G********e
发帖数: 528 | 1 If gamma-H2AX is elevated, how can I tell it is due to apoptosis or DNA
damage?
Thanks, | r***e
发帖数: 2539 | 2 can apoptosis itself activate H2AX? not sure about this.
【在 G********e 的大作中提到】
: If gamma-H2AX is elevated, how can I tell it is due to apoptosis or DNA
: damage?
: Thanks,
| G********e
发帖数: 528 | 3 I'm not confused either, but find quite a few studies by other people.
Either apoptosis induce H2AX phosphorylation or H2AX phosphorylation
regulate apoptosis.
J Biol Chem. 2000 Mar 31;275(13):9390-5.
Initiation of DNA fragmentation during apoptosis induces phosphorylation of
H2AX histone at serine 139.
DNA Repair (Amst). 2006 May 10;5(5):575-90. Epub 2006 Mar 29.
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in
mammalian cells.
Molecular Cell, Volume 23, Issue 1, 121-132, 7 July 2006
Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, but Not for the
Activation of Caspase-3
Nature 458, 591-596 (2 April 2009)
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival
decisions
【在 r***e 的大作中提到】
: can apoptosis itself activate H2AX? not sure about this.
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