w********o
发帖数: 1621 | 1 This should be posted to biology or genetics boards to get the discussion
interesting.
There is a paper published on a long time ago. The difference in
men and women was already explained by genetic traits.
Men don't have the ability to give birth. But their genes want to pass on.
Those genes' challenge is how to survive in the world. The answer is obvious
- they drive men's instinct to spread their sperms (genes) as widely as
possible. In behaviors, men in nature likes to sleep around.... 阅读全帖 |
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D*****r
发帖数: 6791 | 2
Christian
基督教也没明确说自己是建立在“一个万能的人形神存在”的假设基础上啊。你要说地
球生命自然产生可能性很小，那一个万能神自然产生的可能性更小了。这就是为什么人
们用自然原理来解释世界，而不用”万能神“假设。如果这个万能神存在的话，它一定
是忍受了巨大的痛苦，千方百计地隐藏自己和自己创造的过程留下的证据。
演化是非随机的，在不断和周围环境的接触中探索有效利用能源的方式。植物跟叶绿体
联盟转化太阳能，动物跟线粒体联盟掠夺能量储备。
说一个最近的研究吧：蚤状蚤的基因多重复，这些基因的复制件的维护是受环境影响的。
引申一些，生物群体里的基因复制是海量存在的，就算现在随机突变完全停止，现在群
体里已经存在的基因变型的不同组合已经可以维持自然选择所需的多样性了，进化照常
进行，得千年以上才能注意到随机突变停止了。
The Ecoresponsive Genome of Daphnia pulex
http://www.sciencemag.org/content/331/6017/555.abstract?sid=ae7
摘要：
We describe the draft gen... 阅读全帖 |
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g*********d
发帖数: 233 | 3 发表在基因图谱年会的一项跨文化研究指出，东方人的发丝比西方人粗50％的现象
和一段EDAR
基因有关.
SAN DIEGO, CALIFORNIA--Whether you have a poker-straight black mane
or frizzy blond locks, your hair depends on your ancestry. Now
researchers have come closer to figuring out just how hair traits are
passed down. According to a talk presented here last week at the annual
meeting of the American Society of Human Genetics, a single genetic
variant may explain why East Asians have thicker hair fibers than other
populations. The discovery ... 阅读全帖 |
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o********r
发帖数: 775 | 4 今天的nature news:
http://www.nature.com/news/rna-studies-under-fire-1.10502?gobac
RNA studies under fire
High-profile results challenged over statistical analysis of sequence data.
Erika Check Hayden
25 April 2012
Article tools
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High-throughput RNA sequencing has yielded some unexpected results in the
past few years — including some that seem to rewrite conventional wisdom in
genetics. But a few of those findings... 阅读全帖 |
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l**********1
发帖数: 5204 | 5 预先打了伏笔了哈 Wo Kao Nature News
Performance enhancement: Superhuman athletes
Enhancements such as doping are illegal in sport — but if all restrictions
were lifted, science could push human performance to new extremes.
Helen Thompson
18 July 2012
Code breaking
Gene doping — enhancing performance by adding or modifying genes — has
been the subject of locker-room gossip for the past ten years. There are
plenty of natural mutations for which to wish. The Finnish cross-country
skier Eero Mäntyrant... 阅读全帖 |
|
l**********1
发帖数: 5204 | 6 Bingo
Banach and Hilbert Space have been used for
Comprehensive transcriptome analysis of mouse embryonic stem cell
adipogenesis
please refer one Estonia University of Tartu 2011 PhD DISSERTATION
by
KULL M
Title:
Statistical enrichment analysis in algorithms for studying gene regulation
Abstracts:
>
Gene regulation determines the production rate and timing of gene products,
enabling, for instance, the cells of a multicellular organism to be very
different despite the identical genomes. Stati... 阅读全帖 |
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p*****c
发帖数: 20445 | 7 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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h******y
发帖数: 351 | 8 Jaenisch lab最新发表的利用CRISPR同时敲除5个基因的文章。CRISPR前途无限啊。再搞
出几个inducible的CRISPR就更厉害了。
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/C
as-Mediated Genome Engineering
http://www.ncbi.nlm.nih.gov/pubmed/23643243
Cell. 2013 May 1. pii: S0092-8674(13)00467-4. doi: 10.1016/j.cell.2013.04.02
5.
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/C
as-Mediated Genome Engineering.
Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R.
Source
W... 阅读全帖 |
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l**********1
发帖数: 5204 | 9 Now we have GIIRA
pls check,
HTTPS double dot //sourceforge.net/projects/giira/
GIIRA – RNA-Seq Driven Gene Finding Incorporating Ambiguous Reads
Posted on October 16, 2013 By RNA-Seq Blog Administrator
Reply
The reliable identification of genes is a major challenge in genome research
since further analysis depends on the correctness of this initial step.
With high-throughput RNA-Seq data reflecting currently expressed genes, a
particularly meaningful source of information has become commonly av... 阅读全帖 |
|
t*******w
发帖数: 107 | 10 https://www.ncbi.nlm.nih.gov/pubmed/28557981/#comments
FYI all.
Xiaolin Wu2017 May 31 2:11 p.m. (6 days ago) 9 of 9 people found this
helpful
This paper raises important safety issue for gene therapy application of
CRISPR-Cas9. However, there are serious doubts about the results or
interpretation. First of all, the authors listed Top-10 predicted off-target
sites. But all genes are wrong! looking at the sequence they listed (supp.
figure 3), you will not be able to find it in the genes! After ca... 阅读全帖 |
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W*****B
发帖数: 4796 | 11 China calls off controversial hunt for Chinese ‘warrior gene’ in children
Poor results rather than ethical issues stopped studies focused on blood
samples from violent juveniles, source says
Sunday, 17 December 2017, 4:48:PM
The hunt started more than a decade ago with a pool of money, central
government backing and the goal of tracking down a Chinese variant of the so
-called warrior gene.
Similar research was already under way in the United States, Europe and
Japan – studies that suggested cer... 阅读全帖 |
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L*******e
发帖数: 2202 | 12 http://www.huffingtonpost.com/2012/06/12/why-are-there-gay-men_
While female sexuality appears to be more fluid, research suggests that male
gayness is an inborn, unalterable, strongly genetically influenced trait.
But considering that the trait discourages the type of sex that leads to
procreation — that is, sex with women — and would therefore seem to thwart
its own chances of being genetically passed on to the next generation, why
are there gay men at all?
Put differently, why haven't gay man... 阅读全帖 |
|
l**d
发帖数: 472 | 13 Why Do Women Live Longer Than Men?
http://www.time.com/time/printout/0,8816,1827162,00.html
Across the industrialized world, women still live 5 to 10 years longer than
men. Among people over 100 years old, 85% are women, according to Tom Perls,
founder of the New England Centenarian Study at Boston University and
creator of the website LivingTo100.com. Time.com asks him why.
Q: Why do women live longer than men?
A: One important reason is the big delay — and advantage — women have over
men in te... 阅读全帖 |
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a***f
发帖数: 32 | 14 Thanks to Lot..., Wak.... and Shak... again!
Sorry for not responding sooner. I did RT-PCR, as expected, the human
endogenous gene is expressed. But the mouse gene (BAC)is not.
I guess it is correct to say that the mouse transgene should have decent
chance to be expressed if the human orthorlogue is expressed, as a general
rule. But for a given gene, it is very hard to be sure. At least, the
organization of CpG elements and regulatory sequence of gene are very
different from mouse to human, ri... 阅读全帖 |
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s******a
发帖数: 252 | 15 So it's Barkai's student.
1 Science, 1 Nat Genetics.
That's outstanding but not surprising.
Publications:
Tsui K, Dubuis S, Gebbia M, Morse RH, Barkai N, Tirosh I, Nislow C (2011).
Evolution of nucleosome occupancy: conservation of global properties and
divergence of gene-specific patterns. Mol Cell Biol. 31:4348-55.
Dori-Bachash M, Shema E, Tirosh I (2011). Coupled evolution of transcription
and mRNA degradation. PLoS Biol. 9(7):e1001106.
Tirosh I, Barkai N (2011). Inferring regulatory mechani... 阅读全帖 |
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d***s
发帖数: 1062 | 16 谢谢上面两位的帮忙，终于能分析了。
但是分析结果好像不是很好。
大部分的gene sets在WT里upregulated了，但是在KO里就
很少。我分析了好几个gene sets database都是这样。
不仅如此，KO组里一个能看的enrichment plot都没有。
我用的都是默认的parameter，有些parameter是不是应该改一改。
Enrichment in phenotype: WT (4 samples)
701 / 797 gene sets are upregulated in phenotype WT
0 gene sets are significant at FDR < 25%
13 gene sets are significantly enriched at nominal pvalue < 1%
36 gene sets are significantly enriched at nominal pvalue < 5%
Enrichment in phenotype: KO (4 samples)
96 /... 阅读全帖 |
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i*****y
发帖数: 3449 | 17 男与男、女与女，为甚么会有同性恋，科学上迄今仍是谜。但有美国科学家最新以「表
观遗传学」（epigenetics）解释同性恋原因。表观遗传学主要研究环境如何改变基因
表现（gene expression），据指出，当胚胎在母体发育初期，能影响基因表现的「外
延标记」（epi-marks），会向与性别相关的基因发出指令，保护胎儿免受环境影响，
像避免胎儿免受过多睾丸素影响，这足以影响胎儿生殖器官发展、性取向和性别认同。
一般而言，外延标记不会遗传下一代，否则会以父传女、母传子的方式遗传下来，
令女儿较男性化、儿子较女性化，特别强势的外延标记就会导致同性恋倾向。但这理论
仍须研究确定。
http://www.sciencedaily.com/releases/2012/12/121211083212.htm
Epigenetics May Be a Critical Factor Contributing to Homosexuality, Study
Suggests
Dec. 11, 2012 — Epigenetics -- how gene expression is regula... 阅读全帖 |
|
z****0
发帖数: 3942 | 18 Are foods made using biotechnology safe to eat?
by Jonathan Strickland
Agricultural biotechnology is the science of using genes to alter crops. Why
would scientists want to fiddle with a plant's genes? The reasons range
from improving crop yields to designing plants that are resistant to pests
and disease. But are these genetically modified foods safe to eat?
The short answer is yes. Scientists around the world have conducted multiple
studies on genetically modified food and found that the food ... 阅读全帖 |
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w********2
发帖数: 632 | 19 HGT involving prokaryotes
Many studies support the significant role of HGT in the evolution of
prokaryotes (Gogarten et al., 2002; Jain et al., 2003; Kunin and Ouzounis,
2003). The principle sources of novel genes are provided by other prokary-
otes, viruses and MGEs (Fig. 1). In particular, plasmids and composite
mobile elements contribute significantly to HGT between prokaryotes. In some
cases, composite elements and megaplasmids are composed of more than 100
genes (Bentley et al., 2002; Hacke... 阅读全帖 |
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w********2
发帖数: 632 | 20 HGT involving viruses
Viruses undergo frequent HGT but this is typically re- stricted to gene
exchange between viral genomes present in the same infection. Many viral
genomes have few genes (less than 10), which constrains the number and types
of genes that can be expected to increase or even maintain fitness.
Consequently, viruses with small genomes have been rarely reported to
contain non- virally derived genetic elements (Agranovsky et al., 1991;
Becker, 2000; Khatchikian et al., 1989; Masuta... 阅读全帖 |
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v*******e
发帖数: 3714 | 21 2010-11-23 03:14:00 来自: vieplivee (苇浦丽薇)
Scarecrow / 稻草人的评论 5
提示: 有关键情节透露
HFA特别场的票价是$12，好处是导演会在终场时出现，来回答大家的问题。可惜换
了主持人，只听主持人问个没
完。听了一部分我终感不耐，就走开了。导演强调他喜欢找好演员来演戏，让演员自由
发挥的成分很大，经常在拍完一
场的时候还多拍一段，有时演员接下来会做一些很有趣的事情，也许有值得保留的部分
。他的这个拍法，的确达到了让
演员充分自由发挥的效果。此片的最精华之处一定是表演，故事本身的社会现实含义都
不大要紧了。
故事很简单：两个满怀纯粹希望的人，一个看见自己的希望成幻影而崩溃了，另一
个则在结尾走向不可知的未来，
哪怕他自己还信心满满。
那年Al刚拍过不多几个影片，已经大展头角，个个都是担纲。最要紧的大概是他在
前一年刚拍的教父一，那个一飞
冲天啊，哪怕教父的制片还挺不情愿让他来演的，嫌他个头儿太矮。Scarecrow里Al一
点都没那个大哥大的调调了，成
了个逗人恋爱的小可怜，把一个外表和内心一样僵硬的大男人Gene心里所有的柔... 阅读全帖 |
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c*****g
发帖数: 21627 | 22 http://en.wikipedia.org/wiki/Outbreeding_depression
A concept in selective breeding and zoology, outbreeding depression refers
to cases when offspring from crosses between individuals from different
populations have lower fitness than progeny from crosses between individuals
from the same population. (In selective breeding, the concept is opposed to
inbreeding depression). This phenomenon can occur in two ways.
First, selection in one population might produce a large body size, whereas
in anothe... 阅读全帖 |
|
m***e
发帖数: 490 | 23 都来做一下，就几分钟的样子，看看你回去高考还能不能考上
前5个和所谓标准答案一致的，我发包子
(2)
June 26, 2000 — the Human Genome(基因组) Project, a great $3 billion, 15-year task aimed at drawing the
genetic(遗传的) map of humans, is now more than 90 percent completed. The scientific and medical
communities(团体) are very excited about the chances genetic research provides for getting rid of diseases
and prolonging(延长) human life. But those communities and policy(政策) makers also are careful about the
scientific door they are opening as the project... 阅读全帖 |
|
l*********e
发帖数: 5483 | 24 很好，又长知识了
Evidence for attraction based on our immune system?
Sounds odd, but it seems to be true. Researchers studying the immune systems
of mice found that female mice would choose a mate whose MHC genes were the
least similar to her own. MHC stands for major histocompatibility complex.
These genes code for special protein markers that are attached to the
surface of cells and help the body recognize whether a cell belongs to an
organism or if it is an invader such as a bacteria or virus. If a c... 阅读全帖 |
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n********k
发帖数: 2818 | 25 Joke of the day or what?
there is not a most shameless but more shameless!
Results: 33
1.
Viable fertile mice generated from fully pluripotent iPS cells derived from
adult somatic cells.
Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Wang X, Wang L, Zeng F,
Zhou Q.
Stem Cell Rev. 2010 Sep;6(3):390-7.PMID: 20549390 [PubMed - in process]
Related citations
2.
Production of mice using iPS cells and tetraploid complementation.
Zhao XY, Lv Z, Li W, Zeng F, Zhou Q.
Nat Protoc. 2010;5(5):963-71. Epu... 阅读全帖 |
|
z*t
发帖数: 863 | 26 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
|
t*d
发帖数: 1290 | 27 IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', puts them in tiny moulds,
cures them and then turns them out. He can mould almost any shape: discs,
cubes, long sticks, roughened doughn... 阅读全帖 |
|
g******r
发帖数: 139 | 28 OK,what you mean is the cDNA concentration used should be in the linear
region of the reaction.
This concentration would vary for each of the genes, dependent on the
abundance. I did not perform such cDNA dilution pilot experiment for each
gene. I just used 2-4 ng cDNA in the real-time PCR. One would assume the
gene with Ct of 25-31 is within the linear range, if the Ct is >33, it is
possible the cDNA conc is kind of out the range.
And it is true as Isaid that I got no outlier replicates for gen... 阅读全帖 |
|
t*d
发帖数: 1290 | 29 【 以下文字转载自 Biology 讨论区 】
发信人: ttd (oldcat), 信区: Biology
标 题: better way to conquer cancer
发信站: BBS 未名空间站 (Wed Jan 16 14:57:14 2013, 美东)
IMHO, to find novel drug delivering methods might be better ways to conquer
cancer comparing to studying the mechanisms of cancer initiation and
progression.
Nature 491, S58–S60 (22 November 2012)
Nanotechnology: Carrying drugs
When Joseph DeSimone makes nanomedicines, he compares himself to a baker. He
mixes drugs with different chemical 'batters', ... 阅读全帖 |
|
v*****k
发帖数: 7798 | 30 The new frontier of genetic analysis is developing so fast that industry
leader Illumina plans to come out with an iPad app.
Some of Illumina’s ILMN software used in gene sequencing already
runs in the Internet cloud.
Illumina showed off its new “MiGenome” iPad app at the third annual
Consumer Genetics Show in Boston on June 8, pointing out that it will put
genomic information at a person’s fingertips.
Illumina will soon start shipping a lower-price gene sequencing system in
the... 阅读全帖 |
|
M*****h
发帖数: 890 | 31 那看看这篇吧：
GMOs in Food: Genetically Modified Food & Our KidsHarmVille: Part 31 of our
award-winning series "Our Children's Health"
By Jaclyn Gallucci on August 12th, 2010
She calls it Franken-food, genocide.
Strawberries grown from seeds injected with DNA from arctic flounder fish to
make them frost resistant. Seeds pumped with suicide genes that yield an
infertile harvest so corporations can profit from a patent placed on the
plant’s genetic code. Rice injected with traits that make it more
nutri... 阅读全帖 |
|
w*********g
发帖数: 30882 | 32 笔者对此发表以下看法：
（1）卫生部2007年颁布实施《新资源食品管理办法》有意取消了2002年颁布实施
的《转基因食品卫生管理办法》“第五条 转基因食品的食用安全性和营养质量不得低
于对应的原有食品”这个条款，是退步，而不是进步！这种删除的实质是，进一步顺从
邪恶孟山都为首跨国转基因产业的私利与压力，置中国人民持续安全、健康、生存与繁
衍于不顾！
（2）卫生部2007年颁布实施《新资源食品管理办法》有意取消了2002年颁布实施
的《转基因食品卫生管理办法》“第五条”，但是卫生部《新资源食品管理办法》“第
三条”规定：
第三条 新资源食品应当符合《食品卫生法》及有关法规、规章、标准的规定，对
人体不得产生任何急性、亚急性、慢性或其他潜在性健康危害。
依据该第三条规定，在对于抗草甘膦转基因大豆加工的转基因大豆油，检测出超过
俄罗斯对大豆油草甘膦残留量允许标准与中国卫生部对棉籽油草甘膦残留最高限量2.9-
6倍的草甘膦残留量，已经证实对人类健康，特别对青少年、儿童、婴儿与孕妇及其胎
儿，造成极其严重危害情况下，（1）对人类健康不是形成 “潜在性健康危害”而是... 阅读全帖 |
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l*******1
发帖数: 16217 | 33 CRISPR 这个绝对该得，我刚才查了一下 中国和美国FDA 今年已经批准肺癌试验了，前
面英国的报道过治愈过白血病，
The Chinese trial will enrol patients who have metastatic non-small cell
lung cancer and for whom chemotherapy, radiation therapy and other
treatments have failed. “Treatment options are very limited,” says Lu. “
This technique is of great promise in bringing benefits to patients,
especially the cancer patients whom we treat every day.”
Leukaemia success heralds wave of gene-editing therapies
Lu’s team will extract immune cells called T... 阅读全帖 |
|
h***a
发帖数: 312 | 34 来自主题: NextGeneration版 - GMO Do you know that a lot of GMO is present in baby food?
http://www.aaemonline.org/gmopost.html
https://www.youtube.com/watch?v=eeW5yUSqdhY
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant D... 阅读全帖 |
|
L********r
发帖数: 758 | 35 Although your reply is not toward my post, I will try my best to clarify
something for you.
Homosexual behavior is common in prison, but given a freedom of choice, most
of the inmates will choose to intercourse with a partner from different sex
. In your definition, are their sex orientation hetero/homo/bi? In your
thoughts, what caused them to do homosexual behavior? Environment/gene?
And regarding your question of if there is a gene or gene group for
heterosexual preference, it is still hypoth... 阅读全帖 |
|
h***a
发帖数: 312 | 36 http://www.aaemonline.org/gmopost.html
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant DNA
technology" and consists of randomly inserting genetic fragments of DNA from
one organism to ano... 阅读全帖 |
|
g*******3
发帖数: 2520 | 37 早在本版表达过自己的观点，非独立推荐人的推荐信如果写的好，也可以起很大作用。重点是他谈的都是就事实来说话，不是光说你牛啊，牛啊牛。所以这样非独立也就有power了，还有就是讲detail,这样贡献就很清晰了。我block了一些个人信息，但最大可能的保留了原文，基本到了可以被人肉的地步，但只要对后来人有用，被人肉了也在所不辞.在此也要special thank 我的老板，居然花了两个小时在办公室给我修改律师写好的推荐信。
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Dear Sir or Madam:
This letter serves to express my strong support to Dr. Genegun, an immunologist who has made significant contributions to our understanding of immunosenescence --- the decline in immune responsiveness that occu... 阅读全帖 |
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z**n
发帖数: 22303 | 38 先玉335到底是不是转基因？
已有 3198 次阅读 2011-9-18 23:12 |个人分类:环保呐喊|系统分类:科普集锦|关键词
:face 3 农业部 转基因 环保部
蒋高明
先玉335是转基因的吗？环保部说是，农业部说不是。但农业部承认先玉含有
CaMV35S启动子。如果你坚持怀疑它是转基因，人家会说你是造谣，有关部门早就宣布
它不是。如果你拿出事实证明吃了先玉335的动物(老鼠、猪、鸡)出现异常反应，他们
会说“就算它真的影响了生态，也与转基因品种无关。”既然转基因是好的技术，为什
么那么害怕这三个字呢？
先玉335的父本含有PH4CV。而PH4CV的类别编号包括“800/302”；在美国专利
法的规定中，“302”即指“基因修饰”。长长的专利资料文件显示，PH4CV的开发包括
了使用BT和HT转基因技术——这是用于商业化大宗农作物的仅有的两类转基因技术。美
国农业部在核准PH4CV品种的公告中指出，该品种的种植必须遵循“农作物保护法”的
要求，例如，种子必须是新的、成分稳定的同代同样品种，未经批准不得使用子代作为
种子使用；对转基因作物种植... 阅读全帖 |
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h***a
发帖数: 312 | 39 http://www.aaemonline.org/gmopost.html
https://www.youtube.com/watch?v=eeW5yUSqdhY
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant DNA
technology" and consists of randomly inserting geneti... 阅读全帖 |
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y****i
发帖数: 1265 | 40 【 以下文字转载自 Biology 讨论区 】
发信人: yweili (杨威利), 信区: Biology
标 题: 据说哈利波特上nature了
发信站: BBS 未名空间站 (Thu Jan 6 14:13:20 2011, 美东)
发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线====================... 阅读全帖 |
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B********e
发帖数: 19317 | 41 http://evolution.berkeley.edu/evolibrary/article/0_0_0/evo_21
Gene flow
Gene flow — also called migration — is any movement of genes from one
population to another. Gene flow includes lots of different kinds of events,
such as pollen being blown to a new destination or people moving to new
cities or countries. If genes are carried to a population where those genes
previously did not exist, gene flow can be a very important source of
genetic variation. In the graphic below, the gene for brown col |
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p*****m
发帖数: 7030 | 42 今天无厘头ametuer journal club下。。很神的paper
http://www.cell.com/abstract/S0092-8674%2810%2901133-5
很神奇的paper...第一眼我还没明白为啥一片果蝇paper可以有17个机构42个作者 等我
扫了一眼figure就全明白了...
简单来说就是 这票人首先在果蝇里搞了个很简单的行为范式看果蝇对heat的逃避反应
（可以间接的反映nociception 痛觉），然后做了个>10000 RNAi line的screen，找到
些许mutant，挑了一个叫straightjacket看了看expression,也看了看其他种类的行为
，然后声称，自己发现了个新的种类的参与nociception behavior的gene。(PS 这个
gene straightjacket名字咋来的？原来伊之前被发现参与了突触结构的调节，该基因
mutant会表现出seizure-like phenotype，简单说就是癫痫了。。于是作者们可能就根
据这个给它起了个“约束带”的名字 就跟一个癫痫病人被绑在床上差不多。。此为... 阅读全帖 |
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y****i
发帖数: 1265 | 43 发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线==========================
在下面第一篇nature文章中，在2005年《哈里波特与混血王子》出版后，来自澳大利亚
皇家儿童医院的Graig等人，同样对哈里波特中描述的有超能力的巫师wizards and
witches与麻瓜muggle结合后，后代属性问... 阅读全帖 |
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w******e
发帖数: 1187 | 44 孤独的人是可耻的~
Mind and body
The reason loneliness could be bad for your health
Feb 24th 2011 | WASHINGTON, DC | from the print edition
SCIENCE has many uses, but it doesn’t often produce handy pick-up lines.
Recent work on the genetics of disease, however, suggest a way of opening
a conversation with that solitary attractive stranger in a bar: loneliness
can make you ill.
Lonely people, it seems, are at greater risk than the gregarious of
developing
illnesses associated with chronic inflammation, su... 阅读全帖 |
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p*7
发帖数: 45 | 45 There are some rules on how gene regulation is controlled in vivo. The most
basic one was proposed fifty years ago by Monod and Jacob, which was
originally called the "operon model" based on studies in viruses and
bacteria but later proven to be a general rule on the control of gene
expression in all the organisms.
Basically, it says: 1) gene regulation is controlled by cis-elements (i.e.
promoter, enhancer etc.), and trans-regulators (transcription factor,
regulatory RNA etc.). 2), the trans-re... 阅读全帖 |
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l***y
发帖数: 4671 | 46 有没有人做这种在进化过程中被 comment 掉后扔进素材库的 gene？觉得是
epigenetics 的一个很好的方向啊。可以用低等生物，给个合适的进化压力，看看素材
库是如何被打开和拣选的。（俺们现在是用 cancer cell，给进化压力，看 evolution
的过程。但愿俺找出来的不是 mutation 啊。。。俺还是觉得 cancer cell 不该靠掷
骰子）
我们这里有一个组在做那种发育时被表达，以后永远不会被表达的 gene/isoform，hyp
是：在发育某个时期，不同的 chromosome 间形成某种空间结构，使得分别 binding
在不同 chromosome 上的 protein 可以形成 complex，从而启动某些基因在某些起至
位置的转录。之后，这种空间三维结构不再有机会出现，相应的 gene 或者 gene 的某
些 transcript 就被安全地 lock 起来不再被表达。之所以要这么费劲地 lock，是因
为否则会有灾难性后果。但是，在某些病理条件下，这些被 lock 的 gene 又被表达了
，于是就杯具了。
这种远程空间构象导致的 e... 阅读全帖 |
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j*****d
发帖数: 787 | 47 http://the-scientist.com/2011/09/20/plant-rnas-found-in-mammals
+Plant RNAs Found in Mammals
MicroRNAs from plants accumulate in mammalian blood and tissues, where they
can regulate gene expression.
By Cristina Luiggi | September 20, 2011
11 Comments Link thisStumbleTweet thisDreamstime.com, Rewat
WannasukMicroRNAs from common plant crops such as rice and cabbage can be
found in the blood and tissues of humans and other plant-eating mammals,
according to a study published today in Cell Research.... 阅读全帖 |
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s******a
发帖数: 472 | 48 http://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00331
Fifty Years after Jacob and Monod: What Are the Unanswered Questions in Molecular Biology?
=====================================================================
Tomorrow's Molecular Biology
Marc W. Kirschner
Harvard University
Today, the term molecular biology has a rather prosaic sound. After all,
there is little in contemporary biology that isn't molecular. It's hard to
remember that 50 years ago, molecular biology was distinctly ... 阅读全帖 |
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s******y
发帖数: 28562 | 49 我觉得他的文章的意思就是大部分基因的表达程度都和细胞的活跃程度有关，
所以随便乱抓几个都能看出区别来，但是和癌症的机理基本上就是打酱油的关系。
总体意思就是目前的主流方法找出来的marker不能作为推测机理的起点。
他们在faculty 1000上抱怨说他们这篇文章一共投了4年，前后被六个
顶级杂志据了（他们直接点名的几家估计是对他们态度最糟糕的，哈哈哈）
这里是他们在PLoS Comp Biol 发表的文章的摘要。
Bridging the gap between animal or in vitro models and human disease is
essential in medical research. Researchers often suggest that a biological
mechanism is relevant to human cancer from the statistical association of a
gene expression marker (a signature) of this mechanism, that was d... 阅读全帖 |
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s******y
发帖数: 28562 | 50 我觉得他的文章的意思就是大部分基因的表达程度都和细胞的活跃程度有关，
所以随便乱抓几个都能看出区别来，但是和癌症的机理基本上就是打酱油的关系。
总体意思就是目前的主流方法找出来的marker不能作为推测机理的起点。
他们在faculty 1000上抱怨说他们这篇文章一共投了4年，前后被六个
顶级杂志据了（他们直接点名的几家估计是对他们态度最糟糕的，哈哈哈）
这里是他们在PLoS Comp Biol 发表的文章的摘要。
Bridging the gap between animal or in vitro models and human disease is
essential in medical research. Researchers often suggest that a biological
mechanism is relevant to human cancer from the statistical association of a
gene expression marker (a signature) of this mechanism, that was d... 阅读全帖 |
|
