a*******g
发帖数: 2813 | 1 DESCRIPTION OF Traditional Chinese Medicine
Course Name: Traditional Chinese Medicine
Theory Hours: 40 (1 semesters)
Clinical Hours: 40
Objectives:
This course is very foundation of Traditional Chinese Medicine, mainly
focuses on fundamental principles, theory knowledge and diagnostics skills
of Traditional Chinese Medicine. This course is designed to introduce
Chinese medical theories and clinical uses, help users learn basic concepts
in Chinese diagnostics such as diagnosis, symptoms, patterns... 阅读全帖 |
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a*******g
发帖数: 2813 | 2 DESCRIPTION OF Traditional Chinese Medicine
Course Name: Traditional Chinese Medicine
Theory Hours: 40 (1 semesters)
Clinical Hours: 40
Objectives:
This course is very foundation of Traditional Chinese Medicine, mainly
focuses on fundamental principles, theory knowledge and diagnostics skills
of Traditional Chinese Medicine. This course is designed to introduce
Chinese medical theories and clinical uses, help users learn basic concepts
in Chinese diagnostics such as diagnosis, symptoms, patterns... 阅读全帖 |
|
m*****n
发帖数: 5245 | 3 Amgen to Cut Up to 2,600 Jobs
Wednesday August 15, 4:20 pm ET
NEW YORK (AP) -- Biotechnology company Amgen Inc. said late Wednesday it
will cut up to 2,600 jobs and lowering profit guidance because of lower than
expected sales of its anemia drug Aranesp.
The company said it plans to reduce its work force by 12 percent to 14
percent, or between 2,200 and 2,600 positions and will get hit with a
restructuring charge between $600 million and $700 million. Amgen also
reduced its adjusted earnings pe |
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v******V
发帖数: 314 | 4 ☆─────────────────────────────────────☆
mandman (Man Law) 于 (Wed Aug 15 16:35:37 2007) 提到:
Amgen to Cut Up to 2,600 Jobs
Wednesday August 15, 4:20 pm ET
NEW YORK (AP) -- Biotechnology company Amgen Inc. said late Wednesday it
will cut up to 2,600 jobs and lowering profit guidance because of lower than
expected sales of its anemia drug Aranesp.
The company said it plans to reduce its work force by 12 percent to 14
percent, or between 2,200 and 2,600 positions and will get hit with a
restruc |
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G**********n
发帖数: 973 | 5 September 30, 2008, 8:34 am
Pfizer to Cut R&D Jobs, Retreat from Heart-Drug Research
Posted by Jacob Goldstein
In its ongoing struggle to re-invent itself, Pfizer’s going to announce
today that it’s cutting R&D staff and largely getting out of the business
of making new medicines for heart disease, the WSJ reports.
It’s also largely bailing on research in anemia, osteoporosis, liver
disease, muscle disease, obesity, and peripheral artery disease, Forbes
reports, citing a memo from Pfizer R&D chi |
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b**u
发帖数: 2761 | 6 【 以下文字转载自 Missouri 讨论区 】
发信人: Geisha (朔风如解意 容易莫摧残), 信区: Missouri
标 题: zz Amgen to Buy Onyx for $10.4 Billion
发信站: BBS 未名空间站 (Mon Aug 26 12:22:52 2013, 美东)
Although Amgen is the world’s biggest biotechnology company, the drug maker
has been mostly absent from one of the industry’s biggest and fastest-
growing markets: cancer drugs.
It took a big step to fix that on Sunday, agreeing to buy Onyx
Pharmaceuticals for about $10.4 billion in cash to gain access to the
company’s three anticancer treatm... 阅读全帖 |
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f****o
发帖数: 2770 | 7 GENERAL PRINCIPLES
The first step in managing chronic HF is to determine the etiology or
precipitating factors. Treatment of underlying disorders (e.g., anemia,
hyperthyroidism) may obviate the need for treatment of HF.
Nonpharmacologic interventions include cardiac rehabilitation and
restriction of fluid intake (maximum 2 L/day from all sources) and dietary
sodium (approximately 1.5 to 2 g of sodium per day).
Stage A: The emphasis is on identifying and modifying risk factors to
prevent developm |
|
f****o
发帖数: 2770 | 8 GENERAL PRINCIPLES
The first step in managing chronic HF is to determine the etiology or
precipitating factors. Treatment of underlying disorders (e.g., anemia,
hyperthyroidism) may obviate the need for treatment of HF.
Nonpharmacologic interventions include cardiac rehabilitation and
restriction of fluid intake (maximum 2 L/day from all sources) and dietary
sodium (approximately 1.5 to 2 g of sodium per day).
Stage A: The emphasis is on identifying and modifying risk factors to
prevent developm... 阅读全帖 |
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f****o
发帖数: 2770 | 9 复习时间：2.5 weeks
复习材料：protonpass, APhA book, miscellaneous
感觉：考下来感觉难度一般。个别问题觉得没有正确答案，个别问题完全不知道怎么答
。大部分问题还是有底的。
考的范围很广，我的考卷涉及到的题目有：
math 10%(网上有人说会占30%,可能他们错太多，所以naplex系统给他们题目直到做对
为止吧), prescription evaluation, compounding, kinetics, biostatics, heart
failure, arrhythmia, hypertension, anticoagulation, lipids, diabetes,
endocrine, women's health, ADHD, asthma/COPD, ESRD, seizure, oncology
supportive care, basic HIV, opportunitic infection, ID, lots of IDs,
nutrition, electrolytes, gout, GI, pain, p... 阅读全帖 |
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b**o
发帖数: 5769 | 10 ☆─────────────────────────────────────☆
fiorio (那朵花~一定还在某个地方盛开着~) 于 (Sun Jul 8 01:26:21 2012, 美东) 提到:
复习时间：2.5 weeks
复习材料：protonpass, APhA book, miscellaneous
感觉：考下来感觉难度一般。个别问题觉得没有正确答案，个别问题完全不知道怎么答
。大部分问题还是有底的。
考的范围很广，我的考卷涉及到的题目有：
math 10%(网上有人说会占30%,可能他们错太多，所以naplex系统给他们题目直到做对
为止吧), prescription evaluation, compounding, kinetics, biostatics, heart
failure, arrhythmia, hypertension, anticoagulation, lipids, diabetes,
endocrine, women's health, ADHD, asthma/COPD, ESRD, seizure, oncology
sup... 阅读全帖 |
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c****m
发帖数: 626 | 11 ann2008
看很多人问这个考的多不多，那个多不多，每个人的考试侧重点会完全不一样，fioro&
#8232;计算和药物反应不多，不代表你不会被考到。我的计算就很多，也不代表你错的
多，如
果看bulletin,计算的比例就很高，而且好几道TPN的。主要作为一个参
考，而不是复习
的指南。我还被考到几题一样的，我确定我答的是对的，所以
也不要freak out。
我的最后也有profile的题目。
HIV也被考到了
brand 和generic，所以什么都可能考，不过NAPLEX就是一个minimum
competency的考试，大家肯定没问题的。
PhDPharmD
刚刚查了naplex分数，过了，分数居然还不错。 考完觉得要fail了。我的考题是rare
diseases，rare drug names and dosage forms 占据的了整个考试。其他的常
见的东
西也都有，但是都是蜻蜓点水的考一下，一两题的样子。计算也不多。
虽然我没好好复
习，只是看了常见的内容，但... 阅读全帖 |
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a*******n
发帖数: 82 | 12 They are all valuable points!
She was given Zofran, Phenergan and compazine in the other hospital.
MRI of brain was done for evaluation of severe nausea.
For her PMH/PSH, significant for iron-deficiency anemia, treated with iron
supplements in the past; HTN; DLP; h/o C. diff colitis 6 months ago; pAF
with RVR 8 months ago; yearly normal mammogram; normal colonoscopy 3 years
ago; chronic lymphedema from lower extremities; lung nodule with stable CT
followup. She was on dig, amiodarone, coumadin, ... 阅读全帖 |
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I****a
发帖数: 407 | 13 That is exactly my next guess for old female with anemia and renal failure.
She could have amyloid affecting her heart as well as autonomic nerve
contributing nausea. |
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A*******s
发帖数: 9638 | 14 I thought you were vaporized. Congratulations for the right treatment prior
to the diagnosis. And yes, you deserve another internship. lol.
It was a good search for the causes of anemia.
I have a question:
Why do you think she was so nauseated? It doesn't seem to me the lymphoma
invaded the gut although it is possible and GI should be able to catch it. |
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a*******n
发帖数: 82 | 15 They are all valuable points!
She was given Zofran, Phenergan and compazine in the other hospital.
MRI of brain was done for evaluation of severe nausea.
For her PMH/PSH, significant for iron-deficiency anemia, treated with iron
supplements in the past; HTN; DLP; h/o C. diff colitis 6 months ago; pAF
with RVR 8 months ago; yearly normal mammogram; normal colonoscopy 3 years
ago; chronic lymphedema from lower extremities; lung nodule with stable CT
followup. She was on dig, amiodarone, coumadin, ... 阅读全帖 |
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I****a
发帖数: 407 | 16 That is exactly my next guess for old female with anemia and renal failure.
She could have amyloid affecting her heart as well as autonomic nerve
contributing nausea. |
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A*******s
发帖数: 9638 | 17 I thought you were vaporized. Congratulations for the right treatment prior
to the diagnosis. And yes, you deserve another internship. lol.
It was a good search for the causes of anemia.
I have a question:
Why do you think she was so nauseated? It doesn't seem to me the lymphoma
invaded the gut although it is possible and GI should be able to catch it. |
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y***d
发帖数: 33 | 18 在板上潜水有一会了，好像发case的不多啊。是不是这儿attending太多，都没时间写
case了呢？我来抛砖引玉好了。
从今天开始，每星期我会上一个case。 周一history, 周二physical， 周三initial
labs/work up, 周四additional work-up, 周五final diagnosis. 欢迎大家跟贴讨论
。这些case基本上是面向内科resident的。不过attending们也可以复习一下哈。如果
受欢迎的话我会一直贴下去。废话到此为止。 先上第一个case试试反响如何。
CC: bilateral leg swelling and diarrhea
HPI: 72 yo f h/o HTN, diarrhea and pneumatosis intestinalis of unclear
etiology presented to ER for worsening bilateral lower extremity edema and
ongoing diarrhea.
Initially presented 2 month PT... 阅读全帖 |
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I****a
发帖数: 407 | 19 What issue is primary? What issues are secondary?
It is hard to pinpoint at this moment for me w/o knowing any lab values.
This is likely a systemic process with multiple organ system involvement: GI
, vascular and possible renal and heme. I would guess diagnosis is
eventually made by a pivotal biopsy.
How would you work her up?
I would focus on elucidating the cause of anasarca and hypokalemia,
specifically UA, urine protein/creatinin ratio, urine lytes to calculate
transtubular potassium gradi... 阅读全帖 |
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V*****G
发帖数: 337 | 20 Nice to see the lab.
Majority consistent to GI loss (malnutrition/malabsorption)
Edema is due to hypoalbumin and low protein. Originally lower extremity edema was thought to be due to systemic involvement. But when I saw "4+ pitting edema up to low back" on PE on day 2, I knew it could be due to low protein level. I appreciate the good PE you did. :)
Hypokalemia is most likely due to GI loss too.
Other lab abnormalities suggested:
Group 1: Low VitD, low phosphate, low calcium = Vit D deficienc... 阅读全帖 |
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V*****G
发帖数: 337 | 21 I do have a few questions to ask:
1st about the diagnosis: is diagnosis clear when the biopsy result is clear
or when gluten free diet worked? To me, it's the later. It will be more
helpful to ask patient if there is traveling history to Caribean, India,
Southeast Asia etc.If no such a history, then giving diagnosis when biopsy
result is clear might be reasonable to me. Maybe LZ said this somewhere in
the description that I missed. Anyway I am not clear no this at this point.
The other thing is... 阅读全帖 |
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r******h
发帖数: 552 | 22 非常感谢详细回复！！（好多专业词汇啊，抱着辞典读完 :p） 也让我心安不少（当然我不会掉以轻心的）
好，得问问有没有检查CBC和肝肾功能。。。
within
The
anemia
patients
recommend |
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A*******s
发帖数: 9638 | 23 Didn't ask, but he did not complain either. His non-fasting CMP was also
normal.
He did not have any signs of joint pain, skin rash, allergies or anemia. |
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y******a
发帖数: 590 | 24 No I don't think you need to check those. As fionaww mentioned earlier,
ferritin is also a marker for chronic inflammation. But with chronic
inflammation, you will see other abnormalities, like anemia, low albumin, high
platelet count, high ESR, CRP, and LDH. With a normal albumin and PLT, it's
unlikely you have chronic inflammation going on. |
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A*******s
发帖数: 9638 | 25 你的vitamin level是多少？
Vitamin B12 injection， maybe twice a month。 Folate应该是足够了。
结束pregancy后才查一下病因。
有hypothyroidism symptoms, Live function normal, no past medical history,no
family history, not on any other meds except prenatal vitamin(contain 1mg
folic acid per tablet) and oral V12. 想不出what might cause macrocytic
anemia in a young women with healthy life style and good diet. 大家帮我想想
如果你遇到我这样的病人,你怎么处理? |
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I****a
发帖数: 407 | 26 I have seen normal A1C in the case of mild anemia and high red cell turn
over state. I was told there is similar test based on measurement of
glycolated albumin which can help in such situation.
switched
could
formal |
|
A*******s
发帖数: 9638 | 27 Your MCV is not that bad. I would do folate 4 mg daily if nothing else could
be found. |
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I****a
发帖数: 407 | 28 33 y/o white male with history of type I DM on insulin, PVD, s/p fem/pop
bypass 2 years ago who presented to local ER with bloody diarrhea, nausea,
vomiting 2 days after he visited a casino and was reported eating a raw beef
hamburger. He quickly developed AMS and was intubated for airway protection.
His admitting labs were noted having a marked normocytic anemia and his
blood smear was noted having significant agglutination. He has 3+ warm
antibody presence on DAT. His hgb was in low 4s and he ... 阅读全帖 |
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A*******s
发帖数: 9638 | 29 Autoimmune Hemolytic Anemia。
Did he take any abtibotics for the diarrhea? |
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I****a
发帖数: 407 | 30 I agree with you TTP is in differential. For educational purpose, the
classical pentad for TTP are: thrombocytopenia, mcroangiopathic hemolytic
anemia with schistocytosis, fever, renal failure and CNS findings. This
patient has 4 out 5. He has no schistocytosis on multiple blood smears. Can
you make diagnosis of TTP?
came into my mind immediately... |
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I****a
发帖数: 407 | 31 It is good to know this.
also
anemia |
|
w********e
发帖数: 762 | 32 you guys did nor do ferritin from beginning? since we had recently diagnosed
two HLH cases by earlier on. ferritin > 100,000 I think every new anemia pt
deserve a ferritin level
these two also marrow proved HLH
one responded well to steroid, other one started chemo |
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A*******s
发帖数: 9638 | 33 This case is not that simple as you initially claimed.:)
I agree with the endo that this patient can not be diagnosed DM. I posted
the answer at my very first reply but had it revised because our endo specialist,
like againstwind or newprozac, would hammer me badly, lol
A patient with typical clinical symptoms and abnormal OGTT, or abnormal
fasting glucose, is easy to be diagnosed. For one time abnormal OGTT and
normal HgA1c and normal fasting, I would not diagnose DM, and legally would
not st... 阅读全帖 |
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a********n
发帖数: 182 | 34 Hypoglycemia trigger hyperglycemia. Remember Fight or flight? When
hypoglycemia, the negative feedback give body rebound under the influence of
all the hormones including glucocorticoid.
All her anemia,leukopenia,fatigue... caused by Anorexia. She need to see an
anorexia specialist. :) |
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U********e
发帖数: 20 | 35 Morbid obese young female (BMI>45) with severe weeping pedal edema (3+
pitting edema) without cardio or pulmonary conditions.
Already start lasix 40mg po daily-----no improvement
Slightly anemia (Hgb: 10.2), albumin: 3.2
Not on any medication except new start Lasix
Not a good candidate for Ted hose due to her obesity.
Any other outpatient options? I need input from you guys! Thanks |
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B****r
发帖数: 1737 | 36 看了三次医生，没有任何进展。可能下周要收入院了。小地方没有儿童医院，也不知道
该不该换个别的医生。恳请大家帮着瞧瞧 （病人情况如下）。万分感谢。
5 yo female with persistent cough x 14 days and fever x 10 days. Fever runs
102-104 F, but does normalize when given motrin or tylenol. Symptom no
improvement after 4 days of Azithromycin. Began to have loose stool /watery
diarrhea for past 3-4 days. She had complained of abdominal pain (mostly
peri-umbilical) intermittently for the past 2-3 weeks. Has a history of
problems with constipation. Slightly decreased PO intake, ... 阅读全帖 |
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m******r
发帖数: 1904 | 37 【 以下文字转载自 MedicalCareer 讨论区 】
发信人: Blazer (--), 信区: MedicalCareer
标 题: 求助：５岁小孩高烧１０天
发信站: BBS 未名空间站 (Sat Feb 2 23:01:40 2013, 美东)
看了三次医生，没有任何进展。可能下周要收入院了。小地方没有儿童医院，也不知道
该不该换个别的医生。恳请大家帮着瞧瞧 （病人情况如下）。万分感谢。
5 yo female with persistent cough x 14 days and fever x 10 days. Fever runs
102-104 F, but does normalize when given motrin or tylenol. Symptom no
improvement after 4 days of Azithromycin. Began to have loose stool /watery
diarrhea for past 3-4 days. She had complained of abdominal pain (mostly... 阅读全帖 |
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M***D
发帖数: 249 | 38 原来你是个workaholic, 你"hate holidays"和这个男孩"hate holidays "的原因太不
一样了。I asked my nurse checking the boy's finger stick, his glucose level
is only 62. His following labs show his Vitamin D level is only 7 and he has
iron-deficiency anemia. His mother has her own health problems and often "
forgets" to cook meals for him and his siblings. The free lunch provided at
his school is the only meal he can eat on time during weekdays. So the boy
hates holidays because his school will be closed during holidays ... 阅读全帖 |
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w*l
发帖数: 43 | 39 Might be related to anemia, may check CBC. |
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w******y
发帖数: 4871 | 40 I dont know.
but this is the side effect of tamoxifen:
Adverse Reactions Significant
>10%:
Cardiovascular: Vasodilation (41%), flushing (33%), hypertension (11%),
peripheral edema (11%)
Central nervous system: Mood changes (12% to 18%), pain (3% to 16%),
depression (2% to 12%)
Dermatologic: Skin changes (6% to 19%), rash (13%)
Endocrine & metabolic: Hot flashes (3% to 80%), fluid retention (32%),
altered menses (13% to 25%), amenorrhea (16%)
Gastrointestinal: Nausea (5% to 26%), weight loss (23%... 阅读全帖 |
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c*******r
发帖数: 6971 | 41 WASHINGTON (AP) -- The Food and Drug Administration on Tuesday approved
Amgen
's bone strengthening drug, Prolia, for postmenopausal women at risk for
fractures, a potential blockbuster market.
The injectable drug is given once every six months to increase bone mass
and strength.
Analysts think Prolia should bring Amgen billions in revenue after it is
launched. Sales of the company's former top sellers, the anemia drugs,
Aranesp
and Epogen, have dropped in recent years due to safety concerns and... 阅读全帖 |
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b*****h
发帖数: 783 | 42 YMI 是个加拿大的biotech，它本来只有一个EGFR抗体药物－Nimotuzumab,做到后来都
濒临破产了。
后来公司合并了Cytopia, 获得了Cytopia JAK2 inhibitor--CYT387，不过那时CYT387
还在preclinical阶段. JAK inhibitor
目前主要在开发治疗Myeloproliferative Disorder,
(做JAK2 inhibitor 的领头公司是INCY，看看它过去股价的走势就知道大家对JAK
inhibitor的热情。)
YMI 的CYT387正在做phaseI/II的 clinical trial. 因为效果不错。trial的人数扩展
了好几次。
从interim data看，治疗效果和INCY的Ruxolitinib类似，但在对改善anemia的效果比
INCY 的Ruxolitinib还要有希望。
phase II 的fulll data在年底出来。 |
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y*****l
发帖数: 5997 | 43 12/12. Have spt @ 1.75.
YM BioSciences to Report Updated Phase I/II Data for CYT387 at ASH 2011
YM BioSciences Inc. (NYSE Amex: YMI, TSX: YM), today announced it would
report updated results from its Phase I/II myelofibrosis study of CYT387, a
JAK1/JAK2 inhibitor, in a poster session to be held from 6:00pm - 8:00pm on
Monday, December 12th at the 53rd Annual Meeting of the American Society of
Hematology (ASH) being held in San Diego, California. The Company also
reported updated results today fr... 阅读全帖 |
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y*****l
发帖数: 5997 | 44 好像射天狼也是ANX专家，如果FDA能过的话，潜力巨大。
http://seekingalpha.com/article/267816-adventrx-poised-for-run-
Adventrx Pharmaceuticals (ANX) is a specialty pharma company developing two
novel formulations of anti-cancer drugs that are designed to result in less
side effects in addition to a compound in late-stage clinical development
for the treatment of a blood disorder known as sickle cell anemia.
On 3/10/11, ANX reported its 4Q10 and full-year 2010 financial results,
including:
As of 3/1/11, had 23.7 mill... 阅读全帖 |
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y*****l
发帖数: 5997 | 45 http://www.thestreet.com/_yahoo/story/11215926/1/biotech-calend
Updated with corrected FDA approval decision date for Roche's melanoma drug
Zelboraf. It's Oct. 28, 2011, not Nov. 11, 2011, as previously reported.
BOSTON (TheStreet) -- The 2011 FDA drug approval calendar has been updated
and extended through the first quarter of 2012.
For easier reference, this regulatory calendar is organized in chronological
order based on the drug approval decision date. Information on pending FDA
advisory pan... 阅读全帖 |
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y*****l
发帖数: 5997 | 46 来自主题: _pennystock版 - HGSI bot 11. Target cut to 15 from 25.
http://seekingalpha.com/article/302210-today-s-weakness-in-huma
Human Genome Sciences Inc.'s (HGSI) September quarter report announced after
the close yesterday included sales figures for its lead BENLYSTA drug for
lupus that imply a slower ramp-up than is currently built into Wall Street
forward estimates. The company missed both revenue ($34 million versus $36.8
million) and earnings (45c loss versus 38c loss) estimates for the
September quarter.
Furthermore, ... 阅读全帖 |
|
K********g
发帖数: 9389 | 47 【 以下文字转载自 Stock 讨论区 】
发信人: KeepBuying (雁过留声), 信区: Stock
标 题: 2011年11月-2012年1月的FDA的NDA医药股
发信站: BBS 未名空间站 (Wed Nov 2 00:25:56 2011, 美东)
既然成为板斧了，那就为股版添点东西。
下面的医药股是2011年11-2012年1月的FDA的NDA待审批的。大家记住，任何药股的NDA
风险都比较大，要学会炒药股，切忌去赌药股的NDA.下面带星号的我觉得还可以值得研
究。
12/8/2011 Antares Pharma Inc. AIS Anturol Gel (NDA) FDA decision
on Anturol Gel for overactive bladder
12/7/2011 AFFYMAX INC AFFY Peginesatide (NDA) FDA panel to
review Peginesatide for anemia associated with chronic... 阅读全帖 |
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b*****h
发帖数: 783 | 48 Phase1/2 一大半data出来了，还保持了对原来anemia的改善，感觉这一波差不多了，
后面的catalyst， 1,phase1/2 full data 明年1月（基本可以确定positive). 2,在三
期开始前可能会有partner进入。 |
|
b*****h
发帖数: 783 | 49 final PhaseII trial will come out soon. once the anemia benefit confirms,
the possibility of getting partner or buying out will be much higher. |
|
b*****h
发帖数: 783 | 50 most of ppls dont believe the surprise anemia benefit. the lack of placebo
control arm design in undergoing trial also adds some unsure. Anyway, once
the positive phase II data comes out, the future of YMI will be much better. |
|
