l**********c
发帖数: 434 | 1 有可能是主要贡献吗？
A challenge in photodynamic therapy (PDT) cancer treatment is developing
novel methods of singlet oxygen generation using near infrared light.
Titanium
dioxide is a photocatalyst that generates reactive oxygen species (ROS), but
it requires ultraviolet light. Lead sulfide (PbS) quantum dots have a
narrow band
gap, allowing them to tune the absorbed wavelengths of the nanotubes to the
near infrared. To ensure singlet oxygen generation, the photoreactive NO
donor
S-nitroso-cysteine was also bound to the nanotubes, since reaction of NO
with ROS forms singlet oxygen. The nanotubes were prepared using
hydrothermal
synthesis, and PbS quantum dots were attached using a thiolactic acid linker
, which controls both the size of the quantum dots and the light wavelengths
absorbed. The absorption spectrum and PbS band gap were measured using UV-
Visible Spectroscopy, and PbS attachment was verified using Fourier
transform infrared spectroscopy, x-ray diffraction and transmission electron
microscopy. Next, l-cysteine was attached to the quantum dot doped
nanotubes,
and NO infusion led to S-nitroso-cysteine formation. The sample was
irradiated in a Ray-Sorb flask (filtering wavelengths < 600 nm) using a
mercury lamp
while bubbling argon to collect NO in a vial of de-ionized water. The
collected samples were analyzed using UV-Visible Spectroscopy, and nitrite
concentrations were calculated. The results indicate that in near-infrared
light, electron transfer from PbS to the nanotubes results in NO release and
successful singlet oxygen generation. This project’s original approach of
attaching S-nitroso-cysteine to PbS quantum dot decorated titanium dioxide
nanotubes shows promise as a next generation PDT photosensitizer. | A****a
发帖数: 2497 | | l**********c
发帖数: 434 | 3 这是15岁的amy chyao, who is from Williams High School, Plano, TX, 的abstract
for the 2010 Intel International Science and Engineering Fair. She won the
top prize of $75,000
Awards won at the 2010 ISEF***************
Honorable Mention Award - American Chemical Society
Intel ISEF Best of Category Award of $5,000 for Top First Place Winner -
Chemistry - Presented by Intel
Gordon Moore Award $75,000 - The Gordon E. Moore Award
Tuition Scholarship Award in the amount of $8,000 - Office of Naval Research
on behalf of the United States Navy and Marine Corps
UTC Stock with an approximate value of $2,000 - United Technologies
Corporation | b*******g
发帖数: 1309 | 4 Good enough for a high school student! I know nothing in my high school.
The science and chemistry in the project is not too hard, and if all of the
experiments are supervised by a senior graduate student, i think it is very
possible and reasonable.
But in fact, this material is far away from real medical application, since
Pb is highly toxic, and the metabolic behavior of Pb is horrible in human
body, it tends to accumulate in brain.
abstract
the
Research
【在 l**********c 的大作中提到】
: 这是15岁的amy chyao, who is from Williams High School, Plano, TX, 的abstract
: for the 2010 Intel International Science and Engineering Fair. She won the
: top prize of $75,000
: Awards won at the 2010 ISEF***************
: Honorable Mention Award - American Chemical Society
: Intel ISEF Best of Category Award of $5,000 for Top First Place Winner -
: Chemistry - Presented by Intel
: Gordon Moore Award $75,000 - The Gordon E. Moore Award
: Tuition Scholarship Award in the amount of $8,000 - Office of Naval Research
: on behalf of the United States Navy and Marine Corps
| w********h
发帖数: 12367 | 5 美国给很多有天资的高中、大学生无穷多的机会。
我不相信高中生能在这种project里起到什么作用，
无非是上面需要鼓励中学生参与科研，培养下一代科技人才，
下面认为这样可以让实验室和教授脸面好看，
并且在申请NSF grant的时候有outreach的充分证明，
甚至有很多special program财政上支持高中生去掺乎。
对几方都是有好处的，尤其对获奖的个人。
但对谁没好处呢？对广大的silent mass没好处。
（1）纳税人的钱就被这样浪费掉了；
（2）没有条件进入这种实验室的，还得凭真本事。
我以前就带过高中生，个人认为她素质还是很好的，
但实验基本上就是把平台搭好，让她完成点technician的活。
以前西屋奖还是出了很多科学家的，
现在呢，很多人拿了这个奖之后不过是敲开了名校之门，
基本上没有人去做科学了。
but
the
【在 l**********c 的大作中提到】
: 有可能是主要贡献吗？
: A challenge in photodynamic therapy (PDT) cancer treatment is developing
: novel methods of singlet oxygen generation using near infrared light.
: Titanium
: dioxide is a photocatalyst that generates reactive oxygen species (ROS), but
: it requires ultraviolet light. Lead sulfide (PbS) quantum dots have a
: narrow band
: gap, allowing them to tune the absorbed wavelengths of the nanotubes to the
: near infrared. To ensure singlet oxygen generation, the photoreactive NO
: donor
| t******t
发帖数: 3045 | 6 中学生一样可以做实验阿 没有看出描述的实验能有多难做
我觉得恐怕大部分PhD的实验 很多高中生来学学一样可以做
要自己设计实验的话，一般高中生是没戏 | l**********c
发帖数: 434 | 7 干点technician的活就得大奖，对其他独立完成project的参赛者好像不太公平。
而且比赛不是要求独立完成吗？
【在 w********h 的大作中提到】
: 美国给很多有天资的高中、大学生无穷多的机会。
: 我不相信高中生能在这种project里起到什么作用，
: 无非是上面需要鼓励中学生参与科研，培养下一代科技人才，
: 下面认为这样可以让实验室和教授脸面好看，
: 并且在申请NSF grant的时候有outreach的充分证明，
: 甚至有很多special program财政上支持高中生去掺乎。
: 对几方都是有好处的，尤其对获奖的个人。
: 但对谁没好处呢？对广大的silent mass没好处。
: （1）纳税人的钱就被这样浪费掉了；
: （2）没有条件进入这种实验室的，还得凭真本事。
| w********h
发帖数: 12367 | 8 如果高中生都能设计获大奖的实验，我看研究生院都别办了。。。
公平？这世界还有公平。。。。
【在 l**********c 的大作中提到】
: 干点technician的活就得大奖，对其他独立完成project的参赛者好像不太公平。
: 而且比赛不是要求独立完成吗？
| S*****n
发帖数: 6055 | 9 我带的小弟也参加过这个比赛
压根就没有独立完成project的参赛者
【在 l**********c 的大作中提到】
: 干点technician的活就得大奖，对其他独立完成project的参赛者好像不太公平。
: 而且比赛不是要求独立完成吗？
| s*******h
发帖数: 3731 | 10 老大，下次带小弟我去参赛吧。。。让我拿一把这个奖。。。
【在 S*****n 的大作中提到】
: 我带的小弟也参加过这个比赛
: 压根就没有独立完成project的参赛者
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