s******l
发帖数: 125 | 1 这篇Nature Communications paper也太猛了，把一个领域十年的工作给否定了？
Identification of high-quality cancer prognostic markers and metastasis
network modules
http://www.nature.com/ncomms/journal/v1/n4/pdf/ncomms1033.pdf
"In summary, we showed that the concept of 'one-step-clustering' of gene
expression profiles, which has been dominantly used in the past decade, is
not suitable for generating robust gene signatures. Therefore, we developed
an algorithm for identifying prognostic markers that can be used in
combinat | g******1
发帖数: 244 | | t*d
发帖数: 1290 | 3 not a big deal. few people using the so-called 'one-step-clustering' to
identify prognostic markers.
developed
【在 s******l 的大作中提到】
: 这篇Nature Communications paper也太猛了，把一个领域十年的工作给否定了？
: Identification of high-quality cancer prognostic markers and metastasis
: network modules
: http://www.nature.com/ncomms/journal/v1/n4/pdf/ncomms1033.pdf
: "In summary, we showed that the concept of 'one-step-clustering' of gene
: expression profiles, which has been dominantly used in the past decade, is
: not suitable for generating robust gene signatures. Therefore, we developed
: an algorithm for identifying prognostic markers that can be used in
: combinat
| K**4
发帖数: 1015 | 4 标题党
鄙视
developed
【在 s******l 的大作中提到】
: 这篇Nature Communications paper也太猛了，把一个领域十年的工作给否定了？
: Identification of high-quality cancer prognostic markers and metastasis
: network modules
: http://www.nature.com/ncomms/journal/v1/n4/pdf/ncomms1033.pdf
: "In summary, we showed that the concept of 'one-step-clustering' of gene
: expression profiles, which has been dominantly used in the past decade, is
: not suitable for generating robust gene signatures. Therefore, we developed
: an algorithm for identifying prognostic markers that can be used in
: combinat
| w******y
发帖数: 8040 | 5 怎么说呢
该文基本属于自己立个靶子自己打的范围
没有哪个成功的signature是单纯的clustering
都有特别的post hoc处理和/或整合其他信息
而该文就是基本的bootstrap的思想,
能得到robust breast expression signature当然是个好的贡献，
但这段话写的非常annoying,基本属于nonsense
developed
【在 s******l 的大作中提到】
: 这篇Nature Communications paper也太猛了，把一个领域十年的工作给否定了？
: Identification of high-quality cancer prognostic markers and metastasis
: network modules
: http://www.nature.com/ncomms/journal/v1/n4/pdf/ncomms1033.pdf
: "In summary, we showed that the concept of 'one-step-clustering' of gene
: expression profiles, which has been dominantly used in the past decade, is
: not suitable for generating robust gene signatures. Therefore, we developed
: an algorithm for identifying prognostic markers that can be used in
: combinat
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