m********8
发帖数: 314 | 1 RNAi治疗现在发展到什么程度了？难道体内药物递送不再是问题了吗？看这篇文献，这
个药物载体的构建都不在正文里提了。 Supplementary Methods里面的图1（S-Figure
1 Schematic diagrams illustrating the preparation of (DSS)6-liposome-siRNA
and the evaluation in vitro）显示SiRNA和带骨靶向多肽的脂质体混一下就能得到有
效装载SiRNA的靶向性药物了。这个是成熟可靠的方法的话，那么RNAi治疗前景应该非
常好？
A delivery system targeting bone formation surfaces to facilitate RNAi-based
anabolic therapy. Nature Medicine 18, 307–314 (2012) doi:10.1038/nm.2617
http://www.nature.com/nm/journal/v18/n2/extref/nm.2617-S1.pdf |
N****n
发帖数: 294 | 2 看着Alnylam的股票猛长，你会觉得那根本不是个问题。 |
w***a
发帖数: 4361 | 3 看着整个biotech sector 2013年的表现，你会觉得生物wsn的春天已经来了。
【在 N****n 的大作中提到】
: 看着Alnylam的股票猛长，你会觉得那根本不是个问题。
|
A******y
发帖数: 2041 | 4 Biotech is just fine. The problem is the supply side. We have too many Ph.
D.s and most of them are useless. I blame the system that most of them are
poorly trained, and a lot of American Ph.D.s are exceptional..exceptionally
lazy.
Btw, Biotech is the only industry still currently enjoy above 25% margin of
return some of them are even above 50%.
【在 w***a 的大作中提到】
: 看着整个biotech sector 2013年的表现，你会觉得生物wsn的春天已经来了。
|
b****r
发帖数: 17995 | 5 印象中大部分biotech公司三年内都完蛋了？
Ph.
are
exceptionally
of
【在 A******y 的大作中提到】
: Biotech is just fine. The problem is the supply side. We have too many Ph.
: D.s and most of them are useless. I blame the system that most of them are
: poorly trained, and a lot of American Ph.D.s are exceptional..exceptionally
: lazy.
: Btw, Biotech is the only industry still currently enjoy above 25% margin of
: return some of them are even above 50%.
|
g*****n
发帖数: 250 | 6 基因治疗的垮台早已表明RNAi没有前景，但是人们仍然要忽悠。
干细胞治疗还可以苟延残喘几年。
至于Biotech industry，某些方向会消声灭迹，但是，总体上还是会很强。忽悠的东西
总会不断出现。 |
z*t
发帖数: 863 | 7 记得对肝脏效果比较好，ambion的创始人在Austin开了公司，去年的cprit有show mir-
34对肝癌的效果
Figure
based
【在 m********8 的大作中提到】
: RNAi治疗现在发展到什么程度了？难道体内药物递送不再是问题了吗？看这篇文献，这
: 个药物载体的构建都不在正文里提了。 Supplementary Methods里面的图1（S-Figure
: 1 Schematic diagrams illustrating the preparation of (DSS)6-liposome-siRNA
: and the evaluation in vitro）显示SiRNA和带骨靶向多肽的脂质体混一下就能得到有
: 效装载SiRNA的靶向性药物了。这个是成熟可靠的方法的话，那么RNAi治疗前景应该非
: 常好？
: A delivery system targeting bone formation surfaces to facilitate RNAi-based
: anabolic therapy. Nature Medicine 18, 307–314 (2012) doi:10.1038/nm.2617
: http://www.nature.com/nm/journal/v18/n2/extref/nm.2617-S1.pdf
|
A******y
发帖数: 2041 | 8 I know many companies growing just fine. The richest scientist in the US
has found over 20+ companies and they are all still exist or brought by big
pharmas.
【在 b****r 的大作中提到】
: 印象中大部分biotech公司三年内都完蛋了？
:
: Ph.
: are
: exceptionally
: of
|
b****r
发帖数: 17995 | 9 谁是The richest scientist？
big
【在 A******y 的大作中提到】
: I know many companies growing just fine. The richest scientist in the US
: has found over 20+ companies and they are all still exist or brought by big
: pharmas.
|
