l*h
发帖数: 4124 | 1 I don't question the diagnosis of HCC, but the pathology report is of very
low quality, and I don't understand the treatment strategy either.
1. there is no description of microscopic findings, there is no way to tell
if the histological grading is correct or wrong. it seems almost all
pathologists in China have the magic power to give an unequivocal diagnosis
on everything.
2. stomach stromal tumor is rare, spleen stromal tumor is extremely rare. i
simply cannot believe all three tumors occur a... 阅读全帖 |
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l*********i
发帖数: 30 | 2 Thank you so much, leonsean! I appreciate the info and your time although
the info is quite frightening.
Do you refer to UICC's 7th lung cancer TNM classification and staging system
? One thing I am not sure about is that when they say "Separate tumor
nodules in a different ipsilateral lobe", does it mean that the tumor
nodules should be of the same type? In the following article,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351680/
it is mentioned that "satellite tumor" or "direct extent of t... 阅读全帖 |
|
l*********i
发帖数: 30 | 3 Thank you so much, leonsean! I appreciate the info and your time although
the info is quite frightening.
Do you refer to UICC's 7th lung cancer TNM classification and staging system
? One thing I am not sure about is that when they say "Separate tumor
nodules in a different ipsilateral lobe", does it mean that the tumor
nodules should be of the same type? In the following article,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351680/
it is mentioned that "satellite tumor" or "direct extent of t... 阅读全帖 |
|
I****2
发帖数: 1091 | 4 我爷爷是胃癌去世的，确诊的时候已经不能手术了。但是之前症状很明显，基本就是胃
病的症状，他工作很忙所以就没去医院检查，拖了一段时间，吃了些治胃病的药，没有
减轻症状，后来做了胃镜和切片检查，确诊。我GOOGLE了下，基本就是这些症状。某些
癌症基因会遗传，有家族史的要小心
科普下
Adenocarcinoma
Symptoms
Symptoms of this cancer can be pain in the abdomen, weight loss, weakness,
and fatigue. As the tumor increases in size, it can block the passage of
digested food. The tumor can cause obstruction. Obstruction is when the
intestine is blocked and nothing can move through. This causes pain with
severe nausea and vomiting.
The tumor can ... 阅读全帖 |
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A***5
发帖数: 2 | 5 【 以下文字转载自 Biology 讨论区 】
发信人: Asf15 (Abb), 信区: Biology
标 题: Postdoctoral positions are available at Pennsylvania State University College of Medicine
发信站: BBS 未名空间站 (Sun Apr 12 12:12:21 2015, 美东)
Postdoctoral scientist positions are available starting in July 2015 in the
Molecular and Cellular Cancer Biology Lab of Dr. Wei Li. Our lab is part of
Penn State Milton S. Hershey Medical Center and Pennsylvania State
University College of Medicine located in Hershey, Pennsylvania.
We are interested in... 阅读全帖 |
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g****e
发帖数: 1426 | 6 FROM Yahoo MB:
Just reposting the timeline NWBO issued July 27, 2013 for reference.
From NWBO website as of July 27, 2013
"2013
✓ Initiated Phase I/II trial of DCVax-Direct for all inoperable solid
tumors in US
✓German regulatory decision on Phase III trial of DCVax-L for GBM
* Initiate Phase I/II trial of DCVax-Direct for all inoperable solid
tumors in Europe
First results (tumor response) from initial patients in DCVax-
Direct trial
Initiate Phase I/II t... 阅读全帖 |
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r****y
发帖数: 263 | 7 收入申请书模板类别http://user.qzone.qq.com/2915799706/blog/1398824866
Petition letter （参照laoda555超长经验和hotmale的NOID回复写的）：
XX , 2010
U.S. Department of Homeland Security
Citizenship and Immigration Services
RE:Applicaions: I-140 Immigration Visa Petition
Petitioner: Dr. B AA
Beneficiary: Dr. B AA (AXXXXX)
Category: Alien of Extraordinary Ability
Dear Immigration Officer:
The following is respectfully submitted in support of my petition for
classification as a qualified immigrant under the First Preference ... 阅读全帖 |
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g***o
发帖数: 92 | 8 【 以下文字转载自 Postdoc 讨论区 】
发信人: ganbo (niu), 信区: Postdoc
标 题: a new postdoc position available at Duke University for brain tumor study
发信站: BBS 未名空间站 (Thu Jun 16 10:55:59 2011, 美东)
Our lab is part of the Robert Preston Tisch Brain Tumor Center at Duke University. We are seeking Postdoctoral Fellow(s) immediately to start new projects dedicated to understanding pediatric brain tumors, employing biochemical and epigenetic approaches. Ideal candidates will be self-driven individual with strong motiv... 阅读全帖 |
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d*****j
发帖数: 1192 | 9 I had a tumor in a size of ping pong ball in my brain. My neurosurgeon too
said that I had that tumor for at least 10 years. But I didn't have any
symptoms other than the occasional ringing in the ears. I was lucky that I
made an appointment to get a MRI. Tumor doesn't have to be cancer. My
neurologist saw many patients died from benign tumors.
have
age
, |
|
b**********5
发帖数: 7881 | 10 A New York City mom made the ultimate sacrifice — giving up her own life so
her baby girl could live.
Doctors told cancer patient Elizabeth Joice that she would never get
pregnant, so when she did last year, it was something of a miracle.
But joy quickly turned to heartbreak for Elizabeth and her husband Max when
doctors presented her with an impossible challenge: terminate the pregnancy
and begin treatment — or put her life in danger.
It didn’t take Elizabeth long to reach her decision.
“Having... 阅读全帖 |
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o**********e
发帖数: 18403 | 11 【 以下文字转载自 Seattle 讨论区 】
发信人: chcpa (Bay Area CPA), 信区: Seattle
标 题: Learnings-从99% 脑干恶性肿瘤（expected life one year）说起
发信站: BBS 未名空间站 (Sat Sep 20 11:54:01 2014, 美东)
1. 慎重选择家庭医生的重要性（对初始症状的判断、医德以及refer的specialist是否
是专家），
2. 请远离印度医生，远离Overlake hospital,去UW后者Swedish吧: niumum总结的好，
“他们的习惯和民族性决定了他们中大多数人不在乎別人（贱民）的生命。做事投机取
巧，草菅人命” Overlake hospital因为是个一般的医院，所以医生水平平庸是可以预
见的。中国医生和美国医生更靠谱些，尤其是有些中国医生出身医学世家，医德高尚。
3. 如果拿到不好的诊断，大的诊疗中心专家second opinion的重要性，不要轻信一般
诊疗中心做出的结论
4. 自己积极找各种资源及平稳心态的重要性：如果不能平复心情，可去教会读读圣经
，听... 阅读全帖 |
|
o**********e
发帖数: 18403 | 12 【 以下文字转载自 Seattle 讨论区 】
发信人: chcpa (Bay Area CPA), 信区: Seattle
标 题: Learnings-从99% 脑干恶性肿瘤（expected life one year）说起
发信站: BBS 未名空间站 (Sat Sep 20 11:54:01 2014, 美东)
1. 慎重选择家庭医生的重要性（对初始症状的判断、医德以及refer的specialist是否
是专家），
2. 请远离印度医生，远离Overlake hospital,去UW后者Swedish吧: niumum总结的好，
“他们的习惯和民族性决定了他们中大多数人不在乎別人（贱民）的生命。做事投机取
巧，草菅人命” Overlake hospital因为是个一般的医院，所以医生水平平庸是可以预
见的。中国医生和美国医生更靠谱些，尤其是有些中国医生出身医学世家，医德高尚。
3. 如果拿到不好的诊断，大的诊疗中心专家second opinion的重要性，不要轻信一般
诊疗中心做出的结论
4. 自己积极找各种资源及平稳心态的重要性：如果不能平复心情，可去教会读读圣经
，听... 阅读全帖 |
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z**********4
发帖数: 467 | 13 First I sympathize with you.
It is very hard to make initial diagnosis on brain stem disease just based
on initial MR. Statistically speaking, brain tumor is usually supratentorial
for adults. But it could happen in brain stem. So it is obligatory to raise
the concern for brain stem tumor for the doctor who read your first MR scan
and recommended MR followup. I would say any doctors with formal training
would do so.
Obtaining a second MR scan and make the correct diagnosis is much easier.
Simpl... 阅读全帖 |
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c***a
发帖数: 118 | 14 1. 慎重选择家庭医生的重要性（对初始症状的判断、医德以及refer的specialist是否
是专家），
2. 请远离印度医生，远离Overlake hospital,去UW后者Swedish吧: niumum总结的好，
“他们的习惯和民族性决定了他们中大多数人不在乎別人（贱民）的生命。做事投机取
巧，草菅人命” Overlake hospital因为是个一般的医院，所以医生水平平庸是可以预
见的。中国医生和美国医生更靠谱些，尤其是有些中国医生出身医学世家，医德高尚。
3. 如果拿到不好的诊断，大的诊疗中心专家second opinion的重要性，不要轻信一般
诊疗中心做出的结论
4. 自己积极找各种资源及平稳心态的重要性：如果不能平复心情，可去教会读读圣经
，听听礼拜
5. 健康饮食的重要性：从听到99%Pontine Glioma的当天，我开始用Vitamix打各种有
机蔬菜水果汁吃（早上一大杯，下午一大杯），事实证明，在这么stressful的情况，
体重虽然每天减一磅，但是我感觉体力还是很充沛的，我指甲上的小太阳变大了，我的
免疫力也迅速恢复了。我开始所有食品都从whole ... 阅读全帖 |
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y*********u
发帖数: 14561 | 15 关于母狗spay的一些数据参考
======================
在这期dog fancy上看到的，可以做个参考。
在第一次heat之前spay基本上可以把mammary tumor的可能性降到零。
第一次heat之后spay，那么mammary tumor的概率为8／100。
第二次heat之后spay对于降低mammary tumor的可能性就没有任何帮助了，为26／100。
没有KC的成年母狗最终会有26／100患mammary tumor (这比例也太高了吧？）
文章认为关于breeding一次对狗狗身体有好处的说法是毫无科学根据的都市传说。 |
|
d******g
发帖数: 5484 | 16 在这期dog fancy上看到的，可以做个参考。
在第一次heat之前spay基本上可以把mammary tumor的可能性降到零。
第一次heat之后spay，那么mammary tumor的概率为8／100。
第二次heat之后spay对于降低mammary tumor的可能性就没有任何帮助了，为26／100。
没有KC的成年母狗最终会有26／100患mammary tumor (这比例也太高了吧？）
文章认为关于breeding一次对狗狗身体有好处的说法是毫无科学根据的都市传说。 |
|
p******r
发帖数: 6213 | 17 谢谢楼上几位的理解。这世上总有个把整天shame on everyone except herself only
的，不奇怪。如果不give birth，不知道整天shame on们能从哪里串出来，lol。
有关spay的好处，animal control宣传得很多，但风险则根本不提。这里有篇文章，有
兴趣的可以看看：http://www.naiaonline.org/pdfs/longtermhealtheffectsofspayneuterindogs.pdf
摘录如下：
On the positive side, spaying female dogs
• if done before 2.5 years of age, greatly reduces the risk of mammary
tumors, the most common malignant tumors in female dogs
• nearly eliminates the risk of pyometra, which otherwise would affect
about 2... 阅读全帖 |
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l*****o
发帖数: 26631 | 18 On the positive side, neutering male dogs
• eliminates the small risk (probably <1%) of dying from testicular
cancer
• reduces the risk of non-cancerous prostate disorders
• reduces the risk of perianal fistulas
• may possibly reduce the risk of diabetes (data inconclusive)
On the negative side, neutering male dogs
• if done before 1 year of age, significantly increases the risk of
osteosarcoma (bone cancer); this is a
common cancer in medium/large and larger breeds... 阅读全帖 |
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b******a
发帖数: 12216 | 19 还有两篇我觉得比较对我们适用的，我就直接总结一下了。不一点点儿打上来了。有感
兴趣的可以联系我，我给你们scan。
A New Tick Disease: 这篇说的是近期刚刚发现了一种新的deer tick传染的疾病。在
一个80多岁的老太太身上确诊的。Over 4 months, she had experienced progressive
mental decline, becoming increasingly confused. Her gait grew wobbly, and
she didn't have much of an appetite. 这个细菌的名字是 Borrelia miyamotoi（日
本last name有木有，因为是1995年第一次在日本tick上发现的）。这种细菌跟造成
lyme disease的细菌很相近。在美国东北lyme disease比较普遍，可能B. miyamotoi被
underestimate了。现在大家再争论whether a person can test negative for Lyme
and still have L... 阅读全帖 |
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p******d
发帖数: 3737 | 20 Several different concepts are being discussed here:
1. The origin of tumor/cancer(single cell or multiple cells)
2. The existence of CSC. Even if the tumor origin is only one cell (
differentiated or tissue-specific stem cell), the whole tumor is
phenotypically heterogeneous, which has been proven by many many
experiments
. Then do all these cells have the same potential to initiate a new tumor?
Or to be more practical, do all these cells have the same potential to met
or relapse after chemo? |
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r***e
发帖数: 2539 | 21 我表述有问题，当然是先突变，积累突变才最后变肿瘤。
heterogeneity我的理解是 1.有不同的cell type，比如tumor cell, 和正常细胞，包括
endothelial cell, infiltrated immune cell和stromal cell。2.tumor cell本身也应
该是混合的，包括占大部分的获得最佳mutation组合的tumor cell，它们应该是clonal
的，另外获得其他突变的tumor cell应该也存在。
怪. |
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p******d
发帖数: 3737 | 22 I guess these are two different concepts. CSC is to discuss if there are
some unique cells in the tumor that can self-renewal and give rise to
other tumor cells. The question you raised here is about the cell origin
of tumor, which is related with CSC, however not the same concept.Take a
look at this pape:
Crypt stem cells as the cells-of-origin of intestinal cancer.
Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den
Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H.
Some ... 阅读全帖 |
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Z**********g
发帖数: 222 | 23 简单的说，把cancer cells移植在免疫缺陷的小鼠身上，能够:
1.Initiate and maintain a xenograft tumor for serial passages.
2.The xenograft tumor phenotypically recapitulates the original tumor (
maintaining hierarchy of the tumor).
该cancer cells就可以理解为cancer stem cells. |
|
z*t
发帖数: 863 | 24 Just found another examples of transmitable tumors,including species like
dog(CTVT), Tasmanian devil(DFTD)
From the article below
CTVT is down-regulation of MHC-I class helping immuno-evasion
“Many tumors, including CTVT, avoid immunological recognition by down-
regulating classical class I (class Ia) expression and up-regulating
nonclassical class I (class Ib) expression . By expressing class Ib
molecules, tumor cells avoid recognition by natural killer cells and escape
immune recognition by ... 阅读全帖 |
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m**********d
发帖数: 137 | 25 想定量tumor cell里的Reactive oxygen species (ROS)
从invitrogen买的6-carboxy-DCF, 为了确保这个chemical的确能够检测到ROS，首先用
H2O2做了satndard curve：不加DCF,tumor cell有微弱的auto-fluorescence；加DCF的
样品，mean fluorescence intensity（MFI）与H2O2 concentration（0，10，50，100
，500，1000 micro-molar）成线性关系；H2O2 concentration为0的时候，tumor cell
也有较高的endogenous ROS level。整个过程中，对于同一个cell line, FACS的
instrument setting和gating都是一致的。通过这个实验，我觉得比较有把握这个DCF
应该是work了。
然后我给tumor cell不同的treatment和stress，24-72hr,然后用DCF检测细胞内的ROS
水平，之前觉得这些treatment和stress应该up... 阅读全帖 |
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g***o
发帖数: 92 | 26 【 以下文字转载自 Carolinas 讨论区 】
发信人: ganbo (niu), 信区: Carolinas
标 题: a new postdoc position available at Duke University for br
发信站: BBS 未名空间站 (Thu Jun 16 10:56:49 2011, 美东)
发信人: ganbo (niu), 信区: Postdoc
标 题: a new postdoc position available at Duke University for brain tumor study
发信站: BBS 未名空间站 (Thu Jun 16 10:55:59 2011, 美东)
Our lab is part of the Robert Preston Tisch Brain Tumor Center at Duke University. We are seeking Postdoctoral Fellow(s) immediately to start new projects dedicated to underst... 阅读全帖 |
|
O******e
发帖数: 4845 | 27 http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2472.htm
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by
folate receptor-a targeting: first in-human results
Abstract:
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-speci
fic intraoperative fluorescence imaging may improve staging and debulkin
g efforts in cytoreductive surgery and thereby improve prognosis. The ov
erexpression of folate receptor-a (FR-a) in 905% of epithelial ovarian
cancers prom... 阅读全帖 |
|
j*p
发帖数: 411 | 28 1. UCSC genome browser has many ChIP-seq tracks including TFs, Pol2 and
Histone modifications (H3K4me3, H3K27me3, H3K36me3, etc) on different cell
lines(through Encode/Gencode project). You can just active these tracks and
compare with what you have to see if your H3K4me3 data looks normal or not.
2. I suggest you normalize your ChIP-seq signals. For example, your normal
tissue ChIP-seq has total number mappable reads = 10M, your tumor sample has
20M mappable reads, then divide any signal from t... 阅读全帖 |
|
b*****u
发帖数: 75 | 29 In the image, the positively-stained area actually has less cells, thus
doesn't look like a colony. Also as aishang pointed out, the staining
pattern of KI67 is not typical.
For xenograft experiment, tumor size might be a more accurate readout (which
you already have). You can have plot, image of mice with tumor, image of
isolated tumors, western of tumor lysate to confirm the knocking-down. That
is already a bunch of data to show. Ki67 staining might be tricky, due to
highly heterogenous patter... 阅读全帖 |
|
f******g
发帖数: 1003 | 30 老鼠BL6的端粒长度很长，所以在老鼠的端粒没有短到极点时候，老鼠已经死了。当然
这也是一个证据表明，有其他不依赖端粒长度的衰老机制。
因为人的端粒长度很短，随着年龄的增长，端粒不断缩短，尤其是在快速分化增生的器
官中，例如造血系统等。端粒短到阈值后会引起一些列DNA损伤，tumor suppressor，
比如最经典的p53会被激活，来抑制pre-cancer cell,因为端粒变短导致的大量的突变
会引起正常细胞，尤其是干细胞的癌变。
当然tumor suppressor 的激活是双刃剑，一方面抑制肿瘤发生，一方面导致衰老。
所以，如何正确激活干细胞的tumor suppressor，或者如何fine tune tumor
suppressor 将是一个非常有意思的研究衰老的方向。
具体文献请看sean morrison, lenhard rudolph (2012), derric rossi, depinho |
|
w***r
发帖数: 709 | 31 肿瘤 的免疫原性是一定的，肿瘤的基因组和转录组都有非常大的变化，高通量测序也
表明，
不同病人的肿瘤，产生新蛋白的突变在20－100个左右。
Those mutations may not be presented to the immunosystem.That's why only a
small fraction of patients benefit in the study you mentioned. Could you
find a T cell clone reacting to mutant Ras? Moreover, decreased the
immunocheckpoint has a threshold issue similar to chemotherapy, the dosage.
肿瘤就很难再通过突变来逃逸
this is an interesting point, but the assumption here is that all the tumor
cells have to express multiple effective tumor ... 阅读全帖 |
|
n*********s
发帖数: 552 | 32 实验过程：KO和WT bone marrow derived DCs各1million，sc flank打老鼠，7天后在
另一侧flank再打1million BMDCs，7天后flank种1million B16细胞。第一次实验tumor
完全没长。第二次，现在是种了B16后第8天了，打了KO DCs的老鼠tumor很明显，可是
打了WT DCs的还是没有tumor。本来还挺兴奋的，觉得差距挺大，可是WT干脆不长的话
是不是technial problem啊，B16一般几天开始有palpable的tumor呢？不长可能是什么
原因呢? |
|
t******k
发帖数: 5617 | 33 p53的问题在于太重要了，loss of function 和 gain of function mutation都会
induce tumor。当然，大部分tumor里面p53是loss of function的，所以想做药肯定不
是用inhibitor，而是想办法恢复功能，但是小分子很难有这种功效的。
Cancer stem cell是一个很异源性的population，不同cancer里CSC的起源可能完全不
同，甚至在同一个体的tumor中都有可能存在不同来源的CSC。有些cancer，比如某些脑
瘤，deplete了CSC以后，不会再形成新的CSC，而有些tumor，比如breast cancer，
deplete了CSC以后还会形成新的CSC，甚至CSC会从triple positive 向triple
negative发展。CSC的复杂性很大程度上也是和cancer的多源性有关系的。
个性化治疗对某些发病机理相对简单的disease还是很promising的，而且有针对的治疗
至少可以improve survival和life quality。 |
|
g****s
发帖数: 1755 | 34 好文要顶，虽然文字有点偏激但确实是好文。
我自己算是做了将近10年的anticancer,如果在我自己身上发现cancer/tumor我不会选
择任何现在的药物；如果是实体瘤我会选择手术，如果是非实体瘤手术也不要做。
1，药物研发很有点“本末倒置”的味道，一个化合物能否成药，先在动物身上试试效
果以及毒理，几百美元就差不多的成本；为什么非要体外、蛋白、通路乱搞一堆砸了几
百上千万之后再体内动物呢呢？就为了能发文章？Pfizer的抗生素Linezolid主要研发
在1990s,于2000年正式经过FDA批准上市，上市8年都不知道到底作用靶点是50S亚基上
的哪个蛋白，直到2009年才有第一个XRay确认的作用靶标蛋白。
2，任何药物，任何化合物在体内生物起效和代谢过程都不仅仅是个别Pathway的过程；
又回到上面说的，弄个通路可以发文章。Western-blot原本是用类似TLC和显影的方法
把小分子和蛋白结合再现出来，但用来用去又有多少人真正相信WB的结果呢？虽然WB是
生物类文章必备的一道坎儿，但我并不相信WB就真的证明药物分子和作用靶点完好结合
并发挥药物作用。
3，Tumor和... 阅读全帖 |
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s******y
发帖数: 28562 | 35
大致看了一下，数据很有意思啊。是否暗示了Kaposi's sarcoma, non-Hodgkin's
lymphomas, and nonmelanoma skin cancers是用免疫法治疗最有前途的几种癌症？
For most common tumors, e.g. colon, lung, prostate, stomach, esophagus,
pancreas, ovary and breast, cancer rates were roughly twofold higher after
kidney transplantation compared with the general population. Melanoma,
leukemia, hepatobiliary tumors, cervical and vulvovaginal tumors were each
approximately fivefold more common. Testicular and bladder cancers were
increased approximately t... 阅读全帖 |
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x******3
发帖数: 111 | 36 今天终于有人联系我，非常感谢。但我不知道回信成功了没？（请联系我的邮箱
K********[email protected] ）因为前几天一直没有人答复我，很着急，所以我今早去找了
我们的生物信息学部门谈了合作，不然这个周末都过不好了。但是我不知道他们能不能
帮的到我？他们说下周四之前跟我说。不知道还有人愿不愿意帮我看一下 （可能只能
acknowledgement）？
另外，如果您能找到除了下面这篇文章以外的TCGA数据库或者其他数据（BRCA1-MUTANT
肿瘤, 对cisplatin或者carboplatin的生存期）并且能用的话，我们还是很愿意加入进
去的 (可以 co-author)。
我们会在三个月内再投一篇,我希望可以找到一个可以长期合作的伙伴。
I am wondering whether you have time to discuss with the data analysis on
the BRCA1-mutant tumors from the following paper https://tcga-data.nci.nih.
gov/docs/publicatio... 阅读全帖 |
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p*******q
发帖数: 472 | 37 老板好象是系主任和nci brain tumor panel里的头。
http://faculty.mdanderson.org/Wai-KwanAlfred_Yung/
Primary Appointment
Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The
University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Neuro-Oncology, Division of Cancer Medicine,
The University of Texas MD Anderson Cancer Center, Houston, TX
Dr. Wai-Kwan Alfred Yung is a Professor of Neuro-Oncology and Cancer Biology
, as well as the Margaret and Ben Love Chair... 阅读全帖 |
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p*******q
发帖数: 472 | 38 老板好象是系主任和nci brain tumor panel里的头。
http://faculty.mdanderson.org/Wai-KwanAlfred_Yung/
Primary Appointment
Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The
University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Neuro-Oncology, Division of Cancer Medicine,
The University of Texas MD Anderson Cancer Center, Houston, TX
Dr. Wai-Kwan Alfred Yung is a Professor of Neuro-Oncology and Cancer Biology
, as well as the Margaret and Ben Love Chair... 阅读全帖 |
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A***5
发帖数: 2 | 39 Postdoctoral scientist positions are available starting in July 2015 in the
Molecular and Cellular Cancer Biology Lab of Dr. Wei Li. Our lab is part of
Penn State Milton S. Hershey Medical Center and Pennsylvania State
University College of Medicine located in Hershey, Pennsylvania.
We are interested in studying intercellular interactions during tissue
homeostasis and determining how de-regulated interactions among cells
promote cell transformation and tumor progression. The goal of our research... 阅读全帖 |
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m*********D
发帖数: 1727 | 40 （其实生物里有些应用方面的研究还是挺好玩的。就是付出和收获不成正比。我六年前
不去Novartis,就是因为对筛药有兴趣。作出一个药的可能性比中lottery的机会还小。
这个行当真的只合适不愁吃穿的人。回头看看，真希望当年转了行。可太太英文不通找
不到工作，一个家要养，还有两边父母要照顾，这些年我有多少无奈！好在太太愿意和
我一起吃苦，一起为小家奋斗，一步一步，我们也终于看得见隧道那头的亮光了。两边
父母的任务接近完成，孩子一个大学毕业一个也快上大学了。我和太太说，最差就是卖
了房子给儿子上大学，我们自己租个小房子住。
不管你转不转行，早点学习投资理财还是要的。没有希望的日子最难熬，如何把枯燥的
日子过得有希望，也是生活的艺术。我等太太从国内外回来就准备庆祝我们结婚25周年
了。没有钻戒，没有鸽子蛋。但60岁之前退休是我给太太的承诺。下面是我和太太开玩
笑的一个梦，但当太太从local报纸上看到我们研究的报道，她说：真的哟，都上报纸
了。这个要成功了，咱们可以搬到一个气候好的地方舒服舒服地退休了。）
投资理财坛最近流行千万梦，俺博士后挣得少，还不能冒险，能不能也有一个千万梦呢？
昨天... 阅读全帖 |
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v********a
发帖数: 646 | 41 Scientific Manager – Stem Cell (Job 34333)
Are you interested in pioneering Stem Cell Research? We are seeking a
Scientific Manager for the new Developmental Neurobiology Stem Cell
Laboratory. As the Scientific Manager you will lead collaborative research
projects with investigators in the Developmental Neurobiology Department.
The Scientific Manager will be responsible for:
· Developing new differentiation protocols aligned with the
research interests in the department.
· Modeli... 阅读全帖 |
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l***y
发帖数: 4671 | 42 一个可能性就是 clinical samples 不纯。tumor 是 tissue，里面有很多种细胞。比
如说，TCGA 的 BRCA tumor sample 的标准是 60% 以上的细胞核是 tumor cell 的。
sample 里面的免疫细胞往往数量比较大，很多看到的关联，其实是来自于免疫细胞而
不是 tumor cell 的。
可以考虑用 cancer cell line 的 expression 数据看一下，比如说 ccle 的数据。 |
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T*G
发帖数: 600 | 43 我只是简单说一下为什么NGS在Molecular Pathology 现阶段应用很有限，看来你没接
触过NGS interpretation, NGS reliable的interpretation和database大多应用在
prenatal 和一些遗传疾病的检测，为了不同的reference lab 间对case 有相同的
interpretation, ACMG在业内定了disease interpretation 的guideline。"the
medical geneticists do not have the capacity to interpret tumor specimen
either" This is totally wrong, ARE U NUTS? look at how many labs are doing
tumor NGS in both academia and industry. The major difficulty is not
freaking how you get tumor samples, it is how you inte... 阅读全帖 |
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m******c
发帖数: 830 | 44 It's the opposite. Melanoma is the tumor type with the highest mutation load
among all tumor types. Therefore, most immuno-oncology trials start with
melanoma, including PD-1 and tumor vaccines, because high mutation load
means higher tumor immunogenecity. It is a 软柿子. Mutation load in lung
cancer is high, too, and is one of the FDA approved anti-PD-1 therapy
indications. |
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c******r
发帖数: 889 | 45 Severe side effect is expected with chemotherapy, unfortunately, since most
of these agents are cytotoxic, specifically targeting actively dividing
cells-a key trait of cancer cells. Though unpleasant or even horrible, it
saves lives. Whether it helped an individual is very difficult to determine.
The benefit can be appreciated only from large statistic studies.
What kills a cancer patient is usually not the primary tumor but metastases.
The development of a full blown cancer takes decades to fi... 阅读全帖 |
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l********y
发帖数: 2295 | 46 呵呵，接着来。
有个MEN叫 Para Pan （潘帕拉，反正不是潘安了？呵呵）
Para Pan Pee a lot when he's little-MEN1
长大了para有出息了拿了Ph. Med.(临床型博士？)-MEN2A
拿了Ph. Med就加入gang了(俗称学霸？)－MEN2B
MEN1: Para Pan Pee a lot when he's little.
Para=parathyroid tumors.
Pan=pancreatic endocrine tumors
Pee=pituitary tumors.
MEN2A:长大了para有出息了拿了Ph. Med.
Para=parathyroid tumors
Ph.=pheochromocytoma
Med=medulllary thyroid ca
MEN2B: 拿了Ph. Med就加入gang
Ph.=pheochromocytoma
Med=medulllary thyroid ca
gang=ganglioneuromatosis
呵呵，如果有包子刺激还有劲头接着来～～～pony是比较财迷的。。 |
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l********y
发帖数: 2295 | 47 【 以下文字转载自 Pre_Resident_Club 俱乐部 】
发信人: lovelypony (lovelypony), 信区: Pre_Resident_Club
标 题: steps学习的口诀
发信站: BBS 未名空间站 (Fri Oct 22 21:56:46 2010, 美东)
响应老刀的号召，冒个小泡。有很多难记的东西，编过一些口诀，先贡献一个，回头有
空了再慢慢添。大家有好的口诀也都来分享，这样大家都省时省力。
先贡献一个pony比较经典的口诀，认识pony的都会的，呵呵。
for step1:
trinucleotide repeat expansion diseases:
My Ex is Hungry on Fri.
My (大家都Call Tall Girl, CTG)=Myotonic dystrophy
Ex (比较肉麻的Call Ge Ge, CGG)=fragile X syndrome
Hungry (点了个鸡蛋Call An Egg, CAG)=Huntington's disease
Fri (大家AA制的，Go AA, GAA)=Fried... 阅读全帖 |
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d****y
发帖数: 2180 | 48 ☆─────────────────────────────────────☆
zhu84518 (lot) 于 (Wed Aug 8 22:41:34 2012, 美东) 提到:
A previously healthy 32-year-old woman who works as a nurse comes to the
emergency department because of a 3-week history of episodes of dizziness,
nausea, and profuse sweating that resolve with eating. She does not smoke.
She drinks four glasses of wine weekly. Vital signs are within normal limits
. Physical examination shows no abnormalities. While in the emergency
department, she becomes dizzy and... 阅读全帖 |
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e****0
发帖数: 678 | 49 Endometrial hyperplasia types. Risk of cancer treatment
simple 1% Cyclic progestin
complex 3% Cyclic progestin
Simple atypical 8% THA or progestins
Complex atypical 29% THA or progestins
• Prolatinoma and hypothyroidism galactorrhea
• Anesthesia can reduce uterine activity if in the latent phase
• Contraceptive for lactating mother
Progestin-only oral contraceptive
• Pregnancy luteoma
African-ameri... 阅读全帖 |
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