l*****7
发帖数: 8463 | 1 发信人: tuc72416 (FindingNemo), 信区: Biology
标 题: 同一个作者同一个杂志一次撤稿19篇
发信站: BBS 未名空间站 (Fri Oct 28 09:31:33 2016, 美东)
http://retractionwatch.com/2016/10/21/cancer-researcher-retracts-19-studies-at-once/ | l*****7
发帖数: 8463 | 2 Cancer researcher retracts 19 studies at once
with 23 comments
jcheng
Jin Cheng
A former cancer biologist at the Moffitt Cancer Center in Tampa, Florida has
retracted 19 papers from a single journal.
Jin Cheng, who studies how ovarian cancer develops, withdrew 19 papers from
the Journal of Biological Chemistry originally published over the last 15
years, and corrected another. All of the retractions are for image
manipulation.
For example, here’s the notice for “Activation of phosphatidylinositol 3-
kinase/Akt pathway by androgen through interaction of p85α, androgen
receptor, and Src,” a paper originally published in 2003:
This article has been withdrawn by the authors. The same data were used to
represent different experimental conditions. Specifically, lanes 1–3 of the
H2B panel of Fig. 4Bwere reused in lanes 1–3 of the H2B panel from Fig. 6B
. Lanes 1 and 6 of the phospho-Akt panel from Fig. 4C were duplicated. Lanes
3 and 4 of the lower FLAG panel in Fig. 4Cwere reused in lanes 7 and 8 of
the lower FLAG panel in Fig. 5A. The PI(3,4)P2 spots from lanes 1 and 2 from
Fig. 7 were reused in lanes 7 and 8 of the same panel. Additionally, some
PI(4)P1 spots were pasted in. The authors state that the overall conclusions
of this work are not affected.
Cheng has been awarded multiple NIH R01 grants, totaling millions of dollars
, according to NIH RePORTER. A person answering the phone number listed for
Cheng’s lab said he had retired. The email address listed on many of his
papers bounced.
Here are the 19 retractions:
Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through
interaction of p85α, androgen receptor, and Src, cited 125 times, according
to Clarivate Analytics’ Web of Science, formerly part of Thomson Reuters.
Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle
progression, cited 23 times
Akt attenuation of the serine protease activity of HtrA2/Omi through
phosphorylation of serine 212, cited 30 times
Molecular cloning and characterization of the human AKT1 promoter uncovers
its up-regulation by the Src/Stat3 pathway, cited 36 times
ArgBP2γ interacts with Akt and p21-activated kinase-1 and promotes cell
survival, cited 24 times
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis
protein (XIAP), cited 298 times
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by
phosphorylation of ASK1. IMPLICATION OF AKT2 IN CHEMORESISTANCE, cited 158
times
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor
suppressor complex by phosphorylation of tuberin, cited 289 times
Inhibition of JNK by cellular stress- and tumor necrosis factor α-induced
AKT2 through activation of the NFκB pathway in human epithelial cells,
cited 37 times
Positive feedback regulation between Akt2 and MyoD during muscle
differentiation. CLONING OF Akt2 PROMOTER, cited 42 times
MicroRNA MiR-214 regulates ovarian cancer cell stemness by targeting p53/
Nanog, cited 57 times
Identification of Akt interaction protein PHF20/TZP that transcriptionally
regulates p53, cited 11 times
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/
PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant
transformation, cited 52 times
Phosphorylation and activation of androgen receptor by Aurora-A, cited 18
times
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by
targeting FOXO3a in breast cancer, cited 181 times
A small molecule inhibits Akt through direct binding to Akt and preventing
Akt membrane translocation, cited 33 times
IKKϵ phosphorylation of estrogen receptor α Ser-167 and contribution
to tamoxifen resistance in breast cancer, cited 35 times
Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling
through phosphorylation of threonine 120, cited 49 times
MicroRNA-221/222 negatively regulates estrogen receptor α and is associated
with tamoxifen resistance in breast cancer, cited 302 times
The current issue of the JBC also includes a correction of one of Cheng’s
papers, “Long non-coding RNAs (LncRNA) regulated by transforming growth
factor (TGF) β. LncRNA-HIT-MEDIATED TGF-INDUCED EPITHELIAL TO MESENCHYMAL
TRANSITION IN MAMMARY EPITHELIA,” a study that has been cited 17 times.
Update, 11 p.m. Eastern, 10/21/16: Moffitt gave us the following statement:
Moffitt Cancer Center adheres to the highest ethical standards in both
research and clinical care. Moffitt has collaborated with the Journal of
Biological Chemistry to resolve this issue, and review of this matter is
ongoing. Patient care, safety or protocols were not affected in any way.
And University of South Florida Health, with whom the Moffitt is affiliated,
said:
Jin Q. Cheng is not a paid USF Health faculty member. We are unaware of any
investigations at USF regarding his work.
As of today he still holds a courtesy appointment with USF Health. However,
USF reserves the right to address any concerns regarding courtesy
appointments at its discretion.
We will look into this matter to determine if any action if necessary. | c****3
发帖数: 10787 | 3 生物不造假的没几个，以为别人看不出么？
区别是，造假水平高的，装成无意造假，是失误，或者推到学生头上。
造假水平低的，才会被抓住证据。 | l*****7
发帖数: 8463 | 4 还是体制问题
科研本来就是让那些每天酒饱饭足， 无忧无虑，具有好奇心，不缺钱，而又想探索解
惑的人干的。
现在的情况完全不同：tenaure－track造成的压力很大，必需大量灌水拿房顶才能不败
吃香喝辣。生物研究造假已成大问题了。
所以灌水论文，无论多少，都是废物，不能作为进职和拿房顶的依据。
【在 c****3 的大作中提到】
: 生物不造假的没几个，以为别人看不出么？
: 区别是，造假水平高的，装成无意造假，是失误，或者推到学生头上。
: 造假水平低的，才会被抓住证据。
| l*****7
发帖数: 8463 | 5 还有一个著名阿三, 在Duke大学是造假骗钱大王，已经被揭穿。 | c****3
发帖数: 10787 | 6 体制是一方面，另一方面生物的东西本来就特别难。
生物就是逆向工程，好多人还不肯承认，因为承认了就是和达尔文过不去。
这么难的东西逆向工程，技术还和人类的完全不一样，方向错一点就彻底玩完，还有那
么多思维混乱，搞不清自己是在做基础科学还是逆向工程的。
所以你们肯定好多人搞了几年，发现根本不对，只能铤而走险了。
【在 l*****7 的大作中提到】
: 还是体制问题
: 科研本来就是让那些每天酒饱饭足， 无忧无虑，具有好奇心，不缺钱，而又想探索解
: 惑的人干的。
: 现在的情况完全不同：tenaure－track造成的压力很大，必需大量灌水拿房顶才能不败
: 吃香喝辣。生物研究造假已成大问题了。
: 所以灌水论文，无论多少，都是废物，不能作为进职和拿房顶的依据。
| a***e
发帖数: 27968 | 7 老中连做骗子级别都赶不上老印，太失败了
【在 l*****7 的大作中提到】
: 发信人: tuc72416 (FindingNemo), 信区: Biology
: 标 题: 同一个作者同一个杂志一次撤稿19篇
: 发信站: BBS 未名空间站 (Fri Oct 28 09:31:33 2016, 美东)
: http://retractionwatch.com/2016/10/21/cancer-researcher-retracts-19-studies-at-once/
| a*******m
发帖数: 14194 | 8 挖美帝的墙角呀，一个人顶十个董存瑞。
【在 a***e 的大作中提到】
: 老中连做骗子级别都赶不上老印，太失败了
| u****q
发帖数: 24345 | | f******t
发帖数: 19544 | |
|
