b**s 发帖数: 589 | 1 现在作monodisperse PLGA
particle的方法都是什么?普通的solution-precipitation的方法很不可靠。Spray
drier太贵,且分布宽。超声的方法最小也只能做到20 um.
另外要得到5 um的particle怎么分级比较好,用过滤的方法效率很低,离心也不好 |
c*s 发帖数: 2145 | 2 microfluidics, huhu
【在 b**s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 现在作monodisperse PLGA : particle的方法都是什么?普通的solution-precipitation的方法很不可靠。Spray : drier太贵,且分布宽。超声的方法最小也只能做到20 um. : 另外要得到5 um的particle怎么分级比较好,用过滤的方法效率很低,离心也不好
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c*s 发帖数: 2145 | 3 I guess
好
【在 c*s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : microfluidics, huhu
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b**s 发帖数: 589 | 4 I saw some microfluidics like cytometry can do it, but the fasted speed is
10 per second @@
what if I need 1000000000000000000 particles?
好
【在 c*s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : microfluidics, huhu
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c*s 发帖数: 2145 | 5 simple, using 100000000000000000 microfluidics set up, then in second, you get
it :)
is
particle的方法都是什么?普通的solution-precipitation的方法很不可靠。Spray
不
【在 b**s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : I saw some microfluidics like cytometry can do it, but the fasted speed is : 10 per second @@ : what if I need 1000000000000000000 particles? : : 好
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c*******n 发帖数: 1648 | 6 I am a layman of bio stuffs, but how about phase separation method? For
example, say you got a median quality solvent for PLGA and their phase
diagram. You may manipulate conc.,temp, cosolvent, and other parameters of
kinetics of phase separation to get particle size that you want!
【在 b**s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : I saw some microfluidics like cytometry can do it, but the fasted speed is : 10 per second @@ : what if I need 1000000000000000000 particles? : : 好
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c*******n 发帖数: 1648 | 7 Or block copolymer system? to get well defined particle size and morphology?
After that, cleave one block off to get particles:)
【在 b**s 的大作中提到】![](/moin_static193/solenoid/img/up.png) : I saw some microfluidics like cytometry can do it, but the fasted speed is : 10 per second @@ : what if I need 1000000000000000000 particles? : : 好
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c*s 发帖数: 2145 | 8 HEHE, MONODISPERSITY
好
【在 c*******n 的大作中提到】![](/moin_static193/solenoid/img/up.png) : I am a layman of bio stuffs, but how about phase separation method? For : example, say you got a median quality solvent for PLGA and their phase : diagram. You may manipulate conc.,temp, cosolvent, and other parameters of : kinetics of phase separation to get particle size that you want!
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