m*********r
发帖数: 2456 | 1 今天浏览了最近的一篇nature paper，“lincRNAs act in the circuitry controlling pluripotency and differentiation” 看
到第二页就发现了一处明显的错误，还是大牛文章呢， 原文描述如下：
Among these lincRNAs, 13 are associated with endoderm differentiation, 7
with ectoderm differentiation,
5 with neuroectoderm differentiation, 7 with mesoderm differentiation and 2
with the trophectoderm lineage (Fig. 3a).
图见附件，显然5个数字，数错3个， 哎～～～ | m*********r
发帖数: 2456 | | j*p
发帖数: 411 | 3 The lincRNA annotation from Broad is not really good. Many people have
complained about that. For example, in this paper, the authors only give the
chromosome start stop of the predicted lincRNAs, although, we are pretty
sure they have the exon coordinates and splicing structures (because that
was a direct output from either Cufflinks or Scripture). | s*********t
发帖数: 600 | 4 lincRNA的丰度如何？
如果一个细胞里面只表达几个拷贝的话，作用就有限了吧
the
【在 j*p 的大作中提到】
: The lincRNA annotation from Broad is not really good. Many people have
: complained about that. For example, in this paper, the authors only give the
: chromosome start stop of the predicted lincRNAs, although, we are pretty
: sure they have the exon coordinates and splicing structures (because that
: was a direct output from either Cufflinks or Scripture).
| j*p
发帖数: 411 | 5 HOTTIP is an example which only expresses a few copies per cell, but has
been shown an important function. As far as I know, Single cell RNA-FISH
shows literally one spot for HOTTIP.
check this out,
http://www.nature.com/nature/journal/v472/n7341/full/nature0981
【在 s*********t 的大作中提到】
: lincRNA的丰度如何？
: 如果一个细胞里面只表达几个拷贝的话，作用就有限了吧
:
: the
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