E**********y 发帖数: 991 | 1 http://www.ncbi.nlm.nih.gov/pubmed/22848625
这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么
就到了Plos One呢?!大家请评论一下这篇文章scientifically。 |
d***e 发帖数: 8 | 2 只看了一眼abstract, 不过这篇文章好像用了cell line,如果用动物会发的更好
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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p********e 发帖数: 609 | 3 Went through it quickly so don't quote on my comments.
The title is certainly overstated. There are many cavities in this work, to
name a few:
1) CCI -> mTOR inhibition >> autophagy: may or may not related with
autophagy.
2) CCI suppresses necrosis?: not well-defined.
3) Is downregulation of RIP3 a cause or consequence of attenuated cell death
? Not answered.
4) How does CCI regulate the RIP1/RIP3 levels?
... Plus, the quality of the data is not that great.
Just my 2 cents.
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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s****l 发帖数: 395 | 4 哎,做autophagy只给LC3 conversion不给p62 degradation的情况在这篇paper里面又
出现了
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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s******a 发帖数: 472 | 5 按她的知名度和关系要把这个发到比PLOS ONE更好的杂志上我觉得易如反掌。
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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S*********s 发帖数: 304 | 6 这篇paper就是个拼凑的paper
估计White自己都不愿意发。
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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q******g 发帖数: 3858 | 7 估计投了个好杂志,被据了之后,就不想再试了,或者着急要文章, 直接去PLOS ONE
发了就得了。 |
a*******e 发帖数: 245 | 8 貌似是kevin毕业工作了,根本也就不care了,就想赶紧发了吧
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : http://www.ncbi.nlm.nih.gov/pubmed/22848625 : 这篇文章,我觉得做得非常好啊,也有clinical significance,老板也是大牛,怎么 : 就到了Plos One呢?!大家请评论一下这篇文章scientifically。
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E**********y 发帖数: 991 | 9 我也这么觉得
【在 a*******e 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 貌似是kevin毕业工作了,根本也就不care了,就想赶紧发了吧
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E**********y 发帖数: 991 | 10 One problem is autophagy field is goverened by a few people, the so-called
dogma approaches only represent the ideas of a few labs including Klinosky
and Levine. Autophay is such a sophisticated machinery that's responsive to
a diverse array of stimuli. I hardly think p62 is a universal substrate for
all types of selective autophagy process. Granted that not one single
approach could be exclusively relied on, a combination of several key
experiment would triumph over p62 degradation.
【在 s****l 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 哎,做autophagy只给LC3 conversion不给p62 degradation的情况在这篇paper里面又 : 出现了
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r******g 发帖数: 600 | 11 Autophagy的领域被那几个HHMI的人彻底垄断了~ Beclin1 heterozygous的老鼠,根本
就搞不到! 西南的beth是领域大牛也就不说了,几个临床MD什么hills都跑来凑热闹,
Eric Olson也跟着凑热闹,搞的蛋疼死了 |
s****l 发帖数: 395 | 12 这倒是,不过LC3 conversion也不见得就多准,现在连LC3-II到底干了啥也不清楚,被
lipid修饰了的LC3为啥可以导致autophagosome的膜结构延长,以及lipid在膜结构形成
中是如何聚集的也不知道啊
to
for
【在 E**********y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : One problem is autophagy field is goverened by a few people, the so-called : dogma approaches only represent the ideas of a few labs including Klinosky : and Levine. Autophay is such a sophisticated machinery that's responsive to : a diverse array of stimuli. I hardly think p62 is a universal substrate for : all types of selective autophagy process. Granted that not one single : approach could be exclusively relied on, a combination of several key : experiment would triumph over p62 degradation.
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w******y 发帖数: 2504 | 13 Beclin1 heterozygous的老鼠不是都作烂了么?而且还是全身性的.你问谁要了?
Hill做心脏的,感觉什么都做,包括AUTOPHAGY.他最近那篇FOXO的文章感觉有很多问题,
都不知道怎么发的JCI的.
【在 r******g 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Autophagy的领域被那几个HHMI的人彻底垄断了~ Beclin1 heterozygous的老鼠,根本 : 就搞不到! 西南的beth是领域大牛也就不说了,几个临床MD什么hills都跑来凑热闹, : Eric Olson也跟着凑热闹,搞的蛋疼死了
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