q***g
发帖数: 1 | 1 磷酸氯喹（Chloroquine）于上个世纪40年代起用于治疗疟疾，后用于治疗类风湿性关
节炎等。 | q***g
发帖数: 1 | | k**********4
发帖数: 16092 | 3 你为什么要哗众取宠造谣惑众？
【在 q***g 的大作中提到】
: 要屯一点这个老药啊，同志们！
| q***g
发帖数: 1 | 4 我没造谣啊。
【在 k**********4 的大作中提到】
: 你为什么要哗众取宠造谣惑众？
| N**********d
发帖数: 2466 | 5 这种体外结果没有太大意义。比如我拿硝酸体外浸泡肿瘤细胞，杀得死死的，人能喝么？
沒有临床数据就是耍流氓
【在 q***g 的大作中提到】
: 我没造谣啊。
| q******g
发帖数: 3858 | 6 Chloroquine is a lysosomotropic agent that prevents endosomal acidification
[1]. It accumulates inside the acidic parts of the cell, including
endosomes and lysosomes.
This accumulation leads to inhibition of lysosomal enzymes that require an
acidic pH, and prevents fusion of endosomes and lysosomes.
Chloroquine is commonly used to study the role of endosomal acidification in
cellular processes [2, 3], such as the signaling of intracellular TLRs.
Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH,
which leads to inhibition of both fusion of autophagosome with lysosome and
lysosomal protein degradation |
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