z********e
发帖数: 253 | 1 http://blog.sciencenet.cn/blog-281238-793975.html
针灸抗炎的分子机理
Torres-Rosas R, et al. Dopamine mediates vagal modulation of the immune
system by electroacupuncture. Nat Med 2014, 20: 291-295
这篇Nature系列文章目前还不能免费下载全文，但从孙学军老师的博文针灸作用机制新
解释可以找到这篇文章。
Abstract
Previous anti-inflammatory strategies against sepsis, a leading cause of
death in hospitals, had limited efficacy in clinical trials, in part because
they targeted single cytokines and the experimental models failed to mimic
clinical settings. Neuronal networks represent physiological mechanisms,
selected by evolution to control inflammation, that can be exploited for the
treatment of inflammatory and infectious disorders. Here, we report that
sciatic nerve activation with electroacupuncture controls systemic
inflammation and rescues mice from polymicrobial peritonitis.
Electroacupuncture at the sciatic nerve controls systemic inflammation by
inducing vagal activation of aromatic l-amino acid decarboxylase, leading to
the production of dopamine in the adrenal medulla. Experimental models with
adrenolectomized mice mimic clinical adrenal insufficiency4, increase the
susceptibility to sepsis and prevent the anti-inflammatory effects of
electroacupuncture. Dopamine inhibits cytokine production via dopamine type
1 (D1) receptors. D1 receptor agonists suppress systemic inflammation and
rescue mice with adrenal insufficiency from polymicrobial peritonitis. Our
results suggest a new anti-inflammatory mechanism mediated by the sciatic
and vagus nerves that modulates the production of catecholamines in the
adrenal glands. From a pharmacological perspective, the effects of selective
dopamine agonists mimic the anti-inflammatory effects of electroacupuncture
and can provide therapeutic advantages to control inflammation in
infectious and inflammatory disorders.
这篇文章描述了针灸消炎的新发现，将使针灸在未来疾病的治疗上产生“革命性”影响
，它不再仅仅是镇痛那么简单，还可以用来对抗感染引起的炎症，尤其是抗药性细菌感
染。研究表明，对坐骨神经及迷走神经的电针刺激，可以激活肾上腺髓质中的芳香族氨
基酸脱羧酶，从而促进多巴胺的产生，而多巴胺可经由多巴胺1型（D1）受体抑制促炎
细胞因子的合成，从而缓解全身炎症。下图数据显示，经电针刺激后，脂多糖诱导的肿
瘤坏死因子（TNF）、单核细胞趋化蛋白1（MCP-1）、白细胞介素6（IL-6）和干扰素γ
（IFN-γ）等促炎细胞因子的血清浓度明显降低，而且在6小时内未见升高。 | s******y
发帖数: 28562 | 2 应该靠谱。针灸用来消炎早就有记载，只是一直没有找到机理而已。
because
mimic
【在 z********e 的大作中提到】
: http://blog.sciencenet.cn/blog-281238-793975.html
: 针灸抗炎的分子机理
: Torres-Rosas R, et al. Dopamine mediates vagal modulation of the immune
: system by electroacupuncture. Nat Med 2014, 20: 291-295
: 这篇Nature系列文章目前还不能免费下载全文，但从孙学军老师的博文针灸作用机制新
: 解释可以找到这篇文章。
: Abstract
: Previous anti-inflammatory strategies against sepsis, a leading cause of
: death in hospitals, had limited efficacy in clinical trials, in part because
: they targeted single cytokines and the experimental models failed to mimic
|
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