b**s
发帖数: 589 | 1 A novel hydrogel formed from amphiphilic diblock copolypeptides could have
potential uses in biomedical applications. Scientists at the University of
California, Santa Barbara and the University of Delaware found that a small
amount of a diblock copolypeptide amphiphile, when added to water, formed a
network of polymer chains or hydrogel [ Nature (2002) 417, 424].
Amphiphiles have hydrophobic and hydrophilic sections, but most diblock
copolymer amphiphiles assemble into vesicles in water, | b*o
发帖数: 47 | 2
我把那篇文章看了好几遍，还是不明白他们的共聚物是怎么交联的。Or just
micell aggregation? Please help me understand. Thanks.
have
Instead,
two
systems
engineering.
the
【在 b**s 的大作中提到】
: A novel hydrogel formed from amphiphilic diblock copolypeptides could have
: potential uses in biomedical applications. Scientists at the University of
: California, Santa Barbara and the University of Delaware found that a small
: amount of a diblock copolypeptide amphiphile, when added to water, formed a
: network of polymer chains or hydrogel [ Nature (2002) 417, 424].
: Amphiphiles have hydrophobic and hydrophilic sections, but most diblock
: copolymer amphiphiles assemble into vesicles in water,
| b**s
发帖数: 589 | 3
original article
welcome to discuss
http://groups.yahoo.com/group/mitpolymer/files/417424a_r.pdf
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v417/n6887/ful
l/417424a_fs.html
【在 b*o 的大作中提到】
:
: 我把那篇文章看了好几遍，还是不明白他们的共聚物是怎么交联的。Or just
: micell aggregation? Please help me understand. Thanks.
: have
: Instead,
: two
: systems
: engineering.
: the
| b**s
发帖数: 589 | 4
我觉得大概是这样的
这种两亲高分子与普通的两亲高分子的区别在于
1. 因为它是多肽,所以它可以互相缠绕形成蛋白质样的结构，所以憎水的链节在这里
自组装，起到交联点的作用，而且交联强度的顺序是a-helix> b-strand > random coil
2. 而亲水的链节是带电的，互相排斥，无法靠近
所以一吸一斥，使得高分子链既不能聚集成micell,又不能分散在水里形成溶液，以至
於这种两亲高分子在水中形成独特的hydrogel而不是胶体。
small
a
hydrophobic
could
that
【在 b*o 的大作中提到】
:
: 我把那篇文章看了好几遍，还是不明白他们的共聚物是怎么交联的。Or just
: micell aggregation? Please help me understand. Thanks.
: have
: Instead,
: two
: systems
: engineering.
: the
| b*o
发帖数: 47 | 5
里
coil
至
多谢讨论。我明白多月太自组装充当一个交联点，但另一个交联点呢？还是倾向于
micell aggregation, something like in the PEG-b-PLGA case.
【在 b**s 的大作中提到】
:
: 我觉得大概是这样的
: 这种两亲高分子与普通的两亲高分子的区别在于
: 1. 因为它是多肽,所以它可以互相缠绕形成蛋白质样的结构，所以憎水的链节在这里
: 自组装，起到交联点的作用，而且交联强度的顺序是a-helix> b-strand > random coil
: 2. 而亲水的链节是带电的，互相排斥，无法靠近
: 所以一吸一斥，使得高分子链既不能聚集成micell,又不能分散在水里形成溶液，以至
: 於这种两亲高分子在水中形成独特的hydrogel而不是胶体。
: small
: a
|
|
