m*******1
发帖数: 213 | 1 Good one! I heard the same joke from Seinfeld. It is so true! Well, cats are
even more "cunning" -- they meow like a baby to stimulate our maternal/
paternal instincts and we even scoop their shit and proudly call ourselves
cat slaves! Lol
leader |
|
s******p
发帖数: 727 | 2 抓紧时间养娃吧
刚搜到篇文章advanced paternal age is associated with impaired neurocognitive
outcomes during infancy and childhood
我不说, 自己看...... |
|
m**********e
发帖数: 2808 | 3 上图是model 2: Adjusted for Other Parent's age, Mother's Race, Gestational
Age, and Child Gender, Socioeconomic Index, Marital Status, and Maternal and
Paternal Mental Illness
本图是model 1: Adjusted for Other Parent's Age, Mother's Race, Gestational
Age, and Child Gender |
|
m**********e
发帖数: 2808 | 4 绝对同意，他们也意识到这个问题，所以尽量去除“Socioeconomic Index, Marital
Status, and Maternal and
Paternal Mental Illness”来approximate。。。
observational studies这样的问题非常非常多。 |
|
d**********2
发帖数: 831 | 5 Rate of de novo mutations and the importance of father’s age to disease
risk
Nature 488, 471–475 (23 August 2012)
Mutations generate sequence diversity and provide a substrate for selection.
The rate of de novo mutations is therefore of major importance to evolution
. Here we conduct a study of genome-wide mutation rates by sequencing the
entire genomes of 78 Icelandic parent–offspring trios at high coverage. We
show that in our samples, with an average father’s age of 29.7, the average
de novo ... 阅读全帖 |
|
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t*******r
发帖数: 3271 | 7 说真的姑娘你要是不爆降你的pu。。。。你很难搞的。找到了也是以后老公出轨的命。
别以为男人真的喜欢女汉子，还是喜欢说话做事都有女人气息的女人，这是基因决定的。
pu = paternity uncertainty，亲子不确定性。 |
|
m****a
发帖数: 9485 | 8 The Prophet Joseph Smith said: “While one portion of the human race is
judging and condemning the other without mercy, the Great Parent of the
universe looks upon the whole of the human family with a fatherly care and
paternal regard; … He holds the reins of judgment in His hands; He is a
wise Lawgiver, and will judge all men, … ‘not according to what they have
not, but according to what they have,’ those who have lived without law,
will be judged without law, and those who have a law, will be j... 阅读全帖 |
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c**i
发帖数: 6973 | 9 In my original posting, (1) mentioned coins bearing Cleopatra likeness.
Michiko Kakutani, The Woman Who Had the World in Thrall. New York Times, Nov
. 2, 2010 (title in the print).
http://www.nytimes.com/2010/11/02/books/02book.html?_r=1&scp=1&sq=michiko%20cleopatra&st=cse
Note:
(1) Michiko KAKUTANI 角谷 美智子; 1955- ; 日系アメリカ人二世 American born.
(2) The print edition but not online version has a photo of a contemporary
coin, with caption: "[photo credit:] From Cleopatra: A Book. By Stacy Schiff
. A 80... 阅读全帖 |
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l***y
发帖数: 791 | 10 The sound of Sun moving
from solstice to equinox
has projected into paterns in coal,
into life pieces in amber.
I'd pour these two into a blender,
night dark and beaten gold,
and release the heat
that's recorded so very long ago
and as new as yesterday.
New because we are still here,
quick as days going. Quick
as the voices in song, laughing, sighing,
praying, avenging past pains,
burning them all to light.
Trembles climbing from deeper in the earth,
and eyelids opening on their own accord,
thes |
|
l***y
发帖数: 791 | 11 Keats seemed to sing praise for the artwork which preserves beauty against
time and age: beauty triumphed and became the truth of life; while Eliot
embarked upon a dissertation (the master of patern and form in front of a
chinese jar) about movements of an artwork itself and how it was and was not
associated with time. The artist is inspired first, and the art is
resulted later; while we preceive art first and is touched by it later.
therefore, to the audience of art, the end is before the begin |
|
m****a
发帖数: 9485 | 12 The Prophet Joseph Smith said: “While one portion of the human race is
judging and condemning the other without mercy, the Great Parent of the
universe looks upon the whole of the human family with a fatherly care and
paternal regard; … He holds the reins of judgment in His hands; He is a
wise Lawgiver, and will judge all men, … ‘not according to what they have
not, but according to what they have,’ those who have lived without law,
will be judged without law, and those who have a law, will be j... 阅读全帖 |
|
l**********t
发帖数: 5754 | 13
7. To all of you who are at Rome, etc. By this happy arrangement he
sets forth what there is in us worthy of commendation; he says, that
first the Lord through his own kindness made us the objects of his
favor and love; and then that he has called us; and thirdly, that he
has called us to holiness: but this high honor only then exists, when
we are not wanting to our call.
Here a rich truth presents itself to us, to which I shall briefly
refer, and leave it to be meditated u... 阅读全帖 |
|
l**********t
发帖数: 5754 | 14
Or despisest thou the riches of his goodness and forbearance and long-
suffering[64]; not knowing that the goodness of God leadeth thee to
repentance?
"
4. Dost thou despise the riches? etc. It does not seem to me, as some think,
that there is here an argument, conclusive on two grounds, (dilemma,) but
an anticipation of an objection: for as hypocrites are commonly transported
with prosperity, as though they had merited the Lord’s kindness by their
good deeds, and become thus more hardened in t... 阅读全帖 |
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s******l
发帖数: 6898 | 15 版上讨论同性恋婚姻的十分踊跃。
故科普一下这个，同性恋婚姻，其实就是第三个原则“冒犯原则”逐渐被人淡化的结果。
1、伤害原则 Harm Principle
也叫作“不干涉原则”(Non-interference Principle)
19世纪后半期英国自由主义的代表性人物约翰•密尔概括出的一条“极其简
单的原则”，它就是密尔在社会与个人之间所划定的边界,也是合法和非法的边界。
原则如下：
人类之所以有理有权可以个别或者集体地对其中任何成员的行动自由进行干涉,唯
一的目的只是自我防卫。这就是说,权力能够正当地施与文明群体中的任何成员的唯一
的目的只是要防止其对他人的伤害。
这条原则,虽然简单,却蕴含着非常重要的思想内核。从17世纪的英国思想家霍布斯
开始,就从自然状态理论出发,论证了人们从自然状态过渡到社会状态即是为了自保。他
认为,在自然状态下,人是“孤独、贫穷、肮脏、残酷和短命的”,在理性的引导下,人们
从自然状态进入到了社会状态,其目的就是为了自保。 洛克虽然不同意霍布斯对自然状
态的描述,但也同意,人们从自然状态过渡到社会状态的就是为了“生命、自由和... 阅读全帖 |
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G******e
发帖数: 9567 | 16 How many folks know that King James (who commissioned the King James Bible
and to whom it was dedicated) loved men and had sex with them?
A physical weakling, as an adolescent James had shown himself to be a coward
, who liked only to hunt, to read (which he did, prodigiously) and to talk.
To protect himself he wore thick quilted doublets, so padded that they
provided a kind of armor against any assassin who might attack him with a
knife. When he revealed a sexual preference for men, falling in ... 阅读全帖 |
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y****n
发帖数: 1397 | 17 http://www.mitbbs.com/article_t/TrustInJesus/927621.html
Abaya Rubin
Accused
Diocesan
One of seven priests named as defendants in 1984 civil suits filed by a 16
yr old girl seduced by Santiago (Henry) Tamayo and then by six other
Filipino priests in Los Angeles. All fled the country (with support from
Archdiocese) after suits filed. Others include Henry Caboang, Valentine
Tugade, Sylvio Lacar, Victor Balbin, and Angelo Cruces. One of the priests (
not Abaya) fathered the girl's child. Arch... 阅读全帖 |
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O**********0
发帖数: 61 | 18 ☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Nov 1 17:30:19 2011, 美东) 提到:
1:1耶稣基督的仆人保罗，奉召为使徒，特派传神的福音。
1:2这福音是神从前藉众先知，在圣经上所应许的。
1:3论到他儿子，我主耶稣基督。按肉体说，是从大卫后裔生的。
1:4按圣善的灵说，因从死里复活，以大能显明是神的儿子。
1:5我们从他受了恩惠，并使徒的职分，在万国之中叫人为他的名信服真道。
1:6其中也有你们这蒙召属耶稣基督的人。
1:7我写信给你们在罗马为神所爱，奉召作圣徒的众人。愿恩惠平安，从我们的父神，
并主耶稣基督，归与你们。
1：1 首先讲到保罗的身份，是耶稣基督的仆人，是使徒，而他的职责就是传“神的福
音”。一句话，保罗言简意赅的描述了自己的身份和使命。
1：2 其次保罗讲到了福音与旧约的关系，是承传的关系，是在旧约中就应许了的福音。
1：3 按旧约说，耶稣基督是大卫后裔，应验了旧约的预言和神的应许。参见撒母耳记
下7：12
1：4 按新约说，耶稣以复活显明自己是神的儿子。
1：5... 阅读全帖 |
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d******r
发帖数: 5008 | 19
The Dark Side of Pentecostal Enthusiasm: Abraham’s and Sara’s Sacrifice in
Knutby, Sweden
Jone Salomonsen
全文在此：
http://folk.uio.no/leirvik/tekster/SalomonsenKnutby.htm
以下是书中的三个case
Case 1. California: “How Can You Say No to God?”
The first case to be considered is narrated by Carol Delaney like this: On
January 6, 1990 in California, a middle aged bus driver called Cristos
Valenti by Delaney, took his youngest child, his most beloved daughter, with
him in the truck, to faithfully accomplish wha... 阅读全帖 |
|
E*****m
发帖数: 25615 | 20 http://www.npr.org/blogs/thetwo-way/2013/09/18/223760246/judge-
Judge: Boy In Tennessee Can Keep Name 'Messiah'
by SCOTT NEUMAN
September 18, 2013 1:40 PM
A judge has ruled that a Tennessee woman can name her 8-month-old son "
Messiah" — a decision that overturns a ruling last month that drew
international attention to the boy.
In a paternity hearing in August, Jaleesa Martin and Jawaan McCullough
brought a dispute over their son's surname. Martin had given her son the
name Messiah Deshawn Marti... 阅读全帖 |
|
P******l
发帖数: 1648 | 21 Here is my email to Victor Chang a few days ago. There is no response yet.
I also have friends in NCBI who may help me check this(verifying through
multiple samples) with existing online source.
"Are there any paper or tool to show that all these 789 sequences are same
for multiple people from all over the world? (2q13–2q14.1 789 nucleotide
sequence 108305-109093)
It doesn't have to be a big number of samples. Only 38 samples(from
different locations in the world) were tested to draw the con... 阅读全帖 |
|
r****n
发帖数: 8253 | 22 這個說的是解脫后的狀況，並不是說的涅槃。
涅槃，本身是一個可以作為所緣的究竟真實法。
五蘊滅盡，並不是定境，大願比丘搞錯了。而且這個錯誤非常的致命。
我這是第一次注意到大願比丘這方面的嚴重問題，如果patern在，我就會提醒她了。
拒絕涅槃和五蘊的互斥性，認為涅槃只是日常沒有貪嗔癡的狀況，也是大乘思想誕生的
基礎之一。 |
|
a**u
发帖数: 8107 | 23 ☆─────────────────────────────────────☆
boximiya (boxi) 于 (Wed Jan 13 07:14:29 2010, 美东) 提到:
海地发生里氏7级地震，造成巨大人员伤亡
不知道是不是40天序幕的拉开，心情沉重，默哀
☆─────────────────────────────────────☆
boximiya (boxi) 于 (Wed Jan 13 07:18:51 2010, 美东) 提到:
衷心希望说我造谣的同学是对。
☆─────────────────────────────────────☆
bdbd (kakali) 于 (Wed Jan 13 07:26:29 2010, 美东) 提到:
地球肯定不会毁灭的，因为小青说它要毁灭。
明白啦吧？
类比：芙蓉姐姐肯定死不了，如果宋祖德说她要自杀。
☆─────────────────────────────────────☆
ray (百川) 于 (Wed Jan 13 08:35:15 2010, 美东) 提到:
不是说地球会... 阅读全帖 |
|
c*******k
发帖数: 1437 | 24
说不上来, 就是觉得这个节律很好听啊,
接下来的是什么牛儿在农场Mer, Mer, 羊儿在农场绵绵什么的
估计就是让小孩体验各种声音吧. 还有一种patern重复的快乐.
反正当时我们能从一只老虎唱到10只老虎, 虽然有点喘不过气来,
但是其乐无穷, 呵呵 |
|
h*******l
发帖数: 359 | 25 我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
A*L
发帖数: 2357 | 26 你第一天在哪里工作啊？
我第一天工作顿时觉得还是学校啊。。。。我是工科的。。。5555
我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
A*L
发帖数: 2357 | 27 复旦知识女性里面，当然这个说大了，
我当初比较欣赏的是外文系96日文系的袁琛，
给人非常积极向上，活泼开朗的一面。
非常有能力，看到她在最近还去贵州云南等地去支教，
更是让我非常景仰。人长得也非常有气质。
我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
h*******l
发帖数: 359 | 28 我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
A*L
发帖数: 2357 | 29 你第一天在哪里工作啊？
我第一天工作顿时觉得还是学校啊。。。。我是工科的。。。5555
我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
A*L
发帖数: 2357 | 30 复旦知识女性里面，当然这个说大了，
我当初比较欣赏的是外文系96日文系的袁琛，
给人非常积极向上，活泼开朗的一面。
非常有能力，看到她在最近还去贵州云南等地去支教，
更是让我非常景仰。人长得也非常有气质。
我觉得复旦其实不出美女啦，
我第一天工作见到的美女比我四年见到的都多，
复旦出的是知性都市女，白天是职场精英，晚上依旧能风花雪月，
这是小资情调加上精英教育的产物，
全国只此一家，别无分号。
如果想过的好，又想过的有情调，
复旦女生是最佳的paterner。
至于那些众口流传的名字，
当年傻傻的男生只能远观，却走不进她们的生活，
只能说我们装点了她们的青春，
而她们装点了我们的梦。 |
|
s******0
发帖数: 13782 | 31 按照介个patern， 貌似 #8 您也喜欢的？ |
|
wh
发帖数: 141625 | 32 是gogopanda吗？你认识他啊？我以为他很低调内向，原来很会外交，呵呵。
海南人被你说得像段延庆，肚子发声。海南话和粤语或广西白话像吗？我不记得了。
你是不是paternity leave在家啊？女儿乖不乖？吃得睡得好不好？ |
|
j*j
发帖数: 5564 | 33 谢谢flyingsoul！
我的公司paternity leave福利比较差，就一个星期。 |
|
|
m****s
发帖数: 402 | 35 Sam Roweis, NYU Professor, Jumps To Death From Greenwich Village Apartment
NYU professor Sam Roweis jumped to his death from his Greenwich Village apartment Tuesday, and friends and colleagues still cannot understand what could have driven him to such a point of desperation.
The highly-regarded computer science professor leaped from the 16th floor of his building after fighting with his wife over the care of their 15-month-old twins who were born prematurely and had been sick.
A psychotherapist ... 阅读全帖 |
|
c**b
发帖数: 2999 | 36 他有绿卡吗? 他是加拿大公民.
apartment Tuesday, and friends and colleagues still cannot understand what
could have driven him to such a point of desperation.
of his building after fighting with his wife over the care of their 15-month
-old twins who were born prematurely and had been sick.
victim of postpartum depression, saying that "studies suggest men may be
just as likely as women to be depressed when they become parents. The
condition is typically called paternal postnatal depression."
his sharp mind a... 阅读全帖 |
|
G**Y
发帖数: 33224 | 37 我主要确实没怎么用过FP，不知道那个aspect最能提高效率·
要是只是递归/patern matching/不用pass by reference/可以返回函数
这些东西，C其实都可以FP呀。 |
|
N*****m
发帖数: 42603 | 38 unlimited paternity leave？
早分析过了，所谓的unlimited PTO其实还不如quota的 |
|
发帖数: 1 | 39 HOW IDO WORKS
https://www.youtube.com/watch?v=BTVtaB2nU8w&list=
PL0eUjNQs8Qf9SK214nZuK41ffkxvKeA0A
http://idolinguo.org.uk/works.htm
INTERNATIONAL UNDERSTANDING
The idea of an international language is simply to enable people who have no
other language in common to understand one another. Ido (pronounced "ee-doh
") was developed by linguists and scientists over a number of years. It is
the most practical language to be invented, and its usability has been
demonstrated many times, both in writing... 阅读全帖 |
|
y****i
发帖数: 1265 | 40 发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线==========================
在下面第一篇nature文章中，在2005年《哈里波特与混血王子》出版后，来自澳大利亚
皇家儿童医院的Graig等人，同样对哈里波特中描述的有超能力的巫师wizards and
witches与麻瓜muggle结合后，后代属性问... 阅读全帖 |
|
m***f
发帖数: 1622 | 41
扯淡呢，看看高最近两年发表的文章吧
CELL STEM CELL, JBC, STEM CELL, PNAS，都是很不错的
就这样还不能PROMOTION? 在美国都可以tennure了
1. Wu T., Wang H., He J., Kang L., Jiang Y., Liu J., Zhang Y., Kou
Z., Liu L., Zhang X., Gao S. (2011) Reprogramming of trophoblast stem
cells into pluripotent stem cells by Oct4. Stem Cells 2011 Feb 8.
[Epub ahead of print].
2. Kang L., Wu T., Tao Y., Yuan Y., He J., Zhang Y., Luo T., Kou Z.,
Gao S. (2010) Viable mice produced from 3-factor induced pluripotent
stem (iPS) cells through tetrapl... 阅读全帖 |
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n***g
发帖数: 5027 | 42 这个总结不错：
申请精华帖：我了解的Epigenetics牛人一览
我是从C.D.Allis，Danny Reinberg，Tony Kouzarides，Yi Zhang， Yang Shi这几个
人发的文章看起的，这几个人基本上就是目前做表观遗传最牛的一批人了。然后你看看
他们文章citation里面出现频率比较高的人名，那往往就是大牛了，然后一点一点扩展
。个人感觉看CNS及其子刊还是王道。另外推荐一个很好的网站，http://www.epidna.com/ 可以查这个领域最top的lab，也可以查该领域最新的论文。
# ^2 P/ }, _0 h" U8 m) P6 b
; l* o$ y- |- V5 g0 I0 T然后在申请选校的过程中，我也逐渐了解到一些
epigenetics领域的big names和rising stars。所以我感觉看各个牛校的faculty也是
了解一个领域的好学校好lab的方法。我的做法是每看一个学校，就把相关领域做
epigenetics的faculty留下来，然后以后看CNS时或者Journal club上看到熟悉的名字
，就重点关注下。$ ... 阅读全帖 |
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b***t
发帖数: 1104 | 43 Your comment on Down syndrome is incorrect. 95% of Down syndrome is due to
maternal chromosome anomalies. Paternal contribution is small. |
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z*t
发帖数: 863 | 44 有active demethylation与passive demethylation，passive指抑制DNMT活性通过cell
division来“稀释”甲基化水平，而active demethylation在很短的时间内发生，在
胚胎发育早期（合子阶段）一般是1-2个细胞周期左右时间，global甲基化就都消失了
，其中paternal在受精后先消失，maternal再消失。
还有一个问题就是，基因组水平去甲基化后有重建甲基化的过程，那么有什么来指导甲
基化的重建？ |
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