u*******r
发帖数: 2855 | 1 http://www.huffingtonpost.com/2013/02/07/raul-labrador-immigrat
Rep. Raúl Labrador (R-Idaho) warned on Thursday that he won't vote for a
pathway to citizenship for undocumented immigrants and neither will his
fellow House Republicans, a bad sign from someone who is considered one of
the more pro-reform Republicans in the chamber.
"The people that came here illegally knowingly --- I don't think they should
have a path to citizenship," he said on NPR, according to Talking Points
Memo. "If you know... 阅读全帖 |
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j*******e
发帖数: 26 | 2 Science (2003) 299: 223-226
“These caspases cleave many intracellular substrates, ultimately leading to
cell death.”
Why pathway study is important?
"it's importmant for sure. without knowing the central death pathway, how
would people study the regulation of the pathway? Usually signalling pathway
are
conserved between species, so if we know the pathway, we can manipulate
apoptosis. if we want cancer cell to die, we stimulate the death pathway. if
we want degenerating neurons survive, we can pr |
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k*****o
发帖数: 1486 | 3 。。这个，咋说阿。
Pathway比Mechanism要抽象，pathway就是中文“通路，路径”的意思，Mechanism是“
机制”。没有比中文更具体详细的解释方法了。
只要是通路就可以叫pathway, 范围很广，e.g 如上signal transduction的pathway
，metabolic/biosynthetic pathway等等。
Mechanism是机制，比如你看到啥现象了，像是啥化学反应或者一些奇怪的phenotype，
你要解释其背后的原理。
ps个人理解，欢迎排砖。。 |
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b*****d
发帖数: 61690 | 4 “The speaker of the House now has to decide whether or not he is going to
allow the American people to speak,” Gutierrez said. “There are a majority
of Democrats and Republicans who are ready to solve this problem.”
If a “small group” of House Republicans insist on pushing their version of
the bill, he said, that could end in a “stalemate” on the issue.
Goodlatte said the bill could potentially include a “pathway to
legalization,” and differentiated that from a “pathway to citizenship.”
“When yo... 阅读全帖 |
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h*****o
发帖数: 342 | 6 你说的是pathway?
我不是做这个的，所以有待高人来指点。我的理解是mechanism的范畴更广一些。
pathway经常研究的是一个环境刺激如何转化为细胞内的信号并引起相应的生理反应，
比如说信号A->受体B->蛋白激酶C->蛋白酶D->转录因子E等等
mechanism除了pathway外，还包含不同细胞间的相互作用，不同组织间的相互作用，等等 |
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m**********d
发帖数: 137 | 8 分别看p38,JNK,ERK三个pathway的signaling activity，对于p38 pathway，大家认为
哪个phosphorylation target对于p38 pathway特异性更好一些？谢谢 |
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a******e
发帖数: 119 | 9 RT, 我想从reactome或者kegg（其他的database也可以）下载human 所有的pathways以
及每个pathway所包含的genes。 请问这个应该如何批量下载？ 谢谢！ |
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x****s
发帖数: 29 | 10 I think it means the pathway is not working normally as it is supposed to be
. In normal cells, numerous cellular pathways are being precisely regulated
to ensure a normal functional output. However, in the case of cancer, the
situation of pathways is usually found quite different. For example, p53
inactivation is frequently observed in many cancer types. This molecule is
critical in DNA repair, cell cycle as well as apoptosis of host cells.
Therefore, abnormality of this molecule would cause an... 阅读全帖 |
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h*******o
发帖数: 4884 | 11 deregulated pathway means pathway without regulation.
It is different from dysregulated pathway, which is much more commonly seen/
used in scientific writing context. |
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v********a
发帖数: 646 | 12 现在文章的结尾，都喜欢弄个什么mechanism，加一点pathway什么的。请问大家是用
Adobe Illustrator做的呢，还是用专门的Pathway builder 做的呢？
如果是专门的软件，大家一般都是用什么软件来画Pathway?
谢谢 |
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w*******y
发帖数: 60932 | 13 Solar LED Pathway Lights (Set of 6) $10.40 shipped
Enter code 1916539B at checkout
Link:
http://www.homedecorators.com/P/Solar_LED_Pathway_Lights_-_Set_of_6/820/
Give your paths and walkways environmentally-friendly lighting that's as
beautiful as it is bright. The Solar LED Pathway Lights will store sunlight
during the day and cast a bright glow over your outdoor decor at night.
Their energy efficient LED bulbs use a fraction of the power of traditional
incandescent and on average, last ove... 阅读全帖 |
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w*******y
发帖数: 60932 | 14 Kinda hard to price compare these things, but prices seem reasonable enough
to me...
Lighted Pathway Trees (Set of 4) $10
Link:
http://www.bedbathandbeyond.com/product.asp?MC=1&SKU=17284410&RN=2232&
Welcome all your holiday guests with a pathway lined with pre-lit Christmas
trees. Artificial trees feature end-to-end connectors and 45 clear lights.
Outdoor use only (includes stakes). UL approved lights. Includes extra bulbs
and fuses. Each tree measures 24".
Candy Cane LED Solar-Powered Path Mark... 阅读全帖 |
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u*******r
发帖数: 2855 | 15 I think if there is a house bill it would be like:
1. Control border security
2. Give illegal immigrants EAD (and at the best a pathway to green card)
3. Give dreamers a pathway to citizenship
4. STEM
5. Family-based immigration
should |
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r****q
发帖数: 22 | 16 I understand your points. But I don’t agree your intepreation of GAGE at
all. I was trying to be concise in my last reply. Since you've read GAGE
paper in detail and made quite a few misinterpretations, let me clarify
things here.
About consistence. Thoughout GAGE paper, I was talking about consistence
together with biologicl relevance. You may want to double check the paper on
this. If you think to show the consitency of a method is meaningless, what
would be a meaningful property to show inste... 阅读全帖 |
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r****q
发帖数: 22 | 17 ‘RB1 is related to RB’ is a statement, not a prediction or inference. You
may develop this into a problem to solve, but it is nothing more than a
meaningless or trivial one. I don’t see any comparability between solving
this problem and gene set analysis.
I never say experiment evidence is not needed. I just say it was not needed
to do our own verification experiment there. GAGE identified so many
pathways that GSEA and PAGE did not, and whose biological relevance has been
well established in li... 阅读全帖 |
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发帖数: 1 | 18 最近做了wild-type和一个mutant的RNA-seq，分析找到了一些differentially
expressed genes，尝试用GO term, 比如说DAVID，但是得出来的结果感觉不是很有提
示性，都是一些很泛泛的名词，例如morphogenesis，development等。后来我自己看了
这些基因，发现有些WNT pathway的基因被up-regulated，有些其他signaling的
components被down-regulated。请问有什么网站或者哪种分析方法可以专门分析这些
DEGs属于哪些signaling pathways吗？
同时我也发现某些mesoderm的基因有被up-regulated，另外有些endoderm的基因有被
down-regulated，请问有什么网站或者哪种分析方法可以专门分析这些DEGs属于哪个
germ layers吗？
谢谢大家！ |
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l*******8
发帖数: 1745 | 19 对不起，没看懂你的问题。
视觉pathway和眼动pathway是不太一样的。 |
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a***y
发帖数: 852 | 20 不好意思，我再叙述下好了。本来也是外行。
就是说通常所说的"What(ventral) pathway"和"where（dorsal） pathway“之间，除
了经典实验证明的相对独立（就是一边损坏另一边仍然能起作用）之外，有没有关于证
明它们相互联系的实验。
实际上我在想的问题是人类理解video时的信息传递过程，这两者我猜测一定是互相有
交互的。但有没有更详细的实验说明信息交互的方式呢。 |
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S*********e
发帖数: 4 | 21 h1b -> green card -> citizenship，这本身就是pathway啊。h1b直接授予公民那叫
directly grant，至少也得说是expressway |
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t******r
发帖数: 8600 | 22 https://www.businessinsider.com/house-passes-pathway-to-citizenship-daca-
recipients-trump-immigration-2019-6
The House of Representatives passed the Dream and Promise Act, which would
significantly expand protections for DACA recipients and other immigrants
looking for legal status, including permanent citizenship.
The bill passed 237-187, with seven Republicans crossing the aisle and
joining Democrats.
比里根的大赦还要猛啊。 |
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g****m
发帖数: 2 | 23 Call for Papers
Multi-aspect Analysis of Biological Pathways Using High-throughput Data
Sources
A Workshop of 2007 IEEE International Conference on Bioinformatics and
Biomedicine
(IEEE BIBM 2007, co-located with IEEE/WCI/ACM WI-IAT 07 and IEEE GrC 07)
http://www.cis.drexel.edu/faculty/thu/bibm/index.php.htm
San Jose, CA, USA Nov 2-4, 2007
Key Dates
August 10, 2007: Due date for full workshop papers submission (at least two
reviews for each paper)
September 10, 2007: Notification of paper accepta |
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f*********o
发帖数: 38 | 24 metabolism pathways & animal models
有没有同样做这一块的童鞋们也准备回上海的啊？ 糖尿病在上海圈子也很小， 外企中
了解下来Elli是做这一块的。 一起上海聚一聚啊！！我在上海这个领域两年，可以互
相share一些信息啊！
[email protected]
/* */
021 31229017 |
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A*F
发帖数: 2272 | 25 需要若干reviewers帮助peer review两片manuscript
内容是next-gen sequencing, differential gene expression, pathway analysis
请感兴趣的童鞋把简历发到[email protected]
/* */谢谢 |
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u*******r
发帖数: 2855 | 26 haha
"If they want a political victory they’re going to draw a fine red line and
they’re going to say, either a pathway to citizenship or nothing else," he
told NPR. "They know that the Republicans in the House are not going to be
able to vote for that, and then they’re going to be able to beat us over
the head in 2014, and say, look, the Republicans don’t like immigrants.
Which is not true."
should |
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u*******r
发帖数: 2855 | 27 when will be the house bipartisian bill?
but like I said, it is very likely that such a bill doesn't include a
pathway to cizitenship...
path |
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g********s
发帖数: 3652 | 28 我了解波士顿东北大学的pathway
最好直接问学校 |
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y********5
发帖数: 15 | 29 低价处理IBT工具书，及东北大学pathway语言课程教材，Leadership--financial
service专业课的书。书都很新，价格绝对便宜，比网上买或学校书店买二手还划算。
需要的朋友请直接发邮件给我y***********[email protected] or 857-334-0617 |
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e*n
发帖数: 1511 | 31 Walgreens on Tuesday said it will begin selling personal genetic testing
kits on Friday, the first major retail chain in the U.S. to offer the home
tests.
The Deerfield, Ill.-based drugstore chain has an agreement with Pathway, a
startup that offers genetic health and ancestry reports.
But the U.S. Food and Drug Administration told the Chicago Tribune it is
investigating claims made by the San Diego-based company and Walgreens in
marketing its genetic test, which has not been approved by U.S. re |
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s******a
发帖数: 252 | 32 GSEA @ Broad, DAVID @ NCI/NIAID.
Ingenuity Pathway Analysis if you have a license. |
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l******o
发帖数: 3764 | 33 如果有一个pathway，在cell culture 和动物模型里面都显示可能对某种疾病(比如说
糖尿病)有重要关系，
in vitro和动物里面的工作都做的很全面了(including KO mice)
下面如果想扩展到人里面继续搞 有那些可能的思路呢？
这个通路的aganist/antaganist 显然不能给人吃
我想来想去，也只有看看有没有影响功能的SNP
除此之外似乎也没想到什么可以做的了
我见识比较少，还望各位高人不吝赐教哈 |
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s******y
发帖数: 28562 | 34 You need to talk with people who do the medical research, and try to push
your study to translational research or medical research.
For example, at least you should check the relevance of this pathway in real
human diseases |
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G***G
发帖数: 16778 | 35 你在动物里面怎么做的？
怎么得出这个pathway里面各种调节的关系？ |
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h********n
发帖数: 4079 | 36 get patients' tissue (section), do IHC or similar thing to see whether this
pathway dysregulates in patients. |
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s***d
发帖数: 29 | 37 pathway 和 mechanism 是一回事吗？不是的话能不能举个简单的
例子让我搞懂啊？
谢过！ |
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s***d
发帖数: 29 | 38
等等
哦，谢谢，不好意思。pathway 都写错了 |
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o********r
发帖数: 775 | 40 I can’t agree with you at all on the performance validation. To be concise,
I followed the standard paradigm used in the community. You may only want to
challenge this, when (1) you prove concretely that this paradigm is wrong;
(2) you do not use this one in your own research. Your example on ‘RB1
related with RB’ is misleading and improper. One thing is sure here, a good
method has to be consistent, an inconsistent method is never a good method.
We can argue on this for days. But GAGE has been ... 阅读全帖 |
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m******5
发帖数: 1383 | 41 没发现，没觉得比Ihop和pathway studio那样的从文章里捞关键句的方法有区别…… |
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m******5
发帖数: 1383 | 42 the financial situation is a little bit tight
so there would be no chance for me to try too many antibodies……
so could you recommend a pair of antibody anti p38 and phorsphorylated p38
to detect if this pathway is elevated?
Thank you much! |
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a****l
发帖数: 125 | 43 有了microarray data, 5000 多个基因变化，如何做 pathway analysis 和
functional classification? 知道个 GO analysis, 但不知道如何用， 最好有什么
online 的工具，把array 的data 输进去就可以给出结果？
多谢了。 |
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s********s
发帖数: 67 | 44 应该不是控制global protein translation，因为rapamycin处理后部分蛋白表达量增
加。好像有篇paper说和起始密码子前的那段序列有关，记不清了。
在neuron领域，mTOR pathway上的重要蛋白knock out好像都有表型，mTOR knock out
估计直接就死了。 |
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f*******a
发帖数: 671 | 45 不太喜欢。上面免疫方面的东西比较多。感觉不管你输入什么样的list都会有这方面的
pathway.Highly biased. |
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G***G
发帖数: 16778 | 46 hi there,
do you know how to create a network analysis (not pathway) as IPA does?
what databases are those network analysis based on?
another question is how to create a visualization tool to show this
kind of network online? are there any tools for the visualization? |
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n******t
发帖数: 1281 | 47 请推荐可以方便地画metabolic pathway的生物软件。谢谢！ |
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S**o
发帖数: 447 | 48 anyone knows how to download biocarta pathway database? |
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j*********e
发帖数: 13 | 49 以前见到过一期杂志的封面（或是里面一个MODEL的图）是用齿轮咬合关系模拟PATHWAY
-NETWORK的， 忘了是哪种杂志了？有哪位大侠见到过吗？ |
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N******n
发帖数: 3003 | 50 KEGG是个静态的network, 不同的状态下，他的linking应该有变化， 问题是对于任何
一个静态，KEGG的pathway有多少是对的，多少是错的？
根据文献推导，好像false postive, 10-20%, 不知道这个数据对不对？ |
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