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发帖数: 16092 | 1 1. We know what it is
The first cases of AIDS were described in June 1981 and it took more than
two years to identify the virus (HIV) causing the disease. With COVID-19,
the first cases of severe pneumonia were reported in China on December 31,
2019 and by January 7 the virus had already been identified. The genome was
available on day 10. We already know that it is a new coronavirus from group
2B, of the same family as the SARS, which we have called SARSCoV2. The
disease is called COVID-19. It is thought to be related to coronavirus of
bats. Genetic analyses have confirmed that it has a recent natural origin (
between the end of November and the beginning of December) and that,
although viruses live by mutating, its mutation rate may not be very high.
2. We know how to detect the virus
Since January 13, a test to detect the virus has been available.
3. The situation is improving in China
The strong control and isolation measures imposed by China are paying off.
For several weeks now, the number of cases diagnosed every day is decreasing
. A very detailed epidemiological follow-up is being carried out in other
countries; outbreaks are very specific to areas, which can allow them to be
controlled more easily.
4. 80% of cases are mild
The disease causes no symptoms or is mild in 81% of cases. Of course, in the
remaining 14%, it can cause severe pneumonia and in 5% it can become
critical or even fatal. It is still unclear what the death rate may be. Be
it could be lower than some estimates so far.
5. People heal
Much of the reported data relates to the increase in the number of confirmed
cases and the number of deaths, but most infected people are cured. There
are 13 times more cured cases than deaths, and that proportion is increasing.
coronavirus covid-19 health cases
The green line shows the total number of recovered patients
Image: Johns Hopkins University
6. Symptoms appear mild in children
Only 3% of cases occur in people under 20, and mortality under 40 is only 0.
2%. Symptoms are so mild in children that it can go unnoticed.
7. The virus can be wiped clean
The virus can be effectively inactivated from surfaces with a solution of
ethanol (62-71% alcohol), hydrogen peroxide (0.5% hydrogen peroxide) or
sodium hypochlorite (0.1% bleach), in just one minute. Frequent handwashing
with soap and water is the most effective way to avoid contagion.
8. Science is on it, globally
It is the age of international science cooperation. After just over a month,
164 articles could be accessed in PubMed on COVID19 or SARSCov2, as well as
many others available in repositories of articles not yet reviewed. They
are preliminary works on vaccines, treatments, epidemiology, genetics and
phylogeny, diagnosis, clinical aspects, etc. These articles were elaborated
by some 700 authors, distributed throughout the planet. It is cooperative
science, shared and open. In 2003, with the SARS epidemic, it took more than
a year to reach less than half that number of articles. In addition, most
scientific journals have left their publications as open access on the
subject of coronaviruses.
9. There are already vaccine prototypes
Our ability to design new vaccines is spectacular. There are already more
than eight projects underway seeking a vaccine against the new coronavirus.
There are groups that work on vaccination projects against similar viruses.
The vaccine group of the University of Queensland, in Australia, has
announced that it is already working on a prototype using the technique
called “molecular clamp”, a novel technology. This is just one example
that could allow vaccine production in record time. Prototypes may soon be
tested on humans.
10. Antiviral trials are underway
Vaccines are preventive. Right now, the treatment of people who are already
sick is important. There are already more than 80 clinical trials analysing
coronavirus treatments. These are antivirals that have been used for other
infections, which are already approved and that we know are safe.
One of those that has already been tested in humans is remdesivir, a broad-
spectrum antiviral still under study, which has been tested against Ebola
and SARS/MERS.
Another candidate is chloroquine, an antimalarial that has also been seen to
have potent antiviral activity. It is known that chloroquine blocks viral
infection by increasing the pH of the endosome, which is needed for the
fusion of the virus with the cell, thus inhibiting its entry. It has been
demonstrated that this compound blocks the new coronavirus in vitro and it
is already being used in patients with coronavirus pneumonia.
Other proposed trials are based on the use of oseltamivir (which is used
against the influenza virus), interferon-1b (protein with antiviral function
), antisera from people who recovered or monoclonal antibodies to neutralise
the virus. New therapies have been proposed with inhibitory substances,
such as baricitinibine, selected by artificial intelligence.
The 1918 flu pandemic caused more than 25 million deaths in less than 25
weeks. Could something similar happen now? Probably not; we have never been
better prepared to fight | q****5
发帖数: 1660 | | C*********e
发帖数: 1 | 3 确实
【在 q****5 的大作中提到】
: 用处不大，前段时间黑中国，看笑话过头了
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