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发帖数: 16778 | 1 what is the definition of 'deregulated pathway?' | x****s
发帖数: 29 | 2 I think it means the pathway is not working normally as it is supposed to be
. In normal cells, numerous cellular pathways are being precisely regulated
to ensure a normal functional output. However, in the case of cancer, the
situation of pathways is usually found quite different. For example, p53
inactivation is frequently observed in many cancer types. This molecule is
critical in DNA repair, cell cycle as well as apoptosis of host cells.
Therefore, abnormality of this molecule would cause an impaired or
deregulated p53 signaling. | i*********0
发帖数: 915 | 3 就是upregulated+downregulated的pathway集合吧。 | h*******o
发帖数: 4884 | 4 deregulated pathway means pathway without regulation.
It is different from dysregulated pathway, which is much more commonly seen/
used in scientific writing context. |
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