|
d****h
发帖数: 46 | 2 I might find some for you on Monday.
You may want to prioritize on modeling:
Addiction
Parkinson disease
Alzheimer's disease
Amytrophic Lateral Sclerosis
and developing tools for Optogenteics
Cre |
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A*****s
发帖数: 34 | 3 Neuralstem, Inc., a biopharmaceutical company headquartered in Germantown,
Maryland, is seeking
qualified candidates for the position of Manufacturing Associate. The
company focuses on the
development and commercialization of stem cell-based treatments for central
nervous system disease.
Human neural stem cell products in development include NSI-566 which is
currently in clinical trials for
the treatment of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s
disease), chronic spinal cord injury,... 阅读全帖 |
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A*****s
发帖数: 34 | 4 Neuralstem, Inc., a biopharmaceutical company headquartered in Germantown,
Maryland, is seeking
qualified candidates for the position of Manufacturing Associate. The
company focuses on the
development and commercialization of stem cell-based treatments for central
nervous system disease.
Human neural stem cell products in development include NSI-566 which is
currently in clinical trials for
the treatment of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s
disease), chronic spinal cord injury,... 阅读全帖 |
|
w****o
发帖数: 32 | 5 神经科 - Neurology: seeing patient with stroke, epilepsy/seizure, headache,
movement disorder, dementia, neuropathy，neuromuscular disease, brain tumor,
multiple sclerosis, encephalitis/meningitis, etc
精神科 - Psychiatry: ADHD, bipolar,depression, anxiety, OCD，schizophrenia,
psychosis etc., they also seeing patient with behavioral disturbance
They both can do research in neuroscience/neurobiology |
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s*****a
发帖数: 59 | 6 The phenotypic variability of amyotrophic lateral sclerosis
Nature Reviews Neurology 10, 661–670 (2014) doi:10.1038/nrneurol.2014.184
Published online 14 October 2014
Thanks! |
|
m*******n
发帖数: 387 | 7 她在RW和PPP多混过
根据你给的linker：
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation
and functional inactivation of TSC2 by Erk implications for tuberous
sclerosis and cancer pathogenesis. Cell 121(2):179-193, 4/2005. PMID:
15851026.
她先PPP然后在RW
不知道在PPP是学生还是博后 |
|
l********n
发帖数: 260 | 8 Rank full journal title Total Cites IF
1 ca-a cancer journal for clinicians 18,594 115.84
2 new england journal of medicine 268,652 55.873
4 lancet 185,361 45.217
6 nature biotechnology 45,986 41.514
7 nature 617,363 41.456
12 nature materials 64,622 36.503
13 jama-journal of the american medical association 126,479 35.289
14 nature reviews immunology 28,938 34.985
15 nature nanotechnology 34,387 34.048
16 ... 阅读全帖 |
|
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l******n
发帖数: 298 | 10 you mean multiple sclerosis? |
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m*****e
发帖数: 129 | 11 Rank Full Journal Title Total Cites Journal Impact Factor
1 CA-A CANCER JOURNAL FOR CLINICIANS 20,488 131.723
2 NEW ENGLAND JOURNAL OF MEDICINE 283,525 59.558
3 NATURE REVIEWS DRUG DISCOVERY 25,460 47.12
4 LANCET 195,553 44.002
5 NATURE BIOTECHNOLOGY 48,650 43.113
6 NATURE REVIEWS IMMUNOLOGY 31,545 39.416
7 NATURE MATERIALS 72,306 38.891
8 NATURE REVIEWS MOLECULAR CELL BIOLOGY 36,784 38.602
9 NATURE 627,846 ... 阅读全帖 |
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J***2
发帖数: 444 | 12 seems UK guy
papers little
1.J Neurochem. 2009 Apr;109(1):93-104. Epub 2009 Jan 19.
Differential sensitivity of oligodendrocytes and motor neurons to reactive
nitrogen species: implications for multiple sclerosis.
Bishop A, Hobbs KG, Eguchi A, Jeffrey S, Smallwood L, Pennie C, Anderson J,
Estévez AG.
2.J Neurochem. 2009 Apr;109(1):74-84. Epub 2009 Jan 13.
Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a
mechanism of induced adaptive NO resistance in the CNS.
Bishop A, Gooch |
|
p****y
发帖数: 23737 | 13 【 以下文字转载自 Wisdom 讨论区 】
发信人: purity (purity), 信区: Wisdom
标 题: 走过电磁波伤害 重获健康
发信站: BBS 未名空间站 (Sun Nov 29 18:31:37 2009, 美东)
走过电磁波伤害 重获健康
http://www.lapislazuli.org/TradCh/magazine/200911/20091110.html
赵家阅
首先，我要衷心感激雷博士帮我重见光明、恢复行动自如的能力。同时，也请读者包涵
我等了五年才写下我的经历与大家分享。
二○○四年初，我在短短的一个星期内，两眼失明，双腿瘫痪，还未到叁十岁的我，爱
打篮球，喜欢阳光，万万也想不到自己竟会眼盲腿瘸。刹那间失去健康的恐惧和惊吓真
是难以言表。当然立刻就进了医院，经过数天各种密集的检查之後，医生说，不知病因
。病历表上写的是「多发性硬化症」（Multiple Sclerosis) 。简单的解释是自己的免
疫系统攻击自己的中枢神经系统。所以医生给我服用高剂量的类固醇，有口服也有注射
。我的身体可以感觉得到类固醇的威力渗透到我的肝、肾、胃肠消化系统和 |
|
c**i
发帖数: 6973 | 14 Peter Landers, MS Drug's Epic Journey From Folklore to Lab;
Research Into Ancient Chinese Fungus That Propagates Inside Insects Yields
Potential Relief for Multiple Sclerosis. Wall Street Journal, June 22, 2010.
http://online.wsj.com/article/SB10001424052748704256304575320714138159240.html
Note:
(a) Aspirin is acetylsalicylic acid chemically.
A French chemist, Charles Frederic Gerhardt, was the first to prepare
acetylsalicylic acid in 1853, by mixing
(i) acetyl chloride with
(ii) a sodium salt o |
|
|
n*****s
发帖数: 768 | 16 我想了解一下我这个情况是否可以提出医疗诉讼
经过是这样的：
一个半月前得了虹膜炎，眼科医生让我去血检，做风湿因子相关的测试。最近结果
出来了，HLA-B27阳性，结合我自身的症状，基本上可以确认得了强直性脊柱炎。现在
颈，背，胸椎都经常疼。
这几年一直都有间歇性的颈，胸椎疼痛，但一直以为是普通的颈椎病。去年8月份
在家庭医生那里告知我的病痛，让我做一颈跟腰的x-ray。当时结果出来之后医生告诉
我没事，只是肌肉劳损加上一些骨头退化。我就没有太在意了，只是做一些物理治疗。
现在因为血检阳性，我到医院要了当时的x-ray报告和cd。报告中关于腰椎的诊断
是这样的：
1.moderate degenerative changes and sclerosis of the sacroiliac joints,left
greater than right.
2.mild disc space narrowing at l5-s1 and right-sided sacralization of the
ala.
根据这个报告，我当时就已经出现了骶髂关节病变，结合... 阅读全帖 |
|
发帖数: 1 | 17 霍金的名字，许多人都知道。这和概率有什么关系？
霍金患有严重的疾病。至于具体是什么病，许多人可能就说不清楚了。
霍金自述，他在童年时，经常是动作不能自如。他在牛渡口上学时，就越来越笨拙。在
拱桥大学上学时，也就是他刚过21岁生日不久，他不得不住院检查。经常两周的检查，
最后医生断定：他得了一种非常罕见的病症：Amyotropic Lateral Sclerosis。吴忠超
先生译作：肌肉萎缩性侧面硬化病。中国医学文献作：肌萎缩侧索硬化症。
这是一种运动神经元疾病。所谓的运动神经元疾病指病变选择性侵犯脊髓前角细胞、脑
干颅神经运动核以及大脑运动皮质锥体细胞，锥体束的一组进行性疾病。
中国的《实用内科学》中仅用一页半的篇幅介绍了此疾病。“【病理】 椎体束明显脱
髓鞘，与其他传导束境界清楚，轴突变性缺失。大脑皮质运动区的椎体细胞大部分脱失
，部分变性。脑干运动神经核中以舌下神经核的变性最为突出。疑核、三叉神经运动核
、迷走神经背侧核和面神经核也有变性。脊髓前角细胞脱失（以颈髓明显，胸腰髓次之
）、前根变细、神经纤维减少。肌肉出现纤维束性萎缩。”
霍金被告知：他最多只能活二年半。这是多么残酷的... 阅读全帖 |
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c*******c
发帖数: 62 | 18 Congrats on finishing CK!
Thanks for the tips, too. Could this question be describing systemic sclerosis (scleroderma) though?
就是 |
|
f***y
发帖数: 118 | 19 另外CT显示的肺纤维化很厉害了，不可能没有任何呼吸系统的症状吧，我到现在都还很
困惑，
考试时怀疑那是测试的block，是题目的问题，因为这个blcok特别难，好多题目no
idea，其
他的block都还行的。唉，实在不敢想了，觉得这个block做得太烂了。
sclerosis
(scleroderma) though? |
|
l********z
发帖数: 810 | 20 A fullterm male newborn has enlargement of head circumference.cranial
suitures r separated .U/S shows emlargement of lateral ventricles and
thinning of cerebral cortex.The new born uncle had similar abnormalities....
.....diagnosis?
A.Absence of foramen of luska
B.Cerebellar astrocytoma
C.HOLOPROSENCEPHALY
D.Neurofibromatosis
E.Stenosis of aqeduct of sylvius
F.Tuberous sclerosis |
|
l******i
发帖数: 9 | 21 非常感谢老军医。 还有漏了下面的 诊断意见，烦请再修改一下。再谢！
诊断意见：
乙肝相关肾炎（轻－中度弥漫系膜增殖伴早期肾硬化）
Diagnosis:
Nephritis associated with hepatitis B(mild-middle degree of diffuse
mesangial proliferation accompanied with early stage renal sclerosis) |
|
d****2
发帖数: 118 | 22 A 38-year-old woman presents to her primary care provider for a checkup. On standard blood testing, she is found to have an elevated total bilirubin and alkaline phosphatase. Further workup shows an elevated GGT and ANA, c-ANCA is positve, and antimitochondrial antibody is negative. Which of the following tests will reveal the condition mostly commonly associated this patient's diagnosis?
Answer is colonoscopy.
Some questions here: is this case ulcerative colitis with sclerosis cholangitis which |
|
d****2
发帖数: 118 | 23 Some explaination from my MD friend: this is the case of UC with sclerosis
chalongitis. Even though P-ANCA is positive mostly in UC, C-ANCA is positive
too sometimes.
祝所有DXJM考试顺利！ |
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f****t
发帖数: 313 | 24 据说是得了Amyotrophic Lateral Sclerosis (ALS， 运动神经元损伤).由于现在没什
么成熟的治疗方法，想看看能否参加美国的一些新药的临床试验。他家不是特有钱哪种
，是不是在经济上不太可能负担的起啊？有没有这方面经验的阿？bow...... |
|
N***a
发帖数: 149 | 25 MEDICAL ETHICS 137 cases:
________________________
1. A 25- year old mother refused immunization for her 2-month old son. The
social worker spoke to the mother. (Important for Board examination)
Next step in management: immunization should be given for the benefit of the
child.
2. A 30-year old mother refused surgery for suspected appendicitis for her 6
-year old daughter. The social worker spoke to the mother. (Important for
Board examination)
Next step in management: surgical removal of the ap... 阅读全帖 |
|
V*****G
发帖数: 337 | 26 看来该问用药历史，是否服用抗精神病用药。可能这是楼主想考的吧。不过这vaginal bleeding是不是就不管了？这毕竟是主诉呀.
Oculogyric crisis (OGC) is the name of a dystonic reaction to certain drugs
and/or medical conditions. The term "Oculogyric" refers to rotating of
eyeballs,
Causes
Drugs that can trigger an oculogyric crisis include neuroleptics (such as
olanzapine),[2] amantadine,[citation needed] benzodiazepines,[citation
needed] carbamazepine, chloroquine, cisplatin, diazoxide, influenza vaccine,
[citation needed] levodopa,[citation needed] li... 阅读全帖 |
|
n*****s
发帖数: 768 | 27 我想了解一下我这个情况是否可以提出医疗诉讼（不知道发在这里合适否）。
经过是这样的：
一个半月前得了虹膜炎，眼科医生让我去血检，做风湿因子相关的测试。最近结果
出来了，HLA-B27阳性，结合我自身的症状，基本上可以确认得了强直性脊柱炎。现在
颈，背，胸椎都经常疼。
这几年一直都有间歇性的颈，胸椎疼痛，但一直以为是普通的颈椎病。去年8月份
在家庭医生那里告知我的病痛，让我做一颈跟腰的x-ray。当时结果出来之后医生告诉
我没事，只是肌肉劳损加上一些骨头退化。我就没有太在意了，只是做一些物理治疗。
现在因为血检阳性，我到医院要了当时的x-ray报告和cd。报告中关于腰椎的诊断
是这样的：
1.moderate degenerative changes and sclerosis of the sacroiliac joints,left
greater than right.
2.mild disc space narrowing at l5-s1 and right-sided sacralization of the
ala.
根据这个报告，我当时就已... 阅读全帖 |
|
h**s
发帖数: 1757 | 28 Any patient with many neurological symptoms which cannot be explained
by
single nerve defect should be suspected multiple sclerosis. So u need
do MRI
to see the white plaque. Especially young woman.
Woman is always trouble maker,lol... |
|
z**********4
发帖数: 467 | 29 Circumcision could prevent further fugal infection. In the meanwhile, pay
attention to personal hygiene. If the lesion persists, r/o lichen sclerosis
or other precancerous lesions. Or some STD could mimic fugal infection. |
|
J*********4
发帖数: 1274 | 30 9. 26yo WM reports weakness, tingling sensation in left leg, stumbling and
falls, involuntary urinary activity and dizziness. On exam he has nystagmus
and hyperreflexia, slurred speech and lid lag. Symptoms developed over the
last 3 days, but he recalls similar symptoms intermittently in the past.
In what order would you proceed with this patient, clinically?
A. arrange for LP, neurology consult, and serum protein
electrophoresis
B. begin empiric steroid therapy, schedule brain MR... 阅读全帖 |
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b*****l
发帖数: 8603 | 31 2007年的，不知道你们说的是不是这个。祝好。
medical ethics more than hundred cases
Sep 24th, 2007, 12:17pm
1. A 25- year old mother refused immunization for her 2-month old son. The
social worker spoke to the mother. (Important for Board examination)
Next step in management: immunization should be given for the benefit of the
child.
2. A 30-year old mother refused surgery for suspected appendicitis for her 6
-year old daughter. The social worker spoke to the mother. (Important for
Board examination)
Next step in ma... 阅读全帖 |
|
e****0
发帖数: 678 | 32 • leukemia
ALL AML CLL
child adult elderly
BM lymphoblasts 25%myeloblasts
lab Lymphocyte 5000, mature-appearing cells
• Osgood-schlatters disease
Adolescent male athletes
Traction apophysitis—quadriceps tendon put the traction on the
apophysis of the tibial tubercle where patellar tendon inserts.
A firm mass =heterotopic bone formation
Pain can be reproduced by extending the kne... 阅读全帖 |
|
S******1
发帖数: 44 | 33 今天得知了step3的成绩，210+，心里的石头终于落下。终于轮到我给USMLE说再见了。
回顾从step1自己闭门造车考了只带一个9的分数， step2开始参加小组学习，做了所有
能做的题只为拿个99，虽胸有成竹且考试感觉很好，最终但又得到一个9的分数。虽然
这次成绩不高，依然很高兴，毕竟不用发愁如果没过的话住院医开始后没有时间复习该
咋办。过去的3年中得到太多人的帮助 (此处略去人名20个)，绝大多数甚至从未谋面。
今天发贴也是为了回报我们这个社区吧。
自我介绍：毕业>15年，220+/220+/1st/210+；
复习时间：6月，头4个月每天约2-3小时，周末由于陪孩子们玩（前两年欠的太多，你
懂得）及做点家务（再不做但心被老婆炒掉），反而复习不了多少；最后2个月每天4小
时，鼓励自己考了这个2年内再不用受这个罪。
复习资料：随大流，MTB 3, UW CCS, UW step3 Qbank, UW step2 Qbank;
模拟：考前2月，NBME 1 190+, 考前1周，NBME 2 220+;
体会：难，考过不容易，考高分更难。主要是因为没有合适的复习资料。UW的1300... 阅读全帖 |
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a**l
发帖数: 1166 | 34 有个女病人（MUTIPLE SCLEROSIS）， 从肚肌以下基本摊换，医嘱：I/O CATH Q4-6
HRS,病人肥胖，很难看到阴道/尿道，我先插了一短的CATHTER进阴道，第二根才进尿道
，完了后却忘了把阴道里的CATHTER取走，被夜班护士发现，填了INCIDENT REPORT，我
觉得很报谦，是不是很严重的过失呢？ |
|
t*****r
发帖数: 1765 | 35 我在cuny的hunter的RN－BSN，suny和cuny学费一样，
留学生是415一个学分，绿卡减半，下学期好像又要涨一点，
suny是州立系统，cuny是市立系统，
我一个同学BMCC毕业的在我们program，
他BMCC用的paper都可以拿过来接着交，
每次只要挖挖以前的paper拿来交就行了，
说明ASN和BSN很多课其实都差不多的，
就是听说suny downstate学校那边很多黑人，
你实地跑一次去看看，但是他们有自己的medical center，
我选hunter因为地铁方便，在曼哈顿，大部分都是白人和亚裔，部分黑人，
SUNY他们那个program prefer有绿卡的学生，要申请要尽量早点。
RN－BSN Nursing的课都是每学期几个paper APA format，
老师都会提前告诉你要写什么，
最多就是有个期中考，有些没有期中考，
期末一般没有考试，平时就是听老师讲课，
看看老师给的文章，做几个online的certificate考试，
最多一个paper，然后期末就是group presentation。
这种都是给边上班边工作的护士设立的，
很简... 阅读全帖 |
|
w****r
发帖数: 90 | 36 呵呵, 你说的主要是这几年的事了, 这几年制药公司在市场上表现不好是十年前埋下的
原因. 如果你从90年代末就开始炒的话, 应该记得整个市场在IT泡沫一蹶不振时制药股
一支独秀的场面, 尤其是MRK简直是如日中天, Pfizer的价格也至少是现在的一倍. ELN
的case就更不对了, 你说的$26.85时正是Tysabri刚刚被批准上市, 作为治疗mulitiple
sclerosis一线用药, 市场预计超过2个billion的时候. $8.85应该是发现使用中有三
例很罕见的脑部疾病而被FDA从市场上recall的时候, 在这之后ELN的股票还曾到过3块
多呢. 而且对于ELN来说它的accounting的问题远比Tysabri的问题要严重多了. 现在
Tysabri又加了个warning从新回到市场上了, ELN也在慢慢爬升, 虽然我还是不太看好
它. 股票呢, 是看你想做长线还是短线还是day trading了. 如果说做长线, 制药类股
票中的major pharm, 包括PFE, MRK, LLY, JNJ, NVS, GSK, WYE一直以来都是被当作稳
定投资的类型. |
|
M**1
发帖数: 162 | 37 Is there any good website where I could have the translation of some
medicinal terms in English to Chinese? Such as rhabdomyolysis, sclerosis...
Thanks a billion! |
|
R*s
发帖数: 2041 | 38 【 以下文字转载自 Biology 讨论区 】
发信人: deed3 (deed), 信区: Biology
标 题: Great opportunities in GSK-China
发信站: BBS 未名空间站 (Thu May 24 09:58:28 2007)
GlaxoSmithKline (GSK) today announces the appointment of Jingwu Zang to head
a new GSK research and development center in Shanghai, China.
GSK R&D China will focus on research into neurodegeneration with the
objective of creating new medicines for such severe disorders as multiple
sclerosis, Parkinson’s disease, and Alzheimer’s disease. The center will
eventuall |
|
J********n
发帖数: 534 | 39 I totally agree with your comments on bapineuzumab.
However for Tysabri in the US/EU market, it is doing well and I am expecting
it to perform better in the near future although more PML cases are also
expected. Considering the lack of cure for Multiple Sclerosis or Crohn's
disease, I do not think the patients have many other alternative choices
other than Tysabri. |
|
B****a
发帖数: 1526 | 40 http://finance.yahoo.com/news/Teva-to-buy-Cephalon-for-68-rb-55
On Monday May 2, 2011, 8:48 am EDT
By Lewis Krauskopf
NEW YORK (Reuters) - Teva Pharmaceutical Industries Ltd struck a deal to
acquire U.S. specialty drugmaker Cephalon Inc (NasdaqGS:CEPH - News) for
nearly $7 billion, topping an unsolicited bid by Canada's Valeant
Pharmaceuticals International Inc and boosting its brand-name drug business.
Teva's (Tel Aviv:TEVA.TA - News; NasdaqGS:TEVA - News) $81.50-a-share deal
is a nearly 12 per... 阅读全帖 |
|
|
a**e
发帖数: 5094 | 42 most likely "temporal lobe epilepsy with mesial temporal sclerosis"
首选药物治疗，如果效果不好，可以考虑手术
从一开始的evaluation到最后手术，总体花费200k~300k USD。来美国治疗要慎重考虑
。国内北京宣武医院做的数量比较多，价格也会便宜很多 |
|
a**e
发帖数: 5094 | 43 most likely "temporal lobe epilepsy with mesial temporal sclerosis"
首选药物治疗，如果效果不好，可以考虑手术
从一开始的evaluation到最后手术，总体花费200k~300k USD。来美国治疗要慎重考虑
。国内北京宣武医院做的数量比较多，价格也会便宜很多 |
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d**o
发帖数: 618 | 46 另外，就做research的academic而言，想少看病人也只是少看和他研究无关的病人，如
果是他专研的病人他可是想看的越多越好的。如我知道一个做multiple sclerosis
clinical trial的，他是每个participant都要亲自看，亲自做LP的。因此每天也就比私人诊所的还忙的多。 |
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d**o
发帖数: 618 | 47 另外，就做research的academic而言，想少看病人也只是少看和他研究无关的病人，如
果是他专研的病人他可是想看的越多越好的。如我知道一个做multiple sclerosis
clinical trial的，他是每个participant都要亲自看，亲自做LP的。因此每天也就比私人诊所的还忙的多。 |
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V*****G
发帖数: 337 | 48 I do have a few questions to ask:
1st about the diagnosis: is diagnosis clear when the biopsy result is clear
or when gluten free diet worked? To me, it's the later. It will be more
helpful to ask patient if there is traveling history to Caribean, India,
Southeast Asia etc.If no such a history, then giving diagnosis when biopsy
result is clear might be reasonable to me. Maybe LZ said this somewhere in
the description that I missed. Anyway I am not clear no this at this point.
The other thing is... 阅读全帖 |
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A*******s
发帖数: 9638 | 49 Without a biopsy, everything is possible at present.
I would tell family this lesion could be a demyelinating lesion as well,
like Tumefactive multiple sclerosis, which is highly treatable.
How about neurosarcoids?
However, I would do a CT of chest w/wo contrast prior to any biopsy. |
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A*******s
发帖数: 9638 | 50 Muscular dystrophy at least includes the following:
Duchenne muscular dystrophy; Becker's muscular dystrophy; Emery-Dreifuss
muscular dystrophy; Limb-girdle muscular dystrophy; Amyotrophic lateral
sclerosis and Congenital muscular dystrophy
There is no effective treatment so far. |
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