m***n
发帖数: 266 | 1 Tg大於37C，还是小於37C，更容易降解？
为什么PGA-PLA的copolymer随PLA的量增大降解速度增快？ |
c*w
发帖数: 50 | 2
不是很正确。50/50的降解速度最快。原因：
1 with the increase of PLA, the hydrophocibity of PGA-PLA increase,
degradation decrease.
2 with the increase of PGA, the crystallinity of PGA-PLA increase, degradation
decrease.
so, the degradation rate should be considered comprehensively.
【在 m***n 的大作中提到】
: Tg大於37C，还是小於37C，更容易降解？
: 为什么PGA-PLA的copolymer随PLA的量增大降解速度增快？
|
b***e
发帖数: 115 | 3 我想应该是<37度
因为,降解的时候
酶必须有坐落点在高分子上,硬质的坐落点比较好
PLA是比较好的降解材料
随着PLA的含量增大,降解速度变大应该不是很奇怪的现象吧
同时,PLA还有可能发生水解的,所以,因素很多吧
【在 m***n 的大作中提到】
: Tg大於37C，还是小於37C，更容易降解？
: 为什么PGA-PLA的copolymer随PLA的量增大降解速度增快？
|
b***e
发帖数: 115 | 4 第二个说法不是很正确,我觉得
amorphous phase are easier to be degraded, but
pure amorphous phase can not be degraded
i-PHB and a-PHB is a example of this.
so , many factor must be considered.
【在 c*w 的大作中提到】
:
: 不是很正确。50/50的降解速度最快。原因：
: 1 with the increase of PLA, the hydrophocibity of PGA-PLA increase,
: degradation decrease.
: 2 with the increase of PGA, the crystallinity of PGA-PLA increase, degradation
: decrease.
: so, the degradation rate should be considered comprehensively.
|
w******z
发帖数: 29 | 5 牛人们总结一下吧，biomaterials and biodegradability mechanism. Thanks!
degradation |
c*******n
发帖数: 1648 | 6 You are right, PLA degradation is just hydrolysis, nothing to do with bio.... |
c*******n
发帖数: 1648 | 7 Interesting, Please give some detail about why a-PHB degrade slower than
i-PHB? As we all know the crystallinity is crucial for degradation rate at
least for
PLA. Maybe this difference is due to the different degradation mechanism?
degradation
【在 b***e 的大作中提到】
: 第二个说法不是很正确,我觉得
: amorphous phase are easier to be degraded, but
: pure amorphous phase can not be degraded
: i-PHB and a-PHB is a example of this.
: so , many factor must be considered.
|
b**s
发帖数: 589 | 8 PLGA and PHB are all gonna be phased out in the future (becuase they are
too expensive and have some deadly drawbacks), we are doing some new materials
instead,
【在 c*******n 的大作中提到】
: Interesting, Please give some detail about why a-PHB degrade slower than
: i-PHB? As we all know the crystallinity is crucial for degradation rate at
: least for
: PLA. Maybe this difference is due to the different degradation mechanism?
:
: degradation
|
c*w
发帖数: 50 | 9 Vert, M. etc. Biomaterials, 15, P1209, 1994 described the complexicity of
their degradation. |
b***e
发帖数: 115 | 10 PHB是酶降解的
a-PHB本身不能降截
但是和PMMA共混以后可以酶降解
我师兄有篇文章是关于这方面的
大分子上有的
i-PHB可以直接酶降解的
【在 c*******n 的大作中提到】
: Interesting, Please give some detail about why a-PHB degrade slower than
: i-PHB? As we all know the crystallinity is crucial for degradation rate at
: least for
: PLA. Maybe this difference is due to the different degradation mechanism?
:
: degradation
|
b***e
发帖数: 115 | 11 PLA sounds better than PHB
but, what are you doing ?
PLGA and PHB are all gonna be phased out in the future (becuase they are
too expensive and have some deadly drawbacks), we are doing some new materials
instead,
【在 b**s 的大作中提到】
: PLGA and PHB are all gonna be phased out in the future (becuase they are
: too expensive and have some deadly drawbacks), we are doing some new materials
: instead,
|
m***n
发帖数: 266 | 12 问题是PLGA有FDA许可，试验一种新的材料不是不可以，只是拿到FDA许可太花时间了吧。
boss觉得PLGA的deadly drawbacks在哪里呢？
materials
【在 b***e 的大作中提到】
: PLA sounds better than PHB
: but, what are you doing ?
:
: PLGA and PHB are all gonna be phased out in the future (becuase they are
: too expensive and have some deadly drawbacks), we are doing some new materials
: instead,
|
b**s
发帖数: 589 | 13 Acid generated through degradation of PLGA, I just speak from Tissue
engineering aspect. Most
people say that PLGA is popular only because it's FDA approved
。
【在 m***n 的大作中提到】
: 问题是PLGA有FDA许可，试验一种新的材料不是不可以，只是拿到FDA许可太花时间了吧。
: boss觉得PLGA的deadly drawbacks在哪里呢？
:
: materials
|
m***n
发帖数: 266 | 14 旧话重提。 关于温度。如果只有水解，我觉得当polymer is at a
temperatuer higher than its Tg, it should degrade faster as
it becomes more amorphous.
【在 b***e 的大作中提到】
: 我想应该是<37度
: 因为,降解的时候
: 酶必须有坐落点在高分子上,硬质的坐落点比较好
: PLA是比较好的降解材料
: 随着PLA的含量增大,降解速度变大应该不是很奇怪的现象吧
: 同时,PLA还有可能发生水解的,所以,因素很多吧
|
