if they provide GET-based
forms that could generate such URIs. A server SHOULD return 414 (Request-URI
Too Long) status if a URI is longer than the server can handle (see section
10.4.15). |
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l**********n
发帖数: 8443 | 30 although the bound and unbound method in python is not as convenient as in
ruby. in Ruby, Proc is very convenient, just like function in js, because
you can switch context easily. |
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l**********n
发帖数: 8443 | 31 although the bound and unbound method in python is not as convenient as in
ruby. in Ruby, Proc is very convenient, just like function in js, because
you can switch context easily. |
|
C***Y
发帖数: 61 | 32
from
beads
吗？
Here are the details:
Incubate 1at Ab with beads for 1 hr at RT. Wash away the unbound Ab.
Crosslink Ab to beads with Imidoester
Crosslinkers (Pierce). Incubate Nuclear extract (or whole cell lysate) with
beads-Ab.
After washes, elute the co-purified protein complex with low PH glycine
solution instead of boiling beads. |
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s*****0
发帖数: 357 | 33 This is a really good opportunity to get exposure to the knowledge of the
association study. If you are interested in an industry job, this project
will definitely help.
You'd better formulate your question more clearly. What is your plan? Why
going directly to haplotypes without conducting single site tests? How large
and how dense of the coverage you want your haplotype to be? How would you
plan to use the statistical inference to guide your functional study?
Different software (PHASE, PLINK, ... 阅读全帖 |
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H****s
发帖数: 301 | 34 (1). Coat your 96 well plate with NeutrAvidin or streptavidin, 1ug/well,
100ul/well. Let sit O/N in the fridge or 1 hour in the 37 degree incubator.
(2). Biotinylate your whole cell protein using Pierce EZ-link biotinylation
kit.
(3). After coating the plate with NeutrAvidin or streptavidin, wash once
with 1XPBS (200ul/well). Block with blocking solution (1%BSA, 1% milk, 200ul
/well). Room temperature, 30 minutes to 1 hour. After blocking step, dump
all blocking solutions.
(4). Then add your bio... 阅读全帖 |
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s*****a
发帖数: 59 | 35 His-tag protein was overexpressed in HEK293 cells.先用IP 纯化，接着做His-
purification变性条件来第二轮纯化（此顺序是实验需要，不要问为什么）。目前结果
是第一轮IP很好，但是His-purification后蛋白都在unbound fraction. 我用的是
Qiagen Ni-NTA Magnetic Agarose bead,据说适合纯化含量比较少的比如mammalian
cell的蛋白。IP后的蛋白都经过 buffer exchange，也没发现有与Ni resin
uncompatible的成分。请帮忙trouble shooting。会不会因为蛋白浓度太低导致与Ni
resin结合不好？His-purification有没有target protein concentration threshold?
是否需要改用binding capacity更大的Qiagen Ni-NTA agarose (不是magnetic bead)？ |
|
g*********5
发帖数: 2533 | 36 Isolation of nuclei for the co-IP and whole ChIP protocols is based on the
methods of Gendrel et al. (2002, 2005), Johnson et al. (2002), and Nelson et
al. (2006).
METHOD
For extraction and co-IP of nuclear proteins, see Steps 1-39 (Fig. 1). For
the ChIP procedure, see Steps 40-69 (Fig. 2).
Figure 1.
View larger version:
In this page
In a new window
Figure 1.
Flowchart for the timeline and organization for co-IP of nuclear proteins
from Arabidopsis seedlings.
Figure 2.
View larger versio... 阅读全帖 |
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w*********r
发帖数: 488 | 37 you can transform the variable x to its associated probaliliy given that you
know this varible has what kind of distribution. for example:
phi(x)=z, z belongs to [0,1], the unbounded integral is transformed into the
bounded integral ,but you also need to changed the pdf , new pdf is equal to
the "old" pdf times the Jacobian of the transformation. |
|
s****2
发帖数: 44 | 38 Definition of bounded language:
A language L in ∑^* is said to be a bounded language if and only if
exist integer k>=1 exist strings w1,w2,...wk in ∑^* such that L is the
subset of {w1}^*.{w2}^*.{w3}^*...{wk}^*
So how to prove a language is unbounded? |
|
s*********y
发帖数: 8 | 39 noise不是一个deterministic信号，用通常的想法来看average=0是不正确的。
integrator 的 input noise如果是white，output的noise power会随着时间增长
而linearly增长，也就是说output noise 的sigma和时间的square root成正比（phase
noise是unbounded就是这个道理）。于此同时你的output信号amplitude是随时间成正
比（信号 power和时间的平方成正比），所以overall的SNR还是随时间成正比。 |
|
T*******x
发帖数: 8565 | 40
我有个证明，不是特别满意，我想应该有更简洁的。我概述一下：
Let G be such that {1,-1} are in the same component E of C\G.
We want to define an analytic branch of \sqrt(1-z^2). But it
suffices to define one for \sqrt(z^2-1), since they differ by i.
A component is a closed set, so E is closed, so V=C\E is open,
and G is contained in V, so we define the branch in V.
the component E can be unbounded, but if this is the case,
then V is already simply connected (this is the definition
of simple connectedness in Ahlfors, not a sta |
|
B********e
发帖数: 10014 | 41 问题是g(x) unbounded并不意味着g(x)-->inf or g(x)-->-inf,lospital 法则未必能用
。example
sin(x^2)/x -->0, but if you rewrite it as xsin(x^2)/x^2 and use Lospital's r
ule, you will get no limit. |
|
k**a
发帖数: 121 | 42 这个似乎和LP本身一样是NP-hard问题，也就是说除了直接解，没有更好的方法。当然
，针对具体问题，可以试试用Farkas's Lemma:
[Farkas's Lemma] Let A be an m × n matrix and b an m-dimensional vector.
Then, exactly one of the following two statements is true:
1. There exists an x ∈ R^n such that Ax = b and x ≥ 0.
2. There exists a y ∈ R^m such that A'y ≥ 0 and b'y < 0.
where ' denotes transpose.
或者试试dual。如果 optimal dual solution unbounded，那么原本的LP就是
infeasible。
求dual和Farkas's Lemma道理差不多，都是把系数矩阵转置过来，如果你的问题把系数
矩阵转置过来比较好看，可以试试。不过说来说去对于一般的LP，这些都是NP- |
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q********e
发帖数: 1255 | 43 construct a sequence of unit vectors {e_i}, let x=\sum e_i/i.
show {(x,y_k)} unbounded
hint:
you expect
1. e_n perpendicular to both {e_1,e_2,...,e_{n-1}} and {y_1,y_2,...,y_{n-1}}
for all n,
2. |(e_n,y_n)|\geq n[\sum_{i=1 to n-1} sup_k{|(e_i, y_k)|}+n]
,y |
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c*****t
发帖数: 520 | 44 请教parabolic equation收敛到stationary solution 的条件。
Consider parabolic equation
u_t=Lu. (P)
If we know that the second order elliptic equation
Lu=0, (E)
has unique solution v(x), then v(x) is the unique stationary solution of (P).
(We let (P) and (E) have same boundary conditions.)
Under what condition we can say that the solution u(x,t) of (P) converges to
v(x), as t goes to infinity?
In general, if (E) has several solutions v_1(x),...,v_n(x),... 阅读全帖 |
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d******s
发帖数: 180 | 45 http://aimath.org/news/primegaps70m/
第一段就很有料，四月后期投稿，五月中旬便接受，对于一篇55页的paper来说速度惊
人。
Zhang's Theorem on Bounded Gaps Between Primes
by Dan Goldston
In late April 2013 Yitang Zhang of the University of New Hampshire submitted
a paper to the Annals of Mathematics proving that there are infinitely many
pairs of primes that differ by less than 70 million. The proof of this
amazing result was verified with high confidence by several experts in the
field and accepted for publication. A public slightly re... 阅读全帖 |
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x********a
发帖数: 223 | 46 谢谢大家！
A Lifting Theorem for the Time Regularity of Solutions to Abstract Equations
with Unbounded Operators and Applications to Hyperbolic Equations.
The author is Irena Lasiecka and Roberto Triggiani. |
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e****0
发帖数: 678 | 47 • Exaggerated deep tendon reflexes can be seen in lock in syndrome.
• Non bleeding varices are managed with nonselective beta-
adrenergic antagonists, such as propranolol.
• Sclerotherapy, endoscopic band ligation, and surgery are
indicated after a patient has a first episode of variceal bleeding.
• TIPS is a last resort in variceal bleeding unresponsive to
medical and endoscopic intervention.
• Ischemic colitis
CT—thickening of eth bowel ... 阅读全帖 |
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s******r
发帖数: 30 | 48 Thank you very much for your infor. I also read of this unbound ratio
parameter. Seems so much to learn in CNS drug discovery, but very
interesting.
btw, NP-12 has been discontinued due to lack of efficacy in Phase II. But I
really wonder its in vitro PK properties, considering its high lipophilicity
, high logP, low ligand efficiecy....
Thanks. |
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Q******g
发帖数: 607 | 49 [x,p]=i
but x and p are unbounded. |
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Q*T
发帖数: 263 | 50 The original question only requires "closed operator".
Here the meaning of "closed" is totally different from the
definition of "closure" for a set or vector space.
It is absolutely OK that an operator is closed, and in the
same time not defined everywhere on Hilbert space, but only
densely defined.
Such operator could be unbounded. |
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