G***a
发帖数: 27294 | 1 好的话，我就去听了, 这是Vice Chancellor invite的讲座。。。 suppose是good
research
Erin E. Kershaw, MD, assistant professor of medicine, School of Medicine
“Lipolysis in Metabolic Syndrome: Beyond Adipose Tissue.”
Topic Overview:
Obesity and metabolic syndrome are global health threats. Insulin resistance
and metabolic complications of obesity are strongly associated with
intracellular accumulation of triacylglycerol (TG); however, the mechanisms
underlying TG accumulation and its relationship to lipid-induced toxic
metabolic effects (lipotoxicity) remain unclear.
Protection against lipotoxicity requires a carefully regulated balance
between triglyceride synthesis and hydrolysis. Adipose triglyceride lipase (
ATGL) was recently identified as the rate-limiting enzyme mediating TG
hydrolysis and is, therefore, a critical determinant of storage/production
of toxic, as well as essential, lipid metabolites. Nevertheless, ATGL’s
role in these processes, particularly in nonadipose tissues in which ATGL is
also expressed, remains poorly understood.
Kershaw has demonstrated that: (1) ATGL is expressed, highly regulated, and
functionally relevant in adipose and nonadipose tissues and (2) modulation
of ATGL-mediated TG hydrolysis influences lipid and glucose homeostasis in
vitro and in vivo in a tissue/cell type-specific manner.
Emerging evidence indicates that ATGL-mediated TG hydrolysis may
preferentially direct lipids toward oxidation via peroxisome proliferator-
activated receptor alpha (PPARα)-dependent mechanisms, suggesting that
therapeutic activation of ATGL may improve tissue-specific and systemic
lipid homeostasis. In this seminar, Kershaw will review how the
identification of ATGL has led to a drastic revision of the traditional
model of lipolysis, how ATGL-mediated TG hydrolysis influences lipid and
glucose homeostasis in a tissue-specific manner, and how these findings
might influence human disease. | f*******4
发帖数: 116 | | G***a
发帖数: 27294 | 3 那是ｆａｓｈｉｏｎ版～～
【在 f*******4 的大作中提到】
: 不是说不让版上隔空喊话？
| w********6
发帖数: 12977 | | a***a
发帖数: 40617 | 5 看上去不错啊
resistance
mechanisms
【在 G***a 的大作中提到】
: 好的话，我就去听了, 这是Vice Chancellor invite的讲座。。。 suppose是good
: research
: Erin E. Kershaw, MD, assistant professor of medicine, School of Medicine
: “Lipolysis in Metabolic Syndrome: Beyond Adipose Tissue.”
: Topic Overview:
: Obesity and metabolic syndrome are global health threats. Insulin resistance
: and metabolic complications of obesity are strongly associated with
: intracellular accumulation of triacylglycerol (TG); however, the mechanisms
: underlying TG accumulation and its relationship to lipid-induced toxic
: metabolic effects (lipotoxicity) remain unclear.
| G***a
发帖数: 27294 | 6 好，有时间去听听看
【在 a***a 的大作中提到】
: 看上去不错啊
:
: resistance
: mechanisms
|
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