W*****B
发帖数: 4796 | 1 Scientists Are Testing Nitric Oxide to Treat Coronavirus Patients
Scientists in Massachusetts, Italy, and elsewhere are experimenting with a
familiar medical treatment for the new problem of covid-19. They’ve begun
clinical trials meant to find out whether inhaled nitric oxide can save
people who are severely sick from the new coronavirus. This treatment might
even be used preventatively to keep health care workers infection-free.
Nitric oxide, or NO, is a key part of our biology (and not to be confused
with nitrous oxide, aka N2O or laughing gas). It helps our blood vessels
dilate, speeding up blood and oxygen flow around the body. For decades,
nitric oxide has also been repurposed by doctors to relieve blood pressure
in the pulmonary arteries of oxygen-deprived patients whose lungs have
failed. These clotted arteries make it harder for the lungs to process
oxygen, even when it’s being supplied by a ventilator. This use of nitric
oxide was first tested out in blue-faced newborns in the 1990s, becoming an
FDA-approved therapy in 1999; it’s since been expanded to other groups of
patients.
“About a half-million Americans have breathed in NO. Mainly adults with
cardiac surgery and various things and, of course, 30,000 babies a year,”
Warren Zapol, the emeritus anesthetist-in-chief at Massachusetts General
Hospital and a professor at Harvard Medical School, told Gizmodo by phone
this week.
Many people who contract covid-19 suffer no more than a bad cold, but severe
cases can develop acute respiratory distress syndrome (ARDS), a frightening
and deadly condition. The lungs of people with ARDS become flooded with
leaked bodily fluid, cutting off their oxygen supply and effectively
drowning them. Though interventions like invasive ventilation can save
someone with ARDS, it remains a grim prognosis, as septic shock and organ
failure often follow. ARDS isn’t just risky for covid-19 patients, either—
the needed life-saving interventions can expose health care workers to
concentrated, aerosolized doses of virus from a patient.
“This is primarily, first, a lung injury. We all know that. But if you don
’t stop it, it will get to your heart, your liver, the rest of your organs,
and kill you,” said Zapol.
Nitric oxide is already used as a “rescue therapy” for ARDS cases where
people are unable to get enough oxygen through a ventilator. So Zapol and
his colleagues reason that NO could be used for difficult covid-19 cases,
too. But it’s not just the crucial boost to lung function that has Zapol
and his colleagues interested in this treatment.
Nearly two decades ago, scientists in China found evidence that suggested
the gas itself could kill or inhibit the growth of the SARS coronavirus in
patients, while other scientists found the same pattern in the lab. Because
covid-19 is caused by a coronavirus closely related to SARS, called
appropriately SARS-COV-2, they’re hoping this same trick will work against
it.
Zapol and colleagues have begun two randomized, controlled clinical trials
at Massachusetts General Hospital. One will involve covid-19 patients
already dealing with severe respiratory distress; the other will involve
patients with mild to moderate covid-19. In both trials, the hope is that
nitric oxide can stop things from getting worse.
Another trial they hope to get approved and underway would actually test
whether nitric oxide can help protect the medical staff treating these
patients. Zapol’s team theorizes that you can dose health care workers with
nitric oxide before and after their shifts so that the virus has a harder
time infecting them. Though they would temporarily have lower oxygen levels
as a result, in theory they should be able to function and work normally.
“I hate seeing doctors and nurses becoming covid-19 positive. I hate it,”
Zapol said. “So we’ll hopefully see if we can prevent health care workers
from going positive.”
Any potential treatment for covid-19, no matter how useful it’s been for
other conditions, will have to go through the ringer of clinical trials
before it should be widely used. But Zapol’s team is already working with
researchers in Italy and China to test out nitric oxide in patients there,
as part of a longstanding collaboration between the groups. So if it does
work, we’ll have more than one line of evidence to prove it.
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Subscribe | s*****n
发帖数: 1998 | 2 一氧化碳比一氧化氮疗效更好, 见效更快
might
【在 W*****B 的大作中提到】
: Scientists Are Testing Nitric Oxide to Treat Coronavirus Patients
: Scientists in Massachusetts, Italy, and elsewhere are experimenting with a
: familiar medical treatment for the new problem of covid-19. They’ve begun
: clinical trials meant to find out whether inhaled nitric oxide can save
: people who are severely sick from the new coronavirus. This treatment might
: even be used preventatively to keep health care workers infection-free.
: Nitric oxide, or NO, is a key part of our biology (and not to be confused
: with nitrous oxide, aka N2O or laughing gas). It helps our blood vessels
: dilate, speeding up blood and oxygen flow around the body. For decades,
: nitric oxide has also been repurposed by doctors to relieve blood pressure
| L*********s
发帖数: 3063 | | v**e
发帖数: 8422 | 4 是说小留喜欢的气球麽
might
【在 W*****B 的大作中提到】
: Scientists Are Testing Nitric Oxide to Treat Coronavirus Patients
: Scientists in Massachusetts, Italy, and elsewhere are experimenting with a
: familiar medical treatment for the new problem of covid-19. They’ve begun
: clinical trials meant to find out whether inhaled nitric oxide can save
: people who are severely sick from the new coronavirus. This treatment might
: even be used preventatively to keep health care workers infection-free.
: Nitric oxide, or NO, is a key part of our biology (and not to be confused
: with nitrous oxide, aka N2O or laughing gas). It helps our blood vessels
: dilate, speeding up blood and oxygen flow around the body. For decades,
: nitric oxide has also been repurposed by doctors to relieve blood pressure
| n*********7
发帖数: 4682 | 5 笑气是n2o, no是血管扩张剂，能让鸡鸡充血滴，也能让肺动脉扩张降低肺动脉压(新冠
病人肺动脉压高）
猥琐男p都不懂 | m***n
发帖数: 12188 | |
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