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发帖数: 3 | 1 Mol Cell Oncol. 2015 Oct 6;3(2):e1087452. doi: 10.1080/23723556.2015.1087452
. eCollection 2016.
Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival
after ischemia.
Sooyeon L1, Go KL1, Kim JS1.
Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently,
we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury
and identified a novel interaction between SIRT1 and mitochondrial outer
membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation
of MFN2 regulates mitochondria and autophagy in the liver.
KEYWORDS: Autophagy; ischemia/reperfusion; mitochondria; mitofusin 2;
sirtuin 1
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