b******r
发帖数: 111 | 1 马上要选project(Alzheimer,atherosclerosis
)，大家能不能说说 Alzheimer,atherosclerosis两个领域上的牛人，顺便提一下他们
的切入点及未来可能发展前景吧. |
h*******o
发帖数: 4884 | 2 For Alzheimer's
John Q. Trojanowski
Frank M Laferlla
|
c**n
发帖数: 73 | 3 Alzheimer
Virginia Lee
David Holzman
Atherosclerosis
Alan Tall (reverse cholesterol transport)
Daniel Rader(reverse cholesterol transport)
Peter Libby(inflammation)
Jan Breslow (mouse genetics)
Christopher Glass (macrophage gene expression)
【在 b******r 的大作中提到】
: 马上要选project(Alzheimer,atherosclerosis
: )，大家能不能说说 Alzheimer,atherosclerosis两个领域上的牛人，顺便提一下他们
: 的切入点及未来可能发展前景吧.
|
b******r
发帖数: 111 | 4 Thank you so much.
No many bulls in Alzheimer area?
For Atherosclerosis,Mike Brown and Joseph Golstein are not in this list?
【在 c**n 的大作中提到】
: Alzheimer
: Virginia Lee
: David Holzman
: Atherosclerosis
: Alan Tall (reverse cholesterol transport)
: Daniel Rader(reverse cholesterol transport)
: Peter Libby(inflammation)
: Jan Breslow (mouse genetics)
: Christopher Glass (macrophage gene expression)
|
h******y
发帖数: 1374 | 5 做bioinfor的转行做Alzheimer,atherosclerosis了？
【在 b******r 的大作中提到】
: 马上要选project(Alzheimer,atherosclerosis
: )，大家能不能说说 Alzheimer,atherosclerosis两个领域上的牛人，顺便提一下他们
: 的切入点及未来可能发展前景吧.
|
l*h
发帖数: 4124 | 6 现在Alzheimer领域一片混乱。热闹了10年的以为是致病原因的东西被发现是旁观者，
现在重新回到混乱中，无数的理论，看不到可行的证明方法。
【在 b******r 的大作中提到】
: 马上要选project(Alzheimer,atherosclerosis
: )，大家能不能说说 Alzheimer,atherosclerosis两个领域上的牛人，顺便提一下他们
: 的切入点及未来可能发展前景吧.
|
p*****m
发帖数: 7030 | 7 说说看？我对AD挺有兴趣的
【在 l*h 的大作中提到】
: 现在Alzheimer领域一片混乱。热闹了10年的以为是致病原因的东西被发现是旁观者，
: 现在重新回到混乱中，无数的理论，看不到可行的证明方法。
|
w******r
发帖数: 3156 | 8 说的是Abeta吗？能不能展开说说，比如怎么发现它不是主要的致病原因？多谢。
【在 l*h 的大作中提到】
: 现在Alzheimer领域一片混乱。热闹了10年的以为是致病原因的东西被发现是旁观者，
: 现在重新回到混乱中，无数的理论，看不到可行的证明方法。
|
m****n
发帖数: 37 | 9 Virginia Lee
is a strong will women, but she is not very supportive for young postdoc and
leave few research freedom for them.
John, her husband can't be on par with her in science.
David, is very good in politics and networking and devote too little time on
science now. Not good for postdoc either.
Actually, Todd Golde in Mayo is a very smart guy. A little hard to deal with,
but not bad at all. I think he is really serious in science and may give
good advice for students or postdoc.
Mark Matts
【在 c**n 的大作中提到】
: Alzheimer
: Virginia Lee
: David Holzman
: Atherosclerosis
: Alan Tall (reverse cholesterol transport)
: Daniel Rader(reverse cholesterol transport)
: Peter Libby(inflammation)
: Jan Breslow (mouse genetics)
: Christopher Glass (macrophage gene expression)
|
m****n
发帖数: 37 | 10 Frank M Laferlla,
He made a 3xTg mice and become famous.But nowadays, most time he just
repeats himself and, probably due to the limitation of current AD study area
. It hard to see any change in next decade without a breakthrough in AD
theory.
All the study in AD hardly makes very few changes to Ad patients. Maybe
Pittsburgh Dye in fMRI is the best thing for patients in recent years. |
|
|
m****n
发帖数: 37 | 11 Abeta plaques was considered to be the cause of AD a decade ago. Now, people
think soluble Abeta is more likely to be the cause, while Abeta plaques are
just the by product.
Genetic studies provide strong evidence that APP pathway play the pivot
role in AD. Tau also has its share in the game.
However, for sporadic AD patients, no solid evidence yet for any hypothesis.
【在 l*h 的大作中提到】
: 现在Alzheimer领域一片混乱。热闹了10年的以为是致病原因的东西被发现是旁观者，
: 现在重新回到混乱中，无数的理论，看不到可行的证明方法。
|
c**n
发帖数: 73 | 12 Speaking of Brown and Goldstein, I think I failed to mention Helen Hobbs,
who is also in UTSW and a former postdoc of theirs. She discovered PCSK9 by
looking for rare genetic mutations. Now pharmaceutical companies are
looking for inhibitors for PCSK9 for treating high plasma level of LDL.
Brown and Goldstein's place is still a good lab to do science but they are
getting old.
【在 b******r 的大作中提到】
: Thank you so much.
: No many bulls in Alzheimer area?
: For Atherosclerosis,Mike Brown and Joseph Golstein are not in this list?
|
b******r
发帖数: 111 | 13 Great. You guys provide so much information. |
b******r
发帖数: 111 | 14 You know it? I like bench work now.
【在 h******y 的大作中提到】
: 做bioinfor的转行做Alzheimer,atherosclerosis了？
|
b******r
发帖数: 111 | 15 Any 八卦 about bulls in atherosclerosis? |
