h********n
发帖数: 4079 | 1 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
色的, 哪些还不足的? 说出来对大家都会有帮助的.
我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
见.
DrBiologist, 你能不能带头说点啥?
谢谢各位. | n********k
发帖数: 2818 | 2 Ding and also job hunting advice too
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| zc
发帖数: 111 | 3 说多了都白搭
诀窍只有一个-----------------------------------熬
等你熬出头受人崇拜了，你就成鳌拜了
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| p*******r
发帖数: 4048 | 4 Pretty much my case...
All my peers quit. So when finally there were some openings in my field, I
was kind of the only one left...
In my boss' wise words:
Getting a job has to do with market fluctuations much more than
whatever you do.
【在 zc 的大作中提到】
: 说多了都白搭
: 诀窍只有一个-----------------------------------熬
: 等你熬出头受人崇拜了，你就成鳌拜了
:
: .
| h******y
发帖数: 1374 | 5 最好的建议不是应该来自你现在的postdoc老板吗？
hehe
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| h********n
发帖数: 4079 | 6 我现在老板做PI是在70年代, 跟现在不一样啊.
【在 h******y 的大作中提到】
: 最好的建议不是应该来自你现在的postdoc老板吗？
: hehe
:
: .
| h********n
发帖数: 4079 | 7 熬也有时间长短.
【在 zc 的大作中提到】
: 说多了都白搭
: 诀窍只有一个-----------------------------------熬
: 等你熬出头受人崇拜了，你就成鳌拜了
:
: .
| D*********t
发帖数: 370 | 8 Good pubs is important, as you mentioned. An equally important factor
is your research direction – what you do. In the faculty job market, the
hiring department cares more about what they need, which is often in
line with what can bring in funding from the NIH.
Current hot topics include stem cells, small RNAs, genomics, epigenetics,
neurocircuits, systems biology, ... etc. Of course, the high-in-demand
research areas may change once you are ready to be on the job market.
You need to have s
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| h********n
发帖数: 4079 | 9 现在困绕我的一个问题是, 如何建立学术界的connection?
【在 D*********t 的大作中提到】
: Good pubs is important, as you mentioned. An equally important factor
: is your research direction – what you do. In the faculty job market, the
: hiring department cares more about what they need, which is often in
: line with what can bring in funding from the NIH.
: Current hot topics include stem cells, small RNAs, genomics, epigenetics,
: neurocircuits, systems biology, ... etc. Of course, the high-in-demand
: research areas may change once you are ready to be on the job market.
: You need to have s
| D*********t
发帖数: 370 | 10 You shouldn't worry about connections now. You establish yourself
by publishing high-profile papers. Then others will be happy to
"connect" with you.
【在 h********n 的大作中提到】
: 现在困绕我的一个问题是, 如何建立学术界的connection?
| | | n********k
发帖数: 2818 | 11 me too, have asked quite a few bulls, different people have very different
perspectives about this...I always
feel it is very important but most of answers are not for postdoc...it seems
more about pedigree/camps less
about the network...
【在 h********n 的大作中提到】
: 现在困绕我的一个问题是, 如何建立学术界的connection?
| n********k
发帖数: 2818 | 12 So, but from what I see, for junior faculty, it seems connection is pretty
important, is that true?
【在 D*********t 的大作中提到】
: You shouldn't worry about connections now. You establish yourself
: by publishing high-profile papers. Then others will be happy to
: "connect" with you.
| l******u
发帖数: 936 | 13 Max Delbrück 说的"Don't do fashionable science"，
他学生詹裕农实验室首页的座右铭， 呵呵。
【在 D*********t 的大作中提到】
: Good pubs is important, as you mentioned. An equally important factor
: is your research direction – what you do. In the faculty job market, the
: hiring department cares more about what they need, which is often in
: line with what can bring in funding from the NIH.
: Current hot topics include stem cells, small RNAs, genomics, epigenetics,
: neurocircuits, systems biology, ... etc. Of course, the high-in-demand
: research areas may change once you are ready to be on the job market.
: You need to have s
| a******g
发帖数: 129 | 14 That's why you need to go to a big-name lab.
【在 h********n 的大作中提到】
: 现在困绕我的一个问题是, 如何建立学术界的connection?
| D*********t
发帖数: 370 | 15 The important component of "connections" is just name-recognition.
If others know you do good science (because you published in CNS),
they would like to invite you to give a talk, would like to collaborate with
you, and so on. That's how you get connected.
【在 n********k 的大作中提到】
: So, but from what I see, for junior faculty, it seems connection is pretty
: important, is that true?
| D*********t
发帖数: 370 | 16 Yes. That for established gurus to say "I don't give a shit to what others
do!"
【在 l******u 的大作中提到】
: Max Delbrück 说的"Don't do fashionable science"，
: 他学生詹裕农实验室首页的座右铭， 呵呵。
| K****n
发帖数: 5970 | 17 My boss is a young faculty. He entered my school in the same year as i
did.
He launched his job with the help from his Ph.D. advisor, who is a big
bull in my school. My boss is brilliant and super hardworking, but with
only PNAS and no CNS
pretty
【在 n********k 的大作中提到】
: So, but from what I see, for junior faculty, it seems connection is pretty
: important, is that true?
| d*****r
发帖数: 2583 | 18 Delbruck是偶像阿。。
跟Francis Crick一样都是另一个层次的人物。
【在 l******u 的大作中提到】
: Max Delbrück 说的"Don't do fashionable science"，
: 他学生詹裕农实验室首页的座右铭， 呵呵。
| n********k
发帖数: 2818 | 19 so do all (most of ) folks from your lab land a job in a top place? Or has
ever anybody got kicked out? BTW,
how are things going?
【在 a******g 的大作中提到】
: That's why you need to go to a big-name lab.
| n********k
发帖数: 2818 | 20 Sure, but what about before one had CNS...and say the MS, grant reviewing
etc etc...in our case, many/some of
the reviewers are either my boss' friends or from a same lab...and also they
had tri-lab annual retreat with
peoplem's lab and another big lab in stanford, so when I look around, it
seems they would virtually know half
of the people in the field...also, how important/critical to write reviews
as postdoc or junior faculty? That
seems a big boost for some...
with
【在 D*********t 的大作中提到】
: The important component of "connections" is just name-recognition.
: If others know you do good science (because you published in CNS),
: they would like to invite you to give a talk, would like to collaborate with
: you, and so on. That's how you get connected.
| | | a******g
发帖数: 129 | 21 regarding top place, I would say 50%. 20-30% went to decent place. remaining
20-30% go for industry and other careers. If you don't do anything stupid,
you will not be kicked out. Things here are going slowly but fortunately I
got an internal fellowship,quite a relief.
has
【在 n********k 的大作中提到】
: so do all (most of ) folks from your lab land a job in a top place? Or has
: ever anybody got kicked out? BTW,
: how are things going?
| w********h
发帖数: 12367 | 22 I agree.
a hot area + a supportive big boss + numerous quality papers + good
presentation and personal skills = faculty position.
【在 D*********t 的大作中提到】
: Good pubs is important, as you mentioned. An equally important factor
: is your research direction – what you do. In the faculty job market, the
: hiring department cares more about what they need, which is often in
: line with what can bring in funding from the NIH.
: Current hot topics include stem cells, small RNAs, genomics, epigenetics,
: neurocircuits, systems biology, ... etc. Of course, the high-in-demand
: research areas may change once you are ready to be on the job market.
: You need to have s
| p*****m
发帖数: 7030 | 23 你这个算法出来的至少是top school faculty吧 要先当faculty不需要这么多条件
【在 w********h 的大作中提到】
: I agree.
: a hot area + a supportive big boss + numerous quality papers + good
: presentation and personal skills = faculty position.
| w********h
发帖数: 12367 | 24 more or less ah...
【在 p*****m 的大作中提到】
: 你这个算法出来的至少是top school faculty吧 要先当faculty不需要这么多条件
| n********k
发帖数: 2818 | 25 I am doomed now:)))
【在 w********h 的大作中提到】
: more or less ah...
| a********k
发帖数: 2273 | 26 You have good publications, and you are in a hot area. If you can make your
boss a cow, you are qualified~
【在 n********k 的大作中提到】
: I am doomed now:)))
| p*****m
发帖数: 7030 | 27 俺引用某大佬的教导哈 年轻老板 接reviewer活勤快点 写review积极点 干公共活比如
study section啊之类的多一点 一不小心就成了super star了 哈哈
they
【在 n********k 的大作中提到】
: Sure, but what about before one had CNS...and say the MS, grant reviewing
: etc etc...in our case, many/some of
: the reviewers are either my boss' friends or from a same lab...and also they
: had tri-lab annual retreat with
: peoplem's lab and another big lab in stanford, so when I look around, it
: seems they would virtually know half
: of the people in the field...also, how important/critical to write reviews
: as postdoc or junior faculty? That
: seems a big boost for some...
:
| l********g
发帖数: 400 | 28 本版近来铺天盖地的对中国 PI 的恶毒谩骂, 已经让不少 PI 对这个版敬而远之了. 估
计参加这一讨论的 PI 的数量会很有限.
DrBiologist 是带头说了, 有没有 PI 跟上就难说了.
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| p*******r
发帖数: 4048 | 29 I think connections are not that important, but collaborators are. If I
have 5 good collaborators, that's more than enough.
I have a particular style of doing science. Might not work for everybody.
I typically just pick a problem I like and attack it with latest tools.
If the tools are lacking, I invent them.
I almost never pay attention to what's hot right now. In fact I avoid
them. As a result, there are really not many people for me to connect
with. I typically find that people like to connec
【在 n********k 的大作中提到】
: So, but from what I see, for junior faculty, it seems connection is pretty
: important, is that true?
| p*******r
发帖数: 4048 | 30 Most people who ask me for reviews are my fellow grad students during
PhD.
I don't like to write review papers and giving too many talks.
But again just my style. I like to hide for a while and connect with
nobody, then come out with a big paper once every few years.
reviewing
also they
it
reviews
【在 n********k 的大作中提到】
: Sure, but what about before one had CNS...and say the MS, grant reviewing
: etc etc...in our case, many/some of
: the reviewers are either my boss' friends or from a same lab...and also they
: had tri-lab annual retreat with
: peoplem's lab and another big lab in stanford, so when I look around, it
: seems they would virtually know half
: of the people in the field...also, how important/critical to write reviews
: as postdoc or junior faculty? That
: seems a big boost for some...
:
| | | n********k
发帖数: 2818 | 31 well, u are in a wonderland, although I always like to have ur perspectives
but yours never counts, to me:))),
shall say applicable to me...Yeah, seriously I agree with you, that would be
what i would love to do, but I just
don't think i could for a number of reasons...science to me still somewhat a
way of making a living although I
hope there is such day it would be just my luxury hobby and I can do what I
am most passionate about...
【在 p*******r 的大作中提到】
: Most people who ask me for reviews are my fellow grad students during
: PhD.
: I don't like to write review papers and giving too many talks.
: But again just my style. I like to hide for a while and connect with
: nobody, then come out with a big paper once every few years.
:
: reviewing
: also they
: it
: reviews
| n********k
发帖数: 2818 | 32 well, if I have another ten ys to fool around, maybe I would/could do that:)
))...I think my boss would be alright
in the coming ys but a little cow or not would depends on so many factors...
I am the only postdoc so far...it is
so hard for us to get good postdoc, my boss is a bit picky but getting less
and less picky...some we want but
they don't come but the others we don't feel would be a good fit...it is so
hard for a junior lab although the
boss is very decent and the field is filled with p
【在 a********k 的大作中提到】
: You have good publications, and you are in a hot area. If you can make your
: boss a cow, you are qualified~
| f********a
发帖数: 15 | | n********k
发帖数: 2818 | 34 a couple of PIs already spoke, maybe u don't know them
【在 l********g 的大作中提到】
: 本版近来铺天盖地的对中国 PI 的恶毒谩骂, 已经让不少 PI 对这个版敬而远之了. 估
: 计参加这一讨论的 PI 的数量会很有限.
: DrBiologist 是带头说了, 有没有 PI 跟上就难说了.
:
: .
| f**********e
发帖数: 1994 | 35
.
做几年后的当红方向最重要。牛校牛 lab 都是加分用的。
当然，如果赌错就郁闷了。这就是为何地球上千老这么多的原因。
这年头如果不 ride the tide 要找个好 faculty 位置都不简单。不是说完全
不可能，但是进好学校好 program 的绝大多是追热门方向的。我也崇拜那种不管
别人做什么都千山我独行的牛人，但是这种人的存活率在现在实在不高。现在不是
1960 年了，你只要脱离群众一下 funding 就立刻成问题，junior 的 faculty
找不到，你连 career 都不会有。
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| p*******r
发帖数: 4048 | 36 I just think it's impossible to predict what's going to be hot in 5 years.
So I just follow my heart.
If you publish a good paper, then what you do becomes hot.
But I use the latest tools, I think this is important. I think what
becomes hot is largely what's doable, which is tied to tools.
【在 f**********e 的大作中提到】
:
: .
: 做几年后的当红方向最重要。牛校牛 lab 都是加分用的。
: 当然，如果赌错就郁闷了。这就是为何地球上千老这么多的原因。
: 这年头如果不 ride the tide 要找个好 faculty 位置都不简单。不是说完全
: 不可能，但是进好学校好 program 的绝大多是追热门方向的。我也崇拜那种不管
: 别人做什么都千山我独行的牛人，但是这种人的存活率在现在实在不高。现在不是
: 1960 年了，你只要脱离群众一下 funding 就立刻成问题，junior 的 faculty
: 找不到，你连 career 都不会有。
| T****r
发帖数: 4006 | 37 到目前为止，我就认出两个是...
还有谁是，透露一下吧...
【在 n********k 的大作中提到】
: a couple of PIs already spoke, maybe u don't know them
| t*****x
发帖数: 68 | 38 quite a few intriguing points --- support.
【在 D*********t 的大作中提到】
: Good pubs is important, as you mentioned. An equally important factor
: is your research direction – what you do. In the faculty job market, the
: hiring department cares more about what they need, which is often in
: line with what can bring in funding from the NIH.
: Current hot topics include stem cells, small RNAs, genomics, epigenetics,
: neurocircuits, systems biology, ... etc. Of course, the high-in-demand
: research areas may change once you are ready to be on the job market.
: You need to have s
| n****8
发帖数: 23 | 39 social和research 根本是相反的，social 的越多越难deep thinking.
【在 p*******r 的大作中提到】
: Most people who ask me for reviews are my fellow grad students during
: PhD.
: I don't like to write review papers and giving too many talks.
: But again just my style. I like to hide for a while and connect with
: nobody, then come out with a big paper once every few years.
:
: reviewing
: also they
: it
: reviews
| f**********e
发帖数: 1994 | 40 希望你喜欢的方向几年以后会变得很热。不然梦想破灭的时候会非常，非常痛苦。
其实做非热门方向的人心里也都知道找 faculty 会不容易，但是大家会集体
处在自我催眠状态 -- 觉得那个不幸变成千老的一定不是我。我一定会拿到 top
大学的 offer, R01, 从此过着受人尊敬的日子。
dream on. 还是做个热门方向实在。NGS, network, ChIP, whole genome
screening/profiling, 那个热干哪个。那个 DrBiologist 提的超烂方向
（codon usage）我还真作过一阵 -- 想看看它和 protein interaction
有没有关系。结果就是悲剧。前面那个叫人 submit 500 个 applications
的纯粹就是浪费时间 -- 你烂撒到 500 个你老板保证和你翻脸 -- 你丢的起人
他可丢不起呢。
years.
【在 p*******r 的大作中提到】
: I just think it's impossible to predict what's going to be hot in 5 years.
: So I just follow my heart.
: If you publish a good paper, then what you do becomes hot.
: But I use the latest tools, I think this is important. I think what
: becomes hot is largely what's doable, which is tied to tools.
| | | n********k
发帖数: 2818 | 41 well said, but if you know both of them, u would say different:))))...
【在 f**********e 的大作中提到】
: 希望你喜欢的方向几年以后会变得很热。不然梦想破灭的时候会非常，非常痛苦。
: 其实做非热门方向的人心里也都知道找 faculty 会不容易，但是大家会集体
: 处在自我催眠状态 -- 觉得那个不幸变成千老的一定不是我。我一定会拿到 top
: 大学的 offer, R01, 从此过着受人尊敬的日子。
: dream on. 还是做个热门方向实在。NGS, network, ChIP, whole genome
: screening/profiling, 那个热干哪个。那个 DrBiologist 提的超烂方向
: （codon usage）我还真作过一阵 -- 想看看它和 protein interaction
: 有没有关系。结果就是悲剧。前面那个叫人 submit 500 个 applications
: 的纯粹就是浪费时间 -- 你烂撒到 500 个你老板保证和你翻脸 -- 你丢的起人
: 他可丢不起呢。
| f**********e
发帖数: 1994 | 42 你的 sampling method 有一个问题：你只听了 positive cases. 做过 classifier
的人都知道，你的 training set 里头一定要有够多的 negative cases， classifier
才会准。你应该也同时找找一些冲击过 market, 但最后灰头土脸的千老。
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| w******y
发帖数: 8040 | 43 你说的那几个热门方向都很成熟了
申请钱没啥优势吧
【在 f**********e 的大作中提到】
: 希望你喜欢的方向几年以后会变得很热。不然梦想破灭的时候会非常，非常痛苦。
: 其实做非热门方向的人心里也都知道找 faculty 会不容易，但是大家会集体
: 处在自我催眠状态 -- 觉得那个不幸变成千老的一定不是我。我一定会拿到 top
: 大学的 offer, R01, 从此过着受人尊敬的日子。
: dream on. 还是做个热门方向实在。NGS, network, ChIP, whole genome
: screening/profiling, 那个热干哪个。那个 DrBiologist 提的超烂方向
: （codon usage）我还真作过一阵 -- 想看看它和 protein interaction
: 有没有关系。结果就是悲剧。前面那个叫人 submit 500 个 applications
: 的纯粹就是浪费时间 -- 你烂撒到 500 个你老板保证和你翻脸 -- 你丢的起人
: 他可丢不起呢。
| h********n
发帖数: 4079 | 44 离开几个小时就这么热闹.
几年前Lily Jan来我们学校报告那天, 午饭跟我们学生一起吃, 我就问她, 热门领域在
变化, 你怎么应对, 她说的很客气, 但其实就是说, 我不理他们.
others
【在 D*********t 的大作中提到】
: Yes. That for established gurus to say "I don't give a shit to what others
: do!"
| f**********e
发帖数: 1994 | 45 你看，我看方向就这点本事。难怪歇菜。
【在 w******y 的大作中提到】
: 你说的那几个热门方向都很成熟了
: 申请钱没啥优势吧
| h********n
发帖数: 4079 | 46 这个有点难度啊, 上哪儿去找呢?
classifier
【在 f**********e 的大作中提到】
: 你的 sampling method 有一个问题：你只听了 positive cases. 做过 classifier
: 的人都知道，你的 training set 里头一定要有够多的 negative cases， classifier
: 才会准。你应该也同时找找一些冲击过 market, 但最后灰头土脸的千老。
:
: .
| w******y
发帖数: 8040 | 47 像你这样能做hardcore算法的其实赶不赶潮流都无所谓
【在 f**********e 的大作中提到】
: 你看，我看方向就这点本事。难怪歇菜。
| h********n
发帖数: 4079 | 48 上面各位都说到热门领域, 我有个想法: 我不能预测什么领域是热门的, 但我可以大
体相信我的大研究方向在今后20年都不能很好解决, 比如肺癌.
这样, 我就想用比较新的方法去做, 这样结果和数据看上去比较fancy.
各位觉得如何? | f**********e
发帖数: 1994 | 49 做算法的如果不是 CS/Stat/AM 出身的，的确不需要赶潮流, 因为歇菜率太高。
【在 w******y 的大作中提到】
: 像你这样能做hardcore算法的其实赶不赶潮流都无所谓
| f**********e
发帖数: 1994 | 50 总会有几个脱离艰苦生活的千老/万老/亿老会出来晒晒的吧？我个人是觉得把自己的失
败经验
讲一讲会让自己觉得没那么像卢瑟。
【在 h********n 的大作中提到】
: 这个有点难度啊, 上哪儿去找呢?
:
: classifier
| | | f**********e
发帖数: 1994 | 51 我 2002 年进 protein structure prediction 这屁行当的时候就是这样想的。
这鸟问题大家已经日了 20+ 年了，结果唯一的结论是 homology modeling 有用。
这种 long-standing 的问题大家会审美疲劳的。不中。
【在 h********n 的大作中提到】
: 上面各位都说到热门领域, 我有个想法: 我不能预测什么领域是热门的, 但我可以大
: 体相信我的大研究方向在今后20年都不能很好解决, 比如肺癌.
: 这样, 我就想用比较新的方法去做, 这样结果和数据看上去比较fancy.
: 各位觉得如何?
| h********n
发帖数: 4079 | 52 还有, 像"实验功底"这种东西, 各位觉得重要吗? | p*******r
发帖数: 4048 | 53 我基本上是这思路。
【在 h********n 的大作中提到】
: 上面各位都说到热门领域, 我有个想法: 我不能预测什么领域是热门的, 但我可以大
: 体相信我的大研究方向在今后20年都不能很好解决, 比如肺癌.
: 这样, 我就想用比较新的方法去做, 这样结果和数据看上去比较fancy.
: 各位觉得如何?
| p*******r
发帖数: 4048 | 54 我觉得你选错行了。 ：）
我当年也看了一把，决定不做。
我喜欢做新问题，不喜欢啃老骨头。
【在 f**********e 的大作中提到】
: 我 2002 年进 protein structure prediction 这屁行当的时候就是这样想的。
: 这鸟问题大家已经日了 20+ 年了，结果唯一的结论是 homology modeling 有用。
: 这种 long-standing 的问题大家会审美疲劳的。不中。
| p*******r
发帖数: 4048 | 55 我觉得非常重要。
很多学校招人的时候看这个，如果你能说你是哪种方法的专家，比较容易找工作。
【在 h********n 的大作中提到】
: 还有, 像"实验功底"这种东西, 各位觉得重要吗?
| h********n
发帖数: 4079 | 56 谢谢.
【在 p*******r 的大作中提到】
: 我觉得非常重要。
: 很多学校招人的时候看这个，如果你能说你是哪种方法的专家，比较容易找工作。
| w******e
发帖数: 1187 | 57 any advice on finding and learning the latest tool? I would like
to do that too, but don't know how hehe
【在 p*******r 的大作中提到】
: I just think it's impossible to predict what's going to be hot in 5 years.
: So I just follow my heart.
: If you publish a good paper, then what you do becomes hot.
: But I use the latest tools, I think this is important. I think what
: becomes hot is largely what's doable, which is tied to tools.
| y***i
发帖数: 11639 | 58 不能这么说。癌症这领域虽然20年没有医疗结果上的进步，但机制理解方面进步很大
。protein structure prediction 这东西估计多少年什么实质进步都么有。。。。
以大
【在 f**********e 的大作中提到】
: 我 2002 年进 protein structure prediction 这屁行当的时候就是这样想的。
: 这鸟问题大家已经日了 20+ 年了，结果唯一的结论是 homology modeling 有用。
: 这种 long-standing 的问题大家会审美疲劳的。不中。
| w******y
发帖数: 8040 | 59 你有啥特别的新方法吗？
比较新的cancer genomics方法在肺癌领域都用过了。。。
【在 h********n 的大作中提到】
: 上面各位都说到热门领域, 我有个想法: 我不能预测什么领域是热门的, 但我可以大
: 体相信我的大研究方向在今后20年都不能很好解决, 比如肺癌.
: 这样, 我就想用比较新的方法去做, 这样结果和数据看上去比较fancy.
: 各位觉得如何?
| w******e
发帖数: 1187 | 60 targeted delivery~
【在 w******y 的大作中提到】
: 你有啥特别的新方法吗？
: 比较新的cancer genomics方法在肺癌领域都用过了。。。
| | | R******E
发帖数: 159 | 61 呵呵
能生活在 a wonderland
是一种牛
也是一种可遇不可求的幸福
：D
perspectives
be
a
I
【在 n********k 的大作中提到】
: well, u are in a wonderland, although I always like to have ur perspectives
: but yours never counts, to me:))),
: shall say applicable to me...Yeah, seriously I agree with you, that would be
: what i would love to do, but I just
: don't think i could for a number of reasons...science to me still somewhat a
: way of making a living although I
: hope there is such day it would be just my luxury hobby and I can do what I
: am most passionate about...
| h********n
发帖数: 4079 | 62 这个我以前干过一点. 难.
【在 w******e 的大作中提到】
: targeted delivery~
| s*******r
发帖数: 3429 | | h********n
发帖数: 4079 | 64 实力包括啥?
【在 s*******r 的大作中提到】
: 靠实力吧
| D*********t
发帖数: 370 | 65 That's something good to have. But if you don't, there's not much you can
do about it. Just like somebody has a powerful dad and of course he has
better "connections". If your dad is a common person, you just have to
rely on your own hard work until you become recognized.
they
【在 n********k 的大作中提到】
: Sure, but what about before one had CNS...and say the MS, grant reviewing
: etc etc...in our case, many/some of
: the reviewers are either my boss' friends or from a same lab...and also they
: had tri-lab annual retreat with
: peoplem's lab and another big lab in stanford, so when I look around, it
: seems they would virtually know half
: of the people in the field...also, how important/critical to write reviews
: as postdoc or junior faculty? That
: seems a big boost for some...
:
| h********n
发帖数: 4079 | 66 I don't have a powerful dad so I will try to be a powerful dad.
【在 D*********t 的大作中提到】
: That's something good to have. But if you don't, there's not much you can
: do about it. Just like somebody has a powerful dad and of course he has
: better "connections". If your dad is a common person, you just have to
: rely on your own hard work until you become recognized.
:
: they
| n********k
发帖数: 2818 | 67 I have a dream too:)))
【在 h********n 的大作中提到】
: I don't have a powerful dad so I will try to be a powerful dad.
| w******e
发帖数: 1187 | 68 你是有什么targeting ligand？peptide？什么platform？能不能谈谈
为什么觉得比较难？
我挺看好去年nature biotech的aptamer-siRNA conjugate systemic administration
的方向的。希望能继续深入～
【在 h********n 的大作中提到】
: 这个我以前干过一点. 难.
| h********n
发帖数: 4079 | 69 When I just came to US I did folate-targeted drug delivery. We chemically linked toxin to folate with some chemistry that the linker is easier to break in cells. Some cancer cell overexpress folate receptor on cell surface so the folate-toxin will enter cell by endocytosis. However it is technically hard to get the folate-toxin break efficiently to kill cells.
I transferred from Purdue after 1.5 years for other reason. You can check Philip Low at chem dept at Purdue. Also check endocyte.com
【在 w******e 的大作中提到】
: 你是有什么targeting ligand？peptide？什么platform？能不能谈谈
: 为什么觉得比较难？
: 我挺看好去年nature biotech的aptamer-siRNA conjugate systemic administration
: 的方向的。希望能继续深入～
| w******e
发帖数: 1187 | 70 Thx for the info. the major problem w/ targeted delivery seems to be the
targeting ligand. it's really hard to find a targeting ligand that:
1. bind to a surface marker that is a very specific disease marker
2. have good affinity (nM preferred)
3. can internalize efficiently (usually means that the marker it binds
internalize constitutively).
I really want to find a senior cancer researcher to get some insider info
about the authenticity and expression profile of all the cancer surface
biomarker
【在 h********n 的大作中提到】
: When I just came to US I did folate-targeted drug delivery. We chemically linked toxin to folate with some chemistry that the linker is easier to break in cells. Some cancer cell overexpress folate receptor on cell surface so the folate-toxin will enter cell by endocytosis. However it is technically hard to get the folate-toxin break efficiently to kill cells.
: I transferred from Purdue after 1.5 years for other reason. You can check Philip Low at chem dept at Purdue. Also check endocyte.com
| | | h********n
发帖数: 4079 | 71 Are you coming for AACR annual meeting in DC?
BTW, for folate-toxin, the point 1, 2, and 3 are ok. But thinks become
complex after endocytosis.
【在 w******e 的大作中提到】
: Thx for the info. the major problem w/ targeted delivery seems to be the
: targeting ligand. it's really hard to find a targeting ligand that:
: 1. bind to a surface marker that is a very specific disease marker
: 2. have good affinity (nM preferred)
: 3. can internalize efficiently (usually means that the marker it binds
: internalize constitutively).
: I really want to find a senior cancer researcher to get some insider info
: about the authenticity and expression profile of all the cancer surface
: biomarker
| w******e
发帖数: 1187 | 72 I hope I knew this earlier...:)
I guess you are talking about endosomal escape? or chemical conjugation
simply
abrogate the drug property?
I'm hooked with the simplicity of conjugating aptamer with siRNA. both can
achieve certain level of specificity; both can be synthesized in a single
run; the toxicity profile of ONs are widely available due to the gold
rush in anti-sense field... Yet it's a shame that you only have that few
aptamers to choose from (well, only 1 or 2, according to my knowledge
【在 h********n 的大作中提到】
: Are you coming for AACR annual meeting in DC?
: BTW, for folate-toxin, the point 1, 2, and 3 are ok. But thinks become
: complex after endocytosis.
| h********n
发帖数: 4079 | 73 my phd study focused on lung cancer mouse model and miRNA. We used LNA (
collaborate with Santaris Pharma) to treat cancer cell and lung cancer on
mice. But I cannot talk about detail at this time. The ON treatment field
is promising but with some difficulty to overcome.
【在 w******e 的大作中提到】
: I hope I knew this earlier...:)
: I guess you are talking about endosomal escape? or chemical conjugation
: simply
: abrogate the drug property?
: I'm hooked with the simplicity of conjugating aptamer with siRNA. both can
: achieve certain level of specificity; both can be synthesized in a single
: run; the toxicity profile of ONs are widely available due to the gold
: rush in anti-sense field... Yet it's a shame that you only have that few
: aptamers to choose from (well, only 1 or 2, according to my knowledge
| j*****a
发帖数: 658 | 74 女的呆学术界有啥利弊谁给说说？
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| p*******r
发帖数: 4048 | 75 容易找工作， 不容易养小孩。
【在 j*****a 的大作中提到】
: 女的呆学术界有啥利弊谁给说说？
:
: .
| d*****t
发帖数: 242 | 76 为什么不容易养小孩？
【在 p*******r 的大作中提到】
: 容易找工作， 不容易养小孩。
| p*******r
发帖数: 4048 | 77 no time.
【在 d*****t 的大作中提到】
: 为什么不容易养小孩？
| l**********n
发帖数: 240 | 78 我非常同意dr biologist 说过的一句话：
当pi 靠对研究的激情passion。
.
【在 h********n 的大作中提到】
: 板上各位PI, 我很想请各位办一个系列座谈, 可惜没有能力.
: 各位已经坐上教授位子的, 能不能说说怎么从postdoc成为PI. 如何做一个好的博后/学
: 生已经讨论的很多很多了, 大家心里其实都清楚. 可是除了发好文章, 那些有志于成为
: PI的博后该如何努力积累资本, 该建立怎样的能力, 来成为PI, 很多人都不是很清楚.
:
: 各位已经坐上教授位子的, 能不能回顾一下, 你觉得你当年有哪些(能力/资本)比较出
: 色的, 哪些还不足的? 说出来对大家都会有帮助的.
: 我想我没有资格讨论这个话题, 因为我才开始postdoc没多久. 但我很想听听各位的意
: 见.
: DrBiologist, 你能不能带头说点啥?
| h********n
发帖数: 4079 | 79 这话我同意, 或者说, 满足自己喜欢做研究的兴趣.
但最大的困难不是在这里,
困难在于faculty位置太难啊.
【在 l**********n 的大作中提到】
: 我非常同意dr biologist 说过的一句话：
: 当pi 靠对研究的激情passion。
:
: .
|
|
