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发帖数: 712 | 1 The remarkable speed with which biotechnology has become critical to
the practice of life science owes much to a series of technological revolutio
ns. Molecular biologists started the process in the mid-1970s,
when they developed molecular cloning and DNA sequencing. Five years later, a
utomated DNA sequencing took the world of biotechnology by storm, with
its distant promise of making it possible to sequence the entire human
genome. The development of reliable automated sequencing techniques ma | w***g
发帖数: 712 | 2 The PotentiaL of Microarray AnaLysis
The future contains even more promise. "Microarray technology will be as revo
lutionary to life science research as PCR technology, with an even bigger mar
ket potential," says Walter Tian, business development manager in charge of m
icroarrays at Boston-based NEN Life Sci- ence Products. "Our own analysis and
that of others suggest that this market can go over $1 billion in five years,
including chips, other con- sumables, and instruments. We're talking abou | w***g
发帖数: 712 | 3 Using Microarrays
Identifying drug targets provided the initial mar- ket for the microarrays. A
good drug target has extraordinary value for developing pharmaceuti- cals. By
comparing the ways in which genes are expressed in a normal and diseased hear
t, for example, scientists might be able to identify the genes - and hence th
e associated proteins - that are part of the disease process. Researchers cou
ld then use that information to synthesize drugs that interact with these pro
teins, thus re |
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