v********e 发帖数: 1597 | 1 http://www.nature.com/news/long-sought-biological-compass-disco
In the cells of fruit flies, Chinese scientists say that they have found a
biological compass needle: a rod-shaped complex of proteins that can align
with Earth’s weak magnetic field.
The biocompass — whose constituent proteins exist in related forms in other
species, including humans — could explain a long-standing puzzle: how
animals such as birds and insects sense magnetism. It might also become an
invaluable tool for using magnetic fields to control cells, report
researchers led by biophysicist Xie Can at Peking University in Beijing, in
a paper published on 16 November in Nature Materials (S. Qin et al. Nature
Mater. http://dx.doi.org/10.1038/nmat4484; 2015).
“It’s an extraordinary paper,” says Peter Hore, a biochemist at the
University of Oxford, UK. But Xie’s team has not shown that the complex
actually behaves as a biocompass inside living cells, nor explained exactly
how it senses magnetism. “It’s either a very important paper or totally
wrong. I strongly suspect the latter,” says David Keays, a neuroscientist
who studies magnetoreception at the Institute of Molecular Pathology in
Vienna.
Related stories
Neuroscientist fired after dispute over magnetic-protein research
Chinese scientists row over long-sought protein that senses magnetism
Electronics' noise disorients migratory birds
More related stories
Many organisms — ranging from whales to butterflies, and termites to
pigeons — use Earth’s magnetic field to navigate or orient themselves in
space. But the molecular mechanism behind this ability, termed magneto-
reception, is unclear.
Some researchers have pointed to magnetically sensitive proteins called ‘
cryptochromes’, or ‘Cry’. Fruit flies lacking the proteins lose their
sensitivity to magnetic fields, for example. But the Cry proteins alone
cannot act as a compass, says Xie, because they cannot sense the polarity (
north–south orientation) of magnetic fields.
Others have suggested that iron-based minerals might be responsible.
Magnetite, a form of iron oxide, has been found in the beak cells of homing
pigeons. Yet studies suggest that magnetite plays no part in pigeon
magnetoreception.
Xie says that he has found a protein in fruit flies that both binds to iron
and interacts with Cry. Known as CG8198, it binds iron and sulfur atoms and
is involved in fruit-fly circadian rhythms. Together with Cry, it forms a
nanoscale ‘needle’: a rod-like core of CG8198 polymers with an outer layer
of Cry proteins that twists around the core (see 'Protein biocompass').
Credit: S. Qin et al. Nature Mater. http://dx.doi.org/10.1038/nmat4484 (2015).
Using an electron microscope, Xie’s team saw assemblies of these rods
orienting themselves in a weak magnetic field in the same way as compass
needles. Xie gave CG8198 the new name of MagR, for magnetic receptor.
The discovery offers scientists the prospect of using magnetic fields to
control cells. Over the past decade, scientists have commandeered the light-
sensing capacity of some proteins to manipulate neurons, usually by
inserting a fibre-optic cable directly into the brain — a tool called
optogenetics. But magnetosensing proteins have the advantage that they could
be manipulated by magnetic fields outside the brain.
Zhang Sheng-jia, a neuroscientist at Tsinghua University in Beijing, claims
to have already demonstrated this ‘magnetogenetic’ capability. In
September, he provided a surprise preview of Xie’s work when he published a
paper reporting use of the biocompass to manipulate neurons in worms (X.
Long et al. Sci. Bull. http://doi.org/883; 2015). Xie and others complained that Zhang’s early publication violated a collaboration agreement between the two researchers — the details of which are disputed — and asked for it to be retracted. In October, Zhang was fired from his university, a decision that he is contesting.
Xie says that in April, he submitted a Chinese patent application that
includes the use of magnetogenetics and the protein’s magnetic capacity to
manipulate large molecules. He is also starting to look at the structure of
MagR proteins in other animals, including humans. Variants in the human
version of MagR might even relate to differences in people’s sense of
direction, he suggests.
Sceptical voices
Other scientists are not convinced that the biological needles function like
compasses in living organisms. Xie’s team has shown that MagR and Cry are
produced in the same cells in pigeon retinas — the birds’ proposed
magnetoreception centre — but MagR and Cry are found in many cells, says
Keays. “With such a small amount of iron, one has to ask whether in vivo,
at physiological temperatures, MagR is capable of possessing magnetic
properties at all,” he says. “If MagR is the real magnetoreceptor, I’ll
eat my hat.”
“If MagR is the real magnetoreceptor, I’ll eat my hat.”
Xie hopes that others will strengthen his case with further experiments,
such as inactivating the gene for MagR in certain fruit-fly tissues to see
whether it affects the animals’ sense of direction. He published without
doing this work, he says, because he just wanted to report the findings,
which he has been working on for six years.
The lack of an exact mechanism for how the protein complex senses magnetism,
or how any signal it sends might be processed by the brain, gives some
researchers pause. MagR’s biocompass activity might simply be the result of
experimental contamination, says Michael Winklhofer, a magnetism specialist
and Earth scientist at Ludwig Maximilian University of Munich in Germany.
He is planning experiments to follow up on Xie’s team’s findings. If it
holds up, says Winklhofer, then the discovery of MagR “appears to be a
major step forward towards unravelling the molecular basis of
magnetoreception”. |
v********e 发帖数: 1597 | 2 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人
质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做 |
W***o 发帖数: 6519 | 3 剑桥那个人的评论有点酸葡萄:I suspect the latter.... |
v********e 发帖数: 1597 | 4 真金不怕火炼呐,重大突破早期容易遭到质疑,尤其是这个发现不是领域内的大牛做出
来的
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
v**********m 发帖数: 5516 | 5 北大已经不给他时间了。
如果文章不发表,谢就会被踢出北大。我猜功能敲出的文章很快就会显身,也许是某位
提前知道谢灿结果的大牛学霸的实验室。
【在 v********e 的大作中提到】 : 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人 : 质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做
|
k*****n 发帖数: 417 | 6 以前的研究证明CRY敲除果蝇就丧失磁场感应能力,因此CRY被认为是一个磁场感应蛋白
,然而谢灿发现它只具备感光作用,需要和MagR形成蛋白复合物才能发挥感应磁场能力
(至少在体外),MagR是真正的磁感应蛋白。
虽然未有直接的动物行为学实验,但从这部分结果、MagR-CRY结构以及和Fe-S结合看,
我倾向于相信MagR是真正的磁感应蛋白。
【在 v********e 的大作中提到】 : 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人 : 质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做
|
t*******3 发帖数: 2005 | 7 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手
上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不
知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
【在 v**********m 的大作中提到】 : 北大已经不给他时间了。 : 如果文章不发表,谢就会被踢出北大。我猜功能敲出的文章很快就会显身,也许是某位 : 提前知道谢灿结果的大牛学霸的实验室。
|
t*******3 发帖数: 2005 | 8 哪来的剑桥呀,那个人是维也纳的。
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
F*Q 发帖数: 3259 | 9 饶和鲁都要到谢的胡子下捞饭吃,谢才是真正的牛人啊。
【在 t*******3 的大作中提到】 : 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手 : 上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不 : 知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
|
v********e 发帖数: 1597 | 10 保守点的话,还是要等结果出来再说;我很清楚的记得,张生加的文章,在地磁场强度
下大约0.3mT加载,转染了magR的神经元和293T都不能被激活
【在 k*****n 的大作中提到】 : 以前的研究证明CRY敲除果蝇就丧失磁场感应能力,因此CRY被认为是一个磁场感应蛋白 : ,然而谢灿发现它只具备感光作用,需要和MagR形成蛋白复合物才能发挥感应磁场能力 : (至少在体外),MagR是真正的磁感应蛋白。 : 虽然未有直接的动物行为学实验,但从这部分结果、MagR-CRY结构以及和Fe-S结合看, : 我倾向于相信MagR是真正的磁感应蛋白。
|
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|
r*s 发帖数: 2555 | 11 http://news.sina.com.cn/o/2015-10-22/doc-ifxizetf7845100.shtml?
北京奥森公园附近白鼠出没续:白鼠未检出病原体
【在 t*******3 的大作中提到】 : 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手 : 上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不 : 知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
|
t*******3 发帖数: 2005 | |
D*a 发帖数: 6830 | |
s***y 发帖数: 198 | 14 看了这篇,和张撤稿的那篇,张获诺奖是无疑了,因为张开创了一个领域。不管以后大
家怎么评价张的人品,张将彪炳史册。以后学生物的都要学张的快手,学如何保护自己
的课题。
【在 v********e 的大作中提到】 : 真金不怕火炼呐,重大突破早期容易遭到质疑,尤其是这个发现不是领域内的大牛做出 : 来的
|
c***n 发帖数: 196 | 15 下面那句更是酸。
“If MagR is the real magnetoreceptor, I’ll
eat my hat.”
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
c***n 发帖数: 196 | 16 下面那句更是酸。
“If MagR is the real magnetoreceptor, I’ll
eat my hat.”
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
s*******1 发帖数: 188 | 17 从国外呆的时间越长越觉得欧美人,尤其是政客媒体的虚伪,看不得别人的优秀别人的
好,总是一副高人一等的样子,总想充当救世主的角色,要让人感激涕零顶礼膜拜。
所以我共要发展经济,同时也要练好肌肉。
【在 c***n 的大作中提到】 : 下面那句更是酸。 : “If MagR is the real magnetoreceptor, I’ll : eat my hat.”
|
t*******3 发帖数: 2005 | 18 看时间点正好在清华解聘张的前后
【在 D*a 的大作中提到】 : 哈哈发散思维
|
r********k 发帖数: 258 | 19 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张
和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原
认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以
至于他无法完成剩下的工作。谢也是失败者。
张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。
没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。 |
i****g 发帖数: 3896 | 20 现在的数据完全够发nature materials了 这是为啥放弃nature rebuttal投NM的原因
【在 r********k 的大作中提到】 : 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张 : 和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原 : 认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以 : 至于他无法完成剩下的工作。谢也是失败者。 : 张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。 : 没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。
|
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a*******a 发帖数: 4233 | 21 发不出n子刊起码有cell research收。
只要发出来自然有人跟进,白皮不做正好没人抢专利。只要是真的能被重复就不愁不被
承认。关张生家屁事。
不过话又说回来,最近搞的要搞自己的重要期刊的活动还是对的,为什么看白皮的脸色?
【在 r********k 的大作中提到】 : 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张 : 和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原 : 认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以 : 至于他无法完成剩下的工作。谢也是失败者。 : 张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。 : 没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。
|
f*****i 发帖数: 154 | 22 谁做出体内实验,谁发nature 主刊, 毫无置疑
体内实验是最难做的, 无数cns体内实验造假 |
v********e 发帖数: 1597 | 23 http://www.nature.com/news/long-sought-biological-compass-discovered-1.18803
In the cells of fruit flies, Chinese scientists say that they have found a
biological compass needle: a rod-shaped complex of proteins that can align
with Earth’s weak magnetic field.
The biocompass — whose constituent proteins exist in related forms in other
species, including humans — could explain a long-standing puzzle: how
animals such as birds and insects sense magnetism. It might also become an
invaluable tool for using magnetic fields to control cells, report
researchers led by biophysicist Xie Can at Peking University in Beijing, in
a paper published on 16 November in Nature Materials (S. Qin et al. Nature
Mater. http://dx.doi.org/10.1038/nmat4484; 2015).
“It’s an extraordinary paper,” says Peter Hore, a biochemist at the
University of Oxford, UK. But Xie’s team has not shown that the complex
actually behaves as a biocompass inside living cells, nor explained exactly
how it senses magnetism. “It’s either a very important paper or totally
wrong. I strongly suspect the latter,” says David Keays, a neuroscientist
who studies magnetoreception at the Institute of Molecular Pathology in
Vienna.
Related stories
Neuroscientist fired after dispute over magnetic-protein research
Chinese scientists row over long-sought protein that senses magnetism
Electronics' noise disorients migratory birds
More related stories
Many organisms — ranging from whales to butterflies, and termites to
pigeons — use Earth’s magnetic field to navigate or orient themselves in
space. But the molecular mechanism behind this ability, termed magneto-
reception, is unclear.
Some researchers have pointed to magnetically sensitive proteins called ‘
cryptochromes’, or ‘Cry’. Fruit flies lacking the proteins lose their
sensitivity to magnetic fields, for example. But the Cry proteins alone
cannot act as a compass, says Xie, because they cannot sense the polarity (
north–south orientation) of magnetic fields.
Others have suggested that iron-based minerals might be responsible.
Magnetite, a form of iron oxide, has been found in the beak cells of homing
pigeons. Yet studies suggest that magnetite plays no part in pigeon
magnetoreception.
Xie says that he has found a protein in fruit flies that both binds to iron
and interacts with Cry. Known as CG8198, it binds iron and sulfur atoms and
is involved in fruit-fly circadian rhythms. Together with Cry, it forms a
nanoscale ‘needle’: a rod-like core of CG8198 polymers with an outer layer
of Cry proteins that twists around the core (see 'Protein biocompass').
Credit: S. Qin et al. Nature Mater. http://dx.doi.org/10.1038/nmat4484 (2015).
Using an electron microscope, Xie’s team saw assemblies of these rods
orienting themselves in a weak magnetic field in the same way as compass
needles. Xie gave CG8198 the new name of MagR, for magnetic receptor.
The discovery offers scientists the prospect of using magnetic fields to
control cells. Over the past decade, scientists have commandeered the light-
sensing capacity of some proteins to manipulate neurons, usually by
inserting a fibre-optic cable directly into the brain — a tool called
optogenetics. But magnetosensing proteins have the advantage that they could
be manipulated by magnetic fields outside the brain.
Zhang Sheng-jia, a neuroscientist at Tsinghua University in Beijing, claims
to have already demonstrated this ‘magnetogenetic’ capability. In
September, he provided a surprise preview of Xie’s work when he published a
paper reporting use of the biocompass to manipulate neurons in worms (X.
Long et al. Sci. Bull. http://doi.org/883; 2015). Xie and others complained that Zhang’s early publication violated a collaboration agreement between the two researchers — the details of which are disputed — and asked for it to be retracted. In October, Zhang was fired from his university, a decision that he is contesting.
Xie says that in April, he submitted a Chinese patent application that
includes the use of magnetogenetics and the protein’s magnetic capacity to
manipulate large molecules. He is also starting to look at the structure of
MagR proteins in other animals, including humans. Variants in the human
version of MagR might even relate to differences in people’s sense of
direction, he suggests.
Sceptical voices
Other scientists are not convinced that the biological needles function like
compasses in living organisms. Xie’s team has shown that MagR and Cry are
produced in the same cells in pigeon retinas — the birds’ proposed
magnetoreception centre — but MagR and Cry are found in many cells, says
Keays. “With such a small amount of iron, one has to ask whether in vivo,
at physiological temperatures, MagR is capable of possessing magnetic
properties at all,” he says. “If MagR is the real magnetoreceptor, I’ll
eat my hat.”
“If MagR is the real magnetoreceptor, I’ll eat my hat.”
Xie hopes that others will strengthen his case with further experiments,
such as inactivating the gene for MagR in certain fruit-fly tissues to see
whether it affects the animals’ sense of direction. He published without
doing this work, he says, because he just wanted to report the findings,
which he has been working on for six years.
The lack of an exact mechanism for how the protein complex senses magnetism,
or how any signal it sends might be processed by the brain, gives some
researchers pause. MagR’s biocompass activity might simply be the result of
experimental contamination, says Michael Winklhofer, a magnetism specialist
and Earth scientist at Ludwig Maximilian University of Munich in Germany.
He is planning experiments to follow up on Xie’s team’s findings. If it
holds up, says Winklhofer, then the discovery of MagR “appears to be a
major step forward towards unravelling the molecular basis of
magnetoreception”. |
v********e 发帖数: 1597 | 24 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人
质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做 |
W***o 发帖数: 6519 | 25 剑桥那个人的评论有点酸葡萄:I suspect the latter.... |
v********e 发帖数: 1597 | 26 真金不怕火炼呐,重大突破早期容易遭到质疑,尤其是这个发现不是领域内的大牛做出
来的
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
v**********m 发帖数: 5516 | 27 北大已经不给他时间了。
如果文章不发表,谢就会被踢出北大。我猜功能敲出的文章很快就会显身,也许是某位
提前知道谢灿结果的大牛学霸的实验室。
【在 v********e 的大作中提到】 : 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人 : 质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做
|
k*****n 发帖数: 417 | 28 以前的研究证明CRY敲除果蝇就丧失磁场感应能力,因此CRY被认为是一个磁场感应蛋白
,然而谢灿发现它只具备感光作用,需要和MagR形成蛋白复合物才能发挥感应磁场能力
(至少在体外),MagR是真正的磁感应蛋白。
虽然未有直接的动物行为学实验,但从这部分结果、MagR-CRY结构以及和Fe-S结合看,
我倾向于相信MagR是真正的磁感应蛋白。
【在 v********e 的大作中提到】 : 遗憾就是没做功能性试验,做一个基因敲除的果蝇看看有没有什么影响,这也是一些人 : 质疑他的原因,不过这篇文章出来之后,肯定一群人会跟上去做
|
t*******3 发帖数: 2005 | 29 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手
上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不
知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
【在 v**********m 的大作中提到】 : 北大已经不给他时间了。 : 如果文章不发表,谢就会被踢出北大。我猜功能敲出的文章很快就会显身,也许是某位 : 提前知道谢灿结果的大牛学霸的实验室。
|
t*******3 发帖数: 2005 | 30 哪来的剑桥呀,那个人是维也纳的。
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
|
|
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F*Q 发帖数: 3259 | 31 饶和鲁都要到谢的胡子下捞饭吃,谢才是真正的牛人啊。
【在 t*******3 的大作中提到】 : 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手 : 上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不 : 知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
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v********e 发帖数: 1597 | 32 保守点的话,还是要等结果出来再说;我很清楚的记得,张生加的文章,在地磁场强度
下大约0.3mT加载,转染了magR的神经元和293T都不能被激活
【在 k*****n 的大作中提到】 : 以前的研究证明CRY敲除果蝇就丧失磁场感应能力,因此CRY被认为是一个磁场感应蛋白 : ,然而谢灿发现它只具备感光作用,需要和MagR形成蛋白复合物才能发挥感应磁场能力 : (至少在体外),MagR是真正的磁感应蛋白。 : 虽然未有直接的动物行为学实验,但从这部分结果、MagR-CRY结构以及和Fe-S结合看, : 我倾向于相信MagR是真正的磁感应蛋白。
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r*s 发帖数: 2555 | 33 http://news.sina.com.cn/o/2015-10-22/doc-ifxizetf7845100.shtml?cre=newspagepc&mod=f&loc=3&r=a&rfunc=-1
北京奥森公园附近白鼠出没续:白鼠未检出病原体
【在 t*******3 的大作中提到】 : 好像知乎上有饶神经的学生说他们组和谢有合作,那个鲁白组的hellojerry也说自己手 : 上有谢的论文。比较有意思的是按张的说法,他们原来是计划在老鼠身上做实验的,不 : 知进展得如何。联系到龙说张的老鼠被清华处理了,这场戏真是精彩。
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t*******3 发帖数: 2005 | |
D*a 发帖数: 6830 | |
s***y 发帖数: 198 | 36 看了这篇,和张撤稿的那篇,张获诺奖是无疑了,因为张开创了一个领域。不管以后大
家怎么评价张的人品,张将彪炳史册。以后学生物的都要学张的快手,学如何保护自己
的课题。
【在 v********e 的大作中提到】 : 真金不怕火炼呐,重大突破早期容易遭到质疑,尤其是这个发现不是领域内的大牛做出 : 来的
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c***n 发帖数: 196 | 37 下面那句更是酸。
“If MagR is the real magnetoreceptor, I’ll
eat my hat.”
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
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c***n 发帖数: 196 | 38 下面那句更是酸。
“If MagR is the real magnetoreceptor, I’ll
eat my hat.”
【在 W***o 的大作中提到】 : 剑桥那个人的评论有点酸葡萄:I suspect the latter....
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s*******1 发帖数: 188 | 39 从国外呆的时间越长越觉得欧美人,尤其是政客媒体的虚伪,看不得别人的优秀别人的
好,总是一副高人一等的样子,总想充当救世主的角色,要让人感激涕零顶礼膜拜。
所以我共要发展经济,同时也要练好肌肉。
【在 c***n 的大作中提到】 : 下面那句更是酸。 : “If MagR is the real magnetoreceptor, I’ll : eat my hat.”
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t*******3 发帖数: 2005 | 40 看时间点正好在清华解聘张的前后
【在 D*a 的大作中提到】 : 哈哈发散思维
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r********k 发帖数: 258 | 41 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张
和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原
认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以
至于他无法完成剩下的工作。谢也是失败者。
张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。
没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。 |
i****g 发帖数: 3896 | 42 现在的数据完全够发nature materials了 这是为啥放弃nature rebuttal投NM的原因
【在 r********k 的大作中提到】 : 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张 : 和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原 : 认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以 : 至于他无法完成剩下的工作。谢也是失败者。 : 张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。 : 没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。
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a*******a 发帖数: 4233 | 43 发不出n子刊起码有cell research收。
只要发出来自然有人跟进,白皮不做正好没人抢专利。只要是真的能被重复就不愁不被
承认。关张生家屁事。
不过话又说回来,最近搞的要搞自己的重要期刊的活动还是对的,为什么看白皮的脸色?
【在 r********k 的大作中提到】 : 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张 : 和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原 : 认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以 : 至于他无法完成剩下的工作。谢也是失败者。 : 张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。 : 没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。
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f*****i 发帖数: 154 | 44 谁做出体内实验,谁发nature 主刊, 毫无置疑
体内实验是最难做的, 无数cns体内实验造假 |
h*******u 发帖数: 351 | 45 张生家怎么跳出来挺韩春雨了,真是尼玛骗子惜骗子。
【在 r********k 的大作中提到】 : 很重要的领域,但研究结果已被质疑。张的论文先发可能有助于谢的论文过关发表。张 : 和谢的命运已绑在一起,不管情愿不情愿。两人都面临同一问题:实验能不能重复?原 : 认为谢是张谢之争的赢家,看完NATURE的评论,谢失去一位看懂他的工作的合作者,以 : 至于他无法完成剩下的工作。谢也是失败者。 : 张要做的是,不管谢的实验能不能重复,他的实验要能独立重复。 : 没有张的应用工作,从评论来看,谢被再次据稿的可能性很高。
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x****6 发帖数: 4339 | |