n***a
发帖数: 1373 | 1 Down's syndrome is rarely inherited. (Only in case of recurrent Down's
syndrome in multiple pregnancies, it could be due to mom's chromosome
problem.) It is mainly related to maternal age (the egg is old). Down's baby
has three No.21 chromosomes (normal people have two). It is not amutation
thing. Like Sarah Palin, only her last child has Down's. |
|
m****x
发帖数: 2506 | 2 ☆─────────────────────────────────────☆
yx125606 (七饼) 于 (Fri Jun 3 15:45:17 2011, 美东) 提到:
背景：老婆生物PhD第五年，本人化学PhD刚答辩
头胎，B超显示为女娃。预产期5月29日。老婆怀孕早期有spotting及少量出血，早中期
有呕吐烧心等反应。但一直坚持实验室工作，为了生娃之后能够在夏天好好休息。
5月初的一次检查，老婆就已经开了两指。当时可把我们紧张的，不会这么早就要出来
吧，我5月9日要PhD答辩，可不能答辩和娃一起来啊。于是乎每天千叮咛万嘱咐一定要
老婆卧床，不卧床也得坐着，不坐着走路也得慢慢挪。
好容易挨过了我的答辩，到了5月中旬的时候，老婆已经开了3cm多了，连续两个女OB都
说预计是到不了预产期了。于是乎每天就紧张着等啊盼啊，娃早出来几天就几天吧，反
正也足月了。没想到一晃到了5月下旬，一个白胡子老OB说还是只开了几乎4cm，还说很
有可能overdue，让我们做好准备下周接着来检查。
我终日恫吓老婆：“咋还不生，再不生小心医生让你刨，刨了这一个，下个还得刨，再
下一个... 阅读全帖 |
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c**i
发帖数: 6973 | 3 The problem is no test tells you one way or another--except chromosome count
(then again, not all Down syndrome patients/fetuses have three copies of
chromosome 21--some just have an extra arm (of the third 21) attached one of
the two 21s).
As I say it is all about possibilities. Nobody knows for sure until the baby
is born. |
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s******0
发帖数: 1340 | 4 chromosome 8 inversion.其它都正常.现在怀的是老二.我,LP,老大都健康.医生让再验
父母的血,如果我们中有一个也有这个inversion那问题不大,如果都没有要再做检查.
chromosome 8是控制什么的染色体?现在19周,LP伤心死了. |
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c*******u
发帖数: 12899 | 5 ☆─────────────────────────────────────☆
zhuang1 (zhuangzhuang) 于 (Fri Sep 21 13:53:52 2012, 美东) 提到:
如题。女儿9个多月了，有发展滞后，如：6个月才会抬头，7个月才会翻身，现在还不
会坐不会爬，腿不能承重。知道后我网上查了一下，越差越担心。求有经验的妈妈帮助。
我们做了brain MRI，血液测试和基因测试，都没有查出原因。父母双方家族都没有先
例。
现在开始每周做一次physical一次occupacional theraphy。难道这真的会影响孩子一
生吗？谢谢。
---------------------
非常感谢所有回复的朋友，能得到这么多热心人士的回复，不论是给建议的，分享个人
经历的，还是祝福的，我这里都一一谢过了。我仔细看了每一个回帖，认真记下了所有
的建议。总结如下，希望对他人也有帮助。
1，尽快约儿科神经医生查原因，因为hypotonia只是症状，真正的原因还待查。
2，坚持做physical therapy 和occupacional therapy
3，坚持... 阅读全帖 |
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b*******y
发帖数: 12791 | 6 bless
下次记得要求做fetal echo。心脏有问题的话，这个看起来比较准。
google了一下
In most cases, chromosome 10, distal trisomy 10q is due to a chromosomal
balanced translocation in one of the parents.
你和你ld都去检查一下染色体吧。如果任何一方确实有balanced translocation，可以
考虑做IVF，然后受精卵做ccs，这样可以保证把没有问题的受精卵植入。
一定会有下次的。 |
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g****e
发帖数: 1829 | 7 The answer to your questions is NO. A perfectly healthy baby can have thick
NT measurement.
You need to understand why NT thickness is being looked at. It's *
statistically* shown that there is a correlation between thicker NT and
chromosome disorder. However, there is NO causality that says thicker NT
must indicate chromosome disorder. In fact, 95% of fetus with thicker NT are
completely healthy. Even for the other 5%, most of them only have small
problems.
A lot of people panic when they saw a... 阅读全帖 |
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E*********n
发帖数: 144 | 8 非常严重，你想啥呢？赶快去堕了。事实上fetus' chromosome abnormality很少有是
非mosaic的。如果是非mosaic，那meiosis就出问题了，不可能survive pregnancy for
so long. 染色体是按长短编号的，越小号越长，4号很长的一个。唯一例外是21号，
是最短的常染色体，比22号短。其他都是按顺序编号。所以越小号出问题，越严重。你
这个chromosome 4 abnormality，很可能到生的时候或生前就有可能是死胎。面对现实
吧。 |
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s**********h
发帖数: 436 | 9 Re "看mm是说有问题就放弃，还是无论如何都要留吧？如果有问题放弃，还是早点做
CVS，不光身体上，心理上的伤害也小些啊。不然等感觉到胎动了，很难割舍了。"
颈后透明带3.4mm is a very high risk factor. It could be due to chromosome 13
, 18, 21, or 23, or it could be due to less common chromosome problems. And
again, it could be a false alarm, and I do hope it's a false alarm. However,
the risk of CVS is considerably smaller than the risk of an anomaly (an
order of magnitude). From what I heard, the miscarriage rate of CVS is only
0.5-1%, and that includes data from all doctors... 阅读全帖 |
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n***a
发帖数: 1373 | 10 First check whether the baby has other diseases such as heart
disease that is treatable. Otherwise, I Don't know if there is school for
special education for kids with disabilities in China. You can see some
people with Down's syndrome can work or even get married in US. I am sure
education will help them to be more independent.
Down syndrome refers to 3 chromosome 21. People with three chromosome 13 or
18 usually cannot live too long.
法。 |
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A*********1
发帖数: 813 | 11 约OB要尽早约。我的IVF诊所是九周毕业，听三次心跳之后才毕业。那会儿去约的时候
，好几个OB就约到差不多1个月之后。
用这个网站查due date和一些检测的时间点。我觉得很有用。
http://perinatology.com/calculators/Due-Date.htm
第一个trimester各种血液检查，医生开单子，抽个血就可以。测了HIV，血糖，尿蛋白
等等。
以下是基因检测：
1）血液检查Non-Invasive Prenatal Testing (NIPT) 9周－11周
主要是测几个三体和性染色体疾病。最早九周就可以做。从胳膊抽血，测的是在母体血
液里的free fetal DNA。这个也是测的胎盘的细胞。false positive（正常的被当成不
正常）相对比较多，所以如果结果不好，也先不用freak out。
False negative很少很少，但也还是有，33岁的母亲，第二胎，NIPT结果出来low risk
，没有做羊水穿刺，孩子出生是唐氏。这个是已经发表的一个学术文章，网上可以查到
。Boston Herald关于血液检查报道的，也提到一起，血液检查... 阅读全帖 |
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s********e
发帖数: 283 | 12 第一胎。做了一个basic 羊穿，FISH结果正常.医生问我要不要用抽到的羊水做9种染色
体的检查看有没有缺失/重复。不知道这个有没有必要做？我还要自己打电话去保险包
不包，明天我的保险也不一样了，再加上直觉宝宝是健康的，所以比较倾向不做。
不知道我解释的清楚不清楚。这个测试叫做Prenatal michodeletion panel: this
panel test for 9 of the most common and severe deletion/duplications of the
chromosomes, which cannot be detected on a routine chromosome study.
Individually. Each michodeletion syndrome is rare
请版上有经验的妈妈赐教！ |
|
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w****e
发帖数: 93 | 14 高龄产妇35+。先做了maternity T21 plus正常。觉得不放心，在18周时做了一个羊穿
，自己掏腰包加选了microarray 。 普通的羊穿结果没问题，但是microarray 发现了X
(xp22.33)和Y (Yp11.23)染色体PAR1 (pseudoautosomal) 区
上多了一小块, 大小大约0.31M。X,Y染色体的PAR1是SHOX 基因，这个基因的扩增是引
起矮小症ISS (Idiopathic short stature ) 和LWD (软骨生成障碍）的原因。但正常
身高人的染色体里也会发现有这种扩增。
报告说我本人也有这个染色体增扩，所以这个增扩是遗传我的，不是孩子原生的。我的
情况是，身高不高但也算正常158cm，孩子他爹172cm. 小时候爸妈是说过我有好动症，
腿脚没劲，走走就瘫了，但大了也没有什么大问题，除了人容易疲劳之外，还算健康。
Genetic counselor问了我家族的身高，然后就说我是家族型矮小，说这个孩子以后很
可能个子不高，但也不至于不正常。她还说这个是染色体增扩（Gain) 不是缺失（
deletion), 不是那么糟... 阅读全帖 |
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g*********9
发帖数: 3528 | 15 来自原文摘要"A genomic distribution analysis demonstrated that IQ-related
genes were enriched in seven regions of chromosome 7 and the X chromosome."
前三位：
染色体 基因数 比例
ChrX* 25 0.1582
Chr7 14 0.0886
Chr17 11 0.0696
后三位
Chr10 2 0.0190
ChrY* 1 0.0063
Chr14 1 0.0063
读文献要仔细啊同学。 |
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t******l
发帖数: 10908 | 16 也不一定是基因本身，也不排除是 gene expression，比如 X-inactivation。
或者简单的例子，就是中国古代那个西施东施，其实是 identical twins。差别只是两
人 inactivate 了不同的 X chromosome。
[quote]
X-inactivation (also called lyonization) is a process by which one of the
copies of the X chromosome present in female mammals is inactivated.
http://en.wikipedia.org/wiki/X-inactivation
[/quote] |
|
发帖数: 1 | 17 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
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u***s
发帖数: 591 | 18 ☆─────────────────────────────────────☆
chromosome (染色体) 于 (Sun Nov 5 23:34:40 2006) 提到:
模模糊糊记得在哪儿看到如果e-filing，有更大的可能会被转到TSC去。不知道是不是
这样？
☆─────────────────────────────────────☆
fateface (石头夫人) 于 (Mon Nov 6 02:04:17 2006) 提到:
我们自己申请的efiling，EB1a，结果就送到TSC去了。
不知道是不是有统计学意义。
☆─────────────────────────────────────☆
chromosome (染色体) 于 (Mon Nov 6 23:03:38 2006) 提到:
What exactly is e-filing's procedures? some laywers said they don't do that.
I am just wondering how difficult it is for t |
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l*****O
发帖数: 402 | 19 too many possibilities. can't predict.
but in reality, one of the defective sperms from a normal man could win
the race several times. there is one literature that describes such a case.
an asian woman had 3 time miscarriage after birth of her first baby. it
turned out that her husband's chromosomes have a balanced translocation. if
this woman gets pregnant infinitive times, she probably will have 25% normal
kids without translocation, 25% noraml kids with translocation, 50%
miscarriage or still... 阅读全帖 |
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j****n
发帖数: 4358 | 20 【 以下文字转载自 JobHunting 讨论区 】
发信人: Solow (Solow), 信区: JobHunting
标 题: L家第一轮店面 被烙印黑了
发信站: BBS 未名空间站 (Mon Feb 23 16:58:15 2015, 美东)
前面30分钟抓着问了我过去的经历，
做了一个小题目。
然后扔出这个大题 要求O(n)
且输出排序
我先用suffix array, 说不好
然后用hashmap, o(n), 但是输出不排行
恶心的地方，
输入不是string,是流
输出要排序
O(N)
最可气的是 找不到他想要的算法 不让写代码，
最后5分钟,找到他想要的答案，来不及了
好苦啊 为啥大家店面就那几道题，给我这么难的一个
This problem pertains to the field of bioinformatics, but it does not
require any specialized biological knowledge. All DNA is composed of
sequences of four "letters" of nucl... 阅读全帖 |
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G***G
发帖数: 16778 | 21 I want to ask one question about biology here.
suppose a gene's location in a chromosome is from a to b (b>a) with positive
strand.
Now if a sequence is extracted from b to a in the negative strand of the
chromosome, can we say this sequence is the same gene? |
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x****g
发帖数: 342 | 22 好，查了最近流行的wikipedia，再次确认是大吉大补之物:
http://en.wikipedia.org/wiki/Muscadine
Muscadines (Muscadinia rotundifolia) are a grapevine species native to the
present-day southeastern United States that has been extensively cultivated
since the 16th Century. It differs from Vitis spp. in its number of
chromosomes (2n=40 chromosomes) and its morphology. Its recognized range in
the United States extends from New York south to Florida, and west to
Missouri, Kansas, Arkansas, Oklahoma and Texas. They are well ad... 阅读全帖 |
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w********o
发帖数: 1621 | 23 This should be posted to biology or genetics boards to get the discussion
interesting.
There is a paper published on a long time ago. The difference in
men and women was already explained by genetic traits.
Men don't have the ability to give birth. But their genes want to pass on.
Those genes' challenge is how to survive in the world. The answer is obvious
- they drive men's instinct to spread their sperms (genes) as widely as
possible. In behaviors, men in nature likes to sleep around.... 阅读全帖 |
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R**o
发帖数: 311 | 24 你所引用的生物学证据只是一部分，其中大部分发表在Nature，Science，Cell，PNAS
等权威期刊上。
生物方面的科学研究大致可分为：
1）人类基因学。 1993年Hamer最早发现X染色体上的Xq28片段和性取向强烈相关。可其
结果不能被另一个组在1999年重复。但Hamer坚持认为认为是实验上的误差。而最近的
2005
年的一个对人类整个基因组的scan发现在另外3个非X染色体上的片段（7q36, 8p12,
10q26）
和性取向相关：
A linkage between DNA markers on the X-chromosome and male sexual
orientation. Science 261, 321–327(1993)
http://www.sciencemag.org/cgi/reprint/261/5119/321
Linkage between sexual orientation and chromosome Xq28 in males but not in
females. Nature Genetics 11, 248–256 (1... 阅读全帖 |
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R**o
发帖数: 311 | 25 Dower, I have been doing biological research for years. I have been also
following research on homosexuality for many years. I published research
articles in Nature, Science and Cell, even as a first author. I do not
think you are at a better position to talk about homosexuality than I
am.
I have given you several references falling into different lines of
evidence to show the biological basis of homosexuality. However, you
chose to ignore. Here I am posting them one more time. You may simply
... 阅读全帖 |
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n**e
发帖数: 2026 | 26 今年初，美国科学促进会（AAAS）和皮尤研究中心（Pew Research Center）联合公布
的一项调查显示，88％的科学家认为转基因食品可安全食用，持这一看法的公众只有37
％。报告认为差距如此之大的一个可能原因是，三分之二的公众认为科学家对转基因食
品的健康后果没有清晰认识。这就是真正的原因吗？
根据报告全文，皮尤中心给19，984名科学家发出了调查问卷，3748人（18.8%）完成了
问卷调查。其中生物医学学科背景的科学家占50%。报告没有说明50%的生物医学背景是
否能够代表科学家总体的学科构成。更大问题是在这50%的科学家人群中，有多少人的
工作是与转基因作物的研究有关，以什么样的方式相关。报告没有提供任何信息。
由于这些关键信息缺失，88%的科学家相信转基因安全的说法毫无意义。在一个没有代
表性并且无法排除偏向性的样本中调查，科学家相信转基因安全从1%到99%与88%没有任
何不同。好消息是超过半数的美国民众认为转基因不安全。
2012年10月，美国科学发展协会以官方名义（Board of Directors ）抛出了一个反对
转基因标识声明（附录1）。目的就是诱导民... 阅读全帖 |
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y****i
发帖数: 1265 | 27 【 以下文字转载自 Biology 讨论区 】
发信人: yweili (杨威利), 信区: Biology
标 题: 据说哈利波特上nature了
发信站: BBS 未名空间站 (Thu Jan 6 14:13:20 2011, 美东)
发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线====================... 阅读全帖 |
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H********g
发帖数: 43926 | 29 细菌通常一个，古生菌（跟细菌有很多不同的原核生物）可以有多个。
Most bacteria have a single circular molecule of DNA, and typically only a
single origin of replication per circular chromosome.[3]
Most archaea have a single circular molecule of DNA, and several origins of
replication along this circular chromosome.[4] |
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c*****m
发帖数: 1160 | 30 基因检测癌是标准操作啊！癌症都是一些基因突变。举一个例子，慢性粒细胞白血病
https://en.wikipedia.org/wiki/Chronic_myelogenous_leukemia
CML is diagnosed by cytogenetics that detects the translocation t(9;22)(q34;
q11.2) which involves the ABL1 gene in chromosome 9 and the BCR gene in
chromosome 22.
23andme 所说的是 “通过你目前的基因，猜测以后你得各种病得概率”，跟上面这个
检测癌症不是同一个路数。 |
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p***7
发帖数: 449 | 31 唉，这个。。。说得过头了，让人看着心里不舒服了。。。
另外，mm可别assume在宠版的都是X chromosome的，像PALA就是Y chromosome的。 |
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A****e
发帖数: 3180 | 32 ☆─────────────────────────────────────☆
RainingDay (山寨大王) 于 (Fri Jul 8 21:07:12 2011, 美东) 提到:
刚从医生回来。
X光已照， 这个医生说need pin, splint will not solve the problem. herself can
't perform pin surgery, recommended two doctors who specialize this type of
surgery. first office is the one i called yesterday, which back logged one
month later and won't accept any new patient. another one has automated
phone system. left message, and sent x-ray via email, waiting for response.
will make copy for medica... 阅读全帖 |
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M*****e
发帖数: 279 | 33 Yes, you're right. The X chromosome inactivation only occurs in somatic
cells, not germ cells. I know this.
The other post said that the girl get one X from her mother, the other X
from her father. It's true too. However, which X chromosome (from mother or
father) is inactivated in somatic cells is randomly done for girls. How can
the LZ (the original post) be sure that "女性有 2 個 X 染色體，男性只有 1 個
，所以媽媽的智力在遺傳中就占有了更重要的位置"? Our intelligence is
determined by our neurons that are somatic cells, but not |
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t******h
发帖数: 177 | 34 修了道，再来看你说的这些学科，更有意思。
就说遗传学中的基因吧，先是DNA，然后是ritro RNA,现在又有更新的探索。心经中一
句“色不异空，空不异色”可比你这些科学要有趣得多了。
再说你的解剖学吧，佛早在两千五百年前，就把身上的骨头讲得清清楚楚。那时还没有
X光呢。
修了道，再来看科学，觉得更应该修道。送你一个非常著名的科学家的一段话：Janet
D. Rowley
http://www.nytimes.com/2011/02/08/science/08conversation.html
"No. I was doing observationally driven research. That’s the kiss of death
if you’re looking for funding today. We’re so fixated now on hypothesis-
driven research that if you do what I did, it would be called a “fishing
expedition,” a bad thing.
O.K... 阅读全帖 |
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f*****y
发帖数: 2 | 35 Geneticis Research Positions In University of Connecticut
1 Postdoctoral position
1 Graduate Assistantship position
These positions are available immediately for an
investigation of
the structural and functional properties of the
Drosophila Y
chromosome. The study will focus on the
Y-chromosomal regulation of
gene expression during spermatogenesis. Candidates
with
experience/training in genetics, molecular or cell
biology are
encou |
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a***o
发帖数: 129 | 36 The method to make transgenic mice is by microinjection of
your construct DNA into the pronucleus of the fertilized
oocyte. Your construct will integrate into the chromosome
randomly, and usually tandemly in a single chromosome. The
amount of expression is dependent on the copy numbers of
your favorite gene, and also the promoter you choose
Depending on the purpose of your research, you can choose
tissue-specific or ubiquitous promoter. Sometimes, you just
want to use its own promoter. In your c |
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h******b
发帖数: 312 | 37 Science. 2003 May 16;300(5622):1152-5.
Distinct cohesin complexes organize meiotic chromosome domains.
Kitajima TS, Yokobayashi S, Yamamoto M, Watanabe Y.
Department of Biophysics and Biochemistry, Graduate School of Science,
University of Tokyo, Tokyo 113-0033, Japan.
Meiotic cohesin complexes at centromeres behave differently from those along
chromosome arms, but the basis for these differences has remained elusive. The
fission yeast cohesin molecule Rec8 largely replaces its mitotic counterpa |
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l****t
发帖数: 102 | 38 "for the discovery of how chromosomes are protected by telomeres and the
enzyme telomerase"
Elizabeth H. Blackburn
Carol W. Greider
Jack W. Szostak
5 October 2009
The Nobel Assembly at Karolinska Institutet has today decided to award
The Nobel Prize in Physiology or Medicine 2009 jointly to
Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak
for the discovery of
"how chromosomes are protected by telomeres and the enzyme telomerase"
Summary
This year's Nobel Prize in Physiology or Medici |
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o********s
发帖数: 28 | 39 Biochemistry at the chromosome ends and non-coding RNA function
We are seeking motivated Postdoctoral Fellows to join a newly established
laboratory within the Department of
Biochemistry and Biophysics at Texas A&M University to study the molecular
mechanisms of chromosomal
protection/maintenance and the catalysis mechanisms of telomerase,
especially the contribution from its RNA
subunit. We use a combination of X-ray crystallography, biochemistry, yeast
genetics and in vivo cell
biological assa |
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y****i
发帖数: 1265 | 40 发信人: Isaiah (SKIASONARANHR), 信区: Emprise
标 题: 据说哈利波特上nature了
发信站: 水木社区 (Thu Jan 6 09:19:54 2011), 站内
http://blog.renren.com/share/225423167/4622536314
刚看了《哈利波特7上》，无聊的在PubMed里面用"Harry Potter"做关键词搜索文献，
得到32篇文献，居然还有发在Nature上的文章两篇 还有其他牛文若干篇。灰常的欢乐。
附该文章链接： http://www.ncbi.nlm.nih.gov/pubmed/16094345
以免大家以为是我胡诌。最近真是闲的蛋疼。
==========================神==作==分==割==线==========================
在下面第一篇nature文章中，在2005年《哈里波特与混血王子》出版后，来自澳大利亚
皇家儿童医院的Graig等人，同样对哈里波特中描述的有超能力的巫师wizards and
witches与麻瓜muggle结合后，后代属性问... 阅读全帖 |
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c****9
发帖数: 95 | 41 我正在做一种固氮菌的酶切。chromosome材料应该没问题的，quantification是200ng/
ul.所以我用了5ul的chromosome, 1ul EcoR1， 4ul Eco buffer， 30ul diH2O.再分开
入4个小试管里面，保存在37度的水浴里面分别5MIN, 30MIN, 1H, 2H,然后移入65度的
水浴30分钟，再跑胶，但是做了2次，发现DNA都没有被切开。然后换了HindIII和NEB
Buffer2,结果也是没有切开。请教各位这个是哪个环节出问题了呢？是否有更好的办法
做酶切呢？谢谢。 |
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c**i
发帖数: 6973 | 42 supports archaeology, that a single-origin domestication 8 to 9,000 years
years ago at Yangtze Valley (of China) and spread to India, rather than the
competing proposition that Ganges in India independently accomplished the
feat.
研究显示:中国是驯化水稻的原产地. VOA Chinese, May 3, 2011.
http://www.voanews.com/chinese/news
/international/20110503-RICE-ORIGIN-121155584.html
, which cites
Molina J et al, . Proceeding of National Academy Science (PNAS), published
online before print May 2, 2011, doi: 10.1073/pna... 阅读全帖 |
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l***y
发帖数: 4671 | 43 有没有人做这种在进化过程中被 comment 掉后扔进素材库的 gene？觉得是
epigenetics 的一个很好的方向啊。可以用低等生物，给个合适的进化压力，看看素材
库是如何被打开和拣选的。（俺们现在是用 cancer cell，给进化压力，看 evolution
的过程。但愿俺找出来的不是 mutation 啊。。。俺还是觉得 cancer cell 不该靠掷
骰子）
我们这里有一个组在做那种发育时被表达，以后永远不会被表达的 gene/isoform，hyp
是：在发育某个时期，不同的 chromosome 间形成某种空间结构，使得分别 binding
在不同 chromosome 上的 protein 可以形成 complex，从而启动某些基因在某些起至
位置的转录。之后，这种空间三维结构不再有机会出现，相应的 gene 或者 gene 的某
些 transcript 就被安全地 lock 起来不再被表达。之所以要这么费劲地 lock，是因
为否则会有灾难性后果。但是，在某些病理条件下，这些被 lock 的 gene 又被表达了
，于是就杯具了。
这种远程空间构象导致的 e... 阅读全帖 |
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y***i
发帖数: 11639 | 44 多谢。只找到一篇老paper有chromosome 4的特定序列，其他的都没找到。没找到什
么人研究chromosome specific centromere sequence. |
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c******g
发帖数: 243 | 45 大家好。我是国内生物化学出身，目前的工作涉及到一些遗传学内容，但我对遗传学只
知皮毛。有以下几个问题请教大家，请不吝赐教。
（1），工作中常碰到这样一些术语：allele, locus, variant, determinant, 等。能
请哪位专业人士给出以上几个属于的简单解释，或者给出相应的中文表达吗？
（2），碰到以下句子：the major T1D susceptibility locus maps to the class II
loci HLA-DRB1 and HLA-DQB1 on chromosome 6p21。这句话中，class II 指的是什
么？能帮助将这句话翻译成中文吗？
（3），gene 和locus的区别何在？不都是指chromosome上的一段DNA序列吗？
非常感谢您的帮助。 |
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y*****1
发帖数: 73 | 46 One locus means one gene, and describes the position of the gene in one
chromosome.
Human is diploid which has two sets of chromosomes, therefore for one locus
(one gene) should have 2 alleles.
For example, MHC class II is a locus (means a gene), it has 2 alleles (means
2 copies of the gene). One is from your mom and one from your dad.
Allele could also mean variants (polymorphism), means the variation of the
gene sequence. It is caused by mutation during evolution. The MCH is highly
polymorphic... 阅读全帖 |
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t**u
发帖数: 7 | 47 帮朋友贴一个---
Postdoctoral position for Microcell Mediated Chromosome Transfer in Sloan
Kettering Institution, New York, NY.Department of Cancer Biology and
Genetics Center for Cell Engineering Sloan Kettering Institute, New York
Affiliated with Weill Medical College of Cornell University
Looking for individual who has a prior research experience on microcell
mediated chromosome transfer (MMCT).
The positions will focus on mechanistic approaches to understand 1)
reprogramming of somatic cells to plu... 阅读全帖 |
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