b**s
发帖数: 589 | 1 现在作monodisperse PLGA
particle的方法都是什么？普通的solution-precipitation的方法很不可靠。Spray
drier太贵，且分布宽。超声的方法最小也只能做到20 um.
另外要得到5 um的particle怎么分级比较好，用过滤的方法效率很低，离心也不好 |
c*s
发帖数: 2145 | 2 microfluidics, huhu
【在 b**s 的大作中提到】
: 现在作monodisperse PLGA
: particle的方法都是什么？普通的solution-precipitation的方法很不可靠。Spray
: drier太贵，且分布宽。超声的方法最小也只能做到20 um.
: 另外要得到5 um的particle怎么分级比较好，用过滤的方法效率很低，离心也不好
|
c*s
发帖数: 2145 | 3 I guess
好
【在 c*s 的大作中提到】
: microfluidics, huhu
|
b**s
发帖数: 589 | 4 I saw some microfluidics like cytometry can do it, but the fasted speed is
10 per second @@
what if I need 1000000000000000000 particles?
好
【在 c*s 的大作中提到】
: microfluidics, huhu
|
c*s
发帖数: 2145 | 5 simple, using 100000000000000000 microfluidics set up, then in second, you get
it :)
is
particle的方法都是什么？普通的solution-precipitation的方法很不可靠。Spray
不
【在 b**s 的大作中提到】
: I saw some microfluidics like cytometry can do it, but the fasted speed is
: 10 per second @@
: what if I need 1000000000000000000 particles?
:
: 好
|
c*******n
发帖数: 1648 | 6 I am a layman of bio stuffs, but how about phase separation method? For
example, say you got a median quality solvent for PLGA and their phase
diagram. You may manipulate conc.,temp, cosolvent, and other parameters of
kinetics of phase separation to get particle size that you want!
【在 b**s 的大作中提到】
: I saw some microfluidics like cytometry can do it, but the fasted speed is
: 10 per second @@
: what if I need 1000000000000000000 particles?
:
: 好
|
c*******n
发帖数: 1648 | 7 Or block copolymer system? to get well defined particle size and morphology?
After that, cleave one block off to get particles:)
【在 b**s 的大作中提到】
: I saw some microfluidics like cytometry can do it, but the fasted speed is
: 10 per second @@
: what if I need 1000000000000000000 particles?
:
: 好
|
c*s
发帖数: 2145 | 8 HEHE, MONODISPERSITY
好
【在 c*******n 的大作中提到】
: I am a layman of bio stuffs, but how about phase separation method? For
: example, say you got a median quality solvent for PLGA and their phase
: diagram. You may manipulate conc.,temp, cosolvent, and other parameters of
: kinetics of phase separation to get particle size that you want!
|
