a****y
发帖数: 1035 | 1 【 以下文字转载自 Biology 讨论区 】
发信人: dcsj (DCSJ), 信区: Biology
标 题: 乙肝受体的文章出来了，没有大牛来评评？
发信站: BBS 未名空间站 (Tue Nov 13 16:49:48 2012, 美东)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485615/
Sodium taurocholate cotransporting polypeptide is a functional receptor for
human hepatitis B and D virus
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a
major public health problem. Individuals coinfected with its satellite
hepatitis D virus (HDV) have more severe disease. Cellular entry of both
viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large
envelope protein is a key determinant for receptor(s) binding. However, the
identity of the receptor(s) is unknown. Here, by using near zero distance
photo-cross-linking and tandem affinity purification, we revealed that the
receptor-binding region of pre-S1 specifically interacts with sodium
taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane
transporter predominantly expressed in the liver. Silencing NTCP inhibited
HBV and HDV infection, while exogenous NTCP expression rendered
nonsusceptible hepatocarcinoma cells susceptible to these viral infections.
Moreover, replacing amino acids 157–165 of nonfunctional monkey NTCP with
the human counterpart conferred its ability in supporting both viral
infections. Our results demonstrate that NTCP is a functional receptor for
HBV and HDV. | g*******r
发帖数: 129 | 2 光这个带受体功能的蛋白似乎不足以解释为什么亚非洲人易染HBV,而白人则不.
for
large
【在 a****y 的大作中提到】
: 【 以下文字转载自 Biology 讨论区 】
: 发信人: dcsj (DCSJ), 信区: Biology
: 标 题: 乙肝受体的文章出来了，没有大牛来评评？
: 发信站: BBS 未名空间站 (Tue Nov 13 16:49:48 2012, 美东)
: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485615/
: Sodium taurocholate cotransporting polypeptide is a functional receptor for
: human hepatitis B and D virus
: Human hepatitis B virus (HBV) infection and HBV-related diseases remain a
: major public health problem. Individuals coinfected with its satellite
: hepatitis D virus (HDV) have more severe disease. Cellular entry of both
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