s*******y
发帖数: 11 | 1 【 以下文字转载自 Medicine 讨论区 】
发信人: seraphsky (六翼天使), 信区: Medicine
标 题: 急性白血病 求助
关键字: 急性白血病 T细胞
发信站: BBS 未名空间站 (Mon Dec 17 03:30:31 2012, 美东)
朋友的8岁男孩得了急性白血病（在国内）。下面的是他的具体信息。请问这样的处理
是不是合理？请大家多给些建议。代孩子谢谢大家了。
孩子刚开始淋巴结肿大，后发烧，血象白细胞高220,血小板也低，约61.骨穿显示，幼
稚细胞90%,免疫分型T淋巴细胞表达，预处理，强的松敏感，15天骨穿显示缓解还剩5%,
第三十三天显示缓解剩1%,请问问T细胞效果如何
现在要上第四个疗程，医生说他是T淋巴细胞白血病，无法做微小残留检测，不知是否
这样？骨髓细胞检查：粒系增生受抑，占4%,红系增生受抑占1%,淋巴细胞增生极度活跃
，幼稚细胞占90%，该细胞圆形，染色质粗糙，细胞浆量少，蓝色。全片巨核细胞少见
，血小松小簇状可见。POX染色：阴性。PAS染色：阳性46%(阳性物块状、颗粒状）。免
疫分型示T淋系表达.
染色体：46,Xy,29种基因多重PCR阴性。泼尼松预处理，示敏感，第十五天骨穿检查：
幼稚细胞占5%,第三十三天骨穿检查：幼稚细胞占1%，骨髓达完全缓解，行下一疗程化
疗。 | s*****e
发帖数: 404 | 2 Pediatric ALL has better prognosis than adult ALL, cure rate is approximate
80%. I guess the reason that no minimal residue disease can be detected is
because the report mentioned that PCR was negative for 29 genes. FISH study
was not mentioned in the report; some specific chromosome translocations are
very important for prognosis.
Day 33 bone marrow showed no excess blasts (<2%) indicating good treatment
response. ALL usually needs 2-3 years of maintenance therapy. I think
continuing chemotherapy is the right step. I have not treated any pediatric
ALL patients. Above is just my two cents.
Good luck to the kid! | s*******y
发帖数: 11 | 3 非常感谢您的解答，给我们曾强了战胜病魔的信心。
请问这里有没有类似的网站我们可以多了解一下的？
多谢了
approximate
study
are
pediatric
【在 s*****e 的大作中提到】
: Pediatric ALL has better prognosis than adult ALL, cure rate is approximate
: 80%. I guess the reason that no minimal residue disease can be detected is
: because the report mentioned that PCR was negative for 29 genes. FISH study
: was not mentioned in the report; some specific chromosome translocations are
: very important for prognosis.
: Day 33 bone marrow showed no excess blasts (<2%) indicating good treatment
: response. ALL usually needs 2-3 years of maintenance therapy. I think
: continuing chemotherapy is the right step. I have not treated any pediatric
: ALL patients. Above is just my two cents.
: Good luck to the kid!
| A*******s
发帖数: 9638 | 4 Nice answer, many thanks to stareee.
approximate
study
are
pediatric
【在 s*****e 的大作中提到】
: Pediatric ALL has better prognosis than adult ALL, cure rate is approximate
: 80%. I guess the reason that no minimal residue disease can be detected is
: because the report mentioned that PCR was negative for 29 genes. FISH study
: was not mentioned in the report; some specific chromosome translocations are
: very important for prognosis.
: Day 33 bone marrow showed no excess blasts (<2%) indicating good treatment
: response. ALL usually needs 2-3 years of maintenance therapy. I think
: continuing chemotherapy is the right step. I have not treated any pediatric
: ALL patients. Above is just my two cents.
: Good luck to the kid!
| s*****e
发帖数: 404 | 5 http://www.lls.org/
http://www.lls.org/content/nationalcontent/resourcecenter/freee
【在 s*******y 的大作中提到】
: 非常感谢您的解答，给我们曾强了战胜病魔的信心。
: 请问这里有没有类似的网站我们可以多了解一下的？
: 多谢了
:
: approximate
: study
: are
: pediatric
| s*******y
发帖数: 11 | |
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