e**r 发帖数: 1144 | 1 真核细胞里 Ser/Thr Kinase一般都是有很多底物的吧?
有没有只特异磷酸化某一两个蛋白的kinase?
还有,Kinase的特异性主要是Kinase domain决定的还是recruit决定的? |
p*****h 发帖数: 36 | 2 Raf has very few known substrates (MEK)
For the majority, specificity is determined by the activation segment of the
kinase domain.
【在 e**r 的大作中提到】 : 真核细胞里 Ser/Thr Kinase一般都是有很多底物的吧? : 有没有只特异磷酸化某一两个蛋白的kinase? : 还有,Kinase的特异性主要是Kinase domain决定的还是recruit决定的?
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p*****e 发帖数: 93 | 3 more than MEK's substrate.
the
【在 p*****h 的大作中提到】 : Raf has very few known substrates (MEK) : For the majority, specificity is determined by the activation segment of the : kinase domain.
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b*******r 发帖数: 18 | |
p*****h 发帖数: 36 | 5 You mean not just MEK?
Raf does not have a specificity motif. Peptide library approaches give no
definitive results. - this is generally taken as evidence that sequences
outside the kinase domain help anchor substrates.
【在 p*****e 的大作中提到】 : more than MEK's substrate. : : the
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