l*g
发帖数: 46 | 1 下面是我一堂课上的讲义
Repetive elements in query sequences can cause spurious database
matches. These sequences lead to artifically high alignment scores
with database sequences when they are acturally not related to databases
sequences. Alu repeats, low-complexity regions (LCRs) with short period
repeats or overrepresented residues. In fact, one half of protein
sequences in databases contain at least one LCR.
Reason: the LCR sequences do not fit the residue-by-residue sequence
conservation and therefore |
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