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全部话题 - 话题: metabolic
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l****y
发帖数: 486
1
你说的很对,其实 target cancer metabolism的 cancer drug在 cancer metabolism
这个领域出来很多年前就有了,比如常用的chemotherapy的药是 target nucleic acid
metabolism的。正如你所说,这类药的副作用大,原因之一就是metabolism是人的正
常细胞所必须的,从这个角度看,target metabolism 挑战性很大,这其中只有IDH是
个例外,因为它在cancer里有突变,并由突变产生了新的功能,所以原理上我们可以设
计药品只 target 这种新的功能,从而spare normal cells.

ihibitor
l****y
发帖数: 486
2
你说的很对,其实 target cancer metabolism的 cancer drug在 cancer metabolism
这个领域出来很多年前就有了,比如常用的chemotherapy的药是 target nucleic acid
metabolism的。正如你所说,这类药的副作用大,原因之一就是metabolism是人的正
常细胞所必须的,从这个角度看,target metabolism 挑战性很大,这其中只有IDH是
个例外,因为它在cancer里有突变,并由突变产生了新的功能,所以原理上我们可以设
计药品只 target 这种新的功能,从而spare normal cells.

ihibitor
E**E
发帖数: 98
3
【 以下文字转载自 Postdoc 讨论区 】
发信人: EQQE (whatever), 信区: Postdoc
标 题: 匹兹堡大学医学院博士后招聘
发信站: BBS 未名空间站 (Mon Jun 4 00:33:27 2018, 美东)
A postdoctoral position is open for highly motivated candidates in the
laboratory of Dr. Bokai Zhu at the Aging Institute of University of
Pittsburgh School of Medicine. The Zhu lab recently discovered a cell-
autonomous mammalian 12h-clock that runs independently from the circadian
clock to regulate 12h oscillations of gene expression and metabolism (Zhu et
al., Cell Metab... 阅读全帖
s*********n
发帖数: 13
4
来自主题: Pharmaceutical版 - Postdoc Position in Boston Biotech
Position: Postdoctoral Scientist in Diabetes.
The diabetes and obesity group of our company in Boston is committed to
discovering innovative medicines to treat cardiovascular and metabolic
disorders. We have an immediate opening for a postdoctoral scientist in the
areas of metabolic, cardiovascular, and mitochondrial dysfunction research.
The postdoctoral scientist will be responsible for:
 Validating novel targets for diabetes, insulin resistance, and
metabolism in skeletal muscle, l... 阅读全帖
k******a
发帖数: 306
5
If interested, pls contact: d******[email protected]
Positions: Principal Scientist, in vivo Pharmacology, Diabetes
Location: Shanghai, China
Key Objectives/Deliverables:
• Work with diabetes discovery research scientists to develop animal
models and platforms for evaluating novel drug targets and pathways, and to
characterize mechanisms of action in regulating glucose metabolism.
• Develop appropriate animal models for evaluating compound effects on
glucose and lipid metabolism.
•... 阅读全帖
A*******s
发帖数: 9638
6
来自主题: Medicalpractice版 - 世界卫生组织: 手机致癌?
Recommendations on Cell Phone Use and Cancer Risk(ZZ)
Allison Gandey
Information from Industry
Think what it could it cost you not to adopt an EHR system
For office-based physician not adopting an electronic health records(EHR)
system by 2015, Medicare payments are planned to be reduced.
Calculate impact June 22, 2011 — The evidence is limited when it comes to
cell phones and cancer risk, but specialists say common-sense measures can
come into play until the science catches up with technology.
T... 阅读全帖
m*********a
发帖数: 3299
7
来自主题: USANews版 - 杀光亚裔,对美国屁影响没有
Jews .2% of world population, 20% of all Nobel prices, 40% of USA nobel
price, won more than 160 nobels.
All Asian are junk compare to Jewish people in your standard.
Literature[edit source | edit]
Year Laureate Country Rationale
1927 Bergson-Nobel-photo.jpg Henri Bergson[9][10] France "in
recognition of his rich and vitalizing ideas and the brilliant skill with
which they have been presented"[11]
1958 Boris Pasternak cropped.jpg Boris Pasternak[9][10] Sov... 阅读全帖
t**x
发帖数: 20965
8
来自主题: USANews版 - 细节决定成败
In Mar 2015, Jianhua’s parents took him and his brother to Cincinnati
Children’s Hospital Medical Center (CCHMC). Three doctors, William F.
Balistreri, MD (medical director emeritus of liver transplantation), Amy T
Sheil, MD, and Kevin E. Bove, MD (the most experienced CCHMC pathologist),
stated that the injuries were apparently metabolic after reviewing slides of
the biopsy done in SCH. They said that Jianhua’s liver survived an acute
insult, but it had the potential to partially recover. The u... 阅读全帖
f*********o
发帖数: 38
9
来自主题: Classified版 - DMPK 上海药厂招聘
欧美药厂在上海职位,更多职位Available
2. Primary Purpose of Job (Job Summary) 主要工作目标(岗位简介)
To provide DMPK support for drug discovery projects from target assessment
to clinical lead selected (CLS) and to lead efforts of investigating DMPK
issues/problems of drug candidates.
3. Principle Roles & Responsibilities / Accountabilities 主要职责/责任
(Major functions of the position) (职位的首
要职能)
a. Serve as an early nonclinical pharmacokinetics and drug metabolism Rep
. for NCS Chin... 阅读全帖
f*********o
发帖数: 38
10
来自主题: JobMarket版 - DMPK 上海药厂招聘
欧美药厂在上海职位,更多职位Available
2. Primary Purpose of Job (Job Summary) 主要工作目标(岗位简介)
To provide DMPK support for drug discovery projects from target assessment
to clinical lead selected (CLS) and to lead efforts of investigating DMPK
issues/problems of drug candidates.
3. Principle Roles & Responsibilities / Accountabilities 主要职责/责任
(Major functions of the position) (职位的首
要职能)
a. Serve as an early nonclinical pharmacokinetics and drug metabolism Rep
. for NCS Chin... 阅读全帖
r*****u
发帖数: 56
11
来自主题: Postdoc版 - Postdoc position available
A postdoctoral position is immediately available in the newly established
Cheng Lab, Department of Human Nutrition, Food and Exercise, Virginia Tech.
Motivated professionals, who are interested in research on type 2 diabetes,
obesity and cancer [1-7], are welcome to apply. Strong background/expertise
in biochemistry, molecular biology and/or cell biology is required. Previous
experience in signal transduction pathway analysis [1-3,5-7], mitochondrial
function [2,6,7], or redox (oxidation/reducti... 阅读全帖
g**y
发帖数: 1106
12
来自主题: Fitness版 - 正常人每天消耗多少卡呀?
还有 zz
Metabolism slows down gradually as you get older.
Weight highers your metabolism and so does height.
Anyways don't take less that 1,500-1,200 calories a day or your metabolism
will go madly down.
If you didn't know metabolism=calories your body uses to stay active/alive
a****8
发帖数: 2771
13
来自主题: loseweight版 - 闲话减肥 (三)
运动提高基础代谢的说法存疑。
What about your metabolic rate?
One popular claim is that aerobic exercise leads to an increase in your
metabolic rate. However, researchers conducting the HERITAGE Family Study
found that almost six months of aerobic exercise had no effect on resting
metabolic rate [13].
Some studies do show that elite athletes have a higher metabolic rate than
weight-matched controls. However, scientists have been unable to establish
whether this is due to a higher calorie intake, a superior lev
d*****n
发帖数: 760
14
It is all about metabolism.
Fat people may have faster metabolism than slim people, but when compare to
his/her own body weight, the fat burn from metabolism is negligible.
Basically it means even fat people has FASTER metabolism and burns more fat
(in terms of pounds), but it it still not fast enough to keep up with the
body weight! Why? because they don't do exercise, they need to exercise to
burn more.
R******a
发帖数: 1096
15
来自主题: loseweight版 - 谁能帮我看看这个Ingredients吗?
我准备参加一个减肥program,里面要用到的一种辅助产品。能帮我看看吗?安全吗?
有效吗?
Chromium (100 mcg/serving; 200 mcg/day)
Dietary chromium is an essential trace mineral assisting in the metabolism
and use of carbohydrates and fat. Known as the glucose tolerance factor,
chromium promotes the delivery of blood sugar to cells, thereby helping to
maintain normal insulin activity. Chromium also helps maintain healthy
levels of cholesterol and other blood lipids. Due to the role it plays in
metabolism, chromium is commonly added to nat... 阅读全帖
G***a
发帖数: 27294
16
来自主题: loseweight版 - 诺诺你觉得这个讲座咋样?
好的话,我就去听了, 这是Vice Chancellor invite的讲座。。。 suppose是good
research
Erin E. Kershaw, MD, assistant professor of medicine, School of Medicine
“Lipolysis in Metabolic Syndrome: Beyond Adipose Tissue.”
Topic Overview:
Obesity and metabolic syndrome are global health threats. Insulin resistance
and metabolic complications of obesity are strongly associated with
intracellular accumulation of triacylglycerol (TG); however, the mechanisms
underlying TG accumulation and its relationship to lipid-induced tox... 阅读全帖
h******e
发帖数: 91
17
12月记录
链接
Michael Jillian Yoga meltdown :
http://youtu.be/q5nyrD4eM64
http://youtu.be/su2cbxii4mI
--------------------------------------------------------
Michael Jillian Banish Fat, Boost Metabolism
http://youtu.be/FTT4W8ygJ7w
-----------------------------------------------------------
Michaels Jillian No more Trouble Zone
http://youtu.be/EHx3UeZl5YY
-----------------------------------------------------------
Denise Austin: Yoga Cardio Burn Workout
http://youtu.be/0J7vypuJxOc
-------------------... 阅读全帖
y***r
发帖数: 1845
18
http://www.ncbi.nlm.nih.gov/pubmed/20351596
Training with low muscle glycogen enhances fat metabolism in well-trained
cyclists.
Hulston CJ, Venables MC, Mann CH, Martin C, Philp A, Baar K, Jeukendrup AE.
Source
School of Sport and Exercise Sciences, University of Birmingham, Birmingham,
United Kingdom.
Abstract
PURPOSE:
To determine the effects of training with low muscle glycogen on exercise
performance, substrate metabolism, and skeletal muscle adaptation.
METHODS:
Fourteen well-trained cyclis... 阅读全帖
p********3
发帖数: 5750
19
50, 70, 71; 大家注意一下和这几篇文献相关的话题。 另外, 73-75我本人没有看,确实是谈的印度药材, 我在查阅参考文献的时候在搜索Chinese Medicine的时候, 显示有这些文献,我本人没有亲自看这些文献, 也许其中有讲中药的地方。不过这不影响我要表达的意思。
慢慢看:
INTRODUCTION — Plants have been used for medicinal purposes for thousands
of years. All major cultures including Native American, European, South
American, Asian, and African cultures have used botanicals for healing
purposes. As an example, saw palmetto was used for urinary symptoms in men
from Egypt in the 15th century BC [1]. Hippocrates documented... 阅读全帖
O******e
发帖数: 4845
20
来自主题: Biology版 - [合集] 我也来说cancer
☆─────────────────────────────────────☆
icecreamman (qiqi) 于 (Mon Sep 25 17:27:43 2006) 提到:
我不很看好时下的Targeted Therapy,迄今的clinical trial结果都不太好(Gleevec是
例外),针对PI3K,MAPK,EGFR, Ras到B-Raf的各种药,或是毒性太大,或是无疗效。
我自己比较中意angiogenesis和cancer cell metabolism,因此看好VEGF,mTOR,AMPK
,HIF和glycolysis。
我倾向于把癌症看作是metabolic疾病,而不是genetic疾病。我猜测未来的突破也许会
来自elucidation of the metabolic basis of cell transformation and theparies
based on metabolic perturbation。今天来研究代谢,手段方法比三四十年前多了很
多,所以很可能会有意想不到的新发现。
从大的角度上说,我更认同中医对人体对疾病的理
j***z
发帖数: 105
21
Actually understanding cancer metabolism is very challenging due to current
technology constrain. We still cannot measure local metabolite concentration
or accurately capture metabolic flux.
Another reason is that the field is still emerging. A lot of people still do
not believe cancer metabolism means anything. But recent identification of
mutations in metabolic genes means it is more than just an interesting
observation.
h******y
发帖数: 351
22
来自主题: Biology版 - 问一个癌症Metastasis 的问题
Metabolism: Warburg effect revisited
http://www.nature.com/nrc/journal/v8/n4/full/nrc2364.html
It was Otto Warburg who first noted the difference between metabolism in
cancer cells and that in normal adult tissues: cancer cells take up glucose
at higher rates than normal tissue but use a smaller fraction of this
glucose for oxidative phosphorylation.
But how do tumour cells achieve this altered metabolic phenotype? The
authors reasoned that tumour tissue switches pyruvate kinase expression from
... 阅读全帖
r*****u
发帖数: 56
23
来自主题: Biology版 - Postdoc position available
A postdoctoral position is immediately available in the newly established
Cheng Lab, Department of Human Nutrition, Food and Exercise, Virginia Tech.
Motivated professionals, who are interested in research on type 2 diabetes,
obesity and cancer [1-7], are welcome to apply. Strong background/expertise
in biochemistry, molecular biology and/or cell biology is required. Previous
experience in signal transduction pathway analysis [1-3,5-7], mitochondrial
function [2,6,7], or redox (oxidation/reducti... 阅读全帖
s*******e
发帖数: 1389
24
来自主题: Biology版 - 求最新development文献一片
"一直期待着stem cell和cancer有一样的metabolism profile"?
Adult stem cell通常被认为quiescent,怎么可能与Cancer“有一样的metabolism
profile”?
就好比一个人刚跑完200米,一个人在睡觉,你期待这俩人心跳相同?
stem cell只是一个概念,说这类细胞有分化的多能性,并可以自我更新。实际上不同
组织中的干细胞的行为差异巨大。
举个例子,intestinal stem cell: (1)人与人不同。(2)肠道中不同部位的stem
cell不同。(3)同一Cell不同时间不同。
我个人从不期望stem cell有均一的metabolism profile。我现在做的,改变stem cell
metabolism niche,然后去看stem cell的分裂、分化有无变化。

样。
s*******o
发帖数: 2452
25
来自主题: Biology版 - postdoc position available
Funded Positions Available
Postdoctoral Researchers, Graduate/Medical Students, and Technicians
interested in Skeletal Development and Disease Research
Various positions are available in the Karner Laboratory within the Duke
Orthopaedic Cellular, Developmental, and Genome Laboratories at Duke
University School of Medicine. The primary research focus of these positions
will be to create and utilize novel mouse genetic models to study the role
of cellular metabolism during skeletal development and... 阅读全帖
c*******e
发帖数: 11
26
来自主题: Biology版 - Scientist position in Pfizer Cambridge
A scientist position is opened in Pfizer Cambridge. Background in metabolism
is preferred and this position involves major in vivo studies.
Some details are posted as following, and more details can be found online
under the job ID 1050416. Anyone interested in this position can contact me
for further information.Thanks.
Responsibilities
Successful candidates will be expected to:
• Have knowledge and skill sets in cellular and molecular physiology,
particularly in liver metabolism.
•... 阅读全帖

发帖数: 1
27
Two Postdoctoral Fellow positions are available for highly motivated and
productive applicants in the laboratory of Dr. Subhamoy Dasgupta at the
Department of Cell Stress Biology, Roswell Park Cancer Institute, NY- a
National Cancer Institute (NCI) designated comprehensive cancer center. The
Dasgupta lab will be moving to Roswell Park during the summer of 2017 and
the laboratory will be fully functional by July 2017. The laboratory focuses
on discovering novel metabolic adaptations that promote ... 阅读全帖
W******r
发帖数: 789
28
来自主题: ChineseMed版 - 关于糖尿病和胰岛素

我直接贴吧。
Deadly Diabetes Deception
Introduction
If you are an American diabetic, your physician will never tell you that
most cases of diabetes are curable. In fact, if you even mention the "cure"
word around him, he will likely become upset and irrational. His medical
school training only allows him to respond to the word "treatment". For him,
the "cure" word does not exist. Diabetes, in its modern epidemic form, is a
curable disease and has been for at least 40 years. In 2001, the most
recent y... 阅读全帖
A*******s
发帖数: 9638
29
来自主题: MedicalCareer版 - 请教一道step1题目
ETOH is metabolized by alcoholdehydrogenase to acetaldehyde that in turn is
metabolized to acetate by aldehydehydrogenase. Acetate is finally broken to
CO2 and H2O in TCA cycle. Along its various metabolic steps, ETOH
metabolism requires Thiamine as a cofactor and this depletes rapidly.

and
defficiency
x**2
发帖数: 255
30
各位前辈,大家好~
我在读生化博士,第三年刚结束。关于人生、就业,有很多事情看不透,还希望各位前
辈不吝赐教,谢谢!
我的课题是P450酶的药物代谢以及简单的酶动力学。因为用到很多分析化学的试验方法
,之前一直把自己的就业定位在药厂里做分析化学或者drug metabolism的工作(PK/PD
的软件我和学长们都没见过,估计药厂不会找我们去做PK/PD的工作吧?)。但是我来
美国这三年药厂似乎是每况愈下,裁人不断,现在不少有经验的学长和博后都很在为就
业问题头疼,市场上貌似积压了很多人才,身份问题也是个坎儿。前辈们觉得这个就业
市场近几年能有所改善么?
本来想着不行就回国去张江药谷做drug metabolism,但是看了看国内制药公司的网站
,发现很多公司都把仿制药物当块宝,而真正需要做drug metabolism的貌似很少,不
禁又开始为就业发愁。
我是坚决不想做博后的。现在想到这么一条路:我再花2-3年时间把博士拿到,之后能
找到药厂的工作就留在美国,找不到就回国参加司法考试之后找个律师事务所做个专利
律师,或者在国内药厂里做专利申请的工作,不知道大家觉得行不行得通?
或者我... 阅读全帖
c*******e
发帖数: 11
31
来自主题: Pharmaceutical版 - Scientist position in Pfizer Cambridge
A scientist position is opened in Pfizer Cambridge. Background in metabolism
is preferred and this position involves major in vivo studies.
Some details are posted as following, and more details can be found online
under the job ID 1050416. Anyone interested in this position can contact me
for further information.Thanks.
Responsibilities
Successful candidates will be expected to:
• Have knowledge and skill sets in cellular and molecular physiology,
particularly in liver metabolism.
•... 阅读全帖
y*******u
发帖数: 397
32
来自主题: Medicalpractice版 - 求助: 6个月大婴儿肝衰竭 (转载)
他们在西雅图儿童医院
这是最新进展,大家帮看看吧。http://www.huaren.us/dispbbs.asp?boardid=333&Id=1411021
4月9号进ER, 今天4月15日, 6天过去了,宝宝今天还算稳定。给大家说说一些事情,
寻求帮助并希望对其他父母有些借鉴。
第一: 几乎我们接触到的绝大多数医生都不仔细看报告,他们根本就是按照程序准备换
肝,没有一个人相信我们家的宝宝能保住他的肝。这时候如果父母不给孩子最后一线希
望,孩子肯定没法独自战斗了。
第二: 就是医生们现在都很专业,导致很多事情互相扯皮。在我们家宝宝的情况下,就
是杀人。我们一再强调孩子这个病跟长期食用奶粉反应不好有关,所以任何奶粉都得非
常小心。结果他们给孩子的奶粉30个小时内,孩子各方面情况全面恶化,被迫再次大剂
量输血浆和ffp. 以后要成为医生的网友,父母有关孩子生长详细信息的话一定要认真
地听和思考。对于一个小个体,医生的固执就是一个肝或一条命。
第三就是huaren和mitbbs的确是对我们海外需要帮助的人来说最及时。我当时看了
huaren好心人的帖子并下载了建议的paper, 看完后到... 阅读全帖
m*********k
发帖数: 10521
33
=====================================================================
=========================Nature质疑叶诗文事件========================
=============================网友支招抗议============================
http://www.mitbbs.com/mitbbs_article_t.php?board=Biology&gid=31
发信人: zfwang (爱国老将), 信区: Biology
标 题: 对Nature 文章的反驳,作为千老,看不下去了。
发信站: BBS 未名空间站 (Fri Aug 3 10:24:23 2012, 美东)
原文是发在 Olympics 班 对给编辑写信的回复。但现在觉得这还是该生物班的责任。
作为一个科学家,一个中国人,有这么个争议性大的热门课题,放过可惜了。90% 的工
作量是收集数据,但人多力量大,如果后来的收集数据多了,可以裁开发,力度更大。
-----... 阅读全帖
s*******u
发帖数: 9508
34
下面是所有editor的信息,但是没有email地址。 应该能查出来。
大家给这些editor发信吧,comments的作用不是很大。
ABOUT THE EDITORS
Editor-in-Chief
Philip Campbell
London
Education: BSc, aeronautical engineering, University of Bristol; MSc,
astrophysics, Queen Mary and Westfield College, University of London; PhD
and postdoctoral fellowship, upper atmospheric physics, University of
Leicester. Areas of responsibility include: Co-Editor of Editorials,
editorial content and management of Nature, long-term quality of all Nature
Publications.
Ex... 阅读全帖
G***E
发帖数: 392
35
万爽力 Trimetazidine
对于心脏有恙的病人是最常用的,没什么特别的,主要是治疗胸闷,心肌缺血,加大供
氧量的。
这个是队医的失误。没查list就瞎开药。
2014年以前是列在兴奋剂里,现在不属于兴奋剂,但还是被禁止使用的药物。
揪着这个个案不放,是不地道。
再有,个人体验,接触过的澳洲人普遍素质极差,种族歧视严重。自己国旗里还有英帝
的米字旗,还有脸笑话其他真正自己争取完全独立的国家。
附:禁药清单
http://www.usada.org/wp-content/uploads/wada-2016-prohibited-list-en.pdf
S4.HORMONE AND METABOLIC MODULATORS
5.4 Trimetazidine.
https://www.swimmingworldmagazine.com/news/sun-yang-doping-case/
Trimetazidine Will Be Reclassified in 2015
Ben Nichols, WADA Senior Manager of Media Relations, inf... 阅读全帖

发帖数: 1
36
来自主题: Classified版 - position available
Postdoc fellow / research scholar / exchange student positions are available
at Baylor College of Medicine at Houston, Texas. Studies are focused on
epigenomic regulation of metabolism and cognitive functions, involving
nuclear hormone receptors and gene expression regulation in diabetes, autism
, and circadian clock. We are interested in how hypothalamic circadian clock
regulates systemic glucose metabolism, and how physical exercise remodels
skeletal muscle bioenergetics. Approaches include ge... 阅读全帖
n**********o
发帖数: 1016
37
来自主题: Faculty版 - 新当选的99名NAE members
https://www.nae.edu/MediaRoom/178117.aspx
Abadi, Martín, principal scientist, Google Inc., Palo Alto, Calif. For
contributions to the formal theory of computer security.
Abrahamson, Norman A., chief engineering seismologist, Pacific Gas &
Electric Co., Piedmont, Calif. For contributions to seismic hazard
assessment and for leadership in engineering seismology and earthquake
engineering.
Adams, Robert W., senior fellow, Analog Devices Inc., Acton, Mass. For
contributions to digital storage and... 阅读全帖
t*****o
发帖数: 4919
38
来自主题: Food版 - 我建议大家少和咖啡
Daily Coffee May Boost Colon Cancer Survival
By Roni Caryn Rabin August 17, 2015 4:20 pm August 17, 2015 4:20 pm
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Credit William Widmer for The New York Times
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Colon cancer patients who were heavy coffee drinkers had a far lower risk of
dying or having their cancer return than those who did not drink coffee,
with significant benefits starting at two to three cups a day, a new study
found. Patients who drank four cups of caffeinated coffee or mo... 阅读全帖
s******n
发帖数: 110
39
我帮洛杉矶另一所大学的朋友招一个技术员和一个博士后,生物医学方向。有意者请直
接与他联系。此广告六个月内有效。
Posting Details
Classification Title: Lab Technician
Working Title: Research Assistant
Campus: Charles Drew University of Medicine and Science
Region: Los Angeles, California
Job Summary:
Our lab at Division of Cancer Research and Training uses a wide range of
molecular and biochemistry approaches to understand pathogenesis of
metabolic disorder-associated breast cancer and discover novel therapies
from small molecular agents. As a ful... 阅读全帖

发帖数: 1
40
来自主题: JobMarket版 - position available
Postdoc fellow / research scholar / exchange student positions are available
at Baylor College of Medicine at Houston, Texas. Studies are focused on
epigenomic regulation of metabolism and cognitive functions, involving
nuclear hormone receptors and gene expression regulation in diabetes, autism
, and circadian clock. We are interested in how hypothalamic circadian clock
regulates systemic glucose metabolism, and how physical exercise remodels
skeletal muscle bioenergetics. Approaches include ge... 阅读全帖
h*****m
发帖数: 36
41
Postdoctoral Position Investigating the Molecular Pathogenesis of Diabetes
A postdoctoral position is available immediately in the Herman Laboratory of
the division of Diabetes, Endocrinology and Metabolism at Beth Israel
Deaconess Medical Center, Harvard Medical School. The goal of our research
program is to determine the molecular pathogenesis of insulin resistance,
type 2 diabetes, and related metabolic conditions. Current studies focus on
the molecular mechanisms by which liver, adipose ti... 阅读全帖
m*******1
发帖数: 344
42
来自主题: Immigration版 - Sad...EB1B RFE even 3 criteria met
Sorry can't type in Chinese here and for the confusion in my original post.
In my petition letter, I only claimed original contribution and publication,
using judge of others and media report as supporting evidence for
contribution.
However, the IO agreed on media report, judge, and publication, but not on
contribution.
S/he thinks that the recommendation letters are vague.
"these letter are vague, and their comments are not supported by the
evidence. For example, Dr. xx states, "Cell Metabolis... 阅读全帖
l******t
发帖数: 2243
43
来自主题: Immigration版 - Sad...EB1B RFE even 3 criteria met
It seems that the IO gave you very nice instructions on what kinds of
evidence he wants to see. You might have to dig deep into your materials
especially your citations and media reports since they are documentary
evidence, and re-organize them to show "international" and "outstanding".
Letters from people who cited your paper should also be helpful.

发信人: mitbbsll1 (banana), 信区: Immigration
标 题: Re: Sad...EB1B RFE even 3 criteria met
发信站: BBS 未名空间站 (Tue Mar 22 10:09:09 2011, 美东)
Sorry can't t... 阅读全帖
R*******d
发帖数: 13640
44
来自主题: Immigration版 - 包子求一个杂志怎么吹?
My significant contribution to biomedical field is evidenced by the fact
that the journal Cell Metabolism is ranked the top 1st (0.82%) of 122
journals in subject categories Endocrinology & Metabolism when sorted by
Article Influence Score from Journal Citation Reports published by Thomson
Reuters.
According to Journal Citation Reports "The Article Influence determines the
average influence of a journal's articles over the first five years after
publication. It is calculated by dividing a jour... 阅读全帖
M*******T
发帖数: 492
45
In general, personal trainer will not judge a client by their metabolism
rate. Before beging any program, a
personal trainer will need to obtain certain information about a client.
Such as medical history, life style
history....etc
Based on how the condition of the client (Sometimes a client's doctor's
releas is needed), a program is then
designed to fit the specific client's goal.
Also personal trainer will not and should not give nutrition advise, rather
refer client to certified nutritionist.... 阅读全帖
M********e
发帖数: 2528
46
我不知道你是从哪里来的概念,比如“超过3个月以上喂养的实验概不算数?”,比如
科学实验从来不test超过3个月什么的,你是否读过任何文章啊?
下面是引用的综述的文章。
http://www.sciencedirect.com/science/article/pii/S0278691511006
在table3里列了很多研究转基因玉米及其他对动物的影响。在这个就有好几年研究啊。
这些研究结果都没发现转基因比传统育种的更risky。
不过我觉得我的确太闲了。
Table 3.
Impact of GM plant diets in multigenerational studies.

Plant Trait Reference & Funding Species Duration Parameters
Group (n = number of individuals per group) Mai... 阅读全帖
t*******y
发帖数: 10477
47
来自主题: Fishing版 - where to find bass (ZT)
Very good article from http://www.bassresource.com/fish_biology/biology.html
Bass Are
Cold Blooded:
Their body temperature and more importantly, their metabolism is controlled
by water temperature. The warmer the water, the higher their metabolism.
Bass are most active between about 60 degrees and 75 degrees. Below about 50
degrees, their metabolism slows down, causing them to eat infrequently.
Above about 80 degrees, low dissolved oxygen levels in the water place them
under stress. Dead perch m
c******t
发帖数: 1733
48
来自主题: Fitness版 - [bssd] 奔段视频
After burn, it is real.
This study indicates that the EPOC is 1/3 of the calories burned during a
workout. That is pretty significant.
Med Sci Sports Exerc. 2011 Feb 8. [Epub ahead of print]
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours.
Knab AM, Shanely RA, Corbin K, Jin F, Sha W, Nieman DC.
1 Human Performance Laboratory, Appalachian State University, North Carolina
Research Campus, Kannapolis NC 2 UNC Nutrition Research Institute,
University of North Carolina Chapel... 阅读全帖
c******t
发帖数: 1733
49
来自主题: Fitness版 - [bssd] 奔段视频
After burn, it is real.
This study indicates that the EPOC is 1/3 of the calories burned during a
workout. That is pretty significant.
Med Sci Sports Exerc. 2011 Feb 8. [Epub ahead of print]
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours.
Knab AM, Shanely RA, Corbin K, Jin F, Sha W, Nieman DC.
1 Human Performance Laboratory, Appalachian State University, North Carolina
Research Campus, Kannapolis NC 2 UNC Nutrition Research Institute,
University of North Carolina Chapel... 阅读全帖
c****1
发帖数: 5654
50
i should not have said base metabolism, but it does raise your metabolism
after
exercise, how long or how much, it depends on a lot of things like how
muscular
u are...
as long as u are not overeat, eating food can raise ur metabolism too.
healthy food is a good thing for ur body, we need to advocate healthy eat,
regular exercise.
For most fat asians, it is more a change of lifestyle instead of reduction
of
food.
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