m*p 发帖数: 226 | 1 lars2 is leucyl-tRNA synthetase 2, mitochondrial. 谁有这方面的背景? 大量表
达或抑制表达会有什么样的反应? 谢
谢! |
f****y 发帖数: 104 | 2 Looks it is related to longevity in worm. See this paper:
A systematic RNAi screen identifies a critical role for mitochondria in C.
elegans longevity.
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G.
Nat Genet. 2003 Jan;33(1):40-8. Epub 2002 Nov 25.
A classical genetic screen identified a mutation in the mitochondrial leucyl
-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was
associated with longer-lifespan. |
m*p 发帖数: 226 | 3 还有人说lars2 mutation correlates with type ii diabetes。
leucyl
【在 f****y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Looks it is related to longevity in worm. See this paper: : A systematic RNAi screen identifies a critical role for mitochondria in C. : elegans longevity. : Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. : Nat Genet. 2003 Jan;33(1):40-8. Epub 2002 Nov 25. : A classical genetic screen identified a mutation in the mitochondrial leucyl : -tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was : associated with longer-lifespan.
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f***4 发帖数: 886 | 4 表达是组织特异的吗?
这类基因很有意思。。。
【在 m*p 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 还有人说lars2 mutation correlates with type ii diabetes。 : : leucyl
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f****y 发帖数: 104 | 5 没有这个线粒体就要麻烦大了,所以应该那里都有表达的。
【在 f***4 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 表达是组织特异的吗? : 这类基因很有意思。。。
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m*p 发帖数: 226 | 6 线粒体的tRNA synthesis is different from cytoplasm tRNA synthesis? 谁有这方
面的背景, 来扫盲。 谢谢!
【在 f****y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 没有这个线粒体就要麻烦大了,所以应该那里都有表达的。
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