t**x
发帖数: 20965 | 1 请你仔细看看，
良性的三个报告。其中一个是这个德国医生自己的，他承认自己从来没有看过。第一个
genedx，是我们出院(04/13)后一个月报的(05/13)， 这个极有可能就是我们宝宝的结
果，被报呈良性。
https://www.ncbi.nlm.nih.gov/clinvar/variation/92429/
这个变异发现10多年，欧洲基因库收录为恶性。只有美国报称良性，在我们宝宝刚刚出
院。你真得仔细看看时间和事情了。
你没有看到跨国界作假反而。。。你看看荷兰医生的回信。我真怀疑你到底是干什么的
？
这个变异发现了10多年了， 这个德国医生的链接的文献没有说是良性的， 你自己看看
下面德国医生附上的文献。我不是医生，我看不出来说这个变异是良性的。你如果愿意
看看我家宝宝cpt2的两个结果， 一个1.5%酶活性，一个15%酶活性，跟下面的温度相关
吻合得多好。
我家宝宝的下降更多，大概是因为他的变异更多。这个特征的变异很多年了，但是
cchmc和Baylor都没有查出来。你说说他们不知道？！
Here the excerpt von OMIM regarding this mut... 阅读全帖 |
|
t**x
发帖数: 20965 | 2 yangyi和aning我没有跟她/他斗， 我劝你们好好看看德国医生给的参考资料, 这个资
料你怎么得出是benign的结论的：
0018 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 4
CPT2, PHE352CYS AND VAL368ILE [dbSNP:rs2229291] [dbSNP:rs1799821] [ClinVar]
Chen et al. (2005) found an association between 2 thermolabile polymorphisms
in the CPT1 gene and susceptibility to infection-induced acute
encephalopathy-4 (IIAE4; 614212) in Japanese children. The variants were a
1055T-G transversion, resulting in a phe352-to-cys (F352C) substitution (
rs... 阅读全帖 |
|
e***s
发帖数: 1397 | 3 仔细看一下，有AWB的时候，美国和其它大多数发达国家相比，对半自动步枪的管制都
要严格，管理要松一些的 - 我说管制严，管理松 - 因为美国不要license, 但是用一
些莫明其妙的限制管制了硬件。
现在纽约州通过的SB法律，结果是造成的管理和管制比大多数其它发达国家都要严。
希望纽约的今天不是美国的未来...
http://en.wikipedia.org/wiki/AR-15
AR15
Legal status of civilian ownership
Australia
AR-15 rifles, like all semi-automatic rifles, are subject to strong
restrictions of ownership in all states and territories in Australia. The
only means of legally owning an AR-15/M16-type rifle in Australia today
beyond law enforcement is to have a Categor... 阅读全帖 |
|
j*p
发帖数: 411 | 4 攒人品，顺便回答一下 iiiir 的问题。
我们尝试过好几种不同的SNP calling的方法，包括GATK, Samtools, Varscan,
SeqGenes, 等，并且做了SNP array 作为gold standard比较各种方法的prediction
power。
从我们的经验，BWA + GATK 最好，sensitivity 和 specificity 都在95%以上。
以下是GATK 的pipeline
假设你有一个control 样品C 和一个样本样品A的pair-end sequencing，共4个文件，C
_R1.fastq, C_R2.fastq, A_R1.fastq and A_R2.fastq如何通过BWA/GATK去找样品A中
的SNPs (相对于C)
假设assembly 用的是hg19，你的BWA index 在这里：/bwa/indexes/hg19
Check this website if you have any questions:
http://seqanswers.com/wiki/How-to/exome_analysis
#s... 阅读全帖 |
|
j*p
发帖数: 411 | 5 攒人品，顺便回答一下 iiiir 的问题。
我们尝试过好几种不同的SNP calling的方法，包括GATK, Samtools, Varscan,
SeqGenes, 等，并且做了SNP array 作为gold standard比较各种方法的prediction
power。
从我们的经验，BWA + GATK 最好，sensitivity 和 specificity 都在95%以上。
以下是GATK 的pipeline
假设你有一个control 样品C 和一个样本样品A的pair-end sequencing，共4个文件，C
_R1.fastq, C_R2.fastq, A_R1.fastq and A_R2.fastq如何通过BWA/GATK去找样品A中
的SNPs (相对于C)
假设assembly 用的是hg19，你的BWA index 在这里：/bwa/indexes/hg19
Check this website if you have any questions:
http://seqanswers.com/wiki/How-to/exome_analysis
#s... 阅读全帖 |
|
s****l
发帖数: 10462 | 6 这些个星号是什么意思来着？谢谢
CYP2D6*1 - the most common form, considered 'fully functional'; also known
as wild-type, or WT
CYP2D6*2 - normal function except CYP2D6*2XN variants
CYP2D6*3 - nonfunctioning variant
CYP2D6*4 - nonfunctioning variant; the most common variant; rs3892097 |
|
c**i
发帖数: 6973 | 7 (1) India pushes for nuclear triad - paper. RIA Novosti, May 17, 2011.
http://en.rian.ru/mlitary_news/20110517/164076760.html
("India is very close to completing a nuclear triad with the induction of
the first Arihant class nuclear-powered submarine by 2012. The submarine was
floated out on July 26, 2009 and is slated to go for sea trials once its 83
-MW light-water reactor gains full capacity")
Note:
(a) The report cites
Rajat Pandit, Manmohan Singh takes stock of country's nuclear arsenal. Tim... 阅读全帖 |
|
c**i
发帖数: 6973 | 8 ------------------------------Separately
(1) GE and China: Growing Market Overseas, More Jobs at Home. General
Elctric, Aug 25, 2011
http://www.gereports.com/ge-and-china-growing-market-overseas
-more-jobs-at-home/?utm_source=google&utm_medium=cpc&utm
_term=china%20aircraft&utm_campaign=GE%20Aviation%20Response&kmed=ppc
("GE started doing business in China in 1906")
Note:
(a) The announcement stated, "With $17 billion in U.S. exports in 2010, GE
is the nation’s second largest manufacturing expor... 阅读全帖 |
|
R****a
发帖数: 6858 | 9 F-35 又出问题了？
来源: IQ88 于 2013-02-22 13:57:12[档案] [博客] [旧帖] [转至博客] [给我悄悄
话] 本文已被阅读：452次
字体：调大/调小/重置 | 加入书签| 打印| 所有跟帖 | 加跟贴| 查看当前最热讨论主题
http://news.yahoo.com/pentagon-suspends-f-35-flights-due-crack-
WASHINGTON (Reuters) - The Pentagon on Friday suspended the flights of all
51 F-35 fighter planes after a routine inspection revealed a crack on a
turbine blade in the jet engine of an F-35 test aircraft in California.
It was the second grounding of the warplane in two months and marked another
setback ... 阅读全帖 |
|
s********i
发帖数: 17328 | 10 F-35A, conventional take off and landing (CTOL) variant.
F-35B, short-take off and vertical-landing (STOVL) variant.
F-35C, carrier-based CATOBAR (CV) variant. |
|
T**********e
发帖数: 29576 | 11 4w-8w年前泥人和人类大量混合交配，现代欧亚人保留了1%以上的泥人基因，以中国北京
汉族人保留了1.4%为世界最多，平均略高于中国南方汉人。最后泥人很可能融入现代人
种继而消失。
How Neanderthal DNA Changed Humans
------
The researchers analyzed genetic variants in 846 people of non-African
heritage, 176 people from sub-Saharan Africa and a 50,000-year-old
Neanderthal.
The clearest indicator that a gene variant came from a Neanderthal was if
the variant appeared in some non-Africans and the Neanderthal, but not in
the sub-Saharan Africans.
Levels of Neanderthal ancestry differ in E... 阅读全帖 |
|
发帖数: 1 | 12 自己查那几个基因吧
看看携带者有多少
We previously reported that a number of patients show a thermal instable
phenotype of compound hetero/homozygous variants of CPT II. To understand
the mechanism of the metabolic disorder resulting from CPT II deficiency,
the present study investigated CPT II variants in patient fibroblasts, [c.
1102 G>A (p.V368I)] (heterozygous), [c.1102 G>A (p.V368I)] (homozygous
), and
[c.1055 T>G (p.F352C)] (heterozygous) [c.1102 G>A (p.V368I)] (
homozygous)
compared with fibroblasts from... 阅读全帖 |
|
w********2
发帖数: 632 | 13 The Gnome 7 Lambda was a French designed, seven-cylinder, air-cooled rotary
aero engine that was produced under license in Britain and Germany. Powering
several World War I era aircraft types it was claimed to produce 80
horsepower (60 kW) from its capacity of 12 litres (720 cubic inches)
although recorded figures are lower.[1]
Just under 1,000 units were produced in Britain, the majority (967) by the
Daimler Company of Coventry. A 14-cylinder variant was known as the Gnome 14
Lambda-Lambda.
In ... 阅读全帖 |
|
w*********s
发帖数: 2136 | 14 Why Almost Everything You Hear About Medicine Is Wrong
http://www.newsweek.com/2011/01/23/why-almost-everything-you-he
If you follow the news about health research, you risk whiplash. First
garlic lowers bad cholesterol, then—after more study—it doesn’t. Hormone
replacement reduces the risk of heart disease in postmenopausal women, until
a huge study finds that it doesn’t (and that it raises the risk of breast
cancer to boot). Eating a big breakfast cuts your total daily calories, or
not—as a st... 阅读全帖 |
|
w*********s
发帖数: 2136 | 15 Why Almost Everything You Hear About Medicine Is Wrong
http://www.newsweek.com/2011/01/23/why-almost-everything-you-he
If you follow the news about health research, you risk whiplash. First
garlic lowers bad cholesterol, then—after more study—it doesn’t. Hormone
replacement reduces the risk of heart disease in postmenopausal women, until
a huge study finds that it doesn’t (and that it raises the risk of breast
cancer to boot). Eating a big breakfast cuts your total daily calories, or
not—as a st... 阅读全帖 |
|
d******8
发帖数: 1972 | 16 Recent advances in whole-genome sequencing have brought the vision of
personal genomics and genomic medicine
closer to reality. However, current methods lack clinical accuracy and the
ability to describe the context (haplotypes) in
which genome variants co-occur in a cost-effective manner. Here we describe
a low-cost DNA sequencing and
haplotyping process, long fragment read (LFR) technology, which is similar
to sequencing long single DNA molecules
without cloning or separation of metaphase chro... 阅读全帖 |
|
|
|
|
h*****w
发帖数: 244 | 20 to be specific about the Chinese language -- what people
usually refer to as "the Chinese language" is "Han4 Yu3".
"Han4 Yu3" has a lot of different variantions (i.e., called
dialects) especially in terms of accents. in a much lesser
degree are vocabulary and grammar. big accent variantions in
different dialects usually causes total obstruction of
understanding. but vocabuloury and grammar differences are
not as obvious -- there are some variantions, but in the
written form it will not pose as a |
|
b*****n
发帖数: 4976 | 21
你没有发现其中极其基本的逻辑问题吗？2600个不
同版本中比较了其中的几个，就得出了“事实”，还说“介绍十分误导，比如2600不同
版本代表什么意思”。这暴露了某些方面的问题，我不想多说了。
===============================================
我回看这论题各帖,
「2600不同版本」是你在#1 便弄出来的话,
甚么 2600版本?
难道是指一件事有2600个不同讲法?
「2600不同版本」是你由
网站的地址是：
http://dss.collections.imj.org.il/ch/project 中
"2600 variants" 中译过来的中文,
懂英文的知 variants 与 versions (版本)是两码子的事。
抄写上串错子, 多了一个音, 一个句号,
段落次序乱了, 都是一个 variant
即使我在此帖打错了一个字, 也不会影响
我要讲我论点罢 |
|
t*******r
发帖数: 2940 | 22 你应知道你我在这里搞的是民科，但也希望尽可能有依据有道理，吹泡泡就不必了。
因为是民科，所以不严密，让我澄清修正一下这句话：＂ 圣经只有极小部分被破坏，
改写，剪接，修订或篡改。”，以我不专业的眼光看，对文本进行修订是保证文本准确
的正常手段。对本文进行改写或剪辑有两种情况，一种是对已知的错误进行修订，可以
归入修订，另一种是有意或无意的破坏和篡改，可归入破坏和篡改，对文本真正有破坏
作用的是破坏和篡改，因为会破坏文本的艺术和思想。我现在把这句话修正为：“ 圣
经只有极小部分被破坏或篡改。”
你应该已经意识到2600 是variant readings，ranging from a single letter,
sometimes one or more words, to complete variant verse or verses.，不是指
2600不同版本的以赛亚书，＂这暴露了某些方面的问题，我不想多说了。＂ 只看介绍
容易误解，特别是翻译的。
比较相差尽千年的手抄版本，尽管有2600 variant readings，但完全不影响理解以赛
亚书的艺术和思想，confirm ... 阅读全帖 |
|
d***a
发帖数: 13752 | 23 I'm not sure about your point. IRIX and Solaris are pretty good OS... You
are talking about HP stuff.
Sure you can say Darwin and FreeBSD are not SRV4. The point here is that
they are UNIX variants. Linux is also considered a variant of UNIX, though
the source code is totally rewritten to get around of licensing issue. (UNIX
source code from Bell Labs was then open to the public.)
Tons of research papers and PhD theses have been written on UNIX and its
variants, a major advance that UNIX-based s... 阅读全帖 |
|
t****t
发帖数: 6806 | 24 看你具体问题了, 一般是写库用的. 比如说从variant type的调用转换到任意非函数的
调用的接口:
user want to write
variant LHS[...], RHS[...]
RHS = invoke("function", LHS)
given any function (certain limitation applies, e.g. all parameters can be
converted to/from variant)
这个时候你就需要用variadic template来capture函数的signature |
|
g*********d
发帖数: 233 | 25 发表在基因图谱年会的一项跨文化研究指出，东方人的发丝比西方人粗50％的现象
和一段EDAR
基因有关.
SAN DIEGO, CALIFORNIA--Whether you have a poker-straight black mane
or frizzy blond locks, your hair depends on your ancestry. Now
researchers have come closer to figuring out just how hair traits are
passed down. According to a talk presented here last week at the annual
meeting of the American Society of Human Genetics, a single genetic
variant may explain why East Asians have thicker hair fibers than other
populations. The discovery ... 阅读全帖 |
|
w*********s
发帖数: 2136 | 26 Why Almost Everything You Hear About Medicine Is Wrong
http://www.newsweek.com/2011/01/23/why-almost-everything-you-he
If you follow the news about health research, you risk whiplash. First
garlic lowers bad cholesterol, then—after more study—it doesn’t. Hormone
replacement reduces the risk of heart disease in postmenopausal women, until
a huge study finds that it doesn’t (and that it raises the risk of breast
cancer to boot). Eating a big breakfast cuts your total daily calories, or
not—as a st... 阅读全帖 |
|
l**********1
发帖数: 5204 | 27 Ding
plus
>
April 04, 2012
The New Genetics of Autism – Why Environment Matters
by Thomas Insel
>
Last week’s autism news was about prevalence. The CDC reported a 78 percent increase in autism
prevalence since 2002. This week’s autism news is about genetics—three papers in Nature describe new
genes associated with autism. For many people, these two stories seem contradictory or, at best, unrelated.
Increasing prevalence suggests environmental factors like chemicals and microbes changing over the... 阅读全帖 |
|
t*d
发帖数: 1290 | 28 http://www.genomeweb.com//node/980559?hq_e=el&hq_m=1103092&hq_l
----------------------------------------
A recent study by scientists at Yale University suggests that the actual
cost of sequencing may be much higher than some current estimates indicate
since those figures may not factor in the analysis costs that are necessary
for a successful sequencing project.
In the paper, published in Genome Biology last month, Yale's Mark Gerstein
and colleagues consider costs that weren’t taken into accou... 阅读全帖 |
|
u*********1
发帖数: 2518 | 29 拿到某疾病sample的whole-genome sequencing数据，鉴定出SNP；其实不仅SNP，各种
structural variants我也搞到了手上。
请问然后做什么呢？
和已经有的database比较挑出rare variants？
然后看这写variants影响了什么coding region？
甚至和DNAse 1 hypersensitivity或者eQTL比较来找影响到了什么noncoding region？
我感觉WGS之后的下游genetic basis分析然后来找什么致病位点挺傻的，大部分
noncoding region我们都搞不清楚是什么功能。然后作为bioinformatician能做的就这
么多了，不晓得在biology/medicine角度还有什么可以继续探究的思路？
另外，如果我拿到100个甚至500个WGS的data，又应该怎么做呢？做population
genetics？
请前辈高人指教！
谢谢 |
|
l**********1
发帖数: 5204 | 30 看英语没有问题的 人类基因组的新手的话
hg18 hg 19的区别
Why are some variants mapped to hg18 but not hg19?
When the variation data was mapped to hg19, we did our best to come up with
a process that would result in a low error rate, while maximizing the number
of variants kept in hg19. Due to changes in the underlying assembly, some
regions are re-arranged while others contain novel sequence, thus changing
the structure of the region. In most cases the assembly hasn't changed
enough to cause difficultly in remapping,... 阅读全帖 |
|
c********r
发帖数: 189 | 31
学术上，现在普遍用NGS来study家族遗传病或者sporadic genetic conditions。以最
近发现了很多新的基因（Autism，RP等）理论基础是（Rare disease, Rare variants;
和 common disease, rare variants）不同于GWAS的（common disease common
variants）现在看来比GWAS和linkage更易于发现disease allele。感觉几年内还会有
很多的新基因被发现。但是技术是比较成熟的，我感觉应用的关键是对基因功能的研究。
Clinical上，有几个方面： 1）产前的诊断：尤其是现在non-invasive的手段，可以在
母亲血液中分离胎儿DNA，通过NGS诊断。不但可以检测Down syndrome之类的，还可以
检测很多单基因疾病。
2）遗传疾病的确诊。同上 3）细菌和病毒感染的诊断；4）食品和药物安全检测（如前
些日子有人发的文章检测中药制剂，直接测序就可以鉴别用了些啥材料）等等。。。
美国很多人都认为不就的将来所有新生儿都会被直接测序，这必然是一个发展趋势。这
将... 阅读全帖 |
|
u*********1
发帖数: 2518 | 32 我是以一个线虫为基础，做了一些突变体，所以每个线虫都是有血缘关系的
这个在我眼里是多么求之不得的事情。这就好比你做tumor variants的分析，你有
tumor和control，那么这个control样本可以帮你排除掉ＮＮＮＮＮ多的noise；直接看
看mutant都出现了什么新的SNP所以导致了phenotype
这是做cancer genomics最爽的地方，因为有天然的control；而我们做一般complex
disease的就只能依靠common variants的数据库了。
不过我不太明白的是为什么A和Ｂ两个wildtype的phenotype如此不同；既然是wildtype
那genome难道会有很大差别么？（可能是很silly的问题因为我是外行）
anyway，先找到只在mut里产生的variants，做点annotation，或许你就已经找到了你
想要的东西，不用去care什么association power了 |
|
w*****y
发帖数: 1201 | 33 这个看你想找的variant的frequency的，只要你不是找非常低的rare variant，一般来
说，2-4X覆盖基本上够了，测序完之后，做imputation，应该可以找到绝大部分的
variant。 |
|
i*******i
发帖数: 145 | 34 "这个看你想找的variant的frequency的，只要你不是找非常低的rare variant，一般来
说，2-4X覆盖基本上够了"
这个跟variant frequency有什么关系？一个sequenceing run就是一个个体的。 |
|
s****l
发帖数: 10462 | 35 有人愿意讨论这里面提及的测序技术吗？优缺点，可行性，第一手经验等等
这里面谁现在是赢家很清楚，但是可见的将来和更远的将来谁会赢？
http://cen.acs.org/articles/92/i33/Next-Gen-Sequencing-Numbers-
全文拷贝如下
试试看图能不能贴上
/1407973177171.jpg
/1408028636124.jpg
OVER STORY
Next-Gen Sequencing Is A Numbers Game
As technical and cost barriers fall, instrument firms move their systems
into research and clinical markets
By Ann M. Thayer
Department: Business
Keywords: instrumentation, gene sequencing, diagnostics, genomics, cancer
[+]Enlarge
09233-cover-Openercxd_17647969-690
A... 阅读全帖 |
|
C*********m
发帖数: 213 | 36 问题是这样的，我有个基因有19个exons，然后老鼠同源蛋白有两个splicing variants
中间差一段编码的肽段，很短，很可能是microexon引起的，在不同组织里表达不一样
；然后我就想看看人里面的是不是也会有类似的splicing variants，也想找一下
microexon的可能。那就想看序列，看splicing位点，编码序列的比对，可貌似ensembl
.org查起来不太方便。
想问:怎么查找人源蛋白里是否存在类似的splicing variants? |
|
c******e
发帖数: 350 | 37 我几次读到报道，说用next generation sequencing 进行copy number variant的检测
技术还不成熟，因此，high throughput 的copy number variation检测还是用
microarray. 然而，报道的只是个结论，并没有说原因。
版上都是生物技术前沿的斗士们，一定有人会有一些经验和前瞻性的建议。所以，我特
来请教:
1) how microassay is better than next generation sequencing on copy number
detection.
2) If we have a sequencing assay for a targeted gene panel by next
generation sequencing, and want to further detect the copy number variation
on the same genes, what improvement is needed before using the NGS data for
co... 阅读全帖 |
|
发帖数: 1 | 38 很多复杂疾病或者cancer，遗传角度非常复杂，往往gwas什么的找到很多variants
过去的linear model都很难很好通过这些variants来预测disease phenotype
所以有用deep learning来研究causal variants或者什么cancer driver gene的么？深
度学习这么火
找了一下并没有看到，但倒是看到很多deep learning研究noncoding dna function的 |
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发帖数: 1 | 39 很多复杂疾病或者cancer，遗传角度非常复杂，往往gwas什么的找到很多variants
过去的linear model都很难很好通过这些variants来预测disease phenotype
所以有用deep learning来研究causal variants或者什么cancer driver gene的么？深
度学习这么火
找了一下并没有看到，但倒是看到很多deep learning研究noncoding dna function的 |
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发帖数: 1 | 40 首先，训练样本几十个？？？？？那么这个问题就over了。
现在的GWAS，都是几千个的
第二，GWAS主要的对象是common variants；我个人的观点是，部分common variants有
明确的功能，比如对promoter的影响，但影响甚微，比如2-fold差别对于基因表达
第三，就算你 有几千个样本，每个样本几万个SNP， 最后依然不会对治病有啥帮助。
这种研究，就是现代版的算命
GWAS难以重复，大量artifact，计算得到重要SNP，功能研究也是头疼。
个人认为，遗传学的金标准，依然是family linkage study的那些有重大致病作用的
rare mutation。至于GWAS/common variants这一套，我们目前的人类文明水平难以企及 |
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发帖数: 1 | 41 没你想的复杂 就是生物信息general 用词
就是跑软件得到snp信息的意思。
比如你跑一跑gatk pipeline，得到1000个snp variant，这就是一次call
所以make variant call better，就是优化pipeline，得到更符合标准的variant |
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w*********s
发帖数: 2136 | 42 Why Almost Everything You Hear About Medicine Is Wrong
http://www.newsweek.com/2011/01/23/why-almost-everything-you-he
If you follow the news about health research, you risk whiplash. First
garlic lowers bad cholesterol, then—after more study—it doesn’t. Hormone
replacement reduces the risk of heart disease in postmenopausal women, until
a huge study finds that it doesn’t (and that it raises the risk of breast
cancer to boot). Eating a big breakfast cuts your total daily calories, or
not—as a st... 阅读全帖 |
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f**d
发帖数: 768 | 43 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
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w*********s
发帖数: 2136 | 46 【 以下文字转载自 WorldNews 讨论区 】
发信人: whiteclouds (/ 参考消息 /), 信区: WorldNews
标 题: F-35 STEALTH FIGHTER SPY COVER-UP
发信站: BBS 未名空间站 (Thu Nov 11 12:57:49 2010, 美东)
NATIONAL SECURITY ALERT: F-35 STEALTH FIGHTER SPY COVER-UP
November 2, 2010 posted by Gordon Duff ·
“WIKI” STYLE ESPIONAGE LANDS $300 BILLION DOLLAR SUPER-PLANE PLANS
By Gordon Duff STAFF WRITER/Senior Editor
“Another spy disaster like Pollard, shoved under the rug too long due to
pressure from the powerful Israeli lobby.”
On April 21, 2009, t... 阅读全帖 |
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t******n
发帖数: 3113 | 47 问题是台湾的普通话跟大陆的普通话根本就是一样的普通话，就像没有人说香港粤语，
广州粤语，深圳粤语的，就是粤语啊。上海话也是，还浦东上海话是个variant
derived from上海话？不要太搞笑
台湾人真是臆想症大爆发，凭空制造了“台湾普通话”，“台湾闽南话”，“台湾客家
话”，有种给它们换个名字啊？还variant，var它个头iant。。。 |
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c**i
发帖数: 6973 | 48 羅添斌, 潛射雄二測評 劍龍級潛艦大升級. Liberty Times, July 7, 2011.
http://www.libertytimes.com.tw/2011/new/jul/7/today-p1.htm
My comment: I read the news upon its publication at 3 pm. My impression was
Taiwan's aim was aspirational, rather than a reality. After all,
(a) China announced the capability in mid-1980s but Annual Report to
Congress: Military and Secutiry Developments Involving the People's Republic
of China. 2010, by US Department of Defense, stated that enither JL-1 nor -
2 was operational.
(b) Taiw... 阅读全帖 |
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c**i
发帖数: 6973 | 49 (1) Anisimov Sergey and Igor Siletsky, Russia's response to US missile
defense plans. Voice of Russia, Oct 15, 2011
http://english.ruvr.ru/2011/10/15/58784848.html
("US Ambassador to Moscow Michael McFaul said during his address to Congress
this week that Washington will not sign any agreements to the effect that
the American missile defense project is not directed against Russia. Russia
got the message")
Note: In fact, Mr McFaul, who has been Pres Obama's top Russia adviser, is a
nominee for th... 阅读全帖 |
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