e**r
发帖数: 1144 | 1 真核细胞里 Ser/Thr Kinase一般都是有很多底物的吧？
有没有只特异磷酸化某一两个蛋白的kinase？
还有，Kinase的特异性主要是Kinase domain决定的还是recruit决定的？ |
p*****h
发帖数: 36 | 2 Raf has very few known substrates (MEK)
For the majority, specificity is determined by the activation segment of the
kinase domain.
【在 e**r 的大作中提到】
: 真核细胞里 Ser/Thr Kinase一般都是有很多底物的吧？
: 有没有只特异磷酸化某一两个蛋白的kinase？
: 还有，Kinase的特异性主要是Kinase domain决定的还是recruit决定的？
|
p*****e
发帖数: 93 | 3 more than MEK's substrate.
the
【在 p*****h 的大作中提到】
: Raf has very few known substrates (MEK)
: For the majority, specificity is determined by the activation segment of the
: kinase domain.
|
b*******r
发帖数: 18 | |
p*****h
发帖数: 36 | 5 You mean not just MEK?
Raf does not have a specificity motif. Peptide library approaches give no
definitive results. - this is generally taken as evidence that sequences
outside the kinase domain help anchor substrates.
【在 p*****e 的大作中提到】
: more than MEK's substrate.
:
: the
|
