t**x
发帖数: 20965 | 1 In Mar 2015, Jianhua’s parents took him and his brother to Cincinnati
Children’s Hospital Medical Center (CCHMC). Three doctors, William F.
Balistreri, MD (medical director emeritus of liver transplantation), Amy T
Sheil, MD, and Kevin E. Bove, MD (the most experienced CCHMC pathologist),
stated that the injuries were apparently metabolic after reviewing slides of
the biopsy done in SCH. They said that Jianhua’s liver survived an acute
insult, but it had the potential to partially recover. The u... 阅读全帖 |
|
p*******r
发帖数: 156 | 2 Postdoctoral positions available
A postdoctoral position is available in the Laboratory of Cellular and
Molecular Biology at the National Cancer Institute. A focus of current
studies is understanding the contribution of integrin adhesion complexes,
including focal adhesions and invadopodia, to the control of cancer cell
proliferation and survival. A class of proteins called the Arf GTPase-
activating proteins (Arf GAPs), which regulate the Ras-superfamily proteins
Arfs and integrin adhesions, ... 阅读全帖 |
|
|
S***J
发帖数: 1210 | 4 云老师发了个贴说清华目前的找人标准，很多人不相信。特地调研了一下清华生命学院
最近回去的人的情况，如云老师所说，绝大多数都有2cns，如果只有一篇cns，那基本
上还有>2的子刊。这个不仅仅局限于胖老师经常说的结构生物学，而是所有方向都基本
如此。
当然这些新回去的绝大部分都是千青（有些不是的是因为回去那一年千青还没开始）。
网页上的Title有的是教授，有的是研究员，估计当时还没有统一。但校内一律都是副
教授，也就是相当于这边的AP。我还特地打听了一下，国内的TT制度好像没有Tenured
Associate这一档，清华5年考核通过了就是正经的full professor。
有些老师看不上国内的科研，我就仅列出两位回国后的publication，咱就不说颜宁等
这种Early T的个例了。说两个没太有名气的，还没有评上T的，各位老师可以参考一下
，看看自己有没有别人这么productive。
一. Guangshuo Ou （11年回国，千青）
Select item 25342559
1.CYLD mediates ciliogenesis in multiple organs b... 阅读全帖 |
|
o**********e
发帖数: 18403 | 5 【 以下文字转载自 Parenting 讨论区 】
发信人: onetiemyshoe (onetiemyshoe), 信区: Parenting
标 题: 上顶尖大学：华人父母误子弟而不知 (转载)
发信站: BBS 未名空间站 (Wed Jun 10 19:36:45 2015, 美东)
我觉得小孩子爬不爬藤都是自由，多鼓励。
但是小孩子面对反华言论，张口结舌，甚至
参与反华言论。 这是父母的失败，所以华人
大人小孩都应该有不卑不亢维护华人传统的
教育, 几乎所有黑老中
的新闻都要有1分钟立刻能够辩白的训练。
没有的话，即使爬了藤恐怕结果也堪忧。
http://www.mitbbs.com/article_t/JobHunting/32975675.html
发信人: Loveanthony (春雨中的江南), 信区: Military
标 题: 上顶尖大学：华人父母误子弟而不知
发信站: BBS 未名空间站 (Wed Jun 10 00:27:13 2015, 美东)
上顶尖大学：华人父母误子弟而不知
饶毅（北京大学教授）
一般而言，无论海内外的华人父母，大都简单地认为上顶尖... 阅读全帖 |
|
a*******s
发帖数: 117 | 6 Yan, X.; Li, F.; Dozmorov, I.; Frank, M. B.; Dao, M.; Centola, M.; Cao, W.;
Hu, D., External Qi of Yan Xin Qigong induces cell death and gene expression
alterations promoting apoptosis and inhibiting proliferation, migration and
glucose metabolism in small-cell lung cancer cells. Molecular and Cellular
Biochemistry 2012, 363 (1-2), 245-255.(IF 2.329)
Yan, X.; Shen, H.; Jiang, H. J.; Hu, D.; Wang, J.; Wu, X. Q., External Qi of
Yan Xin Qigong Inhibits Activation of Akt, Erk1/2 and NF-kappa B and
I... 阅读全帖 |
|
g*****o
发帖数: 1564 | 7 let me give a try
regulate: mainly in the context of transcription regulation, eg., certain
transcription factor bind to the promoter region of a DNA sequence and
control the rate of the mRNA transcription
modulate: possibly refers to the signaling transduction that certain
signaling molecule (kinase) phosphorylate an amino acid in a downstream
protein and changes its activity
mediate: maybe A -> B -> C, then B mediate the effects from A to C?
vs. |
|
d*****a
发帖数: 506 | 8 唐勇的个人简历
男，汉族，未婚，中国 吉林省户籍，身高175cm，体重70kg，1977年12月26日出生 简
历更新时间：2015-3-19 20:44:00
政治面貌：团员 毕业时间：2013-1-17 毕业学校：Concordia University
Wisconsin
学历：博士 现住地点：上海市 第一专业： Doctor of Physical Therapy
现有职称：暂无 身份证： 保密 第二专业：医药类 临床医学
求职意向
应聘职位类型：高层次人才 求职类型： 全职或者兼职 月薪要求： 面议
具体职位一：医学 具体职位二：学科带头人 具体职位三：
具体职位四： 具体职位五： 希望工作地：上海市 上海
其他工作地：浙江或江苏
工作经历及特长
人才类型：留学生 相关工作时间：7年 外域语种：英语
外语水平：精通 其他外语语种：德语 其他外语水平：一般
普通话水平：标准 计算机能力：精通
教育培训
2010-2013 DPT （Doctor of Ph... 阅读全帖 |
|
o**********e
发帖数: 18403 | 9 【 以下文字转载自 Parenting 讨论区 】
发信人: onetiemyshoe (onetiemyshoe), 信区: Parenting
标 题: 上顶尖大学：华人父母误子弟而不知 (转载)
发信站: BBS 未名空间站 (Wed Jun 10 19:36:45 2015, 美东)
我觉得小孩子爬不爬藤都是自由，多鼓励。
但是小孩子面对反华言论，张口结舌，甚至
参与反华言论。 这是父母的失败，所以华人
大人小孩都应该有不卑不亢维护华人传统的
教育, 几乎所有黑老中
的新闻都要有1分钟立刻能够辩白的训练。
没有的话，即使爬了藤恐怕结果也堪忧。
http://www.mitbbs.com/article_t/JobHunting/32975675.html
发信人: Loveanthony (春雨中的江南), 信区: Military
标 题: 上顶尖大学：华人父母误子弟而不知
发信站: BBS 未名空间站 (Wed Jun 10 00:27:13 2015, 美东)
上顶尖大学：华人父母误子弟而不知
饶毅（北京大学教授）
一般而言，无论海内外的华人父母，大都简单地认为上顶尖... 阅读全帖 |
|
m****s
发帖数: 18160 | 10 【 以下文字转载自 Biology 讨论区 】
发信人: V123 (vvv), 信区: Biology
标 题: zucai 又在招人呢
发信站: BBS 未名空间站 (Tue Jan 29 01:51:05 2013, 美东)
Postdoctoral Research Positions in X-ray crystallography : Columbus, OH,
United States
One postdoctoral position is available immediately in Dr. Zucai Suo’s
laboratory http://chemistry.osu.edu/~suo.3/ to study protein functions and interactions through protein X-ray crystallography. The ideal candidate should have a PhD in structural biology and extensive experience in all aspec... 阅读全帖 |
|
发帖数: 1 | 11 国内某知名CRO公司招聘高级研发总监，10年合成以上工作经验，有靶点选择经验，有
国外工作或者学习背景，博士，70-80万+bonus 上海， 联系方式：QQ/微信：
2839988624 [email protected]/* */
Responsibility:
Lead Group Leaders and Bench scientists to execute chemistry projects well,
to build and maintain positive relationship with clients by providing on-
time and high quality delivery and proactive communications.
·Set up the scientific and operational goal and SOP for the projects
assigned; manage and coach Group Leaders and bench scientists; manage
resource... 阅读全帖 |
|
p*******r
发帖数: 156 | 12 Postdoctoral positions available
A postdoctoral position is available in the Laboratory of Cellular and
Molecular Biology at the National Cancer Institute. A focus of current
studies is understanding the contribution of integrin adhesion complexes,
including focal adhesions and invadopodia, to the control of cancer cell
proliferation and survival. A class of proteins called the Arf GTPase-
activating proteins (Arf GAPs), which regulate the Ras-superfamily proteins
Arfs and integrin adhesions, ... 阅读全帖 |
|
z******n
发帖数: 97 | 13 Genentech is the leading player, you may check their website for their
targeted therapy compounds, however, these approved agents usually can
extend patient life span for 3-5 month, like Trastuzumab emtansine, and the
cost in the US is about 9400 $ per month.
see the following link, or google Antibody-drug conjugate
http://en.wikipedia.org/wiki/Trastuzumab_emtansine
you may also check the kinase inhibitors for cancer, sometimes they also
work,like Imatinib (Gleevec)cost $92,000/year |
|
I****a
发帖数: 407 | 14 ER or PR (+) means tumor's growth some how is dependent on estrogen and it
is a good predictor as one can give either Tamoxifen or aromatase inhibitor
to block the estrogen. Her2/neu + traditionally means that the tumor is more
aggressive and hard to treat. Since Her2/neu monoclone antibody (herceptin)
is introduced, Her2/neu positivity is not that important because we now can
block the her2 pathway with herceptin and even with small tyrosine kinase
inhibitor such as Tykerb.
Overall for your mom... 阅读全帖 |
|
W***M
发帖数: 50 | 15 CML is very treatable since the development of tyrosine kinase inhibitor (
Imatinib). 5 year overall survival increased from 10-20% to 60-70% with TKI.
It is totally worth the money. the key is to take the medicine as long as
it still works. Sometime, CML can be resistant to imatinib, they you can
switch to second generation inhibitor such as dasatinib. |
|
l*h
发帖数: 4124 | 16 请问你说的tki中文是什么？
TKIs are tyrosine kinase inhibitors. Imatinib is one of them.
药是格格列位吗？
yes.
请问如果复发还可以再切除吗？
these patients have close followup after the initial surgery. recurrence
would be caught when it's still small and amenable to removal.
癌变和转移的机率大吗？
GISTs are 癌 by behavior. metastasis is mainly short range ones.
谢谢 |
|
l*h
发帖数: 4124 | 17 which type, renal cell or uroepithelial? if late stage renal cell, some may
respond to tyrosine kinase inhibitors. conventional chemotherapy and
radiation therapy don't show reasonable efficacy. there are less non-
surgical options for uroepithelial. |
|
l*h
发帖数: 4124 | 18 be very careful if you want to take tyrosine kinase inhibitor. if you want
to do it, do it under a physician's close monitoring.
TKIs cause interstitial pneumonitis (this is a very serious condition,
prognosis worse than non-small cell lung cancer) in some patients. in Japan,
about one in every 20 patients on TKI develop this in a relative short time
of period but they are under close monitoring so are detected early and a
small percentage of them (still about 30%) at irreversible stage. in Chin... 阅读全帖 |
|
|
b*****a
发帖数: 2 | 20 谢谢你的帮助。通过搜索Tyrosine Kinase Inhibitor，找到了几篇专业paper，但还没
有明确的答案Imatinib 和 Sunitinib是否适用于我哥的情况。
再次感谢。 |
|
|
j*****t
发帖数: 422 | 22 闺蜜姐姐的儿子在广东佛山，今年17岁，两年前因为经常觉得乏力和疲惫查出来肌酸激
酶过高（2086u/L)，是正常人的十倍。经过各种检查包括基因检测都原因不明。现在只
能保持每3个月检查一次但是没有任何可以治疗的方法。小伙子这个年纪本来应该生龙
活虎的，但是现在总是觉得疲乏无力，大大影响生活质量。闺蜜和她姐姐一家人都非常
焦虑，想知道美国有没有对这个研究比较深入的医院和医生，希望能找出病因，以对症
治疗。请各位帮忙看看能不能提供一点信息。谢谢。 |
|
m*****a
发帖数: 2160 | 23 先去北京协和，至少比来美国便宜方便很多，如果没有解决问题或者不满意，而且经济
条件允许的话，可以考虑来美国（如果北京协和都搞不定，美国是否更有办法还真的很
难说）。美国医院排名可以查USNews，个人推荐Mayo Clinic。大医院都有有专门服务
国际患者的部门 |
|
j*****t
发帖数: 422 | 24 谢谢回复。主要是这个病例非常罕见，广州各大医院都跑遍了都没找到病因。现在都不
知道要看哪个科才对。想看看这边有没有更先进的检测和治疗。Mayo Clinic排名第
一？ |
|
m*****a
发帖数: 2160 | 25 能不能找到原因检测和设备是其次，最重要的是医生的学识和水平，这一点一定要
明确
中国地区间医疗水平差异较大，而且北京协和看疑难杂症的水平远远领先国内其他医院
。因此依然建议先去看北京协和，CK升高的话可以考虑看风湿免疫科。美国的话会根据
患者具体病情推荐科室或就诊方式。
[在 jeannet (两只黄咪) 的大作中提到：]
:谢谢回复。主要是这个病例非常罕见，广州各大医院都跑遍了都没找到病因。现在都
不知道要看哪个科才对。想看看这边有没有更先进的检测和治疗。Mayo Clinic排名第
:一？ |
|
|
发帖数: 1 | 27 两大可能： Polymyositis， metabolic myopathy.
以他的年纪， 后者可能性更大。 Aldolase查过吧， 大剂量激素用过吧。
如果来美国， 各大医学院附属医院， 都应该没问题， 不一定只那顶尖几个。 这个，
不是什么疑难杂症。 |
|
|
u*****a
发帖数: 6276 | 29 转自饶老师的微信朋友圈。
华人父母误子弟而不知：美国顶尖大学的悖论
一般华人父母，无论海内外，简单认为上顶尖大学、研究生院只会对子女有好处
。
这是一种可能，有时也发生。
但是，还有另外一种可能，而且是发生更多、更频繁。
这就是对于大多数华人孩子，上顶尖学校却负面影响其一生。
没人这么说，因为绝大多数华人不知道事实（绝大多数华人或没进过顶尖、或
进过但不愿对外说事实），也因为华人父母简单迷信臆测。
首先定义顶尖。顶尖在数字上一定少于十，特别前五之内。顶尖的研究生院是
只在其专业顶尖的系科，不是以学校为标准。顶尖的大学本科综合性的就哈佛耶鲁普林
斯顿斯坦福，顶尖的理科课就加州理工麻省理工。
美国顶尖研究所院系长期以来很少中国学生，MIT的生物系非常强，估计三十
多年来平均每年接受不到一个中国学生。我自己念研究生旧金山加州大学（UCSF）其神
经生物计划三十多年来恐怕总共不到十个中国学生，其生物化学系说不定三十年不到五
个中国学生。他们了解情况却因为各种原因不说，导致外界不知情。
... 阅读全帖 |
|
o**********e
发帖数: 18403 | 30 我觉得小孩子爬不爬藤都是自由，多鼓励。
但是小孩子面对反华言论，张口结舌，甚至
参与反华言论。 这是父母的失败，所以华人
大人小孩都应该有不卑不亢维护华人传统的
教育, 几乎所有黑老中
的新闻都要有1分钟立刻能够辩白的训练。
没有的话，即使爬了藤恐怕结果也堪忧。
http://www.mitbbs.com/article_t/JobHunting/32975675.html
【 以下文字转载自 Military 讨论区 】
发信人: Loveanthony (春雨中的江南), 信区: Military
标 题: 上顶尖大学：华人父母误子弟而不知
发信站: BBS 未名空间站 (Wed Jun 10 00:27:13 2015, 美东)
上顶尖大学：华人父母误子弟而不知
饶毅（北京大学教授）
一般而言，无论海内外的华人父母，大都简单地认为上顶尖大学或研究生院只会对子女
有好处。这当然是有可能性的，有时也的确会发生。但是，还有另一种可能性，也许发
生更频繁——那就是对于大多数华人的孩子来说，上顶尖学校也可能对其造成影响一生
的负面作用。
一般国内的人会觉得这种说法令人惊讶，海外华人中也不... 阅读全帖 |
|
b********r
发帖数: 19 | 31 【 以下文字转载自 Biology 讨论区 】
发信人: BULLvsBEAR (Calf), 信区: Biology
标 题: 求文献 at "Chem Rev. 2001 Aug;101(8):2381-411."
发信站: BBS 未名空间站 (Sun Sep 27 03:04:21 2009, 美东)
Shabb JB. Physiological substrates of cAMP-dependent protein kinase. Chem
Rev. 2001 Aug;101(8):2381-411.
My e-mail address is z*****[email protected]
Thank you very much. |
|
p*******r
发帖数: 156 | 32 Postdoctoral positions available
A postdoctoral position is available in the Laboratory of Cellular and
Molecular Biology at the National Cancer Institute. A focus of current
studies is understanding the contribution of integrin adhesion complexes,
including focal adhesions and invadopodia, to the control of cancer cell
proliferation and survival. A class of proteins called the Arf GTPase-
activating proteins (Arf GAPs), which regulate the Ras-superfamily proteins
Arfs and integrin adhesions, ... 阅读全帖 |
|
U******E
发帖数: 444 | 33 ARIA 的pipline应该还是不错的，CML milestone 第3代 kinase inhibitor 很快又要
重新上市 |
|
h******3
发帖数: 195 | 34 恩，谢谢，
还有很多介绍抗体啥的或某方面研究（如apoptosis research or kinase research等
）网站，还有wiki也应用了我的文章
是否也可放到contribution？ |
|
c********g
发帖数: 2075 | 35 给老板审过包括CNS在内的杂志一百多篇，自己受邀给5点多的杂志审过5篇，审稿经验
绝对丰富，有信心让我审稿的请联系email: b***[email protected] 或者站短。 多谢了啊啊
啊啊啊啊。
关键词：
cell signaling, especially TGF-beta and Wnt pathways;
Post-translational modifications;
Kinases, phosphatases, ubiquitin ligases and DUBs;
Proteasome functions and regulations;
Cell cycle control, oncogenes and tumor suppressors;
In vitro and in vivo tumor models;
Cancer metastasis.
neuroscience
neural regeneration |
|
V**F
发帖数: 164 | 36 I have referred one ID with the closest background to the manuscript. Sorry
to others.
****
For toxicology journal impact factor >4, one of the top journals in
toxicology.
Key words: Optical coherence tomography, MAPK/ERK kinase (MEK) inhibitors
Please send me your brief background and contact info if you think you will
be able to handle this manuscript.
I will refer you to the editor.
**** |
|
d*****3
发帖数: 9 | 37 Sent to your inbox. Thank you!
Kinases
the |
|
k****o
发帖数: 728 | 38 Update: 收到很多volunteer邮件。多谢大家的兴趣！因为我不是这个领域，所以得花
些时间看大家的expertise。这两天非常忙，估计周五晚和周六会选取几个（至少5-6）
reviewers，给大家发invitation emails！
Kinases |
|
d****5
发帖数: 202 | 39 回报本版，有意者请发信（附简历）到l***[email protected]联系。我也只能推荐，不能保证
能拿到审稿机会。
Title: Features of Large Hinge-Bending Conformational Transitions.
Prediction of Closed Structure from Open State
Abstract:
We performed a detailed analysis of conformational transition pathways for a
set of ten proteins, which undergo large hinge-bending-type motions with 4-
12 Å RMSD (root mean square distance) between open and closed crystal
structures. ANM-MC algorithm generates a targeted pathway between two
conformations, where ... 阅读全帖 |
|
|
u***s
发帖数: 612 | 41 “Overexpression of P21-activated kinase 4 is associated with poor prognosis
in non-small cell lung cancer and promotes migration and invasion", Journal
of Experimental & Clinical Cancer Research
可以推荐三个人，感兴趣的联系我吧。请提供联系方式，一两句话的背景介绍。 |
|
f******6
发帖数: 68 | 42 来自主题: Immigration版 - 审稿转让 现转让一篇英国皇家化学学会的杂志的稿子.
如果有相关的经验,又需要审稿,请把你的名字,单位,非个人的email发到我的邮箱.
Molecular BioSystems
TITLE: Prediction of drug-target interaction by label propagation with
mutual interaction information derived from heterogeneous network
ABSTRACT:
Identification of potential drug-target interaction pairs is very important,
which is not only for providing greater understanding of protein function,
but also for enhancing drug research, especially for drug function
repositioning. Recently, numerous machine learning... 阅读全帖 |
|
p*******i
发帖数: 141 | 43 Gone already~~~
杂志：Apoptosis
标题：Berberine activates Nrf2 nuclear translocation and against apoptosis
induced by high
glucose in renal tubular epithelial cells through a phosphatidylinositol 3-
kinase/Akt-dependent
mechanism
有意者请短信息 简单用英文介绍一下背景，这样可以转发给主编。最后还须看主编的
意向。 |
|
v*******n
发帖数: 8995 | 44 好像非常合适我的背景，请考虑一下我， 谢谢
ying wang
[email protected]
/* */
背景是molecular biology，cancer(ovarian cancer, tumor metastasis)/stem cell
biology
文章有molecular cell 和cancer research
1. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, and Sen GL.DDX6
Orchestrates Mammalian Progenitor Functionthrough the mRNA Degradation and
Translation Pathways. Mol Cell. doi:10.1016/j.molcel.2015.08.014
2. Mistry DS, Chen Y, Wang Y, Sen GL. Transcriptional profiling of SNAI2
regulated genes in primary human kerat... 阅读全帖 |
|
a*********0
发帖数: 268 | 45 转让life science 审稿一篇。Y-27632, a Rho-associated protein kinase
inhibitor, inhibits voltage-dependent K+ channels in rabbit coronary
arterial smooth muscle cells. 需要background 介绍和email，姓名以便推荐。 |
|
i********n
发帖数: 171 | 46 8.Xiaoxianggou attenuates atherosclerotic plaque formation in endogenous
high Ang II ApoE-/- mice via the inhibition of miR-203 on the expression of
Ets-2 in endothelial cells
9.Loss of Raf kinase inhibitor protein is associated with malignant
progression in hepatic fibrosis
10.Bio-fabricated silver nanoparticles preferentially targets gram positive
depending on cell surface charge
11.Rosiglitazone elevates sensitization of drug-resistant oral epidermoid
carcinoma cells to vincristine by G2/M-ph... 阅读全帖 |
|
i********n
发帖数: 171 | 47 Please send your CV to [email protected]/* */ with selected MS#. 请务必认真审稿并及
时提交意见，谢谢
1. Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat
pulmonary arterial smooth muscle cells
2. Fyn-related kinase expression predicts favorable prognosis in patients
with cervical cancer and suppresses malignant progression by regulating
migration and invasion
3. The Protective effect of Citrus limon essential oil on Hepatotoxicity
and nephrotoxicity induced by aspirin in rats
4. ... 阅读全帖 |
|
i********n
发帖数: 171 | 48 请发邮件到[email protected]/* */
1. Synthesis and characterization of chitosan–polyvinylpyrrolidone–
bovin serum albumin coated magnetic iron oxide nanoparticles as potential
carrier for delivery of tamoxifen
2. n-vitro and In-silico anticancer potentials of taxoids isolated from
Taxus wallichiana Zucc
3. Homology modeling and virtual screening for inhibitors of lipid kinase
PI(4)K from Plasmodium
4. Evidence for the involvement of nitric oxide in cholestasis-induced
itch associated... 阅读全帖 |
|
i********n
发帖数: 171 | 49 Send your CV and MS # to [email protected]/* */, and please reply here with MS #.
Thanks
1. In-silico screening for DNA-dependent protein kinase (DNA-PK)
inhibitors: combined homology modeling, docking, molecular dynamic study
followed by biological investigation
2. Fast and long acting neoflavonoids dalbergin isolated from Dalbergia
sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis
3. Synthesis of stable nanosilver particles (AgNPs) by the proteins of
se... 阅读全帖 |
|
i********n
发帖数: 171 | 50 请发简历及你想审稿的文章编号， 尽量会照顾大家，一般给我邮件都有机会，尽量多
选几篇你相关的领域。
同时提醒一下审稿人，请重视审稿质量，希望大家都有下一次审稿机会。
Please email to: [email protected]/* */
1. Identification of novel VP35 inhibitors: virtual screening driven new
scaffolds
2. Long non-coding RNA SNHG5, which is downregulated by estradiol,
suppresses breast cancer cell proliferation
3. anti-inflammatory, analgesic and antipyretic activities of grapevine
leaf extract (Vitis vinifera) in mice and identification of its active
constituents by LC-MS/MS ... 阅读全帖 |
|
