r****e
发帖数: 1375 | 1 hehe
http://www.sciencemag.org/content/334/6053/176.1.full
Science 14 October 2011:
Vol. 334 no. 6053 p. 176
DOI: 10.1126/science.334.6053.176-a
•Letters
Partial Retraction
In our 23 October 2009 Report, “Detection of an Infectious Retrovirus, XMRV
, in blood cells of patients with chronic fatigue syndrome” (1), two of the
coauthors, Silverman and Das Gupta, analyzed DNA samples from chronic
fatigue syndrome (CFS) patients and healthy controls. A reexamination by
Silverman and Das Gupta of the samples they used shows that some of the CFS
peripheral blood mononuclear cell (PBMC) DNA preparations are contaminated
with XMRV plasmid DNA (2). The following figures and table were based on the
contaminated data: Figure 1, single-round PCR detection of XMRV sequences
in CFS PBMC DNA samples; table S1, XMRV sequences previously attributed to
CFS patients; and figure S2, the phylogenetic analysis of those sequences.
Therefore, we are retracting those figures and table.
Robert H. Silverman1,*, Jaydip Das Gupta1, Vincent C. Lombardi2, Francis W.
Ruscetti3, Max A. Pfost2, Kathryn S. Hagen2, Daniel L. Peterson2,†,
Sandra K. Ruscetti4, Rachel K. Bagni5, Cari Petrow-Sadowski6, Bert Gold3,
Michael Dean3, Judy A. Mikovits2
+ Author Affiliations
1Department of Cancer Biology, The Lerner Research Institute, The Cleveland
Clinic Foundation, Cleveland, OH 44195, USA.
2Whittemore Peterson Institute, Reno, NV 89557, USA.
3Laboratory of Experimental Immunology, National Cancer Institute-Frederick,
Frederick, MD 21701, USA.
4Laboratory of Cancer Prevention, National Cancer Institute-Frederick,
Frederick, MD 21701, USA.
5Advanced Technology Program, National Cancer Institute-Frederick, Frederick
, MD 21701, USA.
6Basic Research Program, Scientific Applications International Corporation,
National Cancer Institute-Frederick, Frederick, MD 21701, USA.
+ Author Notes
↵† Present address: Sierra Internal Medicine, 865 Tahoe
Boulevard no. 306, Incline Village, NV 89451, USA.
↵*To whom correspondence should be addressed. E-mail: s*****[email protected]
References and Notes
1.↵ V. C. Lombardi, F. W. Ruscetti, J. Das Gupta, M. A. Pfost, K. S.
Hagen, D. L. Peterson, S. K. Ruscetti, R. K. Bagni, C. Petrow-Sadowski, B.
Gold, M. Dean, R. H. Silverman, J. A. Mikovits, Science 326, 585 (2009).
Abstract/FREE Full Text2.↵ Supporting online material showing the
reanalysis is available at www.sciencemag.org/cgi/content/full/science.
1212182/DC1. Published online 22 September 2011; 10.1126/science.1212182 |
|
